MX2020003821A - Proceso de elaboración de espiroderivados. - Google Patents
Proceso de elaboración de espiroderivados.Info
- Publication number
- MX2020003821A MX2020003821A MX2020003821A MX2020003821A MX2020003821A MX 2020003821 A MX2020003821 A MX 2020003821A MX 2020003821 A MX2020003821 A MX 2020003821A MX 2020003821 A MX2020003821 A MX 2020003821A MX 2020003821 A MX2020003821 A MX 2020003821A
- Authority
- MX
- Mexico
- Prior art keywords
- spiro derivatives
- preparing spiro
- methyl
- intermediates
- derivatives
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 125000003003 spiro group Chemical group 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- GCZUIPVRHLYYOG-UHFFFAOYSA-N 7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl]-1,7-diazaspiro[4.4]nonan-6-one Chemical compound O=C1N(C)CCC11NC(C=2N=C(C=C(C)N=2)C=2C=CC(=CC=2)C(F)(F)F)CC1 GCZUIPVRHLYYOG-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
- C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
- C07C65/10—Salicylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Measuring Volume Flow (AREA)
- Exhaust Gas After Treatment (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762570269P | 2017-10-10 | 2017-10-10 | |
| PCT/US2018/055227 WO2019075073A2 (en) | 2017-10-10 | 2018-10-10 | PROCESS FOR THE PREPARATION OF SPIRO DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020003821A true MX2020003821A (es) | 2023-01-12 |
Family
ID=66100090
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020003821A MX2020003821A (es) | 2017-10-10 | 2018-10-10 | Proceso de elaboración de espiroderivados. |
| MX2022013928A MX2022013928A (es) | 2017-10-10 | 2020-07-13 | Proceso de elaboracion de espiroderivados. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022013928A MX2022013928A (es) | 2017-10-10 | 2020-07-13 | Proceso de elaboracion de espiroderivados. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11149039B2 (enExample) |
| EP (1) | EP3694510A4 (enExample) |
| JP (1) | JP2020536898A (enExample) |
| KR (1) | KR20200068678A (enExample) |
| CN (1) | CN111526874A (enExample) |
| AU (1) | AU2018347349A1 (enExample) |
| CA (1) | CA3077088A1 (enExample) |
| IL (1) | IL273695A (enExample) |
| MA (1) | MA50371A (enExample) |
| MX (2) | MX2020003821A (enExample) |
| SG (1) | SG11202002707VA (enExample) |
| WO (1) | WO2019075073A2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA50371A (fr) | 2017-10-10 | 2021-03-31 | Biogen Inc | Procédé de préparation de dérivés spiro |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US814396A (en) | 1905-05-22 | 1906-03-06 | Joseph R Russell | Burner for liquid fuel. |
| KR0178475B1 (ko) * | 1995-09-14 | 1999-03-20 | 윤덕용 | 신규한 n-비닐락탐 유도체 및 그의 중합체 |
| DE60330456D1 (de) | 2002-07-05 | 2010-01-21 | Targacept Inc | N-aryl diazaspirozyklische verbindungen, deren verwendung und das verfahren zu ihren herstellung |
| US7501528B2 (en) * | 2005-03-15 | 2009-03-10 | Hoffmann-La Roche Inc. | Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives |
| GB0520578D0 (en) | 2005-10-10 | 2005-11-16 | Glaxo Group Ltd | Novel compounds |
| US8143306B2 (en) | 2005-10-10 | 2012-03-27 | Convergence Pharmaceuticals Limited | Methods of treating bipolar disorders |
| TW200728258A (en) | 2005-10-10 | 2007-08-01 | Glaxo Group Ltd | Novel compounds |
| EP1943216B1 (en) | 2005-10-10 | 2010-06-30 | Glaxo Group Limited | Prolinamide derivatives as sodium channel modulators |
| TW200730494A (en) | 2005-10-10 | 2007-08-16 | Glaxo Group Ltd | Novel compounds |
| CA2666136A1 (en) | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents |
| AU2007307638A1 (en) | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Spiro (furo [3, 2-C] pyridine-3-3 ' -indol) -2' (1'H)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain |
| GB0701365D0 (en) | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| CN101641099A (zh) | 2007-01-24 | 2010-02-03 | 葛兰素集团有限公司 | 包含3,5-二氨基-6-(2,3-二氯苯基)-1,2,4-三嗪或r(-)-2,4-二氨基-5-(2,3-二氯苯基)-6-氟甲基嘧啶和nk1的药物组合物 |
| GB0701366D0 (en) | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| GB0706630D0 (en) | 2007-04-04 | 2007-05-16 | Glaxo Group Ltd | Novel compounds |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| TWI466885B (zh) * | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
| EP2477964B1 (en) | 2009-09-14 | 2015-02-11 | Convergence Pharmaceuticals Limited | Process for preparing alpha-carboxamide derivatives |
| US8618303B2 (en) * | 2011-01-07 | 2013-12-31 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives |
| PH12013501895A1 (en) * | 2011-04-26 | 2013-10-14 | Hoffmann La Roche | Ethynyl derivatives as positive allosteric modulators of the mglur5 |
| GB201122113D0 (en) * | 2011-12-22 | 2012-02-01 | Convergence Pharmaceuticals | Novel compounds |
| GB201209015D0 (en) | 2012-05-22 | 2012-07-04 | Convergence Pharmaceuticals | Novel compounds |
| GB201209670D0 (en) | 2012-05-31 | 2012-07-18 | Convergence Pharmaceuticals | Novel compounds |
| HUE042064T2 (hu) * | 2014-08-04 | 2019-06-28 | Merck Patent Gmbh | Pirrolidinon-származékok MetAP-2 inhibitorokként |
| SG11202002200UA (en) | 2017-09-28 | 2020-04-29 | Biogen Inc | Novel salts |
| MA50371A (fr) | 2017-10-10 | 2021-03-31 | Biogen Inc | Procédé de préparation de dérivés spiro |
-
2018
- 2018-10-10 MA MA050371A patent/MA50371A/fr unknown
- 2018-10-10 EP EP18866634.1A patent/EP3694510A4/en not_active Withdrawn
- 2018-10-10 SG SG11202002707VA patent/SG11202002707VA/en unknown
- 2018-10-10 AU AU2018347349A patent/AU2018347349A1/en not_active Withdrawn
- 2018-10-10 CA CA3077088A patent/CA3077088A1/en not_active Withdrawn
- 2018-10-10 JP JP2020520223A patent/JP2020536898A/ja not_active Withdrawn
- 2018-10-10 CN CN201880066263.9A patent/CN111526874A/zh not_active Withdrawn
- 2018-10-10 MX MX2020003821A patent/MX2020003821A/es unknown
- 2018-10-10 KR KR1020207011962A patent/KR20200068678A/ko not_active Withdrawn
- 2018-10-10 US US16/754,044 patent/US11149039B2/en not_active Expired - Fee Related
- 2018-10-10 WO PCT/US2018/055227 patent/WO2019075073A2/en not_active Ceased
-
2020
- 2020-03-30 IL IL273695A patent/IL273695A/en unknown
- 2020-07-13 MX MX2022013928A patent/MX2022013928A/es unknown
-
2021
- 2021-10-15 US US17/502,653 patent/US20220033408A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3694510A2 (en) | 2020-08-19 |
| CN111526874A (zh) | 2020-08-11 |
| JP2020536898A (ja) | 2020-12-17 |
| US20200325144A1 (en) | 2020-10-15 |
| IL273695A (en) | 2020-05-31 |
| MA50371A (fr) | 2021-03-31 |
| KR20200068678A (ko) | 2020-06-15 |
| US20220033408A1 (en) | 2022-02-03 |
| EP3694510A4 (en) | 2021-06-30 |
| MX2022013928A (es) | 2022-11-30 |
| US11149039B2 (en) | 2021-10-19 |
| WO2019075073A2 (en) | 2019-04-18 |
| SG11202002707VA (en) | 2020-04-29 |
| AU2018347349A1 (en) | 2020-04-23 |
| WO2019075073A3 (en) | 2020-04-02 |
| CA3077088A1 (en) | 2019-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO2019012957A2 (es) | Inhibidores de quinasa y usos de los mismos | |
| UY37927A (es) | Proceso para la preparación de 6-(2-hidroxi-2-metilpropoxi)-4-(6-(6-((6-metoxipiridin-3-il)metil)-3,6-diazabiciclo[3.1.1]heptan-3-il)piridin-3-il)pirazolo[1,5-a]piridina-3-carbonitrilo | |
| MX2021007515A (es) | Compuestos de heterociclil piridazina como fungicidas. | |
| CL2015002343A1 (es) | Pirimidinas fusionadas sustituidas con trifluorometilo y sus usos | |
| CO2018010877A2 (es) | Ácido acrílico y métodos de producción del mismo | |
| CR20160501A (es) | Derivados de quinoxalina útiles como amortiguadores del receptor del factor de crecimiento de fibroblastos (fgfr) cinasa | |
| ECSP14020478A (es) | Formas polimórficas de (s)-2-(1-(9h-purin-6-ilamino)propil)-5-fluoro-3-fenilquinazolin-4(3h)-ona | |
| CL2015002654A1 (es) | Polipéptidos de il-22 y proteínas de fusión de il-22 fc y métodos de uso | |
| PE20150641A1 (es) | Antagonistas del receptor st2l y metodos de uso | |
| MX385450B (es) | Procedimiento para la preparación de un inhibidor de poli(adp-ribosa)polimerasa, formas cristalinas, y usos del mismo. | |
| MX2019000664A (es) | Preparacion de 14-metil-16-oxabiciclo[10.3.1]pentadecenos de 3-metil-1,5 ciclopentadecanediona. | |
| MX2017003131A (es) | Metodo para la preparacion de 2-alcoxi ciclohexanol. | |
| ECSP18074962A (es) | Derivados de aminotiazol útiles como agentes antivíricos | |
| CL2017001131A1 (es) | Síntesis de copanlisib y su sal diclorhidrato | |
| AR105774A1 (es) | Procedimiento para la preparación de (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida y su purificación para su uso como principio activo farmacéutico | |
| MX2019006958A (es) | Proceso para la preparacion de (s)-2-((2-((s)-4-(difluorometil)-2- oxooxazolidin-3-il)-5,6-dihidrobenzo[f]imidazo[1,2-d] [1,4]oxazepin-9-il)amino)propanamida. | |
| ZA201701814B (en) | Triazolo[4,5-d]pyrimidines as agonists of the cannabinoid receptor 2 | |
| MX374300B (es) | Sal de trifluoroacetato de agonista de tlr7 y forma cristalina b de la misma, métodos de preparación y usos. | |
| JOP20200110A1 (ar) | متبلورات مضادة جديدة لسلسلة من مركبات مضادة للفيروسات | |
| EP3096762C0 (en) | PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL COMPOUNDS | |
| UY34612A (es) | ?procedimiento para la preparación de derivados de isoxazolina azetidina quirales como agentes antiparasitarios?. | |
| CL2017001463A1 (es) | Poliuretanos termoplásticos novedosos, uso de este material para la preparación de marcos en t para sistemas intrauterinos y marcos en t preparados con este material. | |
| CO2019006395A2 (es) | Polimorfos de sulfonamidas herbicidas | |
| CR20160373A (es) | Ciclopentanos, tetrahidrofuranos y pirrolidinas sustituidas como antagonistas del receptor de orexina | |
| MX2020003821A (es) | Proceso de elaboración de espiroderivados. |