MX2020003821A - Proceso de elaboración de espiroderivados. - Google Patents
Proceso de elaboración de espiroderivados.Info
- Publication number
- MX2020003821A MX2020003821A MX2020003821A MX2020003821A MX2020003821A MX 2020003821 A MX2020003821 A MX 2020003821A MX 2020003821 A MX2020003821 A MX 2020003821A MX 2020003821 A MX2020003821 A MX 2020003821A MX 2020003821 A MX2020003821 A MX 2020003821A
- Authority
- MX
- Mexico
- Prior art keywords
- spiro derivatives
- preparing spiro
- methyl
- intermediates
- derivatives
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 125000003003 spiro group Chemical group 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- GCZUIPVRHLYYOG-UHFFFAOYSA-N 7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl]-1,7-diazaspiro[4.4]nonan-6-one Chemical compound O=C1N(C)CCC11NC(C=2N=C(C=C(C)N=2)C=2C=CC(=CC=2)C(F)(F)F)CC1 GCZUIPVRHLYYOG-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
- C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
- C07C65/10—Salicylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Measuring Volume Flow (AREA)
- Exhaust Gas After Treatment (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762570269P | 2017-10-10 | 2017-10-10 | |
| PCT/US2018/055227 WO2019075073A2 (en) | 2017-10-10 | 2018-10-10 | PROCESS FOR THE PREPARATION OF SPIRO DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020003821A true MX2020003821A (es) | 2023-01-12 |
Family
ID=66100090
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020003821A MX2020003821A (es) | 2017-10-10 | 2018-10-10 | Proceso de elaboración de espiroderivados. |
| MX2022013928A MX2022013928A (es) | 2017-10-10 | 2020-07-13 | Proceso de elaboracion de espiroderivados. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022013928A MX2022013928A (es) | 2017-10-10 | 2020-07-13 | Proceso de elaboracion de espiroderivados. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11149039B2 (enExample) |
| EP (1) | EP3694510A4 (enExample) |
| JP (1) | JP2020536898A (enExample) |
| KR (1) | KR20200068678A (enExample) |
| CN (1) | CN111526874A (enExample) |
| AU (1) | AU2018347349A1 (enExample) |
| CA (1) | CA3077088A1 (enExample) |
| IL (1) | IL273695A (enExample) |
| MA (1) | MA50371A (enExample) |
| MX (2) | MX2020003821A (enExample) |
| SG (1) | SG11202002707VA (enExample) |
| WO (1) | WO2019075073A2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020536898A (ja) | 2017-10-10 | 2020-12-17 | バイオジェン インコーポレイテッド | スピロ誘導体を調製するためのプロセス |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US814396A (en) | 1905-05-22 | 1906-03-06 | Joseph R Russell | Burner for liquid fuel. |
| KR0178475B1 (ko) * | 1995-09-14 | 1999-03-20 | 윤덕용 | 신규한 n-비닐락탐 유도체 및 그의 중합체 |
| EA009789B1 (ru) | 2002-07-05 | 2008-04-28 | Таргасепт, Инк. | N-арилдиазаспирациклические соединения и способы их получения и применения |
| US7501528B2 (en) * | 2005-03-15 | 2009-03-10 | Hoffmann-La Roche Inc. | Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives |
| TW200728258A (en) | 2005-10-10 | 2007-08-01 | Glaxo Group Ltd | Novel compounds |
| ATE472529T1 (de) | 2005-10-10 | 2010-07-15 | Glaxo Group Ltd | Prolinamidderivate als natriumkanalmodulatoren |
| US8143306B2 (en) | 2005-10-10 | 2012-03-27 | Convergence Pharmaceuticals Limited | Methods of treating bipolar disorders |
| TW200730494A (en) | 2005-10-10 | 2007-08-16 | Glaxo Group Ltd | Novel compounds |
| GB0520578D0 (en) | 2005-10-10 | 2005-11-16 | Glaxo Group Ltd | Novel compounds |
| CA2666143A1 (en) | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain |
| WO2008046046A1 (en) | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents |
| GB0701366D0 (en) | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| JP2010516731A (ja) | 2007-01-24 | 2010-05-20 | グラクソ グループ リミテッド | ２−メトキシ−５−（５−トリフルオロメチル−テトラゾール−１−イル）−ベンジル］−（２ｓ−フェニル−ピペリジン−３ｓ−イル）−アミンを含む医薬組成物 |
| GB0701365D0 (en) | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| GB0706630D0 (en) | 2007-04-04 | 2007-05-16 | Glaxo Group Ltd | Novel compounds |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| TWI466885B (zh) * | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
| PL2477964T3 (pl) | 2009-09-14 | 2015-08-31 | Convergence Pharmaceuticals | Proces wytwarzania pochodnych alfa-karboksyamidu |
| US8618303B2 (en) * | 2011-01-07 | 2013-12-31 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives |
| KR101554803B1 (ko) * | 2011-04-26 | 2015-09-21 | 에프. 호프만-라 로슈 아게 | Mglur5의 양성 알로스테릭 조절체로서 에틴일 유도체 |
| GB201122113D0 (en) * | 2011-12-22 | 2012-02-01 | Convergence Pharmaceuticals | Novel compounds |
| GB201209015D0 (en) | 2012-05-22 | 2012-07-04 | Convergence Pharmaceuticals | Novel compounds |
| GB201209670D0 (en) | 2012-05-31 | 2012-07-18 | Convergence Pharmaceuticals | Novel compounds |
| SG11201700832YA (en) * | 2014-08-04 | 2017-03-30 | Merck Patent Gmbh | Pyrrolidinone derivatives as metap-2 inhibitors |
| JP2020536070A (ja) | 2017-09-28 | 2020-12-10 | バイオジェン インコーポレイテッド | 新規な塩 |
| JP2020536898A (ja) | 2017-10-10 | 2020-12-17 | バイオジェン インコーポレイテッド | スピロ誘導体を調製するためのプロセス |
-
2018
- 2018-10-10 JP JP2020520223A patent/JP2020536898A/ja not_active Withdrawn
- 2018-10-10 CN CN201880066263.9A patent/CN111526874A/zh not_active Withdrawn
- 2018-10-10 WO PCT/US2018/055227 patent/WO2019075073A2/en not_active Ceased
- 2018-10-10 US US16/754,044 patent/US11149039B2/en not_active Expired - Fee Related
- 2018-10-10 KR KR1020207011962A patent/KR20200068678A/ko not_active Withdrawn
- 2018-10-10 AU AU2018347349A patent/AU2018347349A1/en not_active Withdrawn
- 2018-10-10 MX MX2020003821A patent/MX2020003821A/es unknown
- 2018-10-10 EP EP18866634.1A patent/EP3694510A4/en not_active Withdrawn
- 2018-10-10 CA CA3077088A patent/CA3077088A1/en not_active Withdrawn
- 2018-10-10 MA MA050371A patent/MA50371A/fr unknown
- 2018-10-10 SG SG11202002707VA patent/SG11202002707VA/en unknown
-
2020
- 2020-03-30 IL IL273695A patent/IL273695A/en unknown
- 2020-07-13 MX MX2022013928A patent/MX2022013928A/es unknown
-
2021
- 2021-10-15 US US17/502,653 patent/US20220033408A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2022013928A (es) | 2022-11-30 |
| US20220033408A1 (en) | 2022-02-03 |
| CA3077088A1 (en) | 2019-04-18 |
| WO2019075073A3 (en) | 2020-04-02 |
| MA50371A (fr) | 2021-03-31 |
| US11149039B2 (en) | 2021-10-19 |
| CN111526874A (zh) | 2020-08-11 |
| IL273695A (en) | 2020-05-31 |
| SG11202002707VA (en) | 2020-04-29 |
| AU2018347349A1 (en) | 2020-04-23 |
| JP2020536898A (ja) | 2020-12-17 |
| WO2019075073A2 (en) | 2019-04-18 |
| US20200325144A1 (en) | 2020-10-15 |
| EP3694510A4 (en) | 2021-06-30 |
| EP3694510A2 (en) | 2020-08-19 |
| KR20200068678A (ko) | 2020-06-15 |
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