JP2020535811A5 - - Google Patents

Info

Publication number

JP2020535811A5

JP2020535811A5 JP2020517953A JP2020517953A JP2020535811A5 JP 2020535811 A5 JP2020535811 A5 JP 2020535811A5 JP 2020517953 A JP2020517953 A JP 2020517953A JP 2020517953 A JP2020517953 A JP 2020517953A JP 2020535811 A5 JP2020535811 A5 JP 2020535811A5

Authority

JP

Japan

Prior art keywords

binding molecule

specific binding

domain

specific

vnar

Prior art date

2018-09-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 230000009870 specific binding Effects 0.000 claims 14
• 239000000427 antigen Substances 0.000 claims 9
• 102000036639 antigens Human genes 0.000 claims 9
• 108091007433 antigens Proteins 0.000 claims 9
• 230000027455 binding Effects 0.000 claims 6
• 210000004027 cell Anatomy 0.000 claims 4
• 125000006850 spacer group Chemical group 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 108060003951 Immunoglobulin Proteins 0.000 claims 2
• 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 2
• 102000018358 immunoglobulin Human genes 0.000 claims 2
• 102000040430 polynucleotide Human genes 0.000 claims 2
• 108091033319 polynucleotide Proteins 0.000 claims 2
• 239000002157 polynucleotide Substances 0.000 claims 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• 102000004506 Blood Proteins Human genes 0.000 claims 1
• 108010017384 Blood Proteins Proteins 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 1
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 210000002744 extracellular matrix Anatomy 0.000 claims 1
• 239000003102 growth factor Substances 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 239000005556 hormone Substances 0.000 claims 1
• 230000005847 immunogenicity Effects 0.000 claims 1
• 230000003834 intracellular effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000012528 membrane Substances 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 230000000813 microbial effect Effects 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1