JP2020535811A - 特異的結合分子 - Google Patents

特異的結合分子 Download PDF

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Publication number
JP2020535811A
JP2020535811A JP2020517953A JP2020517953A JP2020535811A JP 2020535811 A JP2020535811 A JP 2020535811A JP 2020517953 A JP2020517953 A JP 2020517953A JP 2020517953 A JP2020517953 A JP 2020517953A JP 2020535811 A JP2020535811 A JP 2020535811A
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JP
Japan
Prior art keywords
vnar
binding molecule
domain
specific binding
binding
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020517953A
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English (en)
Japanese (ja)
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JP2020535811A5 (enExample
Inventor
ウバー，オビナ
バレル，キャロライン
ポーター，アンドリュー
Original Assignee
エラスモーゲン リミテッド
エラスモーゲン リミテッド
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Application filed by エラスモーゲン リミテッド, エラスモーゲン リミテッド filed Critical エラスモーゲン リミテッド
Publication of JP2020535811A publication Critical patent/JP2020535811A/ja
Publication of JP2020535811A5 publication Critical patent/JP2020535811A5/ja
Priority to JP2023149770A priority Critical patent/JP7818828B2/ja
Priority to JP2025127980A priority patent/JP2025160405A/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2020517953A 2017-09-27 2018-09-27 特異的結合分子 Pending JP2020535811A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023149770A JP7818828B2 (ja) 2017-09-27 2023-09-15 特異的結合分子
JP2025127980A JP2025160405A (ja) 2017-09-27 2025-07-31 特異的結合分子

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762563948P 2017-09-27 2017-09-27
US62/563,948 2017-09-27
US201862667126P 2018-05-04 2018-05-04
US62/667,126 2018-05-04
PCT/EP2018/076333 WO2019063726A1 (en) 2017-09-27 2018-09-27 SPECIFIC BINDING MOLECULES

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023149770A Division JP7818828B2 (ja) 2017-09-27 2023-09-15 特異的結合分子

Publications (2)

Publication Number Publication Date
JP2020535811A true JP2020535811A (ja) 2020-12-10
JP2020535811A5 JP2020535811A5 (enExample) 2021-11-04

Family

ID=63720686

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020517953A Pending JP2020535811A (ja) 2017-09-27 2018-09-27 特異的結合分子
JP2023149770A Active JP7818828B2 (ja) 2017-09-27 2023-09-15 特異的結合分子
JP2025127980A Pending JP2025160405A (ja) 2017-09-27 2025-07-31 特異的結合分子

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023149770A Active JP7818828B2 (ja) 2017-09-27 2023-09-15 特異的結合分子
JP2025127980A Pending JP2025160405A (ja) 2017-09-27 2025-07-31 特異的結合分子

Country Status (7)

Country Link
US (2) US11919949B2 (enExample)
EP (2) EP3688030B1 (enExample)
JP (3) JP2020535811A (enExample)
KR (1) KR102657978B1 (enExample)
CN (1) CN111479825A (enExample)
CA (1) CA3075367A1 (enExample)
WO (1) WO2019063726A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109477084A (zh) * 2016-07-19 2019-03-15 国立研究开发法人农业·食品产业技术综合研究机构 使用等离子体在植物细胞内导入物质的方法
US11414785B2 (en) 2019-08-13 2022-08-16 Waters Technologies Corporation Affinity resins and sample preparation devices based on cartilaginous fish IgNAR derived binding domains
GB202020152D0 (en) 2020-12-18 2021-02-03 Elasmogen Ltd Fast-track humanisation of specific binding molecules
WO2023077287A1 (en) * 2021-11-03 2023-05-11 City university of hong kong shenzhen research institute High-affinity anti-egfp and anti-sars-cov-2 vnar single domain antibodies and use thereof
GB202407865D0 (en) 2024-06-03 2024-07-17 Elasmogen Ltd Self immolative compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015200883A2 (en) * 2014-06-26 2015-12-30 Ossianix, Inc. Semi-synthetic nurse shark vnar libraries for making and using selective binding compounds
JP2016524592A (ja) * 2013-04-23 2016-08-18 ザ ユニバーシティ コート オブ ザ ユニバーシティ オブ アバディーン Ｉｃｏｓｌへの治療上の標的特異的ｖｎａｒドメインの単離

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
AU2002319544B2 (en) 2001-08-10 2008-07-10 Aberdeen University Antigen binding domains from fish
DK1751181T3 (da) 2004-06-02 2012-11-26 Adalta Pty Ltd BINDINGSDELE, DER ER BASERET PÅ HAJ IgNAR-DOMÆNER
US8496933B2 (en) * 2009-11-04 2013-07-30 Laboratorios Silanes, S.A. De C.V. VHNAR anti-cytokine domains
MY167125A (en) * 2011-08-17 2018-08-13 Glaxo Group Ltd Modified proteins and peptides
WO2013167883A1 (en) 2012-05-07 2013-11-14 The University Court Of The University Of Aberdeen Single domain binding molecule

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016524592A (ja) * 2013-04-23 2016-08-18 ザ ユニバーシティ コート オブ ザ ユニバーシティ オブ アバディーン Ｉｃｏｓｌへの治療上の標的特異的ｖｎａｒドメインの単離
WO2015200883A2 (en) * 2014-06-26 2015-12-30 Ossianix, Inc. Semi-synthetic nurse shark vnar libraries for making and using selective binding compounds

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EXPERT OPIN. BIOL. THER., vol. 14, no. 10, JPN6022038396, 2014, pages 1527 - 1539, ISSN: 0005058474 *
MABS, vol. 5, no. 1, JPN6022038397, 2013, pages 80 - 85, ISSN: 0005058475 *
SCIENTIFIC REPORTS, vol. Vol. 7:9676, JPN6022038395, 29 August 2017 (2017-08-29), pages 1 - 13, ISSN: 0005058473 *

Also Published As

Publication number Publication date
EP3688030B1 (en) 2024-12-11
US20200407437A1 (en) 2020-12-31
JP2025160405A (ja) 2025-10-22
JP7818828B2 (ja) 2026-02-24
KR20200062215A (ko) 2020-06-03
KR102657978B1 (ko) 2024-04-16
US12371484B2 (en) 2025-07-29
EP3688030A1 (en) 2020-08-05
CA3075367A1 (en) 2019-04-04
CN111479825A (zh) 2020-07-31
JP2023175822A (ja) 2023-12-12
WO2019063726A1 (en) 2019-04-04
EP4570826A2 (en) 2025-06-18
EP4570826A3 (en) 2025-09-24
US11919949B2 (en) 2024-03-05
US20240247058A1 (en) 2024-07-25

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