JP2020535144A5 - - Google Patents
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- JP2020535144A5 JP2020535144A5 JP2020516857A JP2020516857A JP2020535144A5 JP 2020535144 A5 JP2020535144 A5 JP 2020535144A5 JP 2020516857 A JP2020516857 A JP 2020516857A JP 2020516857 A JP2020516857 A JP 2020516857A JP 2020535144 A5 JP2020535144 A5 JP 2020535144A5
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- Prior art keywords
- alkyl
- group
- inhibitor
- pharmaceutical composition
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 57
- 239000008194 pharmaceutical composition Substances 0.000 claims 32
- 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 claims 21
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 19
- 239000012270 PD-1 inhibitor Substances 0.000 claims 18
- 239000012668 PD-1-inhibitor Substances 0.000 claims 18
- 239000012271 PD-L1 inhibitor Substances 0.000 claims 18
- 229910052757 nitrogen Inorganic materials 0.000 claims 18
- 229940121655 pd-1 inhibitor Drugs 0.000 claims 18
- 229940121656 pd-l1 inhibitor Drugs 0.000 claims 18
- 125000001424 substituent group Chemical group 0.000 claims 18
- 125000003118 aryl group Chemical group 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 229910052799 carbon Inorganic materials 0.000 claims 13
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 125000005842 heteroatom Chemical group 0.000 claims 11
- 229910052760 oxygen Inorganic materials 0.000 claims 11
- 229910052717 sulfur Inorganic materials 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 9
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 claims 7
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 claims 7
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 5
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 5
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 5
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 229940125429 CCR2 chemokine receptor antagonist Drugs 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 229960000106 biosimilars Drugs 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 1
- 125000006625 (C3-C8) cycloalkyloxy group Chemical group 0.000 claims 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims 1
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 1
- 125000001960 7 membered carbocyclic group Chemical group 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 1
- 229940122444 Chemokine receptor antagonist Drugs 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- -1 O-R u Chemical group 0.000 claims 1
- 239000012269 PD-1/PD-L1 inhibitor Substances 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 229960003852 atezolizumab Drugs 0.000 claims 1
- 229950002916 avelumab Drugs 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000002604 chemokine receptor CCR2 antagonist Substances 0.000 claims 1
- 239000002559 chemokine receptor antagonist Substances 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229950009791 durvalumab Drugs 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 125000005241 heteroarylamino group Chemical group 0.000 claims 1
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 229940121653 pd-1/pd-l1 inhibitor Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229950010773 pidilizumab Drugs 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 201000002025 prostate sarcoma Diseases 0.000 claims 1
- 125000001422 pyrrolinyl group Chemical group 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 229940121497 sintilimab Drugs 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 0 C[C@@](C*(CC1)[C@](CC2)C*=C2C(*(Cc2cc(N)c3)COc2c3N)=O)*1c(cc1)cc(C(*)=O)c1N Chemical compound C[C@@](C*(CC1)[C@](CC2)C*=C2C(*(Cc2cc(N)c3)COc2c3N)=O)*1c(cc1)cc(C(*)=O)c1N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023168563A JP2023181168A (ja) | 2017-09-25 | 2023-09-28 | ケモカイン受容体２（ｃｃｒ２）アンタゴニスト及びｐｄ－１／ｐｄ－ｌ１阻害剤を使用した併用療法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762562952P | 2017-09-25 | 2017-09-25 | |
| US62/562,952 | 2017-09-25 | ||
| PCT/US2018/052408 WO2019060820A1 (en) | 2017-09-25 | 2018-09-24 | POLYTHERAPY USING A CHEMOKINE RECEPTOR 2 (CCR2) ANTAGONIST AND A PD-1 / PD-L1 INHIBITOR |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023168563A Division JP2023181168A (ja) | 2017-09-25 | 2023-09-28 | ケモカイン受容体２（ｃｃｒ２）アンタゴニスト及びｐｄ－１／ｐｄ－ｌ１阻害剤を使用した併用療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020535144A JP2020535144A (ja) | 2020-12-03 |
| JP2020535144A5 true JP2020535144A5 (https=) | 2021-11-04 |
| JP7453139B2 JP7453139B2 (ja) | 2024-03-19 |
Family
ID=65810578
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020516857A Active JP7453139B2 (ja) | 2017-09-25 | 2018-09-24 | ケモカイン受容体２（ｃｃｒ２）アンタゴニスト及びｐｄ－１／ｐｄ－ｌ１阻害剤を使用した併用療法 |
| JP2023168563A Pending JP2023181168A (ja) | 2017-09-25 | 2023-09-28 | ケモカイン受容体２（ｃｃｒ２）アンタゴニスト及びｐｄ－１／ｐｄ－ｌ１阻害剤を使用した併用療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023168563A Pending JP2023181168A (ja) | 2017-09-25 | 2023-09-28 | ケモカイン受容体２（ｃｃｒ２）アンタゴニスト及びｐｄ－１／ｐｄ－ｌ１阻害剤を使用した併用療法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US11304952B2 (https=) |
| EP (1) | EP3687525B1 (https=) |
| JP (2) | JP7453139B2 (https=) |
| KR (1) | KR102677442B1 (https=) |
| CN (2) | CN118267479A (https=) |
| AR (1) | AR112831A1 (https=) |
| AU (2) | AU2018335486B8 (https=) |
| BR (1) | BR112020005284A2 (https=) |
| CA (2) | CA3293051A1 (https=) |
| ES (1) | ES3058135T3 (https=) |
| IL (1) | IL273188B2 (https=) |
| MA (1) | MA50665A (https=) |
| MX (1) | MX2020003192A (https=) |
| SG (1) | SG11202002119QA (https=) |
| TW (1) | TWI875682B (https=) |
| WO (1) | WO2019060820A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2904252T3 (es) | 2015-05-21 | 2022-04-04 | Chemocentryx Inc | Moduladores de CCR2 |
| US20190275015A1 (en) * | 2017-09-25 | 2019-09-12 | Chemocentryx, Inc. | Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor |
| US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| IL275898B2 (en) * | 2018-01-08 | 2025-05-01 | Chemocentryx Inc | Methods for treating solid tumors with CCR2 antagonists |
| JP7387616B2 (ja) | 2018-02-22 | 2023-11-28 | ケモセントリックス，インコーポレイティド | Ｐｄ－ｌ１アンタゴニストとしてのインダン－アミン |
| AU2020276277B2 (en) | 2019-05-15 | 2025-03-20 | Chemocentryx, Inc. | Triaryl compounds for treatment of PD-L1 diseases |
| BR112021025888A2 (pt) | 2019-07-10 | 2022-04-26 | Chemocentryx Inc | Indanos como inibidores de pd-l1 |
| CN114555080B (zh) | 2019-10-16 | 2025-10-10 | 凯莫森特里克斯股份有限公司 | 用于治疗pd-l1疾病的杂芳基联苯胺 |
| AU2020368393B2 (en) | 2019-10-16 | 2026-01-08 | Chemocentryx, Inc. | Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases |
| CN114907267A (zh) * | 2021-02-08 | 2022-08-16 | 中国科学院上海药物研究所 | 用于抗肿瘤的药物组合 |
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2018
- 2018-09-24 CN CN202311614899.1A patent/CN118267479A/zh active Pending
- 2018-09-24 KR KR1020207011664A patent/KR102677442B1/ko active Active
- 2018-09-24 MX MX2020003192A patent/MX2020003192A/es unknown
- 2018-09-24 WO PCT/US2018/052408 patent/WO2019060820A1/en not_active Ceased
- 2018-09-24 AU AU2018335486A patent/AU2018335486B8/en active Active
- 2018-09-24 SG SG11202002119QA patent/SG11202002119QA/en unknown
- 2018-09-24 MA MA050665A patent/MA50665A/fr unknown
- 2018-09-24 CA CA3293051A patent/CA3293051A1/en active Pending
- 2018-09-24 IL IL273188A patent/IL273188B2/en unknown
- 2018-09-24 EP EP18857688.8A patent/EP3687525B1/en active Active
- 2018-09-24 CN CN201880062100.3A patent/CN111712242B/zh active Active
- 2018-09-24 AR ARP180102736A patent/AR112831A1/es unknown
- 2018-09-24 US US16/139,745 patent/US11304952B2/en active Active
- 2018-09-24 BR BR112020005284-1A patent/BR112020005284A2/pt not_active Application Discontinuation
- 2018-09-24 JP JP2020516857A patent/JP7453139B2/ja active Active
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- 2018-09-24 CA CA3075638A patent/CA3075638A1/en active Pending
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2023
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2024
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