JP2020534806A5 - - Google Patents
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- Publication number
- JP2020534806A5 JP2020534806A5 JP2020512715A JP2020512715A JP2020534806A5 JP 2020534806 A5 JP2020534806 A5 JP 2020534806A5 JP 2020512715 A JP2020512715 A JP 2020512715A JP 2020512715 A JP2020512715 A JP 2020512715A JP 2020534806 A5 JP2020534806 A5 JP 2020534806A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- acyltransferase
- retinol
- long chain
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 13
- 102000057234 Acyl transferases Human genes 0.000 claims 11
- 108700016155 Acyl transferases Proteins 0.000 claims 11
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 8
- WWDMJSSVVPXVSV-YCNIQYBTSA-N retinyl ester Chemical compound CC1CCCC(C)(C)C1\C=C\C(\C)=C\C=C\C(\C)=C\C(O)=O WWDMJSSVVPXVSV-YCNIQYBTSA-N 0.000 claims 6
- 229960003471 retinol Drugs 0.000 claims 5
- 235000020944 retinol Nutrition 0.000 claims 5
- 239000011607 retinol Substances 0.000 claims 5
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 235000019155 vitamin A Nutrition 0.000 claims 3
- 239000011719 vitamin A Substances 0.000 claims 3
- 229940045997 vitamin a Drugs 0.000 claims 3
- 241000195493 Cryptophyta Species 0.000 claims 2
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 claims 2
- 241000233866 Fungi Species 0.000 claims 2
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 241000235013 Yarrowia Species 0.000 claims 2
- 230000002255 enzymatic effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000004492 retinoid derivatives Chemical class 0.000 claims 2
- 125000000946 retinyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])=C([H])/C([H])=C(C([H])([H])[H])/C([H])=C([H])/C1=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000006471 Fucosyltransferases Human genes 0.000 claims 1
- 108010019236 Fucosyltransferases Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 108700014220 acyltransferase activity proteins Proteins 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- -1 sulfonyl ester Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762562680P | 2017-09-25 | 2017-09-25 | |
| US62/562,680 | 2017-09-25 | ||
| PCT/EP2018/076021 WO2019057996A1 (en) | 2017-09-25 | 2018-09-25 | Production of retinyl esters |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020534806A JP2020534806A (ja) | 2020-12-03 |
| JP2020534806A5 true JP2020534806A5 (enExample) | 2021-10-28 |
| JP7298812B2 JP7298812B2 (ja) | 2023-06-27 |
Family
ID=63708371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020512715A Active JP7298812B2 (ja) | 2017-09-25 | 2018-09-25 | レチニルエステルの生産 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11905542B2 (enExample) |
| EP (1) | EP3688180A1 (enExample) |
| JP (1) | JP7298812B2 (enExample) |
| CN (1) | CN111108212A (enExample) |
| BR (1) | BR112020005769A2 (enExample) |
| WO (1) | WO2019057996A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020005774A2 (pt) * | 2017-09-25 | 2020-09-24 | Dsm Ip Assets B.V. | biossíntese de retinoides |
| CN112522331B (zh) * | 2020-12-09 | 2024-03-22 | 上海克琴科技有限公司 | 一种生物酶催化的羟基频哪酮视黄酸酯的合成方法 |
| EP4626260A2 (en) * | 2022-12-02 | 2025-10-08 | DSM IP Assets B.V. | Fermentatively-produced retinoid containing compositions, and the methdos of making and using the same |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040038209A1 (en) * | 1999-12-24 | 2004-02-26 | Lintig Johannes Von | Method for the production of vitamin a |
| CN103589650A (zh) | 2005-03-18 | 2014-02-19 | 米克罗比亚公司 | 产油酵母和真菌中类胡萝卜素的产生 |
| US8691555B2 (en) | 2006-09-28 | 2014-04-08 | Dsm Ip Assests B.V. | Production of carotenoids in oleaginous yeast and fungi |
| EP2294193A4 (en) | 2008-04-10 | 2012-11-28 | Dsm Ip Assets Bv | PRODUCTION OF CAROTENOIDS IN YEAST AND OLEAGINOUS FUNGI |
| CA2895166C (en) | 2012-12-20 | 2022-10-04 | Dsm Ip Assets B.V. | Acetyl transferases and their use for producing carotenoids |
| KR20140147982A (ko) | 2013-06-20 | 2014-12-31 | 경상대학교산학협력단 | 레티노이드 생산에 관여하는 효소를 코딩하는 유전자를 포함하는 미생물 및 이를 이용한 레티노이드의 생산 방법 |
| CN107532135A (zh) | 2015-04-21 | 2018-01-02 | 帝斯曼知识产权资产管理有限公司 | 萜类化合物的微生物生产 |
-
2018
- 2018-09-25 JP JP2020512715A patent/JP7298812B2/ja active Active
- 2018-09-25 WO PCT/EP2018/076021 patent/WO2019057996A1/en not_active Ceased
- 2018-09-25 EP EP18779342.7A patent/EP3688180A1/en not_active Withdrawn
- 2018-09-25 BR BR112020005769-0A patent/BR112020005769A2/pt not_active Application Discontinuation
- 2018-09-25 US US16/648,872 patent/US11905542B2/en active Active
- 2018-09-25 CN CN201880061522.9A patent/CN111108212A/zh active Pending
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