CN111108212A - 视黄酯的生产 - Google Patents

视黄酯的生产 Download PDF

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Publication number
CN111108212A
CN111108212A CN201880061522.9A CN201880061522A CN111108212A CN 111108212 A CN111108212 A CN 111108212A CN 201880061522 A CN201880061522 A CN 201880061522A CN 111108212 A CN111108212 A CN 111108212A
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CN
China
Prior art keywords
leu
host cell
acyltransferase
ser
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880061522.9A
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English (en)
Chinese (zh)
Inventor
纳塔利·鲍尔奇
保罗·布洛姆奎斯特
立德·多顿
彼得·休斯顿
伊桑·林
珍娜·麦克马洪
约书亚·特鲁哈特
席琳·维亚罗格
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DSM IP Assets BV
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DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of CN111108212A publication Critical patent/CN111108212A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/0102—Diacylglycerol O-acyltransferase (2.3.1.20)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201880061522.9A 2017-09-25 2018-09-25 视黄酯的生产 Pending CN111108212A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762562680P 2017-09-25 2017-09-25
US62/562,680 2017-09-25
PCT/EP2018/076021 WO2019057996A1 (en) 2017-09-25 2018-09-25 Production of retinyl esters

Publications (1)

Publication Number Publication Date
CN111108212A true CN111108212A (zh) 2020-05-05

Family

ID=63708371

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880061522.9A Pending CN111108212A (zh) 2017-09-25 2018-09-25 视黄酯的生产

Country Status (6)

Country Link
US (1) US11905542B2 (enExample)
EP (1) EP3688180A1 (enExample)
JP (1) JP7298812B2 (enExample)
CN (1) CN111108212A (enExample)
BR (1) BR112020005769A2 (enExample)
WO (1) WO2019057996A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112522331A (zh) * 2020-12-09 2021-03-19 上海克琴科技有限公司 一种生物酶催化的羟基频哪酮视黄酸酯的合成方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7472427B2 (ja) * 2017-09-25 2024-04-23 ディーエスエム アイピー アセッツ ビー．ブイ． レチノイドの生合成
US20240216321A1 (en) * 2022-12-02 2024-07-04 Dsm Ip Assets B.V. Fermentatively-produced retinoid containing compositions, and the methdos of making and using the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1423693A (zh) * 1999-12-24 2003-06-11 辛根塔参与股份公司 生产维生素a的方法
CN101218352A (zh) * 2005-03-18 2008-07-09 米克罗比亚精确工程公司 产油酵母和真菌中类胡萝卜素的产生

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691555B2 (en) 2006-09-28 2014-04-08 Dsm Ip Assests B.V. Production of carotenoids in oleaginous yeast and fungi
US20120149886A1 (en) 2008-04-10 2012-06-14 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
CA2895166C (en) 2012-12-20 2022-10-04 Dsm Ip Assets B.V. Acetyl transferases and their use for producing carotenoids
KR20140147982A (ko) 2013-06-20 2014-12-31 경상대학교산학협력단 레티노이드 생산에 관여하는 효소를 코딩하는 유전자를 포함하는 미생물 및 이를 이용한 레티노이드의 생산 방법
CA2980649A1 (en) 2015-04-21 2016-10-27 Dsm Ip Assets B.V. Geranylgeranyl pyrophosphate synthase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1423693A (zh) * 1999-12-24 2003-06-11 辛根塔参与股份公司 生产维生素a的方法
CN101218352A (zh) * 2005-03-18 2008-07-09 米克罗比亚精确工程公司 产油酵母和真菌中类胡萝卜素的产生

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHI-LIANG ERIC YEN等: "DGAT enzymes and triacylglycerol biosynthesis" *
SEUNG-HYE HONG等: "Biochemical properties of retinoid-converting enzymes and biotechnological production of retinoids" *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112522331A (zh) * 2020-12-09 2021-03-19 上海克琴科技有限公司 一种生物酶催化的羟基频哪酮视黄酸酯的合成方法
CN112522331B (zh) * 2020-12-09 2024-03-22 上海克琴科技有限公司 一种生物酶催化的羟基频哪酮视黄酸酯的合成方法

Also Published As

Publication number Publication date
JP2020534806A (ja) 2020-12-03
WO2019057996A1 (en) 2019-03-28
BR112020005769A2 (pt) 2020-09-24
US11905542B2 (en) 2024-02-20
JP7298812B2 (ja) 2023-06-27
EP3688180A1 (en) 2020-08-05
US20200239924A1 (en) 2020-07-30

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Application publication date: 20200505