BR112020005769A2 - produção de ésteres retinílicos - Google Patents

produção de ésteres retinílicos Download PDF

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Publication number
BR112020005769A2
BR112020005769A2 BR112020005769-0A BR112020005769A BR112020005769A2 BR 112020005769 A2 BR112020005769 A2 BR 112020005769A2 BR 112020005769 A BR112020005769 A BR 112020005769A BR 112020005769 A2 BR112020005769 A2 BR 112020005769A2
Authority
BR
Brazil
Prior art keywords
host cell
acyltransferase
carotenoid
long
retinol
Prior art date
Application number
BR112020005769-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Nathalie BALCH
Paul Blomquist
Reed Doten
Peter HOUSTON
Ethan Lam
Jenna MCMAHON
Joshua Trueheart
Celine ViAROUGE
Original Assignee
Dsm Ip Assets B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets B.V. filed Critical Dsm Ip Assets B.V.
Publication of BR112020005769A2 publication Critical patent/BR112020005769A2/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/0102Diacylglycerol O-acyltransferase (2.3.1.20)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Enzymes And Modification Thereof (AREA)
BR112020005769-0A 2017-09-25 2018-09-25 produção de ésteres retinílicos BR112020005769A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762562680P 2017-09-25 2017-09-25
US62/562,680 2017-09-25
PCT/EP2018/076021 WO2019057996A1 (en) 2017-09-25 2018-09-25 Production of retinyl esters

Publications (1)

Publication Number Publication Date
BR112020005769A2 true BR112020005769A2 (pt) 2020-09-24

Family

ID=63708371

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112020005769-0A BR112020005769A2 (pt) 2017-09-25 2018-09-25 produção de ésteres retinílicos

Country Status (6)

Country Link
US (1) US11905542B2 (enExample)
EP (1) EP3688180A1 (enExample)
JP (1) JP7298812B2 (enExample)
CN (1) CN111108212A (enExample)
BR (1) BR112020005769A2 (enExample)
WO (1) WO2019057996A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7472427B2 (ja) * 2017-09-25 2024-04-23 ディーエスエム アイピー アセッツ ビー.ブイ. レチノイドの生合成
CN112522331B (zh) * 2020-12-09 2024-03-22 上海克琴科技有限公司 一种生物酶催化的羟基频哪酮视黄酸酯的合成方法
US20240216321A1 (en) * 2022-12-02 2024-07-04 Dsm Ip Assets B.V. Fermentatively-produced retinoid containing compositions, and the methdos of making and using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001048162A2 (en) * 1999-12-24 2001-07-05 Syngenta Participations Ag Method for the production of vitamin a
CA2602183C (en) 2005-03-18 2014-05-06 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
US8691555B2 (en) 2006-09-28 2014-04-08 Dsm Ip Assests B.V. Production of carotenoids in oleaginous yeast and fungi
US20120149886A1 (en) 2008-04-10 2012-06-14 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
CA2895166C (en) 2012-12-20 2022-10-04 Dsm Ip Assets B.V. Acetyl transferases and their use for producing carotenoids
KR20140147982A (ko) 2013-06-20 2014-12-31 경상대학교산학협력단 레티노이드 생산에 관여하는 효소를 코딩하는 유전자를 포함하는 미생물 및 이를 이용한 레티노이드의 생산 방법
CA2980649A1 (en) 2015-04-21 2016-10-27 Dsm Ip Assets B.V. Geranylgeranyl pyrophosphate synthase

Also Published As

Publication number Publication date
JP2020534806A (ja) 2020-12-03
WO2019057996A1 (en) 2019-03-28
US11905542B2 (en) 2024-02-20
JP7298812B2 (ja) 2023-06-27
EP3688180A1 (en) 2020-08-05
CN111108212A (zh) 2020-05-05
US20200239924A1 (en) 2020-07-30

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements