JP7298812B2 - レチニルエステルの生産 - Google Patents

レチニルエステルの生産 Download PDF

Info

Publication number
JP7298812B2
JP7298812B2 JP2020512715A JP2020512715A JP7298812B2 JP 7298812 B2 JP7298812 B2 JP 7298812B2 JP 2020512715 A JP2020512715 A JP 2020512715A JP 2020512715 A JP2020512715 A JP 2020512715A JP 7298812 B2 JP7298812 B2 JP 7298812B2
Authority
JP
Japan
Prior art keywords
host cell
acyltransferase
retinol
retinoid
retinyl esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020512715A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020534806A5 (enExample
JP2020534806A (ja
Inventor
ナタリー バルチ，
ポール ブロムクィスト，
リード ドーテン，
ピーター ヒューストン，
イーサン ラム，
ジェナ マクマホン，
ジョシュア トゥルーハート，
セリーヌ ヴィアルージュ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of JP2020534806A publication Critical patent/JP2020534806A/ja
Publication of JP2020534806A5 publication Critical patent/JP2020534806A5/ja
Application granted granted Critical
Publication of JP7298812B2 publication Critical patent/JP7298812B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/0102—Diacylglycerol O-acyltransferase (2.3.1.20)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2020512715A 2017-09-25 2018-09-25 レチニルエステルの生産 Active JP7298812B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762562680P 2017-09-25 2017-09-25
US62/562,680 2017-09-25
PCT/EP2018/076021 WO2019057996A1 (en) 2017-09-25 2018-09-25 Production of retinyl esters

Publications (3)

Publication Number Publication Date
JP2020534806A JP2020534806A (ja) 2020-12-03
JP2020534806A5 JP2020534806A5 (enExample) 2021-10-28
JP7298812B2 true JP7298812B2 (ja) 2023-06-27

Family

ID=63708371

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020512715A Active JP7298812B2 (ja) 2017-09-25 2018-09-25 レチニルエステルの生産

Country Status (6)

Country Link
US (1) US11905542B2 (enExample)
EP (1) EP3688180A1 (enExample)
JP (1) JP7298812B2 (enExample)
CN (1) CN111108212A (enExample)
BR (1) BR112020005769A2 (enExample)
WO (1) WO2019057996A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7472427B2 (ja) 2017-09-25 2024-04-23 ディーエスエム アイピー アセッツ ビー．ブイ． レチノイドの生合成
CN112522331B (zh) * 2020-12-09 2024-03-22 上海克琴科技有限公司 一种生物酶催化的羟基频哪酮视黄酸酯的合成方法
US20240216321A1 (en) * 2022-12-02 2024-07-04 Dsm Ip Assets B.V. Fermentatively-produced retinoid containing compositions, and the methdos of making and using the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003518382A (ja) 1999-12-24 2003-06-10 シンジェンタ・パティシペーションズ・アクチェンゲゼルシャフト ビタミンａの製造方法
US20110039299A1 (en) 2006-09-28 2011-02-17 Microbia Precision Engineering Production of carotenoids in oleaginous yeast and fungi

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7851199B2 (en) * 2005-03-18 2010-12-14 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
WO2009126890A2 (en) 2008-04-10 2009-10-15 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
CN105339490A (zh) 2012-12-20 2016-02-17 帝斯曼知识产权资产管理有限公司 乙酰转移酶及其用于产生类胡萝卜素的用途
KR20140147982A (ko) 2013-06-20 2014-12-31 경상대학교산학협력단 레티노이드 생산에 관여하는 효소를 코딩하는 유전자를 포함하는 미생물 및 이를 이용한 레티노이드의 생산 방법
EP3286302A1 (en) 2015-04-21 2018-02-28 DSM IP Assets B.V. Geranylgeranyl pyrophosphate synthase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003518382A (ja) 1999-12-24 2003-06-10 シンジェンタ・パティシペーションズ・アクチェンゲゼルシャフト ビタミンａの製造方法
US20110039299A1 (en) 2006-09-28 2011-02-17 Microbia Precision Engineering Production of carotenoids in oleaginous yeast and fungi

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A. Ruiz, et al.，The Journal of Biological Chemistry，1999年，Vol.274, No.6，p.3834-3841
R. Schreiber, et al.，Biochimica et Biophysica Acta，2012年，1821，p.113-123

Also Published As

Publication number Publication date
US20200239924A1 (en) 2020-07-30
EP3688180A1 (en) 2020-08-05
WO2019057996A1 (en) 2019-03-28
CN111108212A (zh) 2020-05-05
US11905542B2 (en) 2024-02-20
BR112020005769A2 (pt) 2020-09-24
JP2020534806A (ja) 2020-12-03

Similar Documents

Publication Publication Date Title
JP7443656B2 (ja) レチニルエステルの生産
US12252724B2 (en) Biosynthesis of retinoids
JP7513520B2 (ja) レチノールの生産
EP3687488A1 (en) Production of trans-retinal
EP3999634A1 (en) Novel beta-carotene oxidases
JP7298812B2 (ja) レチニルエステルの生産
EP4658235A1 (en) Novel acetyl-transferases
EP3687486A1 (en) Biosynthesis of retinoids
KR20250140585A (ko) 아세틸 전이효소 sb-atf의 신규한 돌연변이체

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210917

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210917

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220825

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220906

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20221206

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230206

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230306

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230516

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230531

R150 Certificate of patent or registration of utility model

Ref document number: 7298812

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150