JP2020534373A5 - - Google Patents
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- JP2020534373A5 JP2020534373A5 JP2020538750A JP2020538750A JP2020534373A5 JP 2020534373 A5 JP2020534373 A5 JP 2020534373A5 JP 2020538750 A JP2020538750 A JP 2020538750A JP 2020538750 A JP2020538750 A JP 2020538750A JP 2020534373 A5 JP2020534373 A5 JP 2020534373A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- pharmaceutically acceptable
- acceptable salt
- compound
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C1=C(*IC(C=C*C=C2)=CC3=C2N=CN2C3=NC(CC*C#N)C2)CC#CC=C1NS(*)(=O)=O Chemical compound *C1=C(*IC(C=C*C=C2)=CC3=C2N=CN2C3=NC(CC*C#N)C2)CC#CC=C1NS(*)(=O)=O 0.000 description 2
- YIKCYQCGMOAMTK-UHFFFAOYSA-N Ic(cc12)ccc1N=CN1C2=NCCC1 Chemical compound Ic(cc12)ccc1N=CN1C2=NCCC1 YIKCYQCGMOAMTK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762561142P | 2017-09-20 | 2017-09-20 | |
| US62/561,142 | 2017-09-20 | ||
| PCT/US2018/052047 WO2019060611A1 (en) | 2017-09-20 | 2018-09-20 | CYCLIC IMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF KINASES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020534373A JP2020534373A (ja) | 2020-11-26 |
| JP2020534373A5 true JP2020534373A5 (enExample) | 2021-11-04 |
| JP7394768B2 JP7394768B2 (ja) | 2023-12-08 |
Family
ID=64457074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020538750A Active JP7394768B2 (ja) | 2017-09-20 | 2018-09-20 | キナーゼ阻害剤としての環状イミノピリミジン誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11254680B2 (enExample) |
| EP (1) | EP3684772B1 (enExample) |
| JP (1) | JP7394768B2 (enExample) |
| KR (1) | KR102796209B1 (enExample) |
| CN (1) | CN111247152B (enExample) |
| AU (1) | AU2018338098B2 (enExample) |
| BR (1) | BR112020005455A2 (enExample) |
| CA (1) | CA3076202A1 (enExample) |
| MX (1) | MX2020003126A (enExample) |
| WO (1) | WO2019060611A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102796209B1 (ko) * | 2017-09-20 | 2025-04-16 | 에이비엠 쎄라퓨틱스 코포레이션 | 키나아제 억제제로서의 시클릭 이미노피리미딘 유도체 |
| TWI817018B (zh) * | 2019-06-28 | 2023-10-01 | 美商艾瑞生藥股份有限公司 | 用於治療ｂｒａｆ相關的疾病和失調症之化合物 |
| ES3018143T3 (en) * | 2019-12-10 | 2025-05-14 | Hoffmann La Roche | New braf inhibitors as paradox breakers |
| WO2021250521A1 (en) | 2020-06-09 | 2021-12-16 | Array Biopharma Inc. | 4-oxo-3,4-dihydroquinazolinon compounds for the treatment of braf-associated diseases and disorders |
| MX2023001312A (es) * | 2020-08-07 | 2023-04-12 | Abm Therapeutics Corp | Inhibidores de quinasa y usos de los mismos. |
| CN114380697A (zh) * | 2021-11-30 | 2022-04-22 | 上海毕得医药科技股份有限公司 | 一种n-甲基乙基胺盐酸盐的制备工艺 |
| TW202409040A (zh) | 2022-07-19 | 2024-03-01 | 大陸商西藏海思科製藥有限公司 | 作為激酶抑制劑的喹唑啉酮衍生物的製備及其用途 |
| CN117209503B (zh) * | 2023-09-13 | 2025-10-17 | 苏州翔实医药发展有限公司 | 一种5,6-二氢咪唑并[1，2-c]喹唑啉及其衍生物合成的方法 |
| WO2025108405A1 (zh) * | 2023-11-22 | 2025-05-30 | 西藏海思科制药有限公司 | 作为激酶抑制剂的喹唑啉酮衍生物的制备及其用途 |
| WO2025153057A1 (zh) * | 2024-01-17 | 2025-07-24 | 海思科医药集团股份有限公司 | 一种含braf抑制剂的药物组合物及其在医药上的应用 |
| WO2025176185A1 (zh) * | 2024-02-23 | 2025-08-28 | 海思科医药集团股份有限公司 | 一种braf抑制剂的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE411996T1 (de) * | 2002-09-30 | 2008-11-15 | Bayer Healthcare Ag | Kondensierte azolpyrimidinderivate |
| PE20081581A1 (es) | 2006-12-21 | 2008-11-12 | Plexxikon Inc | COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA |
| US20100216779A1 (en) | 2007-06-01 | 2010-08-26 | Glaxosmithkline Llc | Imidazopyridine Kinase Inhibitors |
| EP2170830B1 (en) | 2007-07-17 | 2014-10-15 | Plexxikon, Inc. | 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS |
| EP2348020A1 (en) | 2009-12-23 | 2011-07-27 | Esteve Química, S.A. | Preparation process of erlotinib |
| RU2550038C2 (ru) | 2010-12-02 | 2015-05-10 | Медпакто Инк. | Новое производное пуринилпиридиниламино-2,4-дифторфенилсульфонамида, его фармацевтически приемлемая соль, способ его получения и фармацевтическая композиция, обладающая ингибирующей активностью в отношении raf-киназы, содержащая данное соединение в качестве активного ингредиента |
| US20130023531A1 (en) | 2011-01-27 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Pyrimido[5,4-d]pyrimidylamino phenyl sulfonamides as serine/threonine kinase inhibitors |
| WO2012118492A1 (en) * | 2011-03-01 | 2012-09-07 | Array Biopharma Inc. | Heterocyclic sulfonamides as raf inhibitors |
| US8889741B2 (en) | 2012-02-09 | 2014-11-18 | Daiichi Sankyo Company, Limited | Cycloalkane derivatives |
| BR112015005562A2 (pt) * | 2012-09-14 | 2017-08-08 | Eternity Bioscience Inc | compostos de aminoisoquinolina, suas composições e uso dos novos compostos como inibidores da proteína quinase. |
| WO2014047648A1 (en) | 2012-09-24 | 2014-03-27 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| US9321762B2 (en) | 2013-12-11 | 2016-04-26 | Development Center For Biotechnology | Quinazoline compounds, method for preparing the same and use thereof |
| CN105272970A (zh) | 2014-07-03 | 2016-01-27 | 中国药科大学 | 基于色原酮结构的Raf激酶抑制剂及其制备方法和用途 |
| JP6826526B6 (ja) | 2014-07-16 | 2021-03-31 | ディベロップメント センター フォー バイオテクノロジーＤｅｖｅｌｏｐｍｅｎｔ Ｃｅｎｔｅｒ Ｆｏｒ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ | キノキサリン化合物、それを調製する方法およびその使用 |
| KR102796209B1 (ko) * | 2017-09-20 | 2025-04-16 | 에이비엠 쎄라퓨틱스 코포레이션 | 키나아제 억제제로서의 시클릭 이미노피리미딘 유도체 |
-
2018
- 2018-09-20 KR KR1020207010704A patent/KR102796209B1/ko active Active
- 2018-09-20 JP JP2020538750A patent/JP7394768B2/ja active Active
- 2018-09-20 WO PCT/US2018/052047 patent/WO2019060611A1/en not_active Ceased
- 2018-09-20 EP EP18808139.2A patent/EP3684772B1/en active Active
- 2018-09-20 MX MX2020003126A patent/MX2020003126A/es unknown
- 2018-09-20 AU AU2018338098A patent/AU2018338098B2/en active Active
- 2018-09-20 CN CN201880067947.0A patent/CN111247152B/zh active Active
- 2018-09-20 BR BR112020005455-0A patent/BR112020005455A2/pt active Search and Examination
- 2018-09-20 CA CA3076202A patent/CA3076202A1/en active Pending
- 2018-09-20 US US16/648,908 patent/US11254680B2/en active Active
-
2022
- 2022-01-13 US US17/575,292 patent/US11932647B2/en active Active
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