JP2019527682A5 - - Google Patents

Info

Publication number

JP2019527682A5

JP2019527682A5 JP2019500570A JP2019500570A JP2019527682A5 JP 2019527682 A5 JP2019527682 A5 JP 2019527682A5 JP 2019500570 A JP2019500570 A JP 2019500570A JP 2019500570 A JP2019500570 A JP 2019500570A JP 2019527682 A5 JP2019527682 A5 JP 2019527682A5

Authority

JP

Japan

Prior art keywords

substituted

unsubstituted

alkyl

pharmaceutically acceptable

acceptable salt

Prior art date

2017-07-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 125000000217 alkyl group Chemical group 0.000 claims 34
• 239000000651 prodrug Substances 0.000 claims 32
• 229940002612 prodrug Drugs 0.000 claims 32
• 150000003839 salts Chemical class 0.000 claims 32
• 239000012453 solvate Substances 0.000 claims 31
• 239000013078 crystal Substances 0.000 claims 30
• 229910052739 hydrogen Inorganic materials 0.000 claims 29
• 239000001257 hydrogen Substances 0.000 claims 29
• 150000001875 compounds Chemical class 0.000 claims 28
• 150000002431 hydrogen Chemical class 0.000 claims 26
• 125000000623 heterocyclic group Chemical group 0.000 claims 23
• 125000001072 heteroaryl group Chemical group 0.000 claims 18
• 229910052736 halogen Inorganic materials 0.000 claims 17
• 150000002367 halogens Chemical class 0.000 claims 17
• 125000004452 carbocyclyl group Chemical group 0.000 claims 14
• 239000008194 pharmaceutical composition Substances 0.000 claims 12
• 125000003342 alkenyl group Chemical group 0.000 claims 11
• 125000000304 alkynyl group Chemical group 0.000 claims 11
• 201000010099 disease Diseases 0.000 claims 11
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
• 125000003118 aryl group Chemical group 0.000 claims 10
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 10
• 125000004429 atom Chemical group 0.000 claims 8
• 150000004677 hydrates Chemical class 0.000 claims 6
• 102000001253 Protein Kinase Human genes 0.000 claims 5
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
• 108060006633 protein kinase Proteins 0.000 claims 5
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
• 125000002252 acyl group Chemical group 0.000 claims 3
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
• 125000004430 oxygen atom Chemical group O* 0.000 claims 3
• 125000004193 piperazinyl group Chemical group 0.000 claims 3
• 125000003386 piperidinyl group Chemical group 0.000 claims 3
• 229910052717 sulfur Inorganic materials 0.000 claims 3
• 125000004434 sulfur atom Chemical group 0.000 claims 3
• 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
• JGLMVXWAHNTPRF-CMDGGOBGSA-N CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O Chemical compound CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O JGLMVXWAHNTPRF-CMDGGOBGSA-N 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 230000001594 aberrant effect Effects 0.000 claims 2
• 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 238000003419 tautomerization reaction Methods 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 208000019838 Blood disease Diseases 0.000 claims 1
• 208000026350 Inborn Genetic disease Diseases 0.000 claims 1
• 208000023178 Musculoskeletal disease Diseases 0.000 claims 1
• 208000012902 Nervous system disease Diseases 0.000 claims 1
• 208000025966 Neurological disease Diseases 0.000 claims 1
• 208000034038 Pathologic Neovascularization Diseases 0.000 claims 1
• 108091000080 Phosphotransferase Proteins 0.000 claims 1
• 230000002159 abnormal effect Effects 0.000 claims 1
• 238000003556 assay Methods 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 208000016361 genetic disease Diseases 0.000 claims 1
• 208000014951 hematologic disease Diseases 0.000 claims 1
• 208000018706 hematopoietic system disease Diseases 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• 208000030159 metabolic disease Diseases 0.000 claims 1
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
• 125000002757 morpholinyl group Chemical group 0.000 claims 1
• 208000017445 musculoskeletal system disease Diseases 0.000 claims 1
• 230000009826 neoplastic cell growth Effects 0.000 claims 1
• 239000008177 pharmaceutical agent Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 102000020233 phosphotransferase Human genes 0.000 claims 1
• 230000002062 proliferating effect Effects 0.000 claims 1
• 208000020016 psychiatric disease Diseases 0.000 claims 1
• 238000012216 screening Methods 0.000 claims 1
• 239000002904 solvent Substances 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1