AU2017291812B2 - Bicyclic urea kinase inhibitors and uses thereof - Google Patents

Bicyclic urea kinase inhibitors and uses thereof Download PDF

Info

Publication number
AU2017291812B2
AU2017291812B2 AU2017291812A AU2017291812A AU2017291812B2 AU 2017291812 B2 AU2017291812 B2 AU 2017291812B2 AU 2017291812 A AU2017291812 A AU 2017291812A AU 2017291812 A AU2017291812 A AU 2017291812A AU 2017291812 B2 AU2017291812 B2 AU 2017291812B2
Authority
AU
Australia
Prior art keywords
substituted
unsubstituted
ykl
alkyl
certain embodiments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2017291812A
Other languages
English (en)
Other versions
AU2017291812A1 (en
Inventor
Hwan Geun Choi
David E. Fisher
Nathanael S. Gray
Yanke LIANG
Nisma MUJAHID
Alykhan SHAMJI
Thomas Sundberg
Ramnik Xavier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Dana Farber Cancer Institute Inc
Broad Institute Inc
Original Assignee
General Hospital Corp
Dana Farber Cancer Institute Inc
Broad Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp, Dana Farber Cancer Institute Inc, Broad Institute Inc filed Critical General Hospital Corp
Publication of AU2017291812A1 publication Critical patent/AU2017291812A1/en
Application granted granted Critical
Publication of AU2017291812B2 publication Critical patent/AU2017291812B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2017291812A 2016-07-05 2017-07-05 Bicyclic urea kinase inhibitors and uses thereof Active AU2017291812B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662358524P 2016-07-05 2016-07-05
US62/358,524 2016-07-05
PCT/US2017/040722 WO2018009544A1 (en) 2016-07-05 2017-07-05 Bicyclic urea kinase inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
AU2017291812A1 AU2017291812A1 (en) 2019-02-21
AU2017291812B2 true AU2017291812B2 (en) 2023-12-14

Family

ID=59351134

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017291812A Active AU2017291812B2 (en) 2016-07-05 2017-07-05 Bicyclic urea kinase inhibitors and uses thereof

Country Status (10)

Country Link
US (3) US10954242B2 (enExample)
EP (2) EP4047001A3 (enExample)
JP (1) JP7277357B2 (enExample)
KR (1) KR20190075043A (enExample)
CN (1) CN110225914A (enExample)
AU (1) AU2017291812B2 (enExample)
CA (1) CA3069016A1 (enExample)
ES (1) ES2920823T3 (enExample)
IL (1) IL264106B (enExample)
WO (1) WO2018009544A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016014542A1 (en) 2014-07-21 2016-01-28 Dana-Farber Cancer Institute, Inc. Imidazolyl kinase inhibitors and uses thereof
AU2017291812B2 (en) 2016-07-05 2023-12-14 Dana-Farber Cancer Institute, Inc. Bicyclic urea kinase inhibitors and uses thereof
WO2018053373A1 (en) 2016-09-16 2018-03-22 The General Hospital Corporation Uses of satl-inducible kinase (sik) inhibitors for treating osteoporosis
AU2018226771B2 (en) 2017-02-28 2023-11-23 Dana-Farber Cancer Institute, Inc. Uses of pyrimidopyrimidinones as SIK inhibitors
CN111936499B (zh) * 2018-03-30 2023-09-19 法国施维雅药厂 Mat2a的杂二环抑制剂和用于治疗癌症的方法
JPWO2020027200A1 (ja) * 2018-08-01 2021-08-19 小野薬品工業株式会社 軟骨関連疾患治療剤
WO2021062327A1 (en) * 2019-09-27 2021-04-01 Jubilant Biosys Limited Fused pyrimidine compounds, compositions and medicinal applications thereof
GB201915829D0 (en) 2019-10-31 2019-12-18 Cancer Research Tech Ltd Compounds, compositions and therapeutic uses thereof
GB201915831D0 (en) 2019-10-31 2019-12-18 Cancer Research Tech Ltd Compounds, compositions and therapeutic uses thereof
GB201915828D0 (en) 2019-10-31 2019-12-18 Cancer Research Tech Ltd Compounds, compositions and therapeutic uses thereof
WO2021155004A1 (en) * 2020-01-30 2021-08-05 The Regents Of The University Of California Strad-binding agents and uses thereof
EP4143191A2 (en) * 2020-04-28 2023-03-08 iOmx Therapeutics AG Bicyclic kinase inhibitors and uses thereof
WO2021229452A1 (en) * 2020-05-14 2021-11-18 Rhizen Pharmaceuticals Ag Purine derivatives as sik-3 inhibitors
JP2023541052A (ja) * 2020-09-16 2023-09-27 エクセソ バイオファーマ カンパニー リミテッド ピリミドピリミジノン化合物及びそれを含む薬剤学的組成物
AU2021343539A1 (en) * 2020-09-21 2023-05-18 Soltego, Inc. Sik inhibitors and methods of use thereof
CN116801878A (zh) * 2020-10-05 2023-09-22 达纳-法伯癌症研究所股份有限公司 Her2的有效和选择性抑制剂
KR20230117182A (ko) * 2020-12-04 2023-08-07 다인 세라퓨틱스, 인크. 항체-올리고뉴클레오티드 복합체 및 그의 용도
EP4284802A4 (en) * 2021-02-01 2025-01-01 Janssen Biotech, Inc. SMALL MOLECULE INHIBITORS OF SALT-INDUCIBLE KINASES
KR20230053049A (ko) * 2021-10-13 2023-04-21 서울대학교산학협력단 류마티스 관절염 예방 또는 치료용 약학적 조성물 및 건강기능식품
CN116813608B (zh) * 2023-06-08 2024-03-22 英矽智能科技(上海)有限公司 噻唑类化合物及其应用
CN117547615B (zh) * 2023-09-26 2024-12-06 首都医科大学宣武医院 一种纳米囊泡及其制备方法和应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004041821A1 (en) * 2002-11-04 2004-05-21 F. Hoffmann-La Roche Ag Pyrimido compounds having antiproliferative activity (ii)
US20040204427A1 (en) * 2003-04-10 2004-10-14 Yi Chen Pyrimido compounds having antiproliferative activity
WO2005011597A2 (en) * 2003-07-29 2005-02-10 Irm Llc Compounds and compositions as protein kinase inhibitors
WO2010067888A1 (en) * 2008-12-12 2010-06-17 Banyu Pharmaceutical Co.,Ltd. Dihydropyrimidopyrimidine derivatives
WO2014138485A1 (en) * 2013-03-08 2014-09-12 Irm Llc Ex vivo production of platelets from hematopoietic stem cells and the product thereof
WO2014144737A1 (en) * 2013-03-15 2014-09-18 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
US20150203818A1 (en) * 2012-07-20 2015-07-23 The Commom Services Agency Erythroid production

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4231559B2 (ja) 1997-04-23 2009-03-04 オリザ油化株式会社 リポキシゲナーゼ阻害剤
JP2002516327A (ja) 1998-05-26 2002-06-04 ワーナー−ランバート・カンパニー 細胞増殖の阻害剤としての二環式ピリミジンおよび二環式３，４−ジヒドロピリミジン
ID28276A (id) * 1998-10-23 2001-05-10 Hoffmann La Roche Heterolingkar nitrogen bisiklik
US20050202001A1 (en) 2002-04-24 2005-09-15 Han-Mo Koo Enhancement of human epidermal melanogenesis
US7084270B2 (en) 2002-08-14 2006-08-01 Hoffman-La Roche Inc. Pyrimido compounds having antiproliferative activity
AU2003257633A1 (en) 2002-08-21 2004-03-11 Mitsuhiro Okamoto Salt-inducible kinases 2 and use thereof
DE10239042A1 (de) 2002-08-21 2004-03-04 Schering Ag Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel
WO2004048343A1 (en) 2002-11-28 2004-06-10 Schering Aktiengesellschaft Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
US7504396B2 (en) 2003-06-24 2009-03-17 Amgen Inc. Substituted heterocyclic compounds and methods of use
US7442698B2 (en) 2003-07-24 2008-10-28 Amgen Inc. Substituted heterocyclic compounds and methods of use
MY144044A (en) 2004-06-10 2011-07-29 Irm Llc Compounds and compositions as protein kinase inhibitors
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
RU2007111757A (ru) * 2004-08-31 2008-10-10 Ф.Хоффманн-Ля Рош Аг (Ch) Амидные производные 3-фенилдигидропиримидо [4,5-d] пиримидинонов, их получение и использованиев качестве фармацевтических агентов
WO2006024545A1 (en) 2004-09-03 2006-03-09 Stichting Voor De Technische Wetenschappen Fused bicyclic natural compounds and their use as inhibitors of parp and parp-mediated inflammatory processes
EP1841760B1 (en) 2004-12-30 2011-08-10 Exelixis, Inc. Pyrimidine derivatives as kinase modulators and method of use
WO2006104917A2 (en) 2005-03-25 2006-10-05 Glaxo Group Limited Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one derivatives
BRPI0611733A2 (pt) * 2005-06-10 2010-09-28 Irm Llc compostos que mantêm pluripotência de células-tronco embriÈnicas
CA2634047C (en) 2005-12-21 2016-04-12 Novartis Ag Pyrimidinyl aryl urea derivatives being fgf inhibitors
CN101460175A (zh) * 2006-05-15 2009-06-17 Irm责任有限公司 用于fgf受体激酶抑制剂的组合物和方法
WO2008060248A1 (en) 2006-11-15 2008-05-22 S*Bio Pte Ltd. Indole sustituted pyrimidines and use thereof in the treatment of cancer
MX2010005671A (es) 2007-11-28 2010-06-25 Dana Farber Cancer Inst Inc Inhibidores de miristato de moleculas pequeñas contra bcr-abl y metodos de uso.
WO2009122180A1 (en) 2008-04-02 2009-10-08 Medical Research Council Pyrimidine derivatives capable of inhibiting one or more kinases
WO2009152027A1 (en) 2008-06-12 2009-12-17 Merck & Co., Inc. 5,7-dihydro-6h-pyrrolo[2,3-d]pyrimidin-6-one derivatives for mark inhibition
US8455477B2 (en) 2008-08-05 2013-06-04 Merck Sharp & Dohme Corp. Therapeutic compounds
MX2012004032A (es) 2009-10-14 2012-05-08 Bristol Myers Squibb Co Compuestos para el tratamiento de hepatitis c.
CN102816162B (zh) * 2011-06-10 2016-04-27 中国科学院广州生物医药与健康研究院 嘧啶并嘧啶酮类化合物及其药用组合物和应用
HUE027318T2 (en) 2011-09-30 2016-10-28 Oncodesign Sa Macrocyclic FLT3 kinase inhibitors
US9382239B2 (en) 2011-11-17 2016-07-05 Dana-Farber Cancer Institute, Inc. Inhibitors of c-Jun-N-terminal kinase (JNK)
GB201204384D0 (en) 2012-03-13 2012-04-25 Univ Dundee Anti-flammatory agents
IN2014KN02601A (enExample) 2012-04-24 2015-05-08 Vertex Pharma
JP5683634B2 (ja) * 2012-11-28 2015-03-11 株式会社ショーワ 圧力緩衝装置
US9260426B2 (en) 2012-12-14 2016-02-16 Arrien Pharmaceuticals Llc Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
US9586975B2 (en) 2013-03-15 2017-03-07 Oncodesign S.A. Macrocyclic salt-inducible kinase inhibitors
WO2015006492A1 (en) 2013-07-09 2015-01-15 Dana-Farber Cancer Institute, Inc. Kinase inhibitors for the treatment of disease
CN104418860B (zh) * 2013-08-20 2016-09-07 中国科学院广州生物医药与健康研究院 嘧啶并杂环类化合物及其药用组合物和应用
WO2016014542A1 (en) 2014-07-21 2016-01-28 Dana-Farber Cancer Institute, Inc. Imidazolyl kinase inhibitors and uses thereof
AU2015292827B2 (en) 2014-07-21 2019-11-14 Dana-Farber Cancer Institute, Inc. Macrocyclic kinase inhibitors and uses thereof
AU2015300782B2 (en) 2014-08-08 2020-04-16 Dana-Farber Cancer Institute, Inc. Uses of salt-inducible kinase (SIK) inhibitors
KR101850282B1 (ko) 2014-11-26 2018-05-31 한국과학기술연구원 단백질 키나아제 저해제로 유용한 헤테로아릴아민 유도체
CN104482860B (zh) 2014-12-05 2017-10-31 浙江大学宁波理工学院 鱼类形态参数自动测量装置和方法
AU2017291812B2 (en) 2016-07-05 2023-12-14 Dana-Farber Cancer Institute, Inc. Bicyclic urea kinase inhibitors and uses thereof
WO2018053373A1 (en) * 2016-09-16 2018-03-22 The General Hospital Corporation Uses of satl-inducible kinase (sik) inhibitors for treating osteoporosis
AU2018226771B2 (en) 2017-02-28 2023-11-23 Dana-Farber Cancer Institute, Inc. Uses of pyrimidopyrimidinones as SIK inhibitors

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004041821A1 (en) * 2002-11-04 2004-05-21 F. Hoffmann-La Roche Ag Pyrimido compounds having antiproliferative activity (ii)
US20040204427A1 (en) * 2003-04-10 2004-10-14 Yi Chen Pyrimido compounds having antiproliferative activity
WO2005011597A2 (en) * 2003-07-29 2005-02-10 Irm Llc Compounds and compositions as protein kinase inhibitors
WO2010067888A1 (en) * 2008-12-12 2010-06-17 Banyu Pharmaceutical Co.,Ltd. Dihydropyrimidopyrimidine derivatives
US20150203818A1 (en) * 2012-07-20 2015-07-23 The Commom Services Agency Erythroid production
WO2014138485A1 (en) * 2013-03-08 2014-09-12 Irm Llc Ex vivo production of platelets from hematopoietic stem cells and the product thereof
WO2014144737A1 (en) * 2013-03-15 2014-09-18 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Liang, X. et al, Journal of Medicinal Chemistry, 2016, 59(5), 1984-2004 *
Sundberg, T. B. et al, ACS Chemical Biology, 2016, 11(8), 2105-2111 *
Xu, S. et al, Journal of Medicinal Chemistry, 2013, 56(21), 8803-8813 *

Also Published As

Publication number Publication date
IL264106B (en) 2022-04-01
US20200317675A9 (en) 2020-10-08
US12398145B2 (en) 2025-08-26
CN110225914A (zh) 2019-09-10
EP3481830B1 (en) 2022-02-16
IL264106A (en) 2019-01-31
EP4047001A3 (en) 2022-11-30
US10954242B2 (en) 2021-03-23
KR20190075043A (ko) 2019-06-28
EP4047001A2 (en) 2022-08-24
ES2920823T3 (es) 2022-08-10
EP3481830A1 (en) 2019-05-15
US11725011B2 (en) 2023-08-15
JP7277357B2 (ja) 2023-05-18
US20230234959A1 (en) 2023-07-27
AU2017291812A1 (en) 2019-02-21
WO2018009544A1 (en) 2018-01-11
US20210147425A1 (en) 2021-05-20
CA3069016A1 (en) 2018-01-11
US20190315752A1 (en) 2019-10-17
JP2019527682A (ja) 2019-10-03

Similar Documents

Publication Publication Date Title
AU2017291812B2 (en) Bicyclic urea kinase inhibitors and uses thereof
US12209076B2 (en) Imidazolyl kinase inhibitors and uses thereof
EP3172213B1 (en) Macrocyclic kinase inhibitors and uses thereof
AU2016319785C1 (en) Acetamide thienotriazolodiazepines and uses thereof
WO2016022902A1 (en) Diazepane derivatives and uses thereof
WO2016022970A1 (en) Dihydropteridinone derivatives and uses thereof
HK40070345A (en) Bicyclic urea kinase inhibitors and uses thereof
EP4601637A2 (en) Glycogen synthase kinase 3 inhibitors and uses thereof
HK40008957B (en) Bicyclic urea kinase inhibitors and uses thereof

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)