JP2019521964A5 - - Google Patents
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- JP2019521964A5 JP2019521964A5 JP2018559812A JP2018559812A JP2019521964A5 JP 2019521964 A5 JP2019521964 A5 JP 2019521964A5 JP 2018559812 A JP2018559812 A JP 2018559812A JP 2018559812 A JP2018559812 A JP 2018559812A JP 2019521964 A5 JP2019521964 A5 JP 2019521964A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- unsubstituted
- compound
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims description 58
- 125000000217 alkyl group Chemical group 0.000 claims description 54
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 32
- 125000000623 heterocyclic group Chemical group 0.000 claims description 24
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 24
- 108060003345 Adrenergic Receptor Proteins 0.000 claims description 21
- 102000017910 Adrenergic receptor Human genes 0.000 claims description 21
- 125000003118 aryl group Chemical group 0.000 claims description 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 16
- 125000003545 alkoxy group Chemical group 0.000 claims description 14
- 125000001153 fluoro group Chemical group F* 0.000 claims description 14
- 229910052736 halogen Inorganic materials 0.000 claims description 14
- 150000002367 halogens Chemical class 0.000 claims description 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
- 125000005415 substituted alkoxy group Chemical group 0.000 claims description 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 8
- 125000001072 heteroaryl group Chemical group 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 125000003107 substituted aryl group Chemical group 0.000 claims description 8
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 7
- PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 claims description 6
- 150000002431 hydrogen Chemical class 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 4
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000000304 alkynyl group Chemical group 0.000 claims description 4
- 125000004429 atom Chemical group 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 239000000651 prodrug Substances 0.000 claims description 4
- 229940002612 prodrug Drugs 0.000 claims description 4
- PYRKKGOKRMZEIT-UHFFFAOYSA-N 2-[6-(2-cyclopropylethoxy)-9-(2-hydroxy-2-methylpropyl)-1h-phenanthro[9,10-d]imidazol-2-yl]-5-fluorobenzene-1,3-dicarbonitrile Chemical compound C1=C2C3=CC(CC(C)(O)C)=CC=C3C=3NC(C=4C(=CC(F)=CC=4C#N)C#N)=NC=3C2=CC=C1OCCC1CC1 PYRKKGOKRMZEIT-UHFFFAOYSA-N 0.000 claims description 2
- BGAJNPLDJJBRHK-UHFFFAOYSA-N 3-[2-[5-(3-chloro-4-propan-2-yloxyphenyl)-1,3,4-thiadiazol-2-yl]-3-methyl-6,7-dihydro-4h-pyrazolo[4,3-c]pyridin-5-yl]propanoic acid Chemical compound C1=C(Cl)C(OC(C)C)=CC=C1C1=NN=C(N2C(=C3CN(CCC(O)=O)CCC3=N2)C)S1 BGAJNPLDJJBRHK-UHFFFAOYSA-N 0.000 claims description 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 208000026139 Memory disease Diseases 0.000 claims description 2
- 208000029726 Neurodevelopmental disease Diseases 0.000 claims description 2
- DXPOSRCHIDYWHW-UHFFFAOYSA-N Xamoterol Chemical compound C=1C=C(O)C=CC=1OCC(O)CNCCNC(=O)N1CCOCC1 DXPOSRCHIDYWHW-UHFFFAOYSA-N 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims description 2
- 230000001800 adrenalinergic effect Effects 0.000 claims description 2
- 102000016967 beta-1 Adrenergic Receptors Human genes 0.000 claims description 2
- 108010014494 beta-1 Adrenergic Receptors Proteins 0.000 claims description 2
- 102000016966 beta-2 Adrenergic Receptors Human genes 0.000 claims description 2
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 208000029028 brain injury Diseases 0.000 claims description 2
- 229910052805 deuterium Inorganic materials 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 230000000302 ischemic effect Effects 0.000 claims description 2
- 230000004770 neurodegeneration Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 230000035790 physiological processes and functions Effects 0.000 claims description 2
- 208000023504 respiratory system disease Diseases 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 208000037816 tissue injury Diseases 0.000 claims description 2
- 229960004928 xamoterol Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 9
- -1 C1-C5 alkyl linker compound Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 description 15
- 230000037361 pathway Effects 0.000 description 3
- 102000000072 beta-Arrestins Human genes 0.000 description 1
- 108010080367 beta-Arrestins Proteins 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000006433 tumor necrosis factor production Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662336370P | 2016-05-13 | 2016-05-13 | |
| US62/336,370 | 2016-05-13 | ||
| PCT/US2017/032505 WO2017197324A1 (en) | 2016-05-13 | 2017-05-12 | Adrenergic receptor modulating compounds and methods of using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019521964A JP2019521964A (ja) | 2019-08-08 |
| JP2019521964A5 true JP2019521964A5 (enExample) | 2020-05-21 |
Family
ID=60267581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018559812A Pending JP2019521964A (ja) | 2016-05-13 | 2017-05-12 | アドレナリン受容体調節化合物およびその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11173144B2 (enExample) |
| EP (1) | EP3454845A4 (enExample) |
| JP (1) | JP2019521964A (enExample) |
| KR (1) | KR20190017795A (enExample) |
| CN (1) | CN109310651A (enExample) |
| AU (1) | AU2017263657A1 (enExample) |
| BR (1) | BR112018073227A2 (enExample) |
| CA (1) | CA3023763A1 (enExample) |
| MA (1) | MA44994A (enExample) |
| MX (1) | MX2018013812A (enExample) |
| WO (1) | WO2017197324A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11607395B2 (en) | 2019-12-18 | 2023-03-21 | Curasen Therapeutics, Inc. | Methods for improving neurological diseases and disorders |
| JP7734700B2 (ja) | 2020-06-04 | 2025-09-05 | キュラセン セラピューティクス インコーポレイテッド | ベータアドレナリンアゴニストの形態及び組成物 |
| US20240352002A1 (en) * | 2020-11-19 | 2024-10-24 | Curasen Therapeutics, Inc. | Beta adrenergic agonist and methods of using the same |
| US20250213647A1 (en) * | 2022-03-28 | 2025-07-03 | University Of South Florida | Chemokine receptors and alpha1 adrenergic receptors/vasopressin receptors 1a heteromers as drug targets for disease |
| GB202213163D0 (en) * | 2022-09-08 | 2022-10-26 | Cambridge Entpr Ltd | Novel compounds, compositions and therapeutic uses thereof |
| CN115414483B (zh) | 2022-09-26 | 2024-10-29 | 孙良丹 | Adrb1活性抑制剂在作为或制备用于治疗银屑病的制剂中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2619164C2 (de) * | 1976-04-30 | 1985-07-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Indazolyl-(4)-oxy-propanolamine, Verfahren zu ihrer Herstellung und deren Verwendung |
| DE2830211A1 (de) * | 1977-07-21 | 1979-02-01 | Sandoz Ag | Substituierte indol-derivate, ihre herstellung und verwendung |
| DE2905877A1 (de) * | 1979-02-16 | 1980-08-28 | Boehringer Mannheim Gmbh | Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DD150456A5 (de) * | 1979-03-01 | 1981-09-02 | Ciba Geigy Ag | Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols |
| DE3023369A1 (de) * | 1980-06-23 | 1982-01-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Aryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US5098996A (en) * | 1984-10-26 | 1992-03-24 | The United States Of America As Represented By The Department Of Health And Human Services | Process for introducing fluorine into biologically active materials |
| AU1467095A (en) * | 1994-01-29 | 1995-08-15 | Daicel Chemical Industries Ltd. | 4-(2-(3-aryloxy-2-hydroxypropylamino alkyloxy)-5-nitrophenyl)-1,4-dihydropyridines as antihypertensive agents |
| WO2001007026A2 (en) * | 1999-07-22 | 2001-02-01 | Eli Lilly And Company | Improved method of treating type ii diabetes and obesity |
| WO2001078709A2 (en) * | 2000-04-12 | 2001-10-25 | Minerva Biotechnologies Corporation | Treatment of neurodegenerative disease |
| US20040138462A1 (en) * | 2001-05-24 | 2004-07-15 | Minoru Sakurai | Aminoalcohol derivatives |
| KR100742001B1 (ko) * | 2003-03-21 | 2007-07-23 | 다이노젠 파마세우티컬스, 인코포레이티드 | 평활근 모듈레이터 및 알파2 델타 서브유닛 칼슘 채널모듈레이터를 이용한 하부 요로 질환의 치료 방법 |
| JP2008521805A (ja) * | 2004-11-30 | 2008-06-26 | アーテシアン セラピューティクス， インコーポレイテッド | β−アドレナリン作用性受容体およびホスホジエステラーゼに対する阻害活性を有する強心性化合物 |
| US20100216805A1 (en) * | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2011133226A2 (en) | 2010-04-22 | 2011-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method for enhancing learning and memory impaired by neurodegenerative disorders and compounds and compositions for effecting the same |
| WO2015126915A2 (en) | 2014-02-18 | 2015-08-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method of improving cognition and social behavior in humans having deficits therein due to neurological disorders and compounds and compositions therefor |
-
2017
- 2017-05-12 BR BR112018073227-3A patent/BR112018073227A2/pt not_active Application Discontinuation
- 2017-05-12 EP EP17796976.3A patent/EP3454845A4/en not_active Withdrawn
- 2017-05-12 US US16/099,802 patent/US11173144B2/en not_active Expired - Fee Related
- 2017-05-12 AU AU2017263657A patent/AU2017263657A1/en not_active Abandoned
- 2017-05-12 MA MA044994A patent/MA44994A/fr unknown
- 2017-05-12 MX MX2018013812A patent/MX2018013812A/es unknown
- 2017-05-12 KR KR1020187036246A patent/KR20190017795A/ko not_active Withdrawn
- 2017-05-12 CN CN201780038617.4A patent/CN109310651A/zh active Pending
- 2017-05-12 WO PCT/US2017/032505 patent/WO2017197324A1/en not_active Ceased
- 2017-05-12 CA CA3023763A patent/CA3023763A1/en not_active Abandoned
- 2017-05-12 JP JP2018559812A patent/JP2019521964A/ja active Pending
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