JP2020534284A - ワクチン、並びに、呼吸器合胞体ウイルス(rsv)感染症を予防するためのワクチンの作製方法及び使用方法 - Google Patents
ワクチン、並びに、呼吸器合胞体ウイルス(rsv)感染症を予防するためのワクチンの作製方法及び使用方法 Download PDFInfo
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- JP2020534284A JP2020534284A JP2020515680A JP2020515680A JP2020534284A JP 2020534284 A JP2020534284 A JP 2020534284A JP 2020515680 A JP2020515680 A JP 2020515680A JP 2020515680 A JP2020515680 A JP 2020515680A JP 2020534284 A JP2020534284 A JP 2020534284A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6043—Heat shock proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18571—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20241—Use of virus, viral particle or viral elements as a vector
- C12N2760/20243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20271—Demonstrated in vivo effect
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762559167P | 2017-09-15 | 2017-09-15 | |
| US62/559,167 | 2017-09-15 | ||
| PCT/US2018/051054 WO2019055768A1 (en) | 2017-09-15 | 2018-09-14 | VACCINES AND METHODS OF MAKING AND USING VACCINES FOR THE PREVENTION OF SYNCYTIAL RESPIRATORY VIRUS (RSV) INFECTIONS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020534284A true JP2020534284A (ja) | 2020-11-26 |
| JP2020534284A5 JP2020534284A5 (enExample) | 2021-10-21 |
Family
ID=65723867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020515680A Pending JP2020534284A (ja) | 2017-09-15 | 2018-09-14 | ワクチン、並びに、呼吸器合胞体ウイルス(rsv)感染症を予防するためのワクチンの作製方法及び使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20200276297A1 (enExample) |
| EP (1) | EP3681523A4 (enExample) |
| JP (1) | JP2020534284A (enExample) |
| KR (1) | KR20200096904A (enExample) |
| CN (1) | CN111344008A (enExample) |
| AU (1) | AU2018331467A1 (enExample) |
| CA (1) | CA3075990A1 (enExample) |
| WO (1) | WO2019055768A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240113662A (ko) * | 2023-01-13 | 2024-07-23 | 클립스비엔씨 주식회사 | 호흡기 신시치아 바이러스 변이체를 포함하는 호흡기 신시치아 바이러스 백신용 융합단백질 및 이의 제조방법 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3946446A1 (en) * | 2019-04-02 | 2022-02-09 | Sanofi | Antigenic multimeric respiratory syncytial virus polypeptides |
| CN112226450B (zh) * | 2020-08-25 | 2022-10-14 | 北京交通大学 | 一种共表达呼吸道合胞病毒融合前蛋白和黏附糖蛋白的复制缺陷型腺病毒载体疫苗 |
| US20250127872A1 (en) * | 2021-09-29 | 2025-04-24 | Sk Bioscience Co., Ltd. | Recombinant live attenuated rsv vaccine strain and production method therefor |
| CN118930654A (zh) * | 2023-05-12 | 2024-11-12 | 中国科学院微生物研究所 | 一种呼吸道合胞病毒抗原制备方法和应用 |
| CN117720628A (zh) * | 2023-10-12 | 2024-03-19 | 中国科学院微生物研究所 | 一种呼吸道合胞病毒二价抗原制备方法和应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100247621A1 (en) * | 2006-11-30 | 2010-09-30 | Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services | Codon modified immunogenic compositions and methods of use |
| JP2011507514A (ja) * | 2007-12-20 | 2011-03-10 | ワイス・エルエルシー | Gタンパク質を発現する安定な細胞系を用いた、繁殖欠損水疱性口内炎ウイルスベクターをパッケージングする方法 |
| JP2017523139A (ja) * | 2014-06-13 | 2017-08-17 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組合せ物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1224462A (zh) * | 1996-07-15 | 1999-07-28 | 美国政府健康及人类服务部 | 从克隆的核苷酸序列制备减毒呼吸道合胞病毒疫苗的方法 |
| BR0011159A (pt) * | 1999-04-13 | 2002-07-23 | Government Of The Us Dept Of H | Método para produzir vacinas de vìrus rna de fita negativa atenuado a partir de sequências de nucleotìdeos clonados |
| AU2001264824A1 (en) * | 2000-06-01 | 2001-12-11 | St. Jude Children's Research Hospital | Vaccine and gene therapy vector and methods of use thereof |
| AU2002327755A1 (en) * | 2001-09-28 | 2003-04-14 | Rush-Presbyterian-St. Luke's Medical Center | Paramyxoviruses as gene transfer vectors to lung cells |
| CA2477235A1 (en) * | 2002-02-21 | 2003-09-04 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| DE60330966D1 (de) * | 2002-07-26 | 2010-03-04 | Canada Natural Resources | Rekombinante vesicular stomatitis viren als impstoff gegen virale hämorrhagische fieber |
| KR100999316B1 (ko) * | 2003-06-09 | 2010-12-10 | 와이어쓰 엘엘씨 | cDNA로부터의 비분절 네가티브 쇄 RNA 바이러스의회수를 위한 개선된 방법 |
| ATE555208T1 (de) * | 2003-06-13 | 2012-05-15 | Apath Llc | Replikon eines negativsträngigen rna-virus |
| US8287878B2 (en) * | 2004-04-09 | 2012-10-16 | Wyeth Llc | Synergistic attenuation of vesicular stomatitis virus, vectors thereof and immunogenic compositions thereof |
| WO2009025770A2 (en) * | 2007-08-17 | 2009-02-26 | Wyeth | A heterologous prime-boost immunization regimen |
| RU2011122615A (ru) * | 2008-11-05 | 2012-12-20 | Мерк Шарп Энд Домэ Корп. | Живой аттенуированный респираторно-синцитиальный вирус |
| KR102416194B1 (ko) * | 2014-03-01 | 2022-07-04 | 프로펙츄스 바이오사이언스, 인크. | 재조합 이스파한 바이러스 벡터 |
-
2018
- 2018-09-14 WO PCT/US2018/051054 patent/WO2019055768A1/en not_active Ceased
- 2018-09-14 JP JP2020515680A patent/JP2020534284A/ja active Pending
- 2018-09-14 CA CA3075990A patent/CA3075990A1/en active Pending
- 2018-09-14 CN CN201880073897.7A patent/CN111344008A/zh active Pending
- 2018-09-14 KR KR1020207010971A patent/KR20200096904A/ko not_active Ceased
- 2018-09-14 EP EP18856392.8A patent/EP3681523A4/en not_active Withdrawn
- 2018-09-14 AU AU2018331467A patent/AU2018331467A1/en not_active Abandoned
- 2018-09-14 US US16/647,758 patent/US20200276297A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100247621A1 (en) * | 2006-11-30 | 2010-09-30 | Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services | Codon modified immunogenic compositions and methods of use |
| JP2011507514A (ja) * | 2007-12-20 | 2011-03-10 | ワイス・エルエルシー | Gタンパク質を発現する安定な細胞系を用いた、繁殖欠損水疱性口内炎ウイルスベクターをパッケージングする方法 |
| JP2017523139A (ja) * | 2014-06-13 | 2017-08-17 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組合せ物 |
Non-Patent Citations (3)
| Title |
|---|
| IMMUNOLOGY LETTERS, vol. 150, JPN6022030719, 2013, pages 134 - 144, ISSN: 0005012020 * |
| JOURNAL OF VIROLOGY, vol. 82, JPN6022030722, 2008, pages 12191 - 12204, ISSN: 0005012021 * |
| JOURNAL OF VIROLOGY, vol. 88, JPN6022030718, 2014, pages 5122 - 5137, ISSN: 0005012022 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240113662A (ko) * | 2023-01-13 | 2024-07-23 | 클립스비엔씨 주식회사 | 호흡기 신시치아 바이러스 변이체를 포함하는 호흡기 신시치아 바이러스 백신용 융합단백질 및 이의 제조방법 |
| KR102806300B1 (ko) | 2023-01-13 | 2025-05-14 | 클립스비엔씨 주식회사 | 호흡기 신시치아 바이러스 변이체를 포함하는 호흡기 신시치아 바이러스 백신용 융합단백질 및 이의 제조방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019055768A1 (en) | 2019-03-21 |
| KR20200096904A (ko) | 2020-08-14 |
| CA3075990A1 (en) | 2019-03-21 |
| EP3681523A1 (en) | 2020-07-22 |
| AU2018331467A1 (en) | 2020-04-30 |
| US20200276297A1 (en) | 2020-09-03 |
| EP3681523A4 (en) | 2021-12-29 |
| CN111344008A (zh) | 2020-06-26 |
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