JP2020533319A5 - - Google Patents

Download PDF

Info

Publication number
JP2020533319A5
JP2020533319A5 JP2020513872A JP2020513872A JP2020533319A5 JP 2020533319 A5 JP2020533319 A5 JP 2020533319A5 JP 2020513872 A JP2020513872 A JP 2020513872A JP 2020513872 A JP2020513872 A JP 2020513872A JP 2020533319 A5 JP2020533319 A5 JP 2020533319A5
Authority
JP
Japan
Prior art keywords
alkyl
formula
compound
halo
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020513872A
Other languages
English (en)
Japanese (ja)
Other versions
JP7273030B2 (ja
JP2020533319A (ja
JP7273030B6 (ja
Filing date
Publication date
Priority claimed from CN201710801364.3A external-priority patent/CN109467538A/zh
Application filed filed Critical
Publication of JP2020533319A publication Critical patent/JP2020533319A/ja
Publication of JP2020533319A5 publication Critical patent/JP2020533319A5/ja
Priority to JP2023072737A priority Critical patent/JP7603740B2/ja
Publication of JP7273030B2 publication Critical patent/JP7273030B2/ja
Application granted granted Critical
Publication of JP7273030B6 publication Critical patent/JP7273030B6/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020513872A 2017-09-07 2018-09-07 シクロオレフィン置換複素芳香族化合物およびそれらの使用 Active JP7273030B6 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023072737A JP7603740B2 (ja) 2017-09-07 2023-04-26 シクロオレフィン置換複素芳香族化合物およびそれらの使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201710801364.3A CN109467538A (zh) 2017-09-07 2017-09-07 环烯烃取代的杂芳环类化合物及其用途
CN201710801364.3 2017-09-07
PCT/CN2018/104531 WO2019047909A1 (en) 2017-09-07 2018-09-07 HETEROAROMATIC COMPOUNDS SUBSTITUTED WITH CYCLOOLEFINS AND THEIR USE

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023072737A Division JP7603740B2 (ja) 2017-09-07 2023-04-26 シクロオレフィン置換複素芳香族化合物およびそれらの使用

Publications (4)

Publication Number Publication Date
JP2020533319A JP2020533319A (ja) 2020-11-19
JP2020533319A5 true JP2020533319A5 (https=) 2021-10-14
JP7273030B2 JP7273030B2 (ja) 2023-05-12
JP7273030B6 JP7273030B6 (ja) 2024-02-15

Family

ID=65634832

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020513872A Active JP7273030B6 (ja) 2017-09-07 2018-09-07 シクロオレフィン置換複素芳香族化合物およびそれらの使用
JP2023072737A Active JP7603740B2 (ja) 2017-09-07 2023-04-26 シクロオレフィン置換複素芳香族化合物およびそれらの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023072737A Active JP7603740B2 (ja) 2017-09-07 2023-04-26 シクロオレフィン置換複素芳香族化合物およびそれらの使用

Country Status (19)

Country Link
US (3) US11414390B2 (https=)
EP (1) EP3679020A4 (https=)
JP (2) JP7273030B6 (https=)
KR (1) KR102566237B1 (https=)
CN (6) CN109467538A (https=)
AR (1) AR112794A1 (https=)
AU (1) AU2018329047B2 (https=)
CA (1) CA3073782A1 (https=)
CL (1) CL2020000553A1 (https=)
EA (1) EA202090653A1 (https=)
IL (1) IL272923B2 (https=)
MX (1) MX2020002505A (https=)
PE (1) PE20200727A1 (https=)
PH (1) PH12020500408A1 (https=)
SG (1) SG11202001642WA (https=)
TW (1) TWI816693B (https=)
UA (1) UA129118C2 (https=)
WO (1) WO2019047909A1 (https=)
ZA (1) ZA202001448B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109467538A (zh) * 2017-09-07 2019-03-15 和记黄埔医药(上海)有限公司 环烯烃取代的杂芳环类化合物及其用途
MX2020002611A (es) 2017-09-07 2020-07-13 Univ Res Inst Inc Augusta Activador especifico de akt3 y usos del mismo.
CN116209655A (zh) * 2020-11-09 2023-06-02 贝达药业股份有限公司 突变型idh1和idh2抑制剂及其应用
CN118355008A (zh) * 2022-01-11 2024-07-16 正大天晴药业集团股份有限公司 一种1,3,5-三嗪衍生物的制备方法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3555154A (en) 1967-08-16 1971-01-12 Armour Pharma Preparations containing 6 - cycloalkylguanamines and methods for treating inflammatory conditions therewith
US5019574A (en) 1988-09-30 1991-05-28 Chugai Seiyaku Kabushiki Kaisha 3,4-diaminoquinoline and 3,4-diamino-5,6,7,8-tetrahydroquinoline compounds useful for improving psychoneural function
MXPA02003436A (es) 1999-10-07 2002-08-20 Amgen Inc Inhibidores de triazina cinasa.
TWI259081B (en) * 2001-10-26 2006-08-01 Sugen Inc Treatment of acute myeloid leukemia with indolinone compounds
WO2005115242A2 (en) 2004-05-24 2005-12-08 Equusys, Incorporated Animal instrumentation
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
CN101466670B (zh) * 2006-04-07 2013-04-17 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
US20100035863A1 (en) 2006-09-12 2010-02-11 Ucb Pharma, S.A. 2 Amino-Pyrimidine Derivatives As H4 Receptor Antagonists, Processes For Preparing Them And Their Use In Pharmaceutical Compositions
WO2008122378A1 (en) 2007-04-04 2008-10-16 Ucb Pharma, S.A. Novel pyridine derivatives, processes for preparing them, pharmaceutical compositions thereof
JO3240B1 (ar) * 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
WO2009086303A2 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
CN102625799A (zh) * 2009-06-25 2012-08-01 安姆根有限公司 杂环化合物及其用途
WO2011078143A1 (ja) 2009-12-22 2011-06-30 塩野義製薬株式会社 ピリミジン誘導体およびそれらを含有する医薬組成物
MX2012015147A (es) * 2010-06-30 2013-05-01 Amgen Inc Compuestos heterociclicos y su uso como inhibidores de la actividad pi3k.
CA2826464C (en) 2011-03-02 2020-07-28 Lead Discovery Center Gmbh Pharmaceutically active disubstituted triazine derivatives
PT2755965T (pt) 2011-09-12 2017-11-02 Merck Patent Gmbh Novas imidazol aminas como moduladores da atividade quinase
US9321760B2 (en) * 2011-09-12 2016-04-26 Merck Patent Gmbh Aminopyrimidine derivatives for use as modulators of kinase activity
BR112014007310A2 (pt) 2011-09-27 2017-04-04 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inibidores de idh mutante
PE20142098A1 (es) 2012-01-06 2015-01-08 Agios Pharmaceuticals Inc Compuestos terapeuticamente activos y sus metodos de uso
EA026594B1 (ru) * 2012-10-24 2017-04-28 Басф Се Гербицидные азины
CN103044469A (zh) * 2012-11-30 2013-04-17 大连联化化学有限公司 一种制备环戊烯/环己烯-1-硼酸频哪醇酯的方法
WO2014116594A1 (en) 2013-01-23 2014-07-31 The University Of Toledo Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer
CN105517996B (zh) * 2013-07-11 2019-03-26 安吉奥斯医药品有限公司 治疗活性化合物及其使用方法
WO2015003355A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
CN105593215B (zh) 2013-07-11 2019-01-15 安吉奥斯医药品有限公司 用于治疗癌症的作为idh2突变体抑制剂的2,4-或4,6-二氨基嘧啶化合物
AU2014287122B9 (en) * 2013-07-11 2018-11-01 Les Laboratoires Servier N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as IDH2 mutants inhibitors for the treatment of cancer
AU2014295938B2 (en) 2013-08-02 2018-07-19 Les Laboratoires Servier Therapeutically active compounds and their methods of use
AP2016009099A0 (en) * 2013-11-01 2016-03-31 Novartis Ag Aminoheteroaryl benzamides as kinase inhibitors
US10064869B2 (en) 2014-06-04 2018-09-04 Thomas Helledays Stiftelse For Medicinsk Forskning MTH1 inhibitors for treatment of inflammatory and autoimmune conditions
WO2015187088A1 (en) 2014-06-04 2015-12-10 Thomas Helledays Stiftelse För Medicinsk Forskning Mth1 inhibitors for treatment of cancer
DK3330258T3 (da) 2015-07-30 2021-08-16 Chia Tai Tianqing Pharmaceutical Group Co Ltd 1, 3, 5-triazinderivat og fremgangsmåde til anvendelse af samme
WO2017059280A1 (en) 2015-10-02 2017-04-06 The University Of North Carolina At Chapel Hill Novel pan-tam inhibitors and mer/axl dual inhibitors
ES2905915T3 (es) 2015-12-04 2022-04-12 Servier Lab Procedimientos de tratamiento de neoplasias malignas
WO2017096945A1 (zh) * 2015-12-07 2017-06-15 北京康美特科技股份有限公司 含硼有机硅化合物、太阳能电池组件用密封剂以及太阳能电池组件
PL3442947T3 (pl) 2016-04-15 2023-10-02 Epizyme, Inc. Związki arylowe lub heteroarylowe podstawione aminą jako inhibitory ehmt1 i ehmt2
CN107382840B (zh) 2016-05-16 2020-09-01 四川大学 吡啶类化合物及其作为idh功能变异突变体抑制剂类药物的用途
US10676485B2 (en) 2017-08-15 2020-06-09 Abbvie Inc. Macrocyclic MCL-1 inhibitors and methods of use
SG11202001240XA (en) 2017-09-07 2020-03-30 Eisai R&D Man Co Ltd Pentacyclic compound
CN109467538A (zh) * 2017-09-07 2019-03-15 和记黄埔医药(上海)有限公司 环烯烃取代的杂芳环类化合物及其用途

Similar Documents

Publication Publication Date Title
JP2020533319A5 (https=)
JP2024520481A5 (https=)
JP2023533203A5 (https=)
JP2021523200A5 (https=)
RU2395500C2 (ru) 2,4-пиримидиндиамины, применяемые в лечении неопластических болезней, воспалительных и иммунных расстройств
RU2006125377A (ru) Гетероциклические ингибиторы аспартилпротеазы
JP2020169171A5 (https=)
JP2014051526A5 (https=)
JP2021514001A5 (https=)
EA200500018A1 (ru) Бензконденсированные гетероариламидные производные тиенопиридинов, применяемые в качестве терапевтических агентов, фармацевтические композиции, включающие их, и способы их применения
JP2019518766A5 (https=)
JP2021500394A5 (https=)
JP2004516314A5 (https=)
JP2007505902A5 (https=)
JP2011515482A5 (https=)
JP2010533699A5 (https=)
JP2008510770A5 (https=)
RU2005139398A (ru) Циклические сульфонамиды для ингибирования гамма-секретазы
JP2021535207A5 (https=)
JP2017508816A5 (https=)
RU2007128313A (ru) Амиды 3-арил-3-гидрокси-2-аминопропионовой кислоты, амиды 3-гетероарил-3-гидрокси-2-аминопропионовой кислоты и родственные соединения, обладающие обезболивающим и/или иммуностимулирующим действием
JP2005536503A5 (https=)
JP2020504184A5 (https=)
RU2007147344A (ru) Новые производные 2-азетидинона для лечения гиперлипидемических заболеваний
JP2007514691A5 (https=)