JP2020533021A5 - - Google Patents
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- JP2020533021A5 JP2020533021A5 JP2020534820A JP2020534820A JP2020533021A5 JP 2020533021 A5 JP2020533021 A5 JP 2020533021A5 JP 2020534820 A JP2020534820 A JP 2020534820A JP 2020534820 A JP2020534820 A JP 2020534820A JP 2020533021 A5 JP2020533021 A5 JP 2020533021A5
- Authority
- JP
- Japan
- Prior art keywords
- stem cells
- gla
- cells
- delivery molecule
- molecule according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000000130 stem cell Anatomy 0.000 claims 21
- 238000000034 method Methods 0.000 claims 20
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 4
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 229940096437 Protein S Drugs 0.000 claims 3
- 108010066124 Protein S Proteins 0.000 claims 3
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 3
- 102100028885 Vitamin K-dependent protein S Human genes 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 2
- 101000610551 Homo sapiens Prominin-1 Proteins 0.000 claims 2
- 102100040120 Prominin-1 Human genes 0.000 claims 2
- 230000003197 catalytic effect Effects 0.000 claims 2
- UHBYWPGGCSDKFX-VKHMYHEASA-N gamma-carboxy-L-glutamic acid Chemical compound OC(=O)[C@@H](N)CC(C(O)=O)C(O)=O UHBYWPGGCSDKFX-VKHMYHEASA-N 0.000 claims 2
- 102000043253 matrix Gla protein Human genes 0.000 claims 2
- 108010057546 matrix Gla protein Proteins 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 102100022749 Aminopeptidase N Human genes 0.000 claims 1
- 101100009548 Arabidopsis thaliana DHFS gene Proteins 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- -1 CD4f Proteins 0.000 claims 1
- 102100022641 Coagulation factor IX Human genes 0.000 claims 1
- 102100023804 Coagulation factor VII Human genes 0.000 claims 1
- 108010076282 Factor IX Proteins 0.000 claims 1
- 108010023321 Factor VII Proteins 0.000 claims 1
- 108010014173 Factor X Proteins 0.000 claims 1
- 102100031487 Growth arrest-specific protein 6 Human genes 0.000 claims 1
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000923005 Homo sapiens Growth arrest-specific protein 6 Proteins 0.000 claims 1
- 101000994365 Homo sapiens Integrin alpha-6 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims 1
- 101000801254 Homo sapiens Tumor necrosis factor receptor superfamily member 16 Proteins 0.000 claims 1
- 102100032816 Integrin alpha-6 Human genes 0.000 claims 1
- 102000004067 Osteocalcin Human genes 0.000 claims 1
- 108090000573 Osteocalcin Proteins 0.000 claims 1
- 102100037765 Periostin Human genes 0.000 claims 1
- 101710199268 Periostin Proteins 0.000 claims 1
- 101800004937 Protein C Proteins 0.000 claims 1
- 102000017975 Protein C Human genes 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 101100216053 Saccharomycopsis fibuligera GLA1 gene Proteins 0.000 claims 1
- 101800001700 Saposin-D Proteins 0.000 claims 1
- 102100038081 Signal transducer CD24 Human genes 0.000 claims 1
- 108090000190 Thrombin Proteins 0.000 claims 1
- 102100033725 Tumor necrosis factor receptor superfamily member 16 Human genes 0.000 claims 1
- 210000004504 adult stem cell Anatomy 0.000 claims 1
- 230000001640 apoptogenic effect Effects 0.000 claims 1
- 210000003969 blast cell Anatomy 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000004271 bone marrow stromal cell Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 230000003511 endothelial effect Effects 0.000 claims 1
- 229960004222 factor ix Drugs 0.000 claims 1
- 229940012413 factor vii Drugs 0.000 claims 1
- 229940012426 factor x Drugs 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 230000001114 myogenic effect Effects 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 230000004987 nonapoptotic effect Effects 0.000 claims 1
- 230000001582 osteoblastic effect Effects 0.000 claims 1
- 108010025221 plasma protein Z Proteins 0.000 claims 1
- 229960000856 protein c Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000003124 radial glial cell Anatomy 0.000 claims 1
- 229960004072 thrombin Drugs 0.000 claims 1
- 230000001228 trophic effect Effects 0.000 claims 1
- 239000002753 trypsin inhibitor Substances 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762554530P | 2017-09-05 | 2017-09-05 | |
| US201762554533P | 2017-09-05 | 2017-09-05 | |
| US62/554,533 | 2017-09-05 | ||
| US62/554,530 | 2017-09-05 | ||
| US201762569411P | 2017-10-06 | 2017-10-06 | |
| US201762569403P | 2017-10-06 | 2017-10-06 | |
| US62/569,411 | 2017-10-06 | ||
| US62/569,403 | 2017-10-06 | ||
| US201762584565P | 2017-11-10 | 2017-11-10 | |
| US62/584,565 | 2017-11-10 | ||
| US201762593014P | 2017-11-30 | 2017-11-30 | |
| US62/593,014 | 2017-11-30 | ||
| PCT/US2018/049618 WO2019050997A1 (en) | 2017-09-05 | 2018-09-05 | LOAD DISTRIBUTION USEFUL IN STEM CELLS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020533021A JP2020533021A (ja) | 2020-11-19 |
| JP2020533021A5 true JP2020533021A5 (https=) | 2021-10-14 |
| JP7365704B2 JP7365704B2 (ja) | 2023-10-20 |
Family
ID=63714024
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020512854A Pending JP2020533976A (ja) | 2017-09-05 | 2018-09-05 | エキソソームを標的化する方法 |
| JP2020534821A Pending JP2020533404A (ja) | 2017-09-05 | 2018-09-05 | 細胞内送達法 |
| JP2020534820A Active JP7365704B2 (ja) | 2017-09-05 | 2018-09-05 | 幹細胞へのペイロードの送達 |
| JP2024041903A Pending JP2024073589A (ja) | 2017-09-05 | 2024-03-18 | エキソソームを標的化する方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020512854A Pending JP2020533976A (ja) | 2017-09-05 | 2018-09-05 | エキソソームを標的化する方法 |
| JP2020534821A Pending JP2020533404A (ja) | 2017-09-05 | 2018-09-05 | 細胞内送達法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024041903A Pending JP2024073589A (ja) | 2017-09-05 | 2024-03-18 | エキソソームを標的化する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20200407421A1 (https=) |
| EP (3) | EP3679127A1 (https=) |
| JP (4) | JP2020533976A (https=) |
| KR (2) | KR20200050961A (https=) |
| CN (2) | CN111065733A (https=) |
| AU (2) | AU2018330427A1 (https=) |
| BR (2) | BR112020003945A2 (https=) |
| CA (2) | CA3074291A1 (https=) |
| IL (2) | IL272908A (https=) |
| MX (2) | MX2020002250A (https=) |
| PE (2) | PE20201462A1 (https=) |
| SG (2) | SG11202001535RA (https=) |
| WO (3) | WO2019050998A1 (https=) |
| ZA (2) | ZA202000650B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3524617T (pt) | 2013-03-15 | 2023-07-12 | Gladiator Biosciences Inc | Domínios gla como agentes terapêuticos |
| AU2018316166A1 (en) | 2017-08-07 | 2020-02-06 | The Regents Of The University Of California | Platform for generating safe cell therapeutics |
| SG11202001535RA (en) | 2017-09-05 | 2020-03-30 | Gladiator Biosciences Inc | Method of targeting exosomes |
| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| CN110036976B (zh) * | 2019-05-08 | 2021-12-07 | 华南农业大学 | 一种阻断鸡禽白血病病毒垂直传播的方法及其应用 |
| CN110423777A (zh) * | 2019-07-23 | 2019-11-08 | 河南科技大学 | 无荧光染料标记外泌体及其制备方法 |
| CN110711249B (zh) * | 2019-09-19 | 2020-10-27 | 北京化工大学 | 一种溶酶体膜包覆纳米颗粒的制备方法 |
| PH12022550836A1 (en) * | 2019-10-09 | 2023-10-09 | Mayo Found Medical Education & Res | Canine distemper virus hemagglutinin and fusion polypeptides |
| KR102547446B1 (ko) * | 2019-11-29 | 2023-06-26 | 서울대학교산학협력단 | 무표지 폴리다이아세틸렌 리포좀 기반의 엑소좀의 검출 방법 |
| CN111803646B (zh) * | 2020-06-04 | 2022-07-05 | 苏州大学 | 一种实体肿瘤联合治疗组合物 |
| US20210393536A1 (en) * | 2020-06-23 | 2021-12-23 | Board Of Regents, The University Of Texas System | Methods and compositions related to extracellular vesicles |
| KR102659285B1 (ko) * | 2020-08-11 | 2024-04-22 | 경북대학교 산학협력단 | 암세포 유래 엑소좀에 선택적으로 결합하는 펩타이드 및 이의 용도 |
| CN112516110B (zh) * | 2020-10-13 | 2022-05-13 | 北京化工大学 | 一种细胞膜包覆纳米酶的方法 |
| CN112285195B (zh) * | 2020-10-27 | 2021-08-10 | 江南大学 | 一种牛奶外泌体的特征性糖蛋白标志物和牛奶外泌体的特征性标志物分离方法 |
| CN112553152B (zh) * | 2020-10-27 | 2024-09-17 | 重庆市铂而斐细胞生物技术有限公司 | 一种快速提高脂肪间充质干细胞外泌体产量的方法 |
| KR102285160B1 (ko) * | 2020-12-24 | 2021-08-03 | 주식회사 타임바이오 | 전구세포에서 유래한 다기능성 엑소좀을 포함하는 피부염 예방 또는 치료용 약학적 조성물 |
| KR102739746B1 (ko) * | 2021-10-25 | 2024-12-10 | 인하대학교 산학협력단 | 바르토넬라 헨셀라이 유래 세포외 소포체를 이용한 바르토넬라 감염증 진단 방법 |
| CN114940967B (zh) * | 2022-05-09 | 2024-05-31 | 中山大学 | 母乳细胞外囊泡及其在制备骨修复材料中的应用 |
| TWI872888B (zh) * | 2022-12-30 | 2025-02-11 | 財團法人工業技術研究院 | 用於穩定血液中游離核酸及/或外泌體核酸的組成物、含其之試劑與套組以及其用途 |
| CN116421738B (zh) * | 2023-02-28 | 2024-03-19 | 中国医科大学附属第一医院 | 捕获抗原的溶瘤病毒及其药物组合与制备和应用 |
| KR20240154736A (ko) * | 2023-04-18 | 2024-10-28 | 가톨릭대학교 산학협력단 | 면역관문 억제제의 표적화된 전달을 위한 세포외소포체의 용도 |
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| CN105567642B (zh) | 2016-02-01 | 2019-07-12 | 中国科学院生物物理研究所 | 一种着色性干皮病人多能干细胞的制备方法 |
| SG11202001535RA (en) | 2017-09-05 | 2020-03-30 | Gladiator Biosciences Inc | Method of targeting exosomes |
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