JP2020532537A5 - - Google Patents
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- JP2020532537A5 JP2020532537A5 JP2020512453A JP2020512453A JP2020532537A5 JP 2020532537 A5 JP2020532537 A5 JP 2020532537A5 JP 2020512453 A JP2020512453 A JP 2020512453A JP 2020512453 A JP2020512453 A JP 2020512453A JP 2020532537 A5 JP2020532537 A5 JP 2020532537A5
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- cancer
- immune cells
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- 239000003814 drug Substances 0.000 claims 40
- 210000002865 immune cell Anatomy 0.000 claims 33
- 239000000556 agonist Substances 0.000 claims 29
- 102100023606 Retinoic acid receptor alpha Human genes 0.000 claims 26
- 108091008726 retinoic acid receptors α Proteins 0.000 claims 26
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 23
- 238000000034 method Methods 0.000 claims 17
- 102000003702 retinoic acid receptors Human genes 0.000 claims 16
- 108090000064 retinoic acid receptors Proteins 0.000 claims 16
- 206010028980 Neoplasm Diseases 0.000 claims 14
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 10
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 10
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 10
- 230000004069 differentiation Effects 0.000 claims 10
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 10
- 230000001939 inductive effect Effects 0.000 claims 10
- 239000012190 activator Substances 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 9
- 229940079593 drug Drugs 0.000 claims 8
- 238000002619 cancer immunotherapy Methods 0.000 claims 6
- 208000009527 Refractory anemia Diseases 0.000 claims 5
- 206010072684 Refractory cytopenia with unilineage dysplasia Diseases 0.000 claims 5
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 4
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 3
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 3
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 3
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 3
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 3
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 3
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 3
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 3
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims 3
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 3
- 102000017578 LAG3 Human genes 0.000 claims 3
- 101150030213 Lag3 gene Proteins 0.000 claims 3
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 3
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 3
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 3
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 230000003467 diminishing effect Effects 0.000 claims 3
- 230000002708 enhancing effect Effects 0.000 claims 3
- 230000001024 immunotherapeutic effect Effects 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 231100000419 toxicity Toxicity 0.000 claims 3
- 230000001988 toxicity Effects 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 239000005711 Benzoic acid Substances 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 102100039282 Cytochrome P450 26A1 Human genes 0.000 claims 2
- 206010066476 Haematological malignancy Diseases 0.000 claims 2
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 2
- 101000745891 Homo sapiens Cytochrome P450 26A1 Proteins 0.000 claims 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038270 Refractory anaemia with an excess of blasts Diseases 0.000 claims 2
- 208000033501 Refractory anemia with excess blasts Diseases 0.000 claims 2
- 208000032411 Refractory with Excess of Blasts Anemia Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000003098 androgen Substances 0.000 claims 2
- 235000010233 benzoic acid Nutrition 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 230000004060 metabolic process Effects 0.000 claims 2
- 208000016586 myelodysplastic syndrome with excess blasts Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- MUTNCGKQJGXKEM-UHFFFAOYSA-N tamibarotene Chemical group C=1C=C2C(C)(C)CCC(C)(C)C2=CC=1NC(=O)C1=CC=C(C(O)=O)C=C1 MUTNCGKQJGXKEM-UHFFFAOYSA-N 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 125000006017 1-propenyl group Chemical group 0.000 claims 1
- PNAWUIKCVQSLFG-UHFFFAOYSA-N 4-[(4-chloro-3-hydroxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]-2,6-difluorobenzoic acid Chemical compound C1=C2C(C)(C)CCC(C)(C)C2=C(Cl)C(O)=C1C(=O)NC1=CC(F)=C(C(O)=O)C(F)=C1 PNAWUIKCVQSLFG-UHFFFAOYSA-N 0.000 claims 1
- -1 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl Chemical group 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 206010055113 Breast cancer metastatic Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 206010050513 Metastatic renal cell carcinoma Diseases 0.000 claims 1
- 206010052399 Neuroendocrine tumour Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 201000010133 Oligodendroglioma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 208000026149 Primary peritoneal carcinoma Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000007660 Residual Neoplasm Diseases 0.000 claims 1
- 229940096885 Retinoic acid receptor agonist Drugs 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 1
- 229960001467 bortezomib Drugs 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 150000003857 carboxamides Chemical class 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 230000003412 degenerative effect Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 201000003444 follicular lymphoma Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005249 lung adenocarcinoma Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000000564 macroglobulinemia Diseases 0.000 claims 1
- 230000036210 malignancy Effects 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 230000002071 myeloproliferative effect Effects 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 201000002120 neuroendocrine carcinoma Diseases 0.000 claims 1
- 208000016065 neuroendocrine neoplasm Diseases 0.000 claims 1
- 201000011519 neuroendocrine tumor Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 210000001539 phagocyte Anatomy 0.000 claims 1
- 210000004500 stellate cell Anatomy 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 229950010130 tamibarotene Drugs 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762552814P | 2017-08-31 | 2017-08-31 | |
| US62/552,814 | 2017-08-31 | ||
| PCT/US2018/048876 WO2019046591A1 (en) | 2017-08-31 | 2018-08-30 | SELECTIVE RAR AGONISTS IN ASSOCIATION WITH IMMUNE MODULATORS IN ANTICANCER IMMUNOTHERAPY |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020532537A JP2020532537A (ja) | 2020-11-12 |
| JP2020532537A5 true JP2020532537A5 (enExample) | 2021-10-07 |
Family
ID=65436409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020512453A Pending JP2020532537A (ja) | 2017-08-31 | 2018-08-30 | がん免疫治療法のための免疫調節物質と併せたｒａｒ選択的アゴニスト |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US10363272B2 (enExample) |
| EP (1) | EP3675843A4 (enExample) |
| JP (1) | JP2020532537A (enExample) |
| KR (1) | KR20200044889A (enExample) |
| CN (1) | CN111148514A (enExample) |
| AU (1) | AU2018326617B2 (enExample) |
| CA (1) | CA3073953A1 (enExample) |
| IL (1) | IL272971A (enExample) |
| MX (1) | MX2020002262A (enExample) |
| NZ (1) | NZ761401A (enExample) |
| SG (1) | SG11202001479RA (enExample) |
| WO (1) | WO2019046591A1 (enExample) |
| ZA (1) | ZA202001884B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT1937244T (lt) | 2005-09-30 | 2018-11-12 | Io Therapeutics, Llc | Vėžio gydymas specifiniais rxr agonistais |
| US10653650B2 (en) | 2011-12-13 | 2020-05-19 | Io Therapeutics, Inc. | Treatment of diseases by concurrently eliciting remyelination effects and immunomodulatory effects using selective RXR agonists |
| CN110151745A (zh) | 2011-12-13 | 2019-08-23 | Io治疗公司 | 使用rxr激动剂的自身免疫紊乱的治疗 |
| KR102149321B1 (ko) | 2015-10-31 | 2020-08-28 | 아이오 테라퓨틱스, 인크. | Rxr 아고니스트와 갑상선 호르몬의 조합을 사용한 신경계 질환의 치료 |
| NZ745704A (en) | 2016-03-10 | 2019-04-26 | Io Therapeutics Inc | Treatment of muscular disorders with combinations of rxr agonists and thyroid hormones |
| KR102549273B1 (ko) | 2016-03-10 | 2023-06-28 | 아이오 테라퓨틱스, 인크. | Rxr 작용제 및 갑상선 호르몬의 조합을 사용한 자가면역 질환의 치료 |
| CA3069672A1 (en) | 2017-07-13 | 2019-01-17 | Io Therapeutics, Inc. | Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy |
| CA3073953A1 (en) | 2017-08-31 | 2019-03-07 | Io Therapeutics, Inc. | Rar selective agonists in combination with immune modulators for cancer immunotherapy |
| EP3684348A4 (en) | 2017-09-20 | 2021-08-18 | IO Therapeutics, Inc. | TREATMENT OF DISEASES WITH ETERS FROM SELECTIVE RXR AGONISTS |
| US10966950B2 (en) | 2019-06-11 | 2021-04-06 | Io Therapeutics, Inc. | Use of an RXR agonist in treating HER2+ cancers |
| CN112390731B (zh) * | 2020-11-16 | 2022-11-25 | 成都大学 | 一种具有多靶点的维甲酸类衍生物及其制备方法与应用 |
| KR20240115316A (ko) | 2021-12-07 | 2024-07-25 | 아이오 테라퓨틱스, 인크. | 약물 내성 her2+ 암 치료에서의 rxr 작용제의 용도 |
| EP4444287A4 (en) | 2021-12-07 | 2025-05-28 | Io Therapeutics, Inc. | USE OF AN RXR AGONIST AND TAXANES FOR THE TREATMENT OF HER2+ CANCER |
| CN119451672A (zh) | 2022-06-27 | 2025-02-14 | Io治疗公司 | 四氢萘酚的合成及其用途 |
| CN115678915A (zh) * | 2022-08-31 | 2023-02-03 | 中国医学科学院肿瘤医院 | 一种rarg基因敲减稳转细胞株及其构建方法与应用 |
| KR102874422B1 (ko) | 2022-11-04 | 2025-10-22 | 한국원자력연구원 | 무정전 전원을 갖는 환경방사선 감시시스템의 전원 시스템 및 그 방법 |
| WO2026152120A2 (en) | 2025-01-13 | 2026-07-16 | HCW Biologics, Inc. | Chimeric polypeptides and uses thereof |
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2018
- 2018-08-30 CA CA3073953A patent/CA3073953A1/en active Pending
- 2018-08-30 WO PCT/US2018/048876 patent/WO2019046591A1/en not_active Ceased
- 2018-08-30 JP JP2020512453A patent/JP2020532537A/ja active Pending
- 2018-08-30 CN CN201880056488.6A patent/CN111148514A/zh active Pending
- 2018-08-30 AU AU2018326617A patent/AU2018326617B2/en active Active
- 2018-08-30 EP EP18852337.7A patent/EP3675843A4/en active Pending
- 2018-08-30 SG SG11202001479RA patent/SG11202001479RA/en unknown
- 2018-08-30 NZ NZ761401A patent/NZ761401A/en unknown
- 2018-08-30 MX MX2020002262A patent/MX2020002262A/es unknown
- 2018-08-30 US US16/117,372 patent/US10363272B2/en active Active
- 2018-08-30 KR KR1020207008540A patent/KR20200044889A/ko not_active Ceased
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2019
- 2019-06-26 US US16/452,800 patent/US10532073B2/en active Active
- 2019-07-23 US US16/519,544 patent/US10532074B2/en active Active
- 2019-12-12 US US16/711,627 patent/US10874694B2/en active Active
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2020
- 2020-02-27 IL IL272971A patent/IL272971A/en unknown
- 2020-03-24 ZA ZA2020/01884A patent/ZA202001884B/en unknown
- 2020-12-16 US US17/123,577 patent/US11786555B2/en active Active
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