CN111148514A - 与免疫调节剂联合应用于癌症免疫治疗的rar选择性激动剂 - Google Patents
与免疫调节剂联合应用于癌症免疫治疗的rar选择性激动剂 Download PDFInfo
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- CN111148514A CN111148514A CN201880056488.6A CN201880056488A CN111148514A CN 111148514 A CN111148514 A CN 111148514A CN 201880056488 A CN201880056488 A CN 201880056488A CN 111148514 A CN111148514 A CN 111148514A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762552814P | 2017-08-31 | 2017-08-31 | |
| US62/552,814 | 2017-08-31 | ||
| PCT/US2018/048876 WO2019046591A1 (en) | 2017-08-31 | 2018-08-30 | SELECTIVE RAR AGONISTS IN ASSOCIATION WITH IMMUNE MODULATORS IN ANTICANCER IMMUNOTHERAPY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111148514A true CN111148514A (zh) | 2020-05-12 |
Family
ID=65436409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880056488.6A Pending CN111148514A (zh) | 2017-08-31 | 2018-08-30 | 与免疫调节剂联合应用于癌症免疫治疗的rar选择性激动剂 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US10363272B2 (enExample) |
| EP (1) | EP3675843A4 (enExample) |
| JP (1) | JP2020532537A (enExample) |
| KR (1) | KR20200044889A (enExample) |
| CN (1) | CN111148514A (enExample) |
| AU (1) | AU2018326617B2 (enExample) |
| CA (1) | CA3073953A1 (enExample) |
| IL (1) | IL272971A (enExample) |
| MX (1) | MX2020002262A (enExample) |
| NZ (1) | NZ761401A (enExample) |
| SG (1) | SG11202001479RA (enExample) |
| WO (1) | WO2019046591A1 (enExample) |
| ZA (1) | ZA202001884B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112390731A (zh) * | 2020-11-16 | 2021-02-23 | 成都大学 | 一种具有多靶点的维甲酸类衍生物及其制备方法与应用 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006299645B2 (en) | 2005-09-30 | 2011-02-03 | Io Therapeutics, Llc | Treatment of cancer with specific RXR agonists |
| US10653650B2 (en) | 2011-12-13 | 2020-05-19 | Io Therapeutics, Inc. | Treatment of diseases by concurrently eliciting remyelination effects and immunomodulatory effects using selective RXR agonists |
| US20130190395A1 (en) | 2011-12-13 | 2013-07-25 | Dartmouth College | Autoimmune disorder treatment using rxr agonists |
| KR102149321B1 (ko) | 2015-10-31 | 2020-08-28 | 아이오 테라퓨틱스, 인크. | Rxr 아고니스트와 갑상선 호르몬의 조합을 사용한 신경계 질환의 치료 |
| US10835507B2 (en) | 2016-03-10 | 2020-11-17 | Io Therapeutics, Inc. | Treatment of muscular disorders with combinations of RXR agonists and thyroid hormones |
| CA3016876C (en) | 2016-03-10 | 2021-12-28 | Io Therapeutics, Inc. | Treatment of autoimmune diseases with combinations of rxr agonists and thyroid hormones |
| NZ760459A (en) | 2017-07-13 | 2023-05-26 | Io Therapeutics Inc | Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy |
| WO2019046591A1 (en) | 2017-08-31 | 2019-03-07 | Io Therapeutics, Inc. | SELECTIVE RAR AGONISTS IN ASSOCIATION WITH IMMUNE MODULATORS IN ANTICANCER IMMUNOTHERAPY |
| CA3076373A1 (en) | 2017-09-20 | 2019-03-28 | Io Therapeutics, Inc. | Treatment of disease with esters of selective rxr agonists |
| US10966950B2 (en) | 2019-06-11 | 2021-04-06 | Io Therapeutics, Inc. | Use of an RXR agonist in treating HER2+ cancers |
| MX2024006980A (es) | 2021-12-07 | 2024-07-19 | Io Therapeutics Inc | Uso de un agonista de rxr en el tratamiento de cáncer her2+ resistente a fármacos. |
| KR20240119103A (ko) | 2021-12-07 | 2024-08-06 | 아이오 테라퓨틱스, 인크. | Her2+ 암 치료에서의 rxr 작용제 및 탁산의 용도 |
| CN119451672A (zh) * | 2022-06-27 | 2025-02-14 | Io治疗公司 | 四氢萘酚的合成及其用途 |
| KR102874422B1 (ko) | 2022-11-04 | 2025-10-22 | 한국원자력연구원 | 무정전 전원을 갖는 환경방사선 감시시스템의 전원 시스템 및 그 방법 |
Citations (5)
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| WO2001074759A1 (en) * | 2000-04-04 | 2001-10-11 | Allergan, Inc. | Treatment of tumors with rar alpha selective retinoid compounds in combination with other anti-tumor agents |
| US20070077652A1 (en) * | 2004-09-16 | 2007-04-05 | Tony Peled | Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells |
| US20140286973A1 (en) * | 2013-03-15 | 2014-09-25 | The Trustees Of The University Of Pennsylvania | Chimeric antigen receptor specific for folate receptor beta |
| WO2016144976A1 (en) * | 2015-03-09 | 2016-09-15 | Kings College London | Combination therapy with rar alpha agonists for enhancing th1 response |
| WO2017091762A1 (en) * | 2015-11-25 | 2017-06-01 | Io Therapeutics, Inc. | Use of cyp26-resistant rar alpha selective agonists in the treatment of cancer |
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| GB1576007A (en) | 1976-02-11 | 1980-10-01 | Beecham Group Ltd | Hypolipidaemic compositions |
| US4326055A (en) | 1977-12-22 | 1982-04-20 | Hoffmann-La Roche Inc. | Stilbene derivatives |
| US5234926A (en) | 1987-03-20 | 1993-08-10 | Allergan, Inc. | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
| US5324840A (en) | 1992-06-11 | 1994-06-28 | Allergan, Inc. | Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects |
| KR0126300B1 (ko) | 1992-12-28 | 1997-12-26 | 나이토 하루오 | 레티노이드 수용체(rar)에 결합하는 헤테로고리 탄산유도체 |
| CA2138000A1 (en) | 1994-01-03 | 1995-07-04 | John E. Starrett, Jr. | Retinoid-like compounds |
| US5824685A (en) | 1995-02-01 | 1998-10-20 | The Johns Hopkins University School Of Medicine | Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists |
| US6942980B1 (en) | 1995-09-01 | 2005-09-13 | Allergan, Inc. | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities |
| US5958954A (en) | 1995-09-01 | 1999-09-28 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| US5776699A (en) | 1995-09-01 | 1998-07-07 | Allergan, Inc. | Method of identifying negative hormone and/or antagonist activities |
| FR2739557B1 (fr) | 1995-10-09 | 1997-11-14 | Cird Galderma | Utilisation d'un ligand agoniste specifique rar-gamma |
| US5965606A (en) * | 1995-12-29 | 1999-10-12 | Allergan Sales, Inc. | Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity |
| US5877207A (en) | 1996-03-11 | 1999-03-02 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| US5723666A (en) | 1996-06-21 | 1998-03-03 | Allergan | Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
| ES2196361T3 (es) | 1996-08-28 | 2003-12-16 | Inst Nat Sante Rech Med | Combinaciones terapeuticas de antagonistas de rar y agonistas de rxr. |
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