CA3073953A1 - Rar selective agonists in combination with immune modulators for cancer immunotherapy - Google Patents

Rar selective agonists in combination with immune modulators for cancer immunotherapy Download PDF

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Publication number
CA3073953A1
CA3073953A1 CA3073953A CA3073953A CA3073953A1 CA 3073953 A1 CA3073953 A1 CA 3073953A1 CA 3073953 A CA3073953 A CA 3073953A CA 3073953 A CA3073953 A CA 3073953A CA 3073953 A1 CA3073953 A1 CA 3073953A1
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Prior art keywords
car
active agent
cancer
mic
cells
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Pending
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CA3073953A
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English (en)
French (fr)
Inventor
Roshantha A. Chandraratna
Martin E. Sanders
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IO Therapeutics Inc
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IO Therapeutics Inc
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61K2039/80—Vaccine for a specifically defined cancer
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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CA3073953A 2017-08-31 2018-08-30 Rar selective agonists in combination with immune modulators for cancer immunotherapy Pending CA3073953A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762552814P 2017-08-31 2017-08-31
US62/552,814 2017-08-31
PCT/US2018/048876 WO2019046591A1 (en) 2017-08-31 2018-08-30 SELECTIVE RAR AGONISTS IN ASSOCIATION WITH IMMUNE MODULATORS IN ANTICANCER IMMUNOTHERAPY

Publications (1)

Publication Number Publication Date
CA3073953A1 true CA3073953A1 (en) 2019-03-07

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Application Number Title Priority Date Filing Date
CA3073953A Pending CA3073953A1 (en) 2017-08-31 2018-08-30 Rar selective agonists in combination with immune modulators for cancer immunotherapy

Country Status (13)

Country Link
US (5) US10363272B2 (enExample)
EP (1) EP3675843A4 (enExample)
JP (1) JP2020532537A (enExample)
KR (1) KR20200044889A (enExample)
CN (1) CN111148514A (enExample)
AU (1) AU2018326617B2 (enExample)
CA (1) CA3073953A1 (enExample)
IL (1) IL272971A (enExample)
MX (1) MX2020002262A (enExample)
NZ (1) NZ761401A (enExample)
SG (1) SG11202001479RA (enExample)
WO (1) WO2019046591A1 (enExample)
ZA (1) ZA202001884B (enExample)

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CA3069672A1 (en) 2017-07-13 2019-01-17 Io Therapeutics, Inc. Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy
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EP3684348A4 (en) 2017-09-20 2021-08-18 IO Therapeutics, Inc. TREATMENT OF DISEASES WITH ETERS FROM SELECTIVE RXR AGONISTS
US10966950B2 (en) 2019-06-11 2021-04-06 Io Therapeutics, Inc. Use of an RXR agonist in treating HER2+ cancers
CN112390731B (zh) * 2020-11-16 2022-11-25 成都大学 一种具有多靶点的维甲酸类衍生物及其制备方法与应用
KR20240115316A (ko) 2021-12-07 2024-07-25 아이오 테라퓨틱스, 인크. 약물 내성 her2+ 암 치료에서의 rxr 작용제의 용도
EP4444287A4 (en) 2021-12-07 2025-05-28 Io Therapeutics, Inc. USE OF AN RXR AGONIST AND TAXANES FOR THE TREATMENT OF HER2+ CANCER
CN119451672A (zh) 2022-06-27 2025-02-14 Io治疗公司 四氢萘酚的合成及其用途
CN115678915A (zh) * 2022-08-31 2023-02-03 中国医学科学院肿瘤医院 一种rarg基因敲减稳转细胞株及其构建方法与应用
KR102874422B1 (ko) 2022-11-04 2025-10-22 한국원자력연구원 무정전 전원을 갖는 환경방사선 감시시스템의 전원 시스템 및 그 방법
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