AU2018326617B2 - Rar selective agonists in combination with immune modulators for cancer immunotherapy - Google Patents

Rar selective agonists in combination with immune modulators for cancer immunotherapy Download PDF

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AU2018326617B2
AU2018326617B2 AU2018326617A AU2018326617A AU2018326617B2 AU 2018326617 B2 AU2018326617 B2 AU 2018326617B2 AU 2018326617 A AU2018326617 A AU 2018326617A AU 2018326617 A AU2018326617 A AU 2018326617A AU 2018326617 B2 AU2018326617 B2 AU 2018326617B2
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cells
cancer
car
rara
agonist
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AU2018326617A1 (en
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Roshantha A. Chandraratna
Martin E. Sanders
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IO Therapeutics Inc
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IO Therapeutics Inc
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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AU2018326617A 2017-08-31 2018-08-30 Rar selective agonists in combination with immune modulators for cancer immunotherapy Active AU2018326617B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762552814P 2017-08-31 2017-08-31
US62/552,814 2017-08-31
PCT/US2018/048876 WO2019046591A1 (en) 2017-08-31 2018-08-30 SELECTIVE RAR AGONISTS IN ASSOCIATION WITH IMMUNE MODULATORS IN ANTICANCER IMMUNOTHERAPY

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AU2018326617A1 AU2018326617A1 (en) 2020-02-27
AU2018326617B2 true AU2018326617B2 (en) 2022-12-01

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US (5) US10363272B2 (enExample)
EP (1) EP3675843A4 (enExample)
JP (1) JP2020532537A (enExample)
KR (1) KR20200044889A (enExample)
CN (1) CN111148514A (enExample)
AU (1) AU2018326617B2 (enExample)
CA (1) CA3073953A1 (enExample)
IL (1) IL272971A (enExample)
MX (1) MX2020002262A (enExample)
NZ (1) NZ761401A (enExample)
SG (1) SG11202001479RA (enExample)
WO (1) WO2019046591A1 (enExample)
ZA (1) ZA202001884B (enExample)

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US10835507B2 (en) 2016-03-10 2020-11-17 Io Therapeutics, Inc. Treatment of muscular disorders with combinations of RXR agonists and thyroid hormones
CA3016876C (en) 2016-03-10 2021-12-28 Io Therapeutics, Inc. Treatment of autoimmune diseases with combinations of rxr agonists and thyroid hormones
NZ760459A (en) 2017-07-13 2023-05-26 Io Therapeutics Inc Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy
WO2019046591A1 (en) 2017-08-31 2019-03-07 Io Therapeutics, Inc. SELECTIVE RAR AGONISTS IN ASSOCIATION WITH IMMUNE MODULATORS IN ANTICANCER IMMUNOTHERAPY
CA3076373A1 (en) 2017-09-20 2019-03-28 Io Therapeutics, Inc. Treatment of disease with esters of selective rxr agonists
US10966950B2 (en) 2019-06-11 2021-04-06 Io Therapeutics, Inc. Use of an RXR agonist in treating HER2+ cancers
CN112390731B (zh) * 2020-11-16 2022-11-25 成都大学 一种具有多靶点的维甲酸类衍生物及其制备方法与应用
MX2024006980A (es) 2021-12-07 2024-07-19 Io Therapeutics Inc Uso de un agonista de rxr en el tratamiento de cáncer her2+ resistente a fármacos.
KR20240119103A (ko) 2021-12-07 2024-08-06 아이오 테라퓨틱스, 인크. Her2+ 암 치료에서의 rxr 작용제 및 탁산의 용도
CN119451672A (zh) * 2022-06-27 2025-02-14 Io治疗公司 四氢萘酚的合成及其用途
KR102874422B1 (ko) 2022-11-04 2025-10-22 한국원자력연구원 무정전 전원을 갖는 환경방사선 감시시스템의 전원 시스템 및 그 방법

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