ZA202001884B - Rar selective agonists in combination with immune modulators for cancer immunotherapy - Google Patents

Rar selective agonists in combination with immune modulators for cancer immunotherapy

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Publication number
ZA202001884B
ZA202001884B ZA2020/01884A ZA202001884A ZA202001884B ZA 202001884 B ZA202001884 B ZA 202001884B ZA 2020/01884 A ZA2020/01884 A ZA 2020/01884A ZA 202001884 A ZA202001884 A ZA 202001884A ZA 202001884 B ZA202001884 B ZA 202001884B
Authority
ZA
South Africa
Prior art keywords
combination
cancer immunotherapy
selective agonists
immune modulators
rar selective
Prior art date
Application number
ZA2020/01884A
Other languages
English (en)
Inventor
Roshantha A Chandraratna
Martin E Sanders
Original Assignee
Io Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Io Therapeutics Inc filed Critical Io Therapeutics Inc
Publication of ZA202001884B publication Critical patent/ZA202001884B/en

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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]

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ZA2020/01884A 2017-08-31 2020-03-24 Rar selective agonists in combination with immune modulators for cancer immunotherapy ZA202001884B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762552814P 2017-08-31 2017-08-31
PCT/US2018/048876 WO2019046591A1 (en) 2017-08-31 2018-08-30 SELECTIVE RAR AGONISTS IN ASSOCIATION WITH IMMUNE MODULATORS IN ANTICANCER IMMUNOTHERAPY

Publications (1)

Publication Number Publication Date
ZA202001884B true ZA202001884B (en) 2021-10-27

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Application Number Title Priority Date Filing Date
ZA2020/01884A ZA202001884B (en) 2017-08-31 2020-03-24 Rar selective agonists in combination with immune modulators for cancer immunotherapy

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Country Link
US (5) US10363272B2 (enExample)
EP (1) EP3675843A4 (enExample)
JP (1) JP2020532537A (enExample)
KR (1) KR20200044889A (enExample)
CN (1) CN111148514A (enExample)
AU (1) AU2018326617B2 (enExample)
CA (1) CA3073953A1 (enExample)
IL (1) IL272971A (enExample)
MX (1) MX2020002262A (enExample)
NZ (1) NZ761401A (enExample)
SG (1) SG11202001479RA (enExample)
WO (1) WO2019046591A1 (enExample)
ZA (1) ZA202001884B (enExample)

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KR20240115316A (ko) 2021-12-07 2024-07-25 아이오 테라퓨틱스, 인크. 약물 내성 her2+ 암 치료에서의 rxr 작용제의 용도
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