JP2020532537A - がん免疫治療法のための免疫調節物質と併せたrar選択的アゴニスト - Google Patents
がん免疫治療法のための免疫調節物質と併せたrar選択的アゴニスト Download PDFInfo
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- JP2020532537A JP2020532537A JP2020512453A JP2020512453A JP2020532537A JP 2020532537 A JP2020532537 A JP 2020532537A JP 2020512453 A JP2020512453 A JP 2020512453A JP 2020512453 A JP2020512453 A JP 2020512453A JP 2020532537 A JP2020532537 A JP 2020532537A
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Epidemiology (AREA)
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- Medicinal Chemistry (AREA)
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- Biomedical Technology (AREA)
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- Genetics & Genomics (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762552814P | 2017-08-31 | 2017-08-31 | |
| US62/552,814 | 2017-08-31 | ||
| PCT/US2018/048876 WO2019046591A1 (en) | 2017-08-31 | 2018-08-30 | SELECTIVE RAR AGONISTS IN ASSOCIATION WITH IMMUNE MODULATORS IN ANTICANCER IMMUNOTHERAPY |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020532537A true JP2020532537A (ja) | 2020-11-12 |
| JP2020532537A5 JP2020532537A5 (enExample) | 2021-10-07 |
Family
ID=65436409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020512453A Pending JP2020532537A (ja) | 2017-08-31 | 2018-08-30 | がん免疫治療法のための免疫調節物質と併せたrar選択的アゴニスト |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US10363272B2 (enExample) |
| EP (1) | EP3675843A4 (enExample) |
| JP (1) | JP2020532537A (enExample) |
| KR (1) | KR20200044889A (enExample) |
| CN (1) | CN111148514A (enExample) |
| AU (1) | AU2018326617B2 (enExample) |
| CA (1) | CA3073953A1 (enExample) |
| IL (1) | IL272971A (enExample) |
| MX (1) | MX2020002262A (enExample) |
| NZ (1) | NZ761401A (enExample) |
| SG (1) | SG11202001479RA (enExample) |
| WO (1) | WO2019046591A1 (enExample) |
| ZA (1) | ZA202001884B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2623638A1 (en) | 2005-09-30 | 2007-04-12 | Vitae Pharmaceuticals, Inc. | Treatment of cancer with specific rxr agonists |
| US10653650B2 (en) | 2011-12-13 | 2020-05-19 | Io Therapeutics, Inc. | Treatment of diseases by concurrently eliciting remyelination effects and immunomodulatory effects using selective RXR agonists |
| AU2012352149B2 (en) | 2011-12-13 | 2017-06-01 | Io Therapeutics, Inc. | Autoimmune disorder treatment using RXR agonists |
| KR102489706B1 (ko) | 2015-10-31 | 2023-01-17 | 아이오 테라퓨틱스, 인크. | Rxr 아고니스트와 갑상선 호르몬의 조합을 사용한 신경계 질환의 치료 |
| EP3426303B1 (en) | 2016-03-10 | 2022-06-15 | IO Therapeutics, Inc. | Treatment of muscular disorders with combinations of rxr agonists and thyroid hormones |
| MX386643B (es) | 2016-03-10 | 2025-03-19 | Io Therapeutics Inc | Tratamiento contra enfermedades autoinmunitarias con combinaciones de agonistas rxr y hormonas tiroideas. |
| MX2020000467A (es) | 2017-07-13 | 2020-08-03 | Io Therapeutics Inc | Compuestos retinoides y rexinoides inmunomoduladores en combinacion con inmunomoduladores para inmunoterapia contra cancer. |
| CN111148514A (zh) | 2017-08-31 | 2020-05-12 | Io治疗公司 | 与免疫调节剂联合应用于癌症免疫治疗的rar选择性激动剂 |
| US11517549B2 (en) | 2017-09-20 | 2022-12-06 | Io Therapeutics, Inc. | Treatment of disease with esters of selective RXR agonists |
| US10966950B2 (en) | 2019-06-11 | 2021-04-06 | Io Therapeutics, Inc. | Use of an RXR agonist in treating HER2+ cancers |
| CN112390731B (zh) * | 2020-11-16 | 2022-11-25 | 成都大学 | 一种具有多靶点的维甲酸类衍生物及其制备方法与应用 |
| KR20240119103A (ko) | 2021-12-07 | 2024-08-06 | 아이오 테라퓨틱스, 인크. | Her2+ 암 치료에서의 rxr 작용제 및 탁산의 용도 |
| KR20240115316A (ko) | 2021-12-07 | 2024-07-25 | 아이오 테라퓨틱스, 인크. | 약물 내성 her2+ 암 치료에서의 rxr 작용제의 용도 |
| IL317992A (en) * | 2022-06-27 | 2025-02-01 | Io Therapeutics Inc | Processes for preparing tetrahydronaphthalenolic materials and their use |
| KR102874422B1 (ko) | 2022-11-04 | 2025-10-22 | 한국원자력연구원 | 무정전 전원을 갖는 환경방사선 감시시스템의 전원 시스템 및 그 방법 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017091762A1 (en) * | 2015-11-25 | 2017-06-01 | Io Therapeutics, Inc. | Use of cyp26-resistant rar alpha selective agonists in the treatment of cancer |
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| GB1576007A (en) | 1976-02-11 | 1980-10-01 | Beecham Group Ltd | Hypolipidaemic compositions |
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| CA3073953A1 (en) | 2019-03-07 |
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