JP2020530294A5 - - Google Patents

Download PDF

Info

Publication number
JP2020530294A5
JP2020530294A5 JP2020506981A JP2020506981A JP2020530294A5 JP 2020530294 A5 JP2020530294 A5 JP 2020530294A5 JP 2020506981 A JP2020506981 A JP 2020506981A JP 2020506981 A JP2020506981 A JP 2020506981A JP 2020530294 A5 JP2020530294 A5 JP 2020530294A5
Authority
JP
Japan
Prior art keywords
cells
naive
composition
cell
stimulated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020506981A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020530294A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/046151 external-priority patent/WO2019032929A1/en
Publication of JP2020530294A publication Critical patent/JP2020530294A/ja
Publication of JP2020530294A5 publication Critical patent/JP2020530294A5/ja
Priority to JP2023015156A priority Critical patent/JP2023055888A/ja
Priority to JP2024223646A priority patent/JP2025031794A/ja
Pending legal-status Critical Current

Links

JP2020506981A 2017-08-09 2018-08-09 遺伝子操作された細胞を調製するための方法および組成物 Pending JP2020530294A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023015156A JP2023055888A (ja) 2017-08-09 2023-02-03 遺伝子操作された細胞を調製するための方法および組成物
JP2024223646A JP2025031794A (ja) 2017-08-09 2024-12-19 遺伝子操作された細胞を調製するための方法および組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762543359P 2017-08-09 2017-08-09
US62/543,359 2017-08-09
PCT/US2018/046151 WO2019032929A1 (en) 2017-08-09 2018-08-09 METHODS AND COMPOSITIONS FOR PREPARING GENETICALLY MODIFIED CELLS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023015156A Division JP2023055888A (ja) 2017-08-09 2023-02-03 遺伝子操作された細胞を調製するための方法および組成物

Publications (2)

Publication Number Publication Date
JP2020530294A JP2020530294A (ja) 2020-10-22
JP2020530294A5 true JP2020530294A5 (OSRAM) 2021-09-16

Family

ID=63405422

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020506981A Pending JP2020530294A (ja) 2017-08-09 2018-08-09 遺伝子操作された細胞を調製するための方法および組成物
JP2023015156A Pending JP2023055888A (ja) 2017-08-09 2023-02-03 遺伝子操作された細胞を調製するための方法および組成物
JP2024223646A Pending JP2025031794A (ja) 2017-08-09 2024-12-19 遺伝子操作された細胞を調製するための方法および組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023015156A Pending JP2023055888A (ja) 2017-08-09 2023-02-03 遺伝子操作された細胞を調製するための方法および組成物
JP2024223646A Pending JP2025031794A (ja) 2017-08-09 2024-12-19 遺伝子操作された細胞を調製するための方法および組成物

Country Status (12)

Country Link
US (2) US20200239910A1 (OSRAM)
EP (2) EP4516896A3 (OSRAM)
JP (3) JP2020530294A (OSRAM)
KR (2) KR20250096881A (OSRAM)
CN (1) CN111263641B (OSRAM)
AU (2) AU2018313952B2 (OSRAM)
BR (1) BR112020001601A2 (OSRAM)
CA (1) CA3070575A1 (OSRAM)
ES (1) ES2992909T3 (OSRAM)
MA (1) MA49981A (OSRAM)
MX (1) MX2020001491A (OSRAM)
WO (1) WO2019032929A1 (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018218222A1 (en) 2017-05-26 2018-11-29 Goldfless Stephen Jacob High-throughput polynucleotide library sequencing and transcriptome analysis
CN111225675B (zh) 2017-06-02 2024-05-03 朱诺治疗学股份有限公司 使用过继细胞疗法治疗的制品和方法
MX2020001490A (es) 2017-08-09 2020-08-06 Juno Therapeutics Inc Metodos para producir composiciones de celulas geneticamente modificadas y composiciones relacionadas.
PL3704230T3 (pl) 2017-11-01 2025-02-24 Juno Therapeutics, Inc. Proces wytwarzania kompozycji terapeutycznych z komórek zmodyfikowanych genetycznie
JP2021505615A (ja) 2017-12-08 2021-02-18 ジュノー セラピューティクス インコーポレイテッド 細胞療法および関連方法のための表現型マーカー
CN113474450A (zh) * 2018-08-09 2021-10-01 朱诺治疗学股份有限公司 产生工程化细胞的方法以及所述工程化细胞的组合物
WO2020088631A1 (en) 2018-11-01 2020-05-07 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for t cell engineering
US20220220504A1 (en) 2019-05-28 2022-07-14 Miltenyi Biotec B.V. & Co. KG Method for Generation of Genetically Modified T Cells
US20220412954A1 (en) 2019-11-05 2022-12-29 Juno Therapeutics, Inc. Methods of determining attributes of therapeutic t cell compositions
KR20220146480A (ko) * 2020-01-28 2022-11-01 주노 쎄러퓨티크스 인코퍼레이티드 T 세포 형질도입 방법
AU2021265797A1 (en) 2020-04-28 2022-12-08 Lyell Immunopharma, Inc. Methods for culturing cells
KR20230024283A (ko) 2020-05-13 2023-02-20 주노 쎄러퓨티크스 인코퍼레이티드 임상 반응과 관련된 특징을 식별하는 방법 및 이의 용도
CA3184940A1 (en) 2020-07-07 2022-01-13 Jennifer Donglan WU Mic antibodies and binding agents and methods of using the same
US12144827B2 (en) 2021-02-25 2024-11-19 Lyell Immunopharma, Inc. ROR1 targeting chimeric antigen receptor
WO2023230548A1 (en) 2022-05-25 2023-11-30 Celgene Corporation Method for predicting response to a t cell therapy
CN119506185A (zh) * 2023-08-22 2025-02-25 深圳赛桥生物创新技术有限公司 细胞样本处理方法、装置、系统和介质
WO2025097034A1 (en) * 2023-11-03 2025-05-08 Kyverna Therapeutics, Inc. Methods for manufacture of engineered t cells from whole blood samples

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4690915A (en) 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
ES2067018T3 (es) 1988-12-28 1995-03-16 Stefan Miltenyi Procedimiento y materiales para la separacion en alto gradiente magnetico de materiales biologicos.
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
DE4228458A1 (de) 1992-08-27 1994-06-01 Beiersdorf Ag Multicistronische Expressionseinheiten und deren Verwendung
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
WO1996013593A2 (en) 1994-10-26 1996-05-09 Procept, Inc. Soluble single chain t cell receptors
WO1996018105A1 (en) 1994-12-06 1996-06-13 The President And Fellows Of Harvard College Single chain t-cell receptor
US20020150914A1 (en) 1995-06-30 2002-10-17 Kobenhavns Universitet Recombinant antibodies from a phage display library, directed against a peptide-MHC complex
DE19608753C1 (de) 1996-03-06 1997-06-26 Medigene Gmbh Transduktionssystem und seine Verwendung
US6451995B1 (en) 1996-03-20 2002-09-17 Sloan-Kettering Institute For Cancer Research Single chain FV polynucleotide or peptide constructs of anti-ganglioside GD2 antibodies, cells expressing same and related methods
JP2001519143A (ja) 1997-10-02 2001-10-23 スノル・モレキュラー・コーポレーション 可溶性の一本鎖t細胞レセプタータンパク質
WO1999060120A2 (en) 1998-05-19 1999-11-25 Avidex Limited Soluble t cell receptor
WO2000014257A1 (en) 1998-09-04 2000-03-16 Sloan-Kettering Institute For Cancer Research Fusion receptors specific for prostate-specific membrane antigen and uses thereof
AU2472400A (en) 1998-10-20 2000-05-08 City Of Hope CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
US20030235908A1 (en) 2000-02-24 2003-12-25 Xcyte Therapies, Inc. Activation and expansion of cells
US20040191260A1 (en) 2003-03-26 2004-09-30 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
WO2001094944A2 (en) 2000-06-02 2001-12-13 Memorial Sloan-Kettering Cancer Center Artificial antigen presenting cells and methods of use thereof
ATE338124T1 (de) 2000-11-07 2006-09-15 Hope City Cd19-spezifische umgezielte immunzellen
US7070995B2 (en) 2001-04-11 2006-07-04 City Of Hope CE7-specific redirected immune cells
US20090257994A1 (en) 2001-04-30 2009-10-15 City Of Hope Chimeric immunoreceptor useful in treating human cancers
ATE290020T1 (de) 2001-08-31 2005-03-15 Avidex Ltd Löslicher t zell rezeptor
US7939059B2 (en) 2001-12-10 2011-05-10 California Institute Of Technology Method for the generation of antigen-specific lymphocytes
US6992176B2 (en) 2002-02-13 2006-01-31 Technion Research & Development Foundation Ltd. Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
CA2476625A1 (en) 2002-02-20 2003-08-28 Dyax Corp. Mhc-peptide complex binding ligands
US20030170238A1 (en) 2002-03-07 2003-09-11 Gruenberg Micheal L. Re-activated T-cells for adoptive immunotherapy
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
US20050084967A1 (en) 2002-06-28 2005-04-21 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
EP1549748B1 (en) 2002-10-09 2014-10-01 Immunocore Ltd. Single chain recombinant t cell receptors
US20050129671A1 (en) 2003-03-11 2005-06-16 City Of Hope Mammalian antigen-presenting T cells and bi-specific T cells
DK1623017T3 (da) 2003-05-08 2011-01-10 Life Technologies Corp Frembringelse og isolering af antigenspecifikke T-celler
US20090226474A1 (en) 2004-05-27 2009-09-10 Weidanz Jon A Antibodies as T cell receptor mimics, methods of production and uses thereof
US20090304679A1 (en) 2004-05-27 2009-12-10 Weidanz Jon A Antibodies as T cell receptor mimics, methods of production and uses thereof
CA2567814C (en) 2004-05-27 2013-07-23 Jon A. Weidanz Antibodies as t cell receptor mimics, methods of production and uses thereof
ATE475669T1 (de) 2004-06-29 2010-08-15 Immunocore Ltd Einen modifizierten t-zellen-rezeptor exprimierende zellen
AU2008219681A1 (en) * 2007-02-28 2008-09-04 Merck Sharp & Dohme Corp. Combination therapy for treatment of immune disorders
EP2856876B1 (en) 2007-03-30 2018-01-31 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
DK2520643T3 (da) 2007-12-07 2020-01-20 Miltenyi Biotec Bv & Co Kg Prøvebehandlingssystemer og -fremgangsmåder
US8479118B2 (en) 2007-12-10 2013-07-02 Microsoft Corporation Switching search providers within a browser search box
US20120164718A1 (en) 2008-05-06 2012-06-28 Innovative Micro Technology Removable/disposable apparatus for MEMS particle sorting device
JP5173594B2 (ja) 2008-05-27 2013-04-03 キヤノン株式会社 管理装置、画像形成装置及びそれらの処理方法
CA2777053A1 (en) 2009-10-06 2011-04-14 The Board Of Trustees Of The University Of Illinois Human single-chain t cell receptors
CA2779526C (en) 2009-11-03 2022-12-06 City Of Hope Truncated epiderimal growth factor receptor (egfrt) for transduced t cell selection
WO2012048341A1 (en) 2010-10-08 2012-04-12 President And Fellows Of Harvard College High-throughput single cell barcoding
ES2730951T3 (es) 2010-10-08 2019-11-13 Harvard College Secuenciación inmune de alto rendimiento
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
CN110200997A (zh) * 2011-03-23 2019-09-06 弗雷德哈钦森癌症研究中心 用于细胞免疫治疗的方法和组合物
EA201391449A1 (ru) 2011-04-01 2014-03-31 Мемориал Слоан-Кеттеринг Кэнсер Сентер Антитела против пептидов цитозоля
US8398282B2 (en) 2011-05-12 2013-03-19 Delphi Technologies, Inc. Vehicle front lighting assembly and systems having a variable tint electrowetting element
ES2687954T3 (es) 2011-11-11 2018-10-30 Fred Hutchinson Cancer Research Center Inmunoterapia de linfocitos T dirigidos a ciclina A1 contra el cáncer
EP3594245A1 (en) 2012-02-13 2020-01-15 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
WO2013126726A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Double transgenic t cells comprising a car and a tcr and their methods of use
RU2018130123A (ru) 2012-05-03 2018-11-07 Фред Хатчинсон Кансэр Рисёч Сентер Клетка, экспрессирующая t-клеточный рецептор (tcr), для применения в клеточной иммунотерапии
IL293944A (en) 2012-08-20 2022-08-01 Hutchinson Fred Cancer Res Method and preparations for cellular immunotherapy
CN104853766A (zh) 2012-10-02 2015-08-19 纪念斯隆-凯特琳癌症中心 用于免疫疗法的组合物和方法
WO2014097442A1 (ja) 2012-12-20 2014-06-26 三菱電機株式会社 車載装置及びプログラム
US10119134B2 (en) 2013-03-15 2018-11-06 Abvitro Llc Single cell bar-coding for antibody discovery
ES2828982T3 (es) * 2013-05-14 2021-05-28 Univ Texas Aplicación humana de células t de receptor de antígeno quimérico (car) diseñadas
US9108442B2 (en) 2013-08-20 2015-08-18 Ricoh Company, Ltd. Image forming apparatus
AU2015249554B2 (en) * 2014-04-23 2021-08-19 Juno Therapeutics, Inc. Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy
CN107074929B (zh) 2014-05-02 2021-09-03 宾夕法尼亚大学董事会 嵌合自身抗体受体t细胞的组合物和方法
TWI751102B (zh) 2014-08-28 2022-01-01 美商奇諾治療有限公司 對cd19具專一性之抗體及嵌合抗原受體
MX378730B (es) 2014-09-15 2025-03-11 Abvitro Llc Secuenciacion de bibliotecas de nucleotidos de alto rendimiento
JP6753851B2 (ja) 2014-12-05 2020-09-09 メモリアル スローン ケタリング キャンサー センター Gタンパク質共役受容体を標的化する抗体および使用の方法
ES2899779T3 (es) 2014-12-05 2022-03-14 Memorial Sloan Kettering Cancer Center Receptores antigénicos quiméricos dirigidos a receptor acoplado a proteína G y usos de los mismos
ES2966099T3 (es) 2014-12-05 2024-04-18 Memorial Sloan Kettering Cancer Center Receptores de antígeno quiméricos dirigidos al antígeno de maduración de células B y usos de los mismos
HUE053995T2 (hu) 2014-12-05 2021-08-30 Memorial Sloan Kettering Cancer Center B-sejt-érési antigént célzó antitestek és alkalmazási eljárások
HRP20220893T1 (hr) * 2015-04-08 2022-10-14 Novartis Ag Cd20 terapije, cd22 terapije, i kombinirane terapije sa stanicom koja eksprimira cd19 kimerni antigenski receptor
WO2016166568A1 (en) * 2015-04-16 2016-10-20 Juno Therapeutics Gmbh Methods, kits and apparatus for expanding a population of cells
AU2016253964B2 (en) 2015-04-27 2022-07-07 Abvitro Llc Methods of sequencing, determining, pairing, and validating therapeutic agents and disease specific antigens
CN108369230B (zh) 2015-09-25 2021-09-17 阿布维特罗有限责任公司 用于对天然配对t细胞受体序列进行t细胞受体靶向鉴别的高通量方法
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés

Similar Documents

Publication Publication Date Title
JP2020530294A5 (OSRAM)
Maeda et al. Regeneration of CD8αβ T cells from T-cell–derived iPSC imparts potent tumor antigen-specific cytotoxicity
Gargett et al. Different cytokine and stimulation conditions influence the expansion and immune phenotype of third-generation chimeric antigen receptor T cells specific for tumor antigen GD2
CN111263641B (zh) 用于制备基因工程化细胞的方法和组合物
KR102229421B1 (ko) 항원-특이적 t 세포 식별, 농축, 및/또는 증식을 위한 시약 및 방법
JP2021505168A5 (OSRAM)
Ptáčková et al. A new approach to CAR T-cell gene engineering and cultivation using piggyBac transposon in the presence of IL-4, IL-7 and IL-21
JP5934897B2 (ja) T細胞レセプターβ鎖遺伝子及びα鎖遺伝子
JP2022185055A (ja) 組換え受容体を発現している細胞を増大させるための試薬
JP2021501604A5 (OSRAM)
JP2021505615A5 (OSRAM)
US11299552B2 (en) Eliminating MHC restriction from the T cell receptor as a strategy for immunotherapy
CN105473731A (zh) 自身癌抗原特异性cd8+t细胞的分离及增殖方法
JP2020527036A (ja) 癌免疫療法用mr1制限t細胞受容体
Matsuzaki et al. A rare population of tumor antigen-specific CD4+ CD8+ double-positive αβ T lymphocytes uniquely provide CD8-independent TCR genes for engineering therapeutic T cells
KR20240161837A (ko) 생체내 지속성 및 치료학적 활성 및 이의 증식을 위한 nkt-세포 서브세트
JP2021536260A (ja) 抗原特異的car−t細胞を拡大増殖する方法、それに関連する組成物及び使用
Blaeschke et al. Human HLA-A* 02: 01/CHM1+ allo-restricted T cell receptor transgenic CD8+ T cells specifically inhibit Ewing sarcoma growth in vitro and in vivo
JPWO2019113557A5 (OSRAM)
CN111826353B (zh) 调节t细胞功能和反应的方法
JP2022500038A (ja) 癌免疫療法用mr1制限t細胞受容体
Hillerdal et al. Avidity characterization of genetically engineered T-cells with novel and established approaches
Hu et al. Application of adoptive cell therapy in malignant melanoma
Weinstein-Marom et al. Genetic modification of tumor-infiltrating lymphocytes via retroviral transduction
KR20230022868A (ko) 재조합 수용체를 발현하는 공여자-배치 세포의 제조 방법