JP2020529839A5 - - Google Patents
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- JP2020529839A5 JP2020529839A5 JP2019572470A JP2019572470A JP2020529839A5 JP 2020529839 A5 JP2020529839 A5 JP 2020529839A5 JP 2019572470 A JP2019572470 A JP 2019572470A JP 2019572470 A JP2019572470 A JP 2019572470A JP 2020529839 A5 JP2020529839 A5 JP 2020529839A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 148
- 239000000427 antigen Substances 0.000 claims description 49
- 102000036639 antigens Human genes 0.000 claims description 49
- 108091007433 antigens Proteins 0.000 claims description 49
- 102000039446 nucleic acids Human genes 0.000 claims description 13
- 108020004707 nucleic acids Proteins 0.000 claims description 13
- 150000007523 nucleic acids Chemical class 0.000 claims description 13
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 108091008874 T cell receptors Proteins 0.000 claims description 8
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 5
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 4
- 102000016978 Orphan receptors Human genes 0.000 claims description 4
- 108070000031 Orphan receptors Proteins 0.000 claims description 4
- 108020003175 receptors Proteins 0.000 claims description 4
- 102000005962 receptors Human genes 0.000 claims description 4
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 4
- 206010005003 Bladder cancer Diseases 0.000 claims description 3
- 206010006187 Breast cancer Diseases 0.000 claims description 3
- 208000026310 Breast neoplasm Diseases 0.000 claims description 3
- 206010009944 Colon cancer Diseases 0.000 claims description 3
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 3
- 206010033128 Ovarian cancer Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 3
- 206010060862 Prostate cancer Diseases 0.000 claims description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 3
- 206010038389 Renal cancer Diseases 0.000 claims description 3
- 206010039491 Sarcoma Diseases 0.000 claims description 3
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 3
- 206010057644 Testis cancer Diseases 0.000 claims description 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 3
- 208000002495 Uterine Neoplasms Diseases 0.000 claims description 3
- 201000005188 adrenal gland cancer Diseases 0.000 claims description 3
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 201000000053 blastoma Diseases 0.000 claims description 3
- 208000029742 colonic neoplasm Diseases 0.000 claims description 3
- 201000008184 embryoma Diseases 0.000 claims description 3
- 208000005017 glioblastoma Diseases 0.000 claims description 3
- 201000010982 kidney cancer Diseases 0.000 claims description 3
- 208000032839 leukemia Diseases 0.000 claims description 3
- 201000005202 lung cancer Diseases 0.000 claims description 3
- 208000020816 lung neoplasm Diseases 0.000 claims description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 3
- 201000001441 melanoma Diseases 0.000 claims description 3
- 210000005036 nerve Anatomy 0.000 claims description 3
- 201000002528 pancreatic cancer Diseases 0.000 claims description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 3
- 201000003120 testicular cancer Diseases 0.000 claims description 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 3
- 206010046766 uterine cancer Diseases 0.000 claims description 3
- 239000013598 vector Substances 0.000 claims description 3
- 210000004027 cell Anatomy 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 238000000034 method Methods 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1710838.2A GB201710838D0 (en) | 2017-07-05 | 2017-07-05 | Bispecific antibodies |
| GB1710838.2 | 2017-07-05 | ||
| PCT/GB2018/051916 WO2019008379A1 (en) | 2017-07-05 | 2018-07-05 | BISPECIFIC ANTIBODIES DIRECTED AGAINST ROR1 AND CD3 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020529839A JP2020529839A (ja) | 2020-10-15 |
| JP2020529839A5 true JP2020529839A5 (enExample) | 2021-08-12 |
Family
ID=59592717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019572470A Pending JP2020529839A (ja) | 2017-07-05 | 2018-07-05 | Ｒｏｒ１及びｃｄ３に対する二重特異性抗体 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11306142B2 (enExample) |
| EP (2) | EP3645565B1 (enExample) |
| JP (1) | JP2020529839A (enExample) |
| CN (1) | CN110891972B (enExample) |
| AU (1) | AU2018295479A1 (enExample) |
| CA (1) | CA3068200A1 (enExample) |
| DK (1) | DK3645565T3 (enExample) |
| ES (1) | ES2906361T3 (enExample) |
| GB (1) | GB201710838D0 (enExample) |
| MX (1) | MX2019015349A (enExample) |
| WO (1) | WO2019008379A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201710835D0 (en) * | 2017-07-05 | 2017-08-16 | Ucl Business Plc | ROR1 Antibodies |
| CN111662382A (zh) * | 2019-03-06 | 2020-09-15 | 瑞阳(苏州)生物科技有限公司 | 特异结合cd3的抗体、抗原结合片段和单链抗体可变区片段及其应用 |
| KR102503349B1 (ko) | 2019-05-14 | 2023-02-23 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| JP7611171B2 (ja) * | 2019-05-23 | 2025-01-09 | ベロスビオ・インコーポレイテッド | 抗ｒｏｒ１／抗ｃｄ３二重特異性結合分子 |
| CN114127110B (zh) * | 2019-05-30 | 2022-07-01 | 山东博安生物技术股份有限公司 | 抗cgrp抗体及其应用 |
| TWI841790B (zh) * | 2019-09-30 | 2024-05-11 | 大陸商和鉑醫藥（上海）有限責任公司 | 靶向cd3的抗體、雙特異性抗體及其用途 |
| US12006366B2 (en) | 2020-06-11 | 2024-06-11 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| CN114085288A (zh) * | 2020-08-24 | 2022-02-25 | 岸迈生物科技(苏州)有限公司 | 抗ror1抗体 |
| PE20250740A1 (es) | 2021-02-02 | 2025-03-13 | Numab Therapeutics AG | Anticuerpos multiespecificos con especificidad para ror1 y cd3 |
| AU2022227686A1 (en) | 2021-02-25 | 2023-07-27 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| JP2024513238A (ja) * | 2021-04-09 | 2024-03-22 | ソレント・セラピューティクス・インコーポレイテッド | 抗ｒｏｒ１／抗ｃｄ３二重特異性抗体を発現する腫瘍溶解性ウイルス |
| US20250121081A1 (en) * | 2021-12-28 | 2025-04-17 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Anti-ror1 antibody, and anti-ror1 antibody-drug conjugate and medical uses thereof |
| GB202216284D0 (en) | 2022-11-02 | 2022-12-14 | Ucl Business Ltd | Self-regulation |
| WO2024094151A1 (en) * | 2022-11-03 | 2024-05-10 | Hansoh Bio Llc | Multi-specific antibody and medical use thereof |
| CN120712345A (zh) * | 2022-12-30 | 2025-09-26 | 上药生物治疗（香港）有限公司 | 表达趋化因子受体的细胞及其用途 |
| WO2025061032A1 (zh) * | 2023-09-18 | 2025-03-27 | 南京蓬勃生物科技有限公司 | 靶向人源ror1和cd3的双特异性抗体 |
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-
2017
- 2017-07-05 GB GBGB1710838.2A patent/GB201710838D0/en not_active Ceased
-
2018
- 2018-07-05 CA CA3068200A patent/CA3068200A1/en active Pending
- 2018-07-05 CN CN201880045360.XA patent/CN110891972B/zh active Active
- 2018-07-05 ES ES18742577T patent/ES2906361T3/es active Active
- 2018-07-05 EP EP18742577.2A patent/EP3645565B1/en active Active
- 2018-07-05 US US16/628,404 patent/US11306142B2/en active Active
- 2018-07-05 AU AU2018295479A patent/AU2018295479A1/en not_active Abandoned
- 2018-07-05 EP EP21206411.7A patent/EP3985026A1/en active Pending
- 2018-07-05 MX MX2019015349A patent/MX2019015349A/es unknown
- 2018-07-05 JP JP2019572470A patent/JP2020529839A/ja active Pending
- 2018-07-05 WO PCT/GB2018/051916 patent/WO2019008379A1/en not_active Ceased
- 2018-07-05 DK DK18742577.2T patent/DK3645565T3/da active
-
2022
- 2022-03-18 US US17/698,657 patent/US20220204621A1/en not_active Abandoned
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