MX2019015349A - Anticuerpos biespecificos para receptor 1 huerfano tipo receptor de tirosina cinasa (ror1) y grupo de diferenciacion 3 (cd3). - Google Patents

Anticuerpos biespecificos para receptor 1 huerfano tipo receptor de tirosina cinasa (ror1) y grupo de diferenciacion 3 (cd3).

Info

Publication number
MX2019015349A
MX2019015349A MX2019015349A MX2019015349A MX2019015349A MX 2019015349 A MX2019015349 A MX 2019015349A MX 2019015349 A MX2019015349 A MX 2019015349A MX 2019015349 A MX2019015349 A MX 2019015349A MX 2019015349 A MX2019015349 A MX 2019015349A
Authority
MX
Mexico
Prior art keywords
bispecific antibodies
ror1
receptor
tcr
subunit
Prior art date
Application number
MX2019015349A
Other languages
English (en)
Inventor
Amit Nathwani
Satyen Gohil
Peruta Marco Della
Original Assignee
Ucl Business Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucl Business Ltd filed Critical Ucl Business Ltd
Publication of MX2019015349A publication Critical patent/MX2019015349A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen anticuerpos biespecíficos los cuales se unen selectivamente al receptor 1 huérfano tipo receptor de tirosina cinasa (ROR1) y la subunidad CD3 del receptor de linfocito T (TCR), su producción y su uso. También se describe el uso de los anticuerpos biespecíficos en el tratamiento de cáncer.
MX2019015349A 2017-07-05 2018-07-05 Anticuerpos biespecificos para receptor 1 huerfano tipo receptor de tirosina cinasa (ror1) y grupo de diferenciacion 3 (cd3). MX2019015349A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1710838.2A GB201710838D0 (en) 2017-07-05 2017-07-05 Bispecific antibodies
PCT/GB2018/051916 WO2019008379A1 (en) 2017-07-05 2018-07-05 BISPECIFIC ANTIBODIES DIRECTED AGAINST ROR1 AND CD3

Publications (1)

Publication Number Publication Date
MX2019015349A true MX2019015349A (es) 2020-07-20

Family

ID=59592717

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019015349A MX2019015349A (es) 2017-07-05 2018-07-05 Anticuerpos biespecificos para receptor 1 huerfano tipo receptor de tirosina cinasa (ror1) y grupo de diferenciacion 3 (cd3).

Country Status (11)

Country Link
US (2) US11306142B2 (es)
EP (2) EP3645565B1 (es)
JP (1) JP2020529839A (es)
CN (1) CN110891972B (es)
AU (1) AU2018295479A1 (es)
CA (1) CA3068200A1 (es)
DK (1) DK3645565T3 (es)
ES (1) ES2906361T3 (es)
GB (1) GB201710838D0 (es)
MX (1) MX2019015349A (es)
WO (1) WO2019008379A1 (es)

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WO2020237173A1 (en) * 2019-05-23 2020-11-26 VelosBio Inc. Anti-ror1/anti-cd3 bispecific binding molecules
WO2020239014A1 (zh) * 2019-05-30 2020-12-03 山东博安生物技术有限公司 抗cgrp抗体及其应用
KR20220071263A (ko) * 2019-09-30 2022-05-31 하버 바이오메드 (쑤저우) 컴퍼니 리미티드 Cd3을 표적으로 하는 항체, 이중 특이성 항체 및 이의 용도
US12006366B2 (en) 2020-06-11 2024-06-11 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
CN113480656B (zh) * 2020-08-24 2022-06-03 岸迈生物科技(苏州)有限公司 抗ror1抗体
EP4288451A1 (en) 2021-02-02 2023-12-13 Numab Therapeutics AG Multispecific antibodies having specificity for ror1 and cd3
WO2023125619A1 (zh) * 2021-12-28 2023-07-06 江苏恒瑞医药股份有限公司 抗ror1抗体和抗ror1抗体药物偶联物及其医药用途
GB202216284D0 (en) 2022-11-02 2022-12-14 Ucl Business Ltd Self-regulation
WO2024094151A1 (en) * 2022-11-03 2024-05-10 Hansoh Bio Llc Multi-specific antibody and medical use thereof

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Also Published As

Publication number Publication date
US11306142B2 (en) 2022-04-19
JP2020529839A (ja) 2020-10-15
ES2906361T3 (es) 2022-04-18
CA3068200A1 (en) 2019-01-10
US20200157218A1 (en) 2020-05-21
GB201710838D0 (en) 2017-08-16
EP3645565A1 (en) 2020-05-06
EP3645565B1 (en) 2021-12-15
CN110891972B (zh) 2023-05-30
AU2018295479A1 (en) 2020-01-16
DK3645565T3 (da) 2022-02-14
EP3985026A1 (en) 2022-04-20
CN110891972A (zh) 2020-03-17
US20220204621A1 (en) 2022-06-30
WO2019008379A1 (en) 2019-01-10

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