ATE209258T1 - Verwendung von rna-polymerase zur verbesserung von nukeinsaeure-amplifikationsverfahren - Google Patents

Verwendung von rna-polymerase zur verbesserung von nukeinsaeure-amplifikationsverfahren

Info

Publication number
ATE209258T1
ATE209258T1 AT95929679T AT95929679T ATE209258T1 AT E209258 T1 ATE209258 T1 AT E209258T1 AT 95929679 T AT95929679 T AT 95929679T AT 95929679 T AT95929679 T AT 95929679T AT E209258 T1 ATE209258 T1 AT E209258T1
Authority
AT
Austria
Prior art keywords
template
rna
dna
reagents
rna polymerase
Prior art date
Application number
AT95929679T
Other languages
English (en)
Inventor
Roy Sooknanan
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Application granted granted Critical
Publication of ATE209258T1 publication Critical patent/ATE209258T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT95929679T 1994-07-15 1995-07-13 Verwendung von rna-polymerase zur verbesserung von nukeinsaeure-amplifikationsverfahren ATE209258T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27525094A 1994-07-15 1994-07-15
PCT/CA1995/000423 WO1996002668A1 (en) 1994-07-15 1995-07-13 Use of rna polymerase to improve nucleic acid amplification process

Publications (1)

Publication Number Publication Date
ATE209258T1 true ATE209258T1 (de) 2001-12-15

Family

ID=23051486

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95929679T ATE209258T1 (de) 1994-07-15 1995-07-13 Verwendung von rna-polymerase zur verbesserung von nukeinsaeure-amplifikationsverfahren

Country Status (12)

Country Link
US (1) US6025134A (de)
EP (1) EP0776376B1 (de)
JP (1) JP3881009B2 (de)
KR (1) KR100392551B1 (de)
AT (1) ATE209258T1 (de)
AU (1) AU711115B2 (de)
CA (1) CA2195209C (de)
DE (1) DE69524105T2 (de)
DK (1) DK0776376T3 (de)
ES (1) ES2168380T3 (de)
PT (1) PT776376E (de)
WO (1) WO1996002668A1 (de)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712127A (en) 1996-04-29 1998-01-27 Genescape Inc. Subtractive amplification
AU4938497A (en) 1996-11-12 1998-06-03 Visible Genetics Inc. Method and kit for direct isothermal sequencing of nucleic acids
ZA989950B (en) 1997-11-17 1999-05-04 Akzo Nobel Nv Transcription based amplification of double stranded DNA targets
EP1056884B9 (de) * 1998-02-27 2002-07-24 PamGene B.V. Verfahren zur unspezifischen amplifizierung einer nukleinsäure
WO2000000638A2 (en) * 1998-06-26 2000-01-06 Akzo Nobel N.V. Tagging of rna amplicons generated by transcription-based amplification
CA2336539A1 (en) * 1998-07-31 2000-02-10 Gen-Probe Incorporated Reversible inhibiting probes
WO2003064679A2 (en) 2002-01-30 2003-08-07 Id Biomedical Corporation Methods for detecting vancomycin-resistant microorganisms and compositions therefor
US7384741B2 (en) 2002-05-17 2008-06-10 The United States Of America As Represented By The Department Of Health And Human Services Molecular identification of Aspergillus species
US20040018494A1 (en) * 2002-07-25 2004-01-29 Shurtliff Roxanne N Isothermal transcription based amplification assay for detection and quantification of guanylyl cyclase C
EP1545575A4 (de) 2002-09-19 2006-04-05 Us Gov Health & Human Serv P. ariasi polypeptide, p. perniciosus polypeptide und anwendungsverfahren
MXPA05004714A (es) 2002-10-29 2006-03-17 Us Gov Health & Human Serv Polipeptidos de lutzomyia longipalpis y metodos de uso.
EP1945780B1 (de) 2005-10-14 2015-09-16 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Tollwutvirusvektorsysteme sowie zusammensetzungen und verfahren dazu
ATE541057T1 (de) 2006-02-13 2012-01-15 Us Gov Health & Human Serv Primer und sonden für den nachweis und die unterscheidung von typen und subtypen des influenzavirus
US8053181B2 (en) 2006-03-14 2011-11-08 Oregon Health & Science University Methods for detecting a Mycobacterium tuberculosis infection
CA2947292C (en) 2006-12-27 2019-07-23 Emory University Compositions and methods for the treatment of infections and tumors
EP2125868B1 (de) 2007-02-28 2015-06-10 The Govt. Of U.S.A. As Represented By The Secretary Of The Department Of Health And Human Services Brachyurie-polypeptide und verwendungsverfahren
EP2868754A1 (de) 2008-04-10 2015-05-06 Genenews Corporation Verfahren zur Bestimmung der Wahrscheinlichkeit von kolorektalem Krebs in einer Person
JP2012503206A (ja) 2008-09-22 2012-02-02 オレゴン ヘルス アンド サイエンス ユニバーシティ Ｍｙｃｏｂａｃｔｅｒｉｕｍｔｕｂｅｒｃｕｌｏｓｉｓ感染を検出するための方法
JP5520961B2 (ja) 2008-11-28 2014-06-11 エモリー ユニバーシティ 感染症および腫瘍を処置するための方法
US20120004133A1 (en) 2009-02-20 2012-01-05 The Johns Hopkins University Method for the diagnosis of age-associated vascular disorders
US8835117B2 (en) 2009-05-29 2014-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Nucleic acids for detection and discrimination of genotypes of Chlamydophila psittaci
CA2763321C (en) 2009-05-29 2018-10-16 Ventana Medical Systems, Inc. Methods of scoring gene copy number in a biological sample using in situ hybridization
WO2010138908A1 (en) 2009-05-29 2010-12-02 Ventana Medical Systems, Inc. Igfir gene copy number as a prognostic marker in a non-small cell lung cancer
WO2011038290A2 (en) 2009-09-25 2011-03-31 The U. S. A., As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to hiv-1 and their use
WO2011047340A1 (en) 2009-10-16 2011-04-21 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Insertion of foreign genes in rubella virus and their stable expression in a live, attenuated viral vaccine
EP2501397B1 (de) 2009-11-20 2017-10-04 Oregon Health and Science University Verfahren zum hervorrufen einer immunantwort auf tuberkulose
EP2558596B1 (de) 2010-04-16 2018-03-14 The Government Of The United States Of America As Reresented By The Secretary Of The Department Of Health & Human Services Echtzeit-pcr-test zum nachweis von bakteriellen erregern von atemwegserkrankungen
US9828637B2 (en) 2010-04-18 2017-11-28 Wake Forest University Health Sciences Methods of predicting predisposition to or risk of kidney disease
CN104689314B (zh) 2010-06-16 2018-02-02 高等教育联邦系统-匹兹堡大学 内质蛋白的抗体及其用途
US20130316338A1 (en) 2010-06-29 2013-11-28 The United States Government As Represented By The Department Of Veterans Affairs CCR6 As A Biomarker of Alzheimer's Disease
SI2611925T1 (en) 2010-08-30 2018-04-30 Dow Agrosciences, Llc Potassium Cancer Virus (SCBV) amplifier and its use in plant functional genomics
BR112013004691A2 (pt) 2010-08-30 2017-11-21 Dow Agrosciences Llc construto de dna de ativação gênica marcada de milho, população marcada de plantas de milho, método para geração da mesma e método para gerar uma planta de milho marcada
WO2012103250A2 (en) 2011-01-25 2012-08-02 Almac Diagnostics Limited Colon cancer gene expression signatures and methods of use
US9150644B2 (en) 2011-04-12 2015-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
WO2012151111A1 (en) 2011-05-04 2012-11-08 Htg Molecular Diagnostics, Inc. Quantitative nuclease protection assay (qnpa) and sequencing (qnps) improvements
WO2013006684A1 (en) 2011-07-05 2013-01-10 The Gov. Of The U.S.A. As Represented By The Secretary Of The Dept. Of Health And Human Services. Hiv-1 genotyping assay for global surveillance of hiv-1 drug resistance
US20140234360A1 (en) 2011-09-30 2014-08-21 The United States of America, as represented by the Secretary, Dept.of Health and Human Services Influenza vaccine
JP6181660B2 (ja) 2011-11-15 2017-08-16 ユニヴェルシテ リブル ドゥ ブリュッセル 血中のストレプトコッカス・ニューモニエの検出
AR090204A1 (es) 2012-02-29 2014-10-29 Dow Agrosciences Llc Potenciador viral baciliforme de caña de azucar (scbv) y su uso en la genomica funcional de plantas
US9421250B2 (en) 2012-03-23 2016-08-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pathogenic phlebovirus isolates and compositions and methods of use
WO2013148147A1 (en) 2012-03-26 2013-10-03 The U.S.A., As Represented By The Secretary Dept. Of Health And Human Services Dna methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms
US9566329B2 (en) 2012-04-06 2017-02-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Live, attenuated rubella vector to express vaccine antigens
AU2013252785B2 (en) 2012-04-27 2017-05-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of CpG oligonucleotides co-formulated with an antibiotic to accelarate wound healing
US9803251B2 (en) 2012-05-03 2017-10-31 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods of detecting influenza virus
US9394574B2 (en) 2012-06-12 2016-07-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for detecting Legionella nucleic acids in a sample
WO2013192100A1 (en) 2012-06-18 2013-12-27 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods and compositions for detecting jc virus
WO2014043518A1 (en) 2012-09-14 2014-03-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Brachyury protein, non-poxvirus non-yeast vectors encoding brachyury protein, and their use
US9775895B2 (en) 2012-12-12 2017-10-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HIV therapeutics and methods of making and using same
JP6426110B2 (ja) 2013-02-01 2018-11-21 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ 人口多能性幹細胞（ｉｐｓｃ）由来の網膜色素上皮（ｒｐｅ）細胞を生成するための方法
EP2956169B1 (de) 2013-02-12 2018-04-11 THE UNITED STATES OF AMERICA, represented by the S Monoklonale antikörper zur neutralisierung von noroviren
US10612088B2 (en) 2013-03-14 2020-04-07 The Broad Institute, Inc. Massively multiplexed RNA sequencing
WO2014172661A1 (en) 2013-04-19 2014-10-23 The Regent Of The University Of California Lone star virus
US10000556B2 (en) 2013-05-09 2018-06-19 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Single-domain VHH antibodies directed to norovirus GI.1 and GII.4 and their use
EP3399055A1 (de) 2013-10-22 2018-11-07 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Zusammensetzungen und verfahren zur erkennung von influenzaviren
US10398772B2 (en) 2014-01-08 2019-09-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Ras pathways as markers of protection against HIV and methods to improve vaccine efficacy
US20170058366A1 (en) 2014-02-21 2017-03-02 The United States of America, as represented by th e Secretary, Dept. of Health and Human Services Hiv-2 nucleic acids and methods of detection
US20170044631A1 (en) 2014-04-14 2017-02-16 The Unite States of America, as represented by the Secretary, Dept. of Health and Human Services Methods for rapid detection and identification of viral nucleic acids
WO2015199976A1 (en) 2014-06-24 2015-12-30 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Target activated microdissection
US20170268070A1 (en) 2014-07-30 2017-09-21 Mor Research Applications Ltd. Prognostic methods and systems of treatment for acute lymphoblastic leukemia
JP6811706B2 (ja) 2014-07-31 2021-01-13 ザ ホンコン ユニヴァーシティ オブ サイエンス アンド テクノロジー Ｅｐｈａ４に対するヒトモノクローナル抗体及びそれらの使用
EP3754027A1 (de) 2014-12-01 2020-12-23 The Broad Institute, Inc. Verfahren zur in-situ-bestimmung der nähe von nukleinsäuren
US10072070B2 (en) 2014-12-05 2018-09-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Potent anti-influenza A neuraminidase subtype N1 antibody
WO2016134144A1 (en) 2015-02-20 2016-08-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods and reagents for detecting ebola virus
EP3268462B1 (de) 2015-03-11 2021-08-11 The Broad Institute, Inc. Genotyp- und phänotypkupplung
EP3337908A4 (de) 2015-08-18 2019-01-23 The Broad Institute, Inc. Verfahren und zusammensetzungen zur veränderung der funktion und struktur von chromatinschleifen und/oder -domänen
WO2017062246A1 (en) 2015-10-05 2017-04-13 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Human rota virus g9p[6] strain and use as a vaccine
WO2017192589A1 (en) 2016-05-02 2017-11-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to influenza ha and their use and identification
US11155885B2 (en) 2016-05-20 2021-10-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Real-time reverse transcriptase-polymerase chain reaction assay with modified probe for the diagnosis of rabies viruses and other lyssaviruses
WO2018005284A1 (en) 2016-06-27 2018-01-04 The United State Of America, As Represented By The Secretary, Department Of Health And Human Services Methods and compositions for influenza a virus subtyping
US12209292B2 (en) 2016-08-26 2025-01-28 The Broad Institute, Inc. Nucleic acid amplification assays for detection of pathogens
WO2018106545A1 (en) 2016-12-06 2018-06-14 Oregon State University Compositions and methods for enhanced production of enduracidin in a genetically engineered strain of streptomyces fungicidicus
US11708613B2 (en) 2017-05-03 2023-07-25 The United States of America, as Represened by the Secretary, Department of Health and Human Services Rapid detection of Zika virus by reverse transcription loop-mediated isothermal amplification
WO2018232028A1 (en) 2017-06-14 2018-12-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Detection of blaimp antibacterial resistance genes
GB201710838D0 (en) 2017-07-05 2017-08-16 Ucl Business Plc Bispecific antibodies
ES2974557T3 (es) 2017-09-25 2024-06-27 Fred Hutchinson Cancer Center Perfiles in situ de alta eficiencia dirigidos a todo el genoma
US20200255828A1 (en) 2017-10-04 2020-08-13 The Broad Institute, Inc. Methods and compositions for altering function and structure of chromatin loops and/or domains
WO2019133727A1 (en) 2017-12-29 2019-07-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Universal influenza virus probe set for enrichment of any influenza virus nucleic acid
WO2019152860A1 (en) 2018-02-02 2019-08-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Random amplification methods for extremely low input nucleic acids
CN112770742A (zh) 2018-07-27 2021-05-07 阿佩塔生物科学有限公司 用于治疗蠕形螨引起的眼部和面部疾病的多杀菌素制剂
US12188099B2 (en) 2018-12-12 2025-01-07 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Integrated proviral sequencing assay
US12009061B2 (en) 2019-04-10 2024-06-11 University of Pittsburgh—of the Commonwealth System of Higher Education Computational filtering of methylated sequence data for predictive modeling
US20220214332A1 (en) 2019-05-30 2022-07-07 Oregon Health & Science University Methods for Detecting A Mycobacterium Tuberculosis Infection
CN114641580A (zh) 2019-07-23 2022-06-17 斯奈普Dna 检测和监测病原体的系统和方法
US11844800B2 (en) 2019-10-30 2023-12-19 Massachusetts Institute Of Technology Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
WO2022056078A1 (en) 2020-09-11 2022-03-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rnase h-assisted detection assay for rna (radar)
IL308870A (en) 2021-05-26 2024-01-01 Centarix Biotech Ltd Methods for identifying critically short telomeres
WO2024191684A1 (en) 2023-03-10 2024-09-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Detection of hepatitis c virus ribonucleic acid from whole blood using reverse transcription loop-mediated isothermal amplification

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5130238A (en) * 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
EP0731175A3 (de) * 1989-07-11 2004-05-26 Gen-Probe Incorporated Oligonukleotid-Sonden für Nukleinsäure von HIV
WO1991004340A1 (en) * 1989-09-20 1991-04-04 Cambridge Biotech Corporation In vitro, isothermal nucleic acid amplification
DE69029401T2 (de) * 1989-09-21 1997-07-10 Camborne Ind Plc Wiedergewinnung von schrott

Also Published As

Publication number Publication date
EP0776376B1 (de) 2001-11-21
CA2195209A1 (en) 1996-02-01
DE69524105D1 (de) 2002-01-03
AU3336695A (en) 1996-02-16
US6025134A (en) 2000-02-15
JPH11505402A (ja) 1999-05-21
AU711115B2 (en) 1999-10-07
PT776376E (pt) 2002-05-31
EP0776376A1 (de) 1997-06-04
CA2195209C (en) 2008-09-23
JP3881009B2 (ja) 2007-02-14
KR100392551B1 (ko) 2003-10-30
WO1996002668A1 (en) 1996-02-01
ES2168380T3 (es) 2002-06-16
DE69524105T2 (de) 2002-07-18
DK0776376T3 (da) 2002-02-18

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