CN113993901A - 四价双特异性抗体、其制备方法和用途 - Google Patents

四价双特异性抗体、其制备方法和用途 Download PDF

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CN113993901A
CN113993901A CN202180003485.8A CN202180003485A CN113993901A CN 113993901 A CN113993901 A CN 113993901A CN 202180003485 A CN202180003485 A CN 202180003485A CN 113993901 A CN113993901 A CN 113993901A
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antibody
seq
light chain
heavy chain
fab
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赵杰
黄浩旻
朱祯平
朱云霞
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Sunshine Guojian Pharmaceutical Shanghai Co Ltd
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Sunshine Guojian Pharmaceutical Shanghai Co Ltd
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Priority to CN202111641110.2A priority Critical patent/CN114262379B/zh
Priority to CN202111641121.0A priority patent/CN114349865B/zh
Priority to CN202111644268.5A priority patent/CN114349866B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract

提供了一种基于共同轻链的结构对称的四价双特异性抗体及其构建方法。制备的四价双特异性抗体具有与单抗相似甚至更优的生物学活性和理化性质，可以用于治疗各种炎性疾病、癌症和其它疾病。

Description

PCT国内申请，说明书已公开。

Claims (40)

  1. PCT国内申请，权利要求书已公开。
CN202180003485.8A 2020-04-29 2021-04-19 四价双特异性抗体、其制备方法和用途 Pending CN113993901A (zh)

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Application Number Priority Date Filing Date Title
CN202111641110.2A CN114262379B (zh) 2020-04-29 2021-04-19 一种pd-1/vegf四价双特异性抗体、其制备方法和用途
CN202111641121.0A CN114349865B (zh) 2020-04-29 2021-04-19 一种pd-1/lag-3四价双特异性抗体、其制备方法和用途
CN202111644268.5A CN114349866B (zh) 2020-04-29 2021-04-19 一种PD-1/TGF-beta四价双特异性抗体、其制备方法和用途

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CN2020103571344 2020-04-29
CN202010357134.4A CN113563473A (zh) 2020-04-29 2020-04-29 四价双特异性抗体、其制备方法和用途
PCT/CN2021/088153 WO2021218684A1 (zh) 2020-04-29 2021-04-19 四价双特异性抗体、其制备方法和用途

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CN202111641121.0A Division CN114349865B (zh) 2020-04-29 2021-04-19 一种pd-1/lag-3四价双特异性抗体、其制备方法和用途
CN202111644268.5A Division CN114349866B (zh) 2020-04-29 2021-04-19 一种PD-1/TGF-beta四价双特异性抗体、其制备方法和用途
CN202111641110.2A Division CN114262379B (zh) 2020-04-29 2021-04-19 一种pd-1/vegf四价双特异性抗体、其制备方法和用途

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CN202111641121.0A Active CN114349865B (zh) 2020-04-29 2021-04-19 一种pd-1/lag-3四价双特异性抗体、其制备方法和用途
CN202111644268.5A Active CN114349866B (zh) 2020-04-29 2021-04-19 一种PD-1/TGF-beta四价双特异性抗体、其制备方法和用途
CN202111641110.2A Active CN114262379B (zh) 2020-04-29 2021-04-19 一种pd-1/vegf四价双特异性抗体、其制备方法和用途
CN202180003485.8A Pending CN113993901A (zh) 2020-04-29 2021-04-19 四价双特异性抗体、其制备方法和用途

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CN202111641121.0A Active CN114349865B (zh) 2020-04-29 2021-04-19 一种pd-1/lag-3四价双特异性抗体、其制备方法和用途
CN202111644268.5A Active CN114349866B (zh) 2020-04-29 2021-04-19 一种PD-1/TGF-beta四价双特异性抗体、其制备方法和用途
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US (1) US20220259330A1 (zh)
EP (4) EP4050031A1 (zh)
JP (6) JP2022540319A (zh)
CN (5) CN113563473A (zh)
ES (1) ES2974323T3 (zh)
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CN113563473A (zh) * 2020-04-29 2021-10-29 三生国健药业（上海）股份有限公司 四价双特异性抗体、其制备方法和用途
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TW202421193A (zh) * 2022-09-28 2024-06-01 美商英塞特公司 抗ｐｄ－１／ｌａｇ－３雙特異性抗體及其用途

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