CN113227151A - 抗her2/pd1双特异性抗体 - Google Patents
抗her2/pd1双特异性抗体 Download PDFInfo
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- CN113227151A CN113227151A CN201980068587.0A CN201980068587A CN113227151A CN 113227151 A CN113227151 A CN 113227151A CN 201980068587 A CN201980068587 A CN 201980068587A CN 113227151 A CN113227151 A CN 113227151A
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Abstract
一种抗HER2/PD1双特异性抗体、制备方法和在抗肿瘤中的应用。具体地，单链可变片段scFv和免疫球蛋白抗体IgG通过肽接头连接获得双特异性抗体，该双特异性抗体能同时靶向肿瘤细胞表面分子HER2抗原和T淋巴细胞表面分子PD1。实验结果显示，提供的双特异性抗体，能够抑制HER2阳性肿瘤细胞的增殖，同时能够阻断PD‑1/PD‑L1的结合，解除T细胞的抑制状态，发挥抗肿瘤的作用。
Description
PCT国内申请，说明书已公开。
Claims (22)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811376950.9 | 2018-11-19 | ||
| CN201811376950.9A CN111196856A (zh) | 2018-11-19 | 2018-11-19 | 抗her2/pd1双特异性抗体 |
| PCT/CN2019/112467 WO2020103629A1 (zh) | 2018-11-19 | 2019-10-22 | 抗her2/pd1双特异性抗体 |
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| CN113227151A true CN113227151A (zh) | 2021-08-06 |
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| CN201811376950.9A Pending CN111196856A (zh) | 2018-11-19 | 2018-11-19 | 抗her2/pd1双特异性抗体 |
| CN201980068587.0A Pending CN113227151A (zh) | 2018-11-19 | 2019-10-22 | 抗her2/pd1双特异性抗体 |
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| US (1) | US20230287139A1 (zh) |
| EP (1) | EP3885367A4 (zh) |
| JP (1) | JP7165265B2 (zh) |
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| WO (1) | WO2020103629A1 (zh) |
Cited By (1)
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| WO2023236844A1 (zh) * | 2022-06-10 | 2023-12-14 | 三优生物医药(上海)有限公司 | 靶向her2和pd-l1的双特异性抗体及其制备方法和应用 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113754775A (zh) * | 2020-06-02 | 2021-12-07 | 三生国健药业（上海）股份有限公司 | 一种抗pd-l1和her2的双特异性抗体 |
| CN113967195A (zh) * | 2020-07-22 | 2022-01-25 | 三生国健药业（上海）股份有限公司 | 抗her2/pd1双特异性抗体冻干制剂及其制备方法 |
| CN114057882B (zh) * | 2020-07-31 | 2023-01-06 | 山东博安生物技术股份有限公司 | 多价多特异性抗体 |
| CN114195900B (zh) * | 2020-09-17 | 2024-02-23 | 普米斯生物技术(珠海)有限公司 | 一种抗4-1bb/pd-l1双特异性抗体及其用途 |
| CN117295765A (zh) * | 2021-05-11 | 2023-12-26 | 德琪(杭州)生物有限公司 | 新型抗cd276抗体及其用途 |
| CN113943371B (zh) * | 2021-11-01 | 2023-05-05 | 达石药业(广东)有限公司 | 一种抗her2/抗pd-l1双功能抗体及其应用 |
| CN114685675B (zh) * | 2022-04-27 | 2023-02-03 | 深圳市汉科生物工程有限公司 | 双特异性抗体及其在治疗癌症中的用途 |
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| WO2017136562A2 (en) * | 2016-02-02 | 2017-08-10 | Kadmon Corporation, Llc | Bispecific binding proteins for pd-l1 and kdr |
| WO2018090950A1 (zh) * | 2016-11-18 | 2018-05-24 | 北京韩美药品有限公司 | 抗pd‐1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备 |
| US20180318417A1 (en) * | 2015-01-14 | 2018-11-08 | Compass Therapeutics Llc | Multispecific immunomodulatory antigen-binding constructs |
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| DE69936946T2 (de) * | 1998-05-06 | 2008-05-15 | Genentech, Inc., South San Francisco | Reinigung von Antikörpern durch Ionenaustauschchromatographie |
| US9777067B2 (en) * | 2012-09-27 | 2017-10-03 | Massachusetts Institute Of Technology | HER2- and VEGF-A-binding proteins with enhanced stability |
| JP6871155B2 (ja) * | 2014-07-25 | 2021-05-12 | メモリアル スローン ケタリング キャンサー センター | 二重特異性ｈｅｒ２及びｃｄ３結合分子 |
| WO2018014260A1 (en) * | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| CN108341871A (zh) * | 2017-01-24 | 2018-07-31 | 三生国健药业（上海）股份有限公司 | 抗pd-1单克隆抗体及其制备方法和应用 |
| CN106986939B (zh) * | 2017-03-27 | 2019-06-07 | 顺昊细胞生物技术（天津）股份有限公司 | 抗pd-1和tem-8双特异性抗体及其应用 |
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2018
- 2018-11-19 CN CN201811376950.9A patent/CN111196856A/zh active Pending
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- 2019-10-22 EP EP19886519.8A patent/EP3885367A4/en active Pending
- 2019-10-22 WO PCT/CN2019/112467 patent/WO2020103629A1/zh unknown
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- 2019-10-22 CN CN201980068587.0A patent/CN113227151A/zh active Pending
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|---|---|---|---|---|
| US20180318417A1 (en) * | 2015-01-14 | 2018-11-08 | Compass Therapeutics Llc | Multispecific immunomodulatory antigen-binding constructs |
| WO2017136562A2 (en) * | 2016-02-02 | 2017-08-10 | Kadmon Corporation, Llc | Bispecific binding proteins for pd-l1 and kdr |
| WO2018090950A1 (zh) * | 2016-11-18 | 2018-05-24 | 北京韩美药品有限公司 | 抗pd‐1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2023236844A1 (zh) * | 2022-06-10 | 2023-12-14 | 三优生物医药(上海)有限公司 | 靶向her2和pd-l1的双特异性抗体及其制备方法和应用 |
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| EP3885367A4 (en) | 2022-07-27 |
| US20230287139A1 (en) | 2023-09-14 |
| CN111196856A (zh) | 2020-05-26 |
| EP3885367A1 (en) | 2021-09-29 |
| JP7165265B2 (ja) | 2022-11-02 |
| WO2020103629A1 (zh) | 2020-05-28 |
| JP2022507679A (ja) | 2022-01-18 |
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