JP2020527594A5 - - Google Patents

Info

Publication number

JP2020527594A5

JP2020527594A5 JP2020503018A JP2020503018A JP2020527594A5 JP 2020527594 A5 JP2020527594 A5 JP 2020527594A5 JP 2020503018 A JP2020503018 A JP 2020503018A JP 2020503018 A JP2020503018 A JP 2020503018A JP 2020527594 A5 JP2020527594 A5 JP 2020527594A5

Authority

JP

Japan

Prior art keywords

seq

antibody

pharmaceutical combination

bst1

antigen

Prior art date

2018-07-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
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• 239000000427 antigen Substances 0.000 claims 11
• 102000036639 antigens Human genes 0.000 claims 11
• 108091007433 antigens Proteins 0.000 claims 11
• 125000003275 alpha amino acid group Chemical group 0.000 claims 7
• 102100029824 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 Human genes 0.000 claims 4
• 101000794082 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 Proteins 0.000 claims 4
• 101001099051 Homo sapiens GPI inositol-deacylase Proteins 0.000 claims 4
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 3
• 201000011510 cancer Diseases 0.000 claims 3
• UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical class O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 claims 3
• 238000006467 substitution reaction Methods 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 230000004540 complement-dependent cytotoxicity Effects 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• NMUSYJAQQFHJEW-UHFFFAOYSA-N 5-Azacytidine Natural products O=C1N=C(N)N=CN1C1C(O)C(O)C(CO)O1 NMUSYJAQQFHJEW-UHFFFAOYSA-N 0.000 claims 1
• XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 claims 1
• NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims 1
• 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
• 102000009109 Fc receptors Human genes 0.000 claims 1
• 108010087819 Fc receptors Proteins 0.000 claims 1
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 206010038389 Renal cancer Diseases 0.000 claims 1
• 238000007792 addition Methods 0.000 claims 1
• 229960002756 azacitidine Drugs 0.000 claims 1
• 239000000969 carrier Substances 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
• 230000001472 cytotoxic effect Effects 0.000 claims 1
• 230000037430 deletion Effects 0.000 claims 1
• 238000012217 deletion Methods 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000000890 drug combination Substances 0.000 claims 1
• 238000009472 formulation Methods 0.000 claims 1
• 201000010536 head and neck cancer Diseases 0.000 claims 1
• 208000014829 head and neck neoplasm Diseases 0.000 claims 1
• 201000010982 kidney cancer Diseases 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1