JP2020527574A5 - - Google Patents
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- Publication number
- JP2020527574A5 JP2020527574A5 JP2020502343A JP2020502343A JP2020527574A5 JP 2020527574 A5 JP2020527574 A5 JP 2020527574A5 JP 2020502343 A JP2020502343 A JP 2020502343A JP 2020502343 A JP2020502343 A JP 2020502343A JP 2020527574 A5 JP2020527574 A5 JP 2020527574A5
- Authority
- JP
- Japan
- Prior art keywords
- joint
- pharmaceutical composition
- items
- knee
- cooling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 claims description 271
- 238000001816 cooling Methods 0.000 claims description 227
- 210000003127 knee Anatomy 0.000 claims description 137
- 229960002504 capsaicin Drugs 0.000 claims description 132
- 235000017663 capsaicin Nutrition 0.000 claims description 132
- 239000008194 pharmaceutical composition Substances 0.000 claims description 132
- 239000012530 fluid Substances 0.000 claims description 93
- 208000006820 Arthralgia Diseases 0.000 claims description 69
- 210000001519 tissue Anatomy 0.000 claims description 63
- 238000002347 injection Methods 0.000 claims description 56
- 239000007924 injection Substances 0.000 claims description 56
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 51
- 229960004194 lidocaine Drugs 0.000 claims description 51
- 210000000629 knee joint Anatomy 0.000 claims description 38
- 201000008482 osteoarthritis Diseases 0.000 claims description 37
- 206010006784 Burning sensation Diseases 0.000 claims description 33
- 239000000203 mixture Substances 0.000 claims description 33
- 230000001052 transient effect Effects 0.000 claims description 33
- 208000002193 Pain Diseases 0.000 claims description 31
- 238000002560 therapeutic procedure Methods 0.000 claims description 24
- 229940124641 pain reliever Drugs 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 21
- 239000003589 local anesthetic agent Substances 0.000 claims description 17
- 239000002826 coolant Substances 0.000 claims description 11
- 230000003467 diminishing effect Effects 0.000 claims description 10
- 230000000007 visual effect Effects 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 3
- 230000003349 osteoarthritic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 409
- -1 Polyethylene Polymers 0.000 description 27
- 229920001223 polyethylene glycol Polymers 0.000 description 27
- 210000001872 metatarsal bone Anatomy 0.000 description 26
- 208000005890 Neuroma Diseases 0.000 description 25
- 239000004698 Polyethylene Substances 0.000 description 23
- 239000002202 Polyethylene glycol Substances 0.000 description 23
- 125000000350 glycoloyl group Chemical group O=C([*])C([H])([H])O[H] 0.000 description 23
- 229920000573 polyethylene Polymers 0.000 description 23
- 239000002904 solvent Substances 0.000 description 22
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 16
- 238000009472 formulation Methods 0.000 description 12
- 210000001503 joint Anatomy 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000003607 modifier Substances 0.000 description 9
- 230000003204 osmotic effect Effects 0.000 description 9
- 239000011780 sodium chloride Substances 0.000 description 8
- 239000002738 chelating agent Substances 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 239000003963 antioxidant agent Substances 0.000 description 6
- 210000002683 foot Anatomy 0.000 description 6
- 208000004296 neuralgia Diseases 0.000 description 5
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical group CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 239000001632 sodium acetate Substances 0.000 description 3
- 235000017281 sodium acetate Nutrition 0.000 description 3
- YKPUWZUDDOIDPM-VURMDHGXSA-N zucapsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C/C(C)C)=CC=C1O YKPUWZUDDOIDPM-VURMDHGXSA-N 0.000 description 3
- 229960002860 zucapsaicin Drugs 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 210000000544 articulatio talocruralis Anatomy 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- DYLIWHYUXAJDOJ-OWOJBTEDSA-N (e)-4-(6-aminopurin-9-yl)but-2-en-1-ol Chemical compound NC1=NC=NC2=C1N=CN2C\C=C\CO DYLIWHYUXAJDOJ-OWOJBTEDSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000002917 arthritic effect Effects 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 210000003797 carpal joint Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000002310 elbow joint Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 210000004394 hip joint Anatomy 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 229960004393 lidocaine hydrochloride Drugs 0.000 description 1
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000001483 monosaccharide substituent group Chemical group 0.000 description 1
- 150000002894 organic compounds Chemical group 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 210000000323 shoulder joint Anatomy 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023081213A JP7738031B2 (ja) | 2017-07-20 | 2023-05-17 | カプサイシンを使用した疼痛の治療のための方法及び組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762535003P | 2017-07-20 | 2017-07-20 | |
| US62/535,003 | 2017-07-20 | ||
| PCT/US2018/043094 WO2019018769A1 (en) | 2017-07-20 | 2018-07-20 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN USING CAPSAICINE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023081213A Division JP7738031B2 (ja) | 2017-07-20 | 2023-05-17 | カプサイシンを使用した疼痛の治療のための方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020527574A JP2020527574A (ja) | 2020-09-10 |
| JP2020527574A5 true JP2020527574A5 (enExample) | 2021-08-26 |
| JP7282736B2 JP7282736B2 (ja) | 2023-05-29 |
Family
ID=65016186
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502343A Active JP7282736B2 (ja) | 2017-07-20 | 2018-07-20 | カプサイシンを使用した疼痛の治療のための方法及び組成物 |
| JP2023081213A Active JP7738031B2 (ja) | 2017-07-20 | 2023-05-17 | カプサイシンを使用した疼痛の治療のための方法及び組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023081213A Active JP7738031B2 (ja) | 2017-07-20 | 2023-05-17 | カプサイシンを使用した疼痛の治療のための方法及び組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20200206166A1 (enExample) |
| EP (1) | EP3654961B1 (enExample) |
| JP (2) | JP7282736B2 (enExample) |
| CN (1) | CN111201015A (enExample) |
| AU (1) | AU2018302342B2 (enExample) |
| BR (1) | BR112020000989A2 (enExample) |
| CA (1) | CA3069540A1 (enExample) |
| ES (1) | ES3018268T3 (enExample) |
| IL (1) | IL272036B2 (enExample) |
| MX (1) | MX2020000488A (enExample) |
| WO (1) | WO2019018769A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL272036B2 (en) | 2017-07-20 | 2025-01-01 | Centrexion Therapeutics Corp | Methods and compositions for treating pain using capsaicin |
| JP2021534207A (ja) * | 2018-08-24 | 2021-12-09 | セントレクシオン セラピューティクス コーポレイション | 膝関節痛の治療のためのカプサイシン連続投薬方法 |
| CN114028540B (zh) * | 2021-11-26 | 2023-10-17 | 海南鑫开源医药科技有限公司 | 一种具有镇痛作用的组合物、微针贴片及其制备方法以及应用 |
| CN115006379B (zh) * | 2021-12-28 | 2023-12-15 | 南京清普生物科技有限公司 | 一种trpv1激动剂原位膜剂组合物，及其制备方法和用途 |
| JP2025534350A (ja) * | 2022-09-30 | 2025-10-15 | エクステンド バイオサイエンシズ インコーポレーテッド | 長時間作用型副甲状腺ホルモン |
Family Cites Families (66)
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| US4599342A (en) | 1984-01-16 | 1986-07-08 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
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| US5021450A (en) | 1989-05-30 | 1991-06-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | New class of compounds having a variable spectrum of activities for capsaicin-like responses, compositions and uses thereof |
| US5431914A (en) | 1992-04-17 | 1995-07-11 | Adekunle; Michael | Method of treating an internal condition by external application of capsaicin without the need for systemic absorption |
| US5985860A (en) | 1992-06-03 | 1999-11-16 | Toppo; Frank | System for transdermal delivery of pain relieving substances |
| US5318960A (en) | 1992-06-03 | 1994-06-07 | Frank Toppo | System for transdermal delivery of pain relieving substances |
| EP0646372B1 (de) | 1993-09-30 | 1999-03-31 | Medichemie Ag | Capsaicin enthaltendes Arzneimittel zur Behandlung chronischer Rhinopathie |
| US5762963A (en) | 1995-06-07 | 1998-06-09 | Emory University | Method and compositions for controlling oral and pharyngeal pain using capsaicinoids |
| US6248788B1 (en) | 1996-11-06 | 2001-06-19 | The Regents Of The University Of California | Therapeutic method with capsaicin and capasicin analogs |
| WO1998020867A1 (en) | 1996-11-15 | 1998-05-22 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Pharmaceutical compositions containing vanilloid agonists in combination with vanilloid antagonists |
| US6060060A (en) | 1997-01-31 | 2000-05-09 | Bmb Patent Holding Corporation | Analgesic compositions from sweet peppers and methods of use thereof |
| ATE219674T1 (de) | 1997-03-13 | 2002-07-15 | James N Campbell | Zusammensetzung enthaltend capsaicin oder seine analogen und lokalanästhetika |
| JP2002514221A (ja) | 1997-05-27 | 2002-05-14 | アルゴス ファーマシューティカル コーポレーション | カプサイシノイド及びその強化薬を含有する鎮痛薬組成物 |
| WO2002076444A1 (en) | 2001-03-22 | 2002-10-03 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services | Molecular neurochirurgerie for pain control administering locally capsaicin or resiniferatoxin |
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| JP2006513267A (ja) | 2002-12-18 | 2006-04-20 | アルゴルクス ファーマスーティカルズ，インク | カプサイシノイドの投与 |
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| MX2007006253A (es) | 2004-11-24 | 2007-10-18 | Anesiva Inc | Formulacion de gel de capsaicinoide y usos para esta. |
| ES2355109T3 (es) | 2004-12-22 | 2011-03-22 | Mestex Ag | Mezcla de un agonista de receptor de vainilloide con una sustancia inhibidora de la regeneración nerviosa, su utilización para la fabricación de un analgésico y procedimiento de aplicación de este fármaco. |
| WO2006069452A1 (de) | 2004-12-28 | 2006-07-06 | Mestex Ag | Verwendung eines vanilloidrezeptoragonisten zusammen mit einem glycosaminoglycan oder proteoglycan für die herstellung eines mittels zur behandlung von gelenkschmerzen und verfahren zur applikation dieses mittels |
| PL1838301T3 (pl) | 2004-12-28 | 2015-08-31 | Mestex Ag | Użycie resiniferatotoksyny (RTX) dla wytwarzania środka leczącego stany bólowe |
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| JP7100635B2 (ja) * | 2016-11-02 | 2022-07-13 | セントレクシオン セラピューティクス コーポレイション | 安定な水性カプサイシン注射製剤およびその医学的使用 |
| WO2018217937A1 (en) | 2017-05-24 | 2018-11-29 | Concentric Analgesics, Inc. | Prodrugs of phenolic trpv1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia |
| IL272036B2 (en) | 2017-07-20 | 2025-01-01 | Centrexion Therapeutics Corp | Methods and compositions for treating pain using capsaicin |
-
2018
- 2018-07-20 IL IL272036A patent/IL272036B2/en unknown
- 2018-07-20 CA CA3069540A patent/CA3069540A1/en active Pending
- 2018-07-20 ES ES18834548T patent/ES3018268T3/es active Active
- 2018-07-20 CN CN201880055069.0A patent/CN111201015A/zh active Pending
- 2018-07-20 US US16/631,277 patent/US20200206166A1/en not_active Abandoned
- 2018-07-20 WO PCT/US2018/043094 patent/WO2019018769A1/en not_active Ceased
- 2018-07-20 EP EP18834548.2A patent/EP3654961B1/en active Active
- 2018-07-20 JP JP2020502343A patent/JP7282736B2/ja active Active
- 2018-07-20 BR BR112020000989-0A patent/BR112020000989A2/pt unknown
- 2018-07-20 AU AU2018302342A patent/AU2018302342B2/en active Active
- 2018-07-20 MX MX2020000488A patent/MX2020000488A/es unknown
-
2020
- 2020-08-04 US US16/984,384 patent/US11026903B2/en active Active
-
2021
- 2021-06-04 US US17/339,414 patent/US12201594B2/en active Active
-
2023
- 2023-05-17 JP JP2023081213A patent/JP7738031B2/ja active Active
-
2024
- 2024-12-17 US US18/984,070 patent/US20250312298A1/en active Pending
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