CA3069540A1 - Methods and compositions for treatment of pain using capsaicin - Google Patents
Methods and compositions for treatment of pain using capsaicin Download PDFInfo
- Publication number
- CA3069540A1 CA3069540A1 CA3069540A CA3069540A CA3069540A1 CA 3069540 A1 CA3069540 A1 CA 3069540A1 CA 3069540 A CA3069540 A CA 3069540A CA 3069540 A CA3069540 A CA 3069540A CA 3069540 A1 CA3069540 A1 CA 3069540A1
- Authority
- CA
- Canada
- Prior art keywords
- joint
- cooling article
- knee
- exterior surface
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/10—Cooling bags, e.g. ice-bags
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0039—Leg or parts thereof
- A61F2007/0042—Knee
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762535003P | 2017-07-20 | 2017-07-20 | |
| US62/535,003 | 2017-07-20 | ||
| PCT/US2018/043094 WO2019018769A1 (en) | 2017-07-20 | 2018-07-20 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN USING CAPSAICINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3069540A1 true CA3069540A1 (en) | 2019-01-24 |
Family
ID=65016186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3069540A Pending CA3069540A1 (en) | 2017-07-20 | 2018-07-20 | Methods and compositions for treatment of pain using capsaicin |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20200206166A1 (enExample) |
| EP (1) | EP3654961B1 (enExample) |
| JP (2) | JP7282736B2 (enExample) |
| CN (1) | CN111201015A (enExample) |
| AU (1) | AU2018302342B2 (enExample) |
| BR (1) | BR112020000989A2 (enExample) |
| CA (1) | CA3069540A1 (enExample) |
| ES (1) | ES3018268T3 (enExample) |
| IL (1) | IL272036B2 (enExample) |
| MX (1) | MX2020000488A (enExample) |
| WO (1) | WO2019018769A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL272036B2 (en) | 2017-07-20 | 2025-01-01 | Centrexion Therapeutics Corp | Methods and compositions for treating pain using capsaicin |
| JP2021534207A (ja) * | 2018-08-24 | 2021-12-09 | セントレクシオン セラピューティクス コーポレイション | 膝関節痛の治療のためのカプサイシン連続投薬方法 |
| CN114028540B (zh) * | 2021-11-26 | 2023-10-17 | 海南鑫开源医药科技有限公司 | 一种具有镇痛作用的组合物、微针贴片及其制备方法以及应用 |
| CN115006379B (zh) * | 2021-12-28 | 2023-12-15 | 南京清普生物科技有限公司 | 一种trpv1激动剂原位膜剂组合物,及其制备方法和用途 |
| JP2025534350A (ja) * | 2022-09-30 | 2025-10-15 | エクステンド バイオサイエンシズ インコーポレーテッド | 長時間作用型副甲状腺ホルモン |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4599342A (en) | 1984-01-16 | 1986-07-08 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US5099030A (en) | 1987-03-09 | 1992-03-24 | The Procter & Gamble Company | Novel compounds, pharmaceutical compositions, and methods for treating inflammation and pain |
| US5021450A (en) | 1989-05-30 | 1991-06-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | New class of compounds having a variable spectrum of activities for capsaicin-like responses, compositions and uses thereof |
| US5431914A (en) | 1992-04-17 | 1995-07-11 | Adekunle; Michael | Method of treating an internal condition by external application of capsaicin without the need for systemic absorption |
| US5985860A (en) | 1992-06-03 | 1999-11-16 | Toppo; Frank | System for transdermal delivery of pain relieving substances |
| US5318960A (en) | 1992-06-03 | 1994-06-07 | Frank Toppo | System for transdermal delivery of pain relieving substances |
| EP0646372B1 (de) | 1993-09-30 | 1999-03-31 | Medichemie Ag | Capsaicin enthaltendes Arzneimittel zur Behandlung chronischer Rhinopathie |
| US5762963A (en) | 1995-06-07 | 1998-06-09 | Emory University | Method and compositions for controlling oral and pharyngeal pain using capsaicinoids |
| US6248788B1 (en) | 1996-11-06 | 2001-06-19 | The Regents Of The University Of California | Therapeutic method with capsaicin and capasicin analogs |
| WO1998020867A1 (en) | 1996-11-15 | 1998-05-22 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Pharmaceutical compositions containing vanilloid agonists in combination with vanilloid antagonists |
| US6060060A (en) | 1997-01-31 | 2000-05-09 | Bmb Patent Holding Corporation | Analgesic compositions from sweet peppers and methods of use thereof |
| ATE219674T1 (de) | 1997-03-13 | 2002-07-15 | James N Campbell | Zusammensetzung enthaltend capsaicin oder seine analogen und lokalanästhetika |
| JP2002514221A (ja) | 1997-05-27 | 2002-05-14 | アルゴス ファーマシューティカル コーポレーション | カプサイシノイド及びその強化薬を含有する鎮痛薬組成物 |
| WO2002076444A1 (en) | 2001-03-22 | 2002-10-03 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services | Molecular neurochirurgerie for pain control administering locally capsaicin or resiniferatoxin |
| US20040146590A1 (en) | 2001-03-22 | 2004-07-29 | Iadarola Michael J | Molecular neurochirurgie for pain control administering locally capsaicin or resinferatoxin |
| US20030104085A1 (en) | 2001-12-05 | 2003-06-05 | Yeomans David C. | Methods and compositions for treating back pain |
| CA2493041C (en) | 2002-07-19 | 2011-08-16 | Dominik Meyer | Injectable pharmaceutical composition for treating post-operative joint pain comprising an amide local anesthetic |
| JP2006513267A (ja) | 2002-12-18 | 2006-04-20 | アルゴルクス ファーマスーティカルズ,インク | カプサイシノイドの投与 |
| US20040161481A1 (en) | 2002-12-18 | 2004-08-19 | Algorx | Administration of capsaicinoids |
| EA012599B1 (ru) | 2003-04-10 | 2009-10-30 | Ньюроджескс, Инк. | Способы и композиции для введения агонистов trpv1 |
| EP2298287B1 (en) | 2003-12-19 | 2018-04-11 | Novo Nordisk Health Care AG | Stabilised compositions of factor VII polypeptides |
| US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| MX2007006253A (es) | 2004-11-24 | 2007-10-18 | Anesiva Inc | Formulacion de gel de capsaicinoide y usos para esta. |
| ES2355109T3 (es) | 2004-12-22 | 2011-03-22 | Mestex Ag | Mezcla de un agonista de receptor de vainilloide con una sustancia inhibidora de la regeneración nerviosa, su utilización para la fabricación de un analgésico y procedimiento de aplicación de este fármaco. |
| WO2006069452A1 (de) | 2004-12-28 | 2006-07-06 | Mestex Ag | Verwendung eines vanilloidrezeptoragonisten zusammen mit einem glycosaminoglycan oder proteoglycan für die herstellung eines mittels zur behandlung von gelenkschmerzen und verfahren zur applikation dieses mittels |
| PL1838301T3 (pl) | 2004-12-28 | 2015-08-31 | Mestex Ag | Użycie resiniferatotoksyny (RTX) dla wytwarzania środka leczącego stany bólowe |
| US20060222690A1 (en) * | 2005-03-30 | 2006-10-05 | Bley Keith R | Low-concentration capsaicin patch and methods for treating neuropathic pain |
| US20080160487A1 (en) | 2006-12-29 | 2008-07-03 | Fairfield Language Technologies | Modularized computer-aided language learning method and system |
| US8158682B2 (en) | 2008-09-12 | 2012-04-17 | Vallinex, Inc. | Instillation administration of capsaicinoids for the treatment of pain |
| CN101507818B (zh) | 2008-12-15 | 2010-11-10 | 中国人民武装警察部队医学院 | 辣椒碱β-环糊精包合物及包合物的脂质体及凝胶 |
| US8637569B2 (en) | 2009-10-22 | 2014-01-28 | Api Genesis, Llc | Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds |
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| BR112014005358A8 (pt) * | 2011-09-09 | 2017-10-03 | Propella Therapeutics Inc | Composições compreendendo agonista seletivo de trpv1 e seus usos |
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| EP2879660A1 (de) | 2012-08-03 | 2015-06-10 | Mestex AG | Resiniferatoxin-lösung |
| JP6695140B2 (ja) * | 2012-11-12 | 2020-05-20 | ヴィズリ・ヘルス・サイエンスィズ・エルエルシー | 水性カプサイシノイド配合物ならびにその製造法および使用法 |
| GB201304662D0 (en) | 2013-03-14 | 2013-05-01 | Sigmoid Pharma Ltd | Compositions |
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| WO2015198350A1 (en) | 2014-06-25 | 2015-12-30 | Synergia Bio Sciences Private Limited | A pharmaceutical oil-in-water nano-emulsion |
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| AU2015306063A1 (en) | 2014-08-19 | 2017-04-13 | Mandishora Israel MUZARI | Capsaicinoids and uses thereof as medicaments |
| US20180311189A1 (en) | 2014-11-13 | 2018-11-01 | Centrexion Therapeutics Corporation | Capsaicinoids for Use in Treating ACRAL Lick Granuloma |
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| HK1253050A1 (zh) | 2015-02-02 | 2019-06-06 | 英仕柏集团有限责任公司 | 稳定的富马酸二烷基酯组合物 |
| MX2017015322A (es) | 2015-05-29 | 2018-03-28 | Sun Pharmaceutical Ind Ltd | Composicion farmaceutica oral de isotretinoin. |
| EP3302442B1 (en) | 2015-06-03 | 2024-10-16 | Triastek, Inc. | Dosage forms and use thereof |
| WO2017087803A1 (en) | 2015-11-20 | 2017-05-26 | Sorrento Therapeutics, Inc. | Methods for pain treatment using resiniferatoxin |
| AU2017210315A1 (en) * | 2016-01-22 | 2018-08-16 | Centrexion Therapeutics Corporation | Capsaicin sequential dosing method for treatment of morton's neuroma pain |
| WO2017147146A1 (en) | 2016-02-23 | 2017-08-31 | Concentric Analgesics, Inc. | Prodrugs of phenolic trpv1 agonists |
| WO2017205534A1 (en) | 2016-05-25 | 2017-11-30 | Concentric Analgesics, Inc. | Prodrugs of phenolic trpv1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia |
| JP7100635B2 (ja) * | 2016-11-02 | 2022-07-13 | セントレクシオン セラピューティクス コーポレイション | 安定な水性カプサイシン注射製剤およびその医学的使用 |
| WO2018217937A1 (en) | 2017-05-24 | 2018-11-29 | Concentric Analgesics, Inc. | Prodrugs of phenolic trpv1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia |
| IL272036B2 (en) | 2017-07-20 | 2025-01-01 | Centrexion Therapeutics Corp | Methods and compositions for treating pain using capsaicin |
-
2018
- 2018-07-20 IL IL272036A patent/IL272036B2/en unknown
- 2018-07-20 CA CA3069540A patent/CA3069540A1/en active Pending
- 2018-07-20 ES ES18834548T patent/ES3018268T3/es active Active
- 2018-07-20 CN CN201880055069.0A patent/CN111201015A/zh active Pending
- 2018-07-20 US US16/631,277 patent/US20200206166A1/en not_active Abandoned
- 2018-07-20 WO PCT/US2018/043094 patent/WO2019018769A1/en not_active Ceased
- 2018-07-20 EP EP18834548.2A patent/EP3654961B1/en active Active
- 2018-07-20 JP JP2020502343A patent/JP7282736B2/ja active Active
- 2018-07-20 BR BR112020000989-0A patent/BR112020000989A2/pt unknown
- 2018-07-20 AU AU2018302342A patent/AU2018302342B2/en active Active
- 2018-07-20 MX MX2020000488A patent/MX2020000488A/es unknown
-
2020
- 2020-08-04 US US16/984,384 patent/US11026903B2/en active Active
-
2021
- 2021-06-04 US US17/339,414 patent/US12201594B2/en active Active
-
2023
- 2023-05-17 JP JP2023081213A patent/JP7738031B2/ja active Active
-
2024
- 2024-12-17 US US18/984,070 patent/US20250312298A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210299072A1 (en) | 2021-09-30 |
| JP2020527574A (ja) | 2020-09-10 |
| US20200360314A1 (en) | 2020-11-19 |
| MX2020000488A (es) | 2020-10-28 |
| ES3018268T3 (en) | 2025-05-14 |
| BR112020000989A2 (pt) | 2020-07-14 |
| AU2018302342A1 (en) | 2020-02-06 |
| IL272036B1 (en) | 2024-09-01 |
| JP2023116457A (ja) | 2023-08-22 |
| US20250312298A1 (en) | 2025-10-09 |
| WO2019018769A1 (en) | 2019-01-24 |
| CN111201015A (zh) | 2020-05-26 |
| EP3654961A1 (en) | 2020-05-27 |
| JP7282736B2 (ja) | 2023-05-29 |
| AU2018302342B2 (en) | 2024-08-08 |
| US12201594B2 (en) | 2025-01-21 |
| JP7738031B2 (ja) | 2025-09-11 |
| EP3654961A4 (en) | 2021-04-21 |
| US11026903B2 (en) | 2021-06-08 |
| EP3654961C0 (en) | 2025-01-08 |
| IL272036A (en) | 2020-03-31 |
| US20200206166A1 (en) | 2020-07-02 |
| IL272036B2 (en) | 2025-01-01 |
| EP3654961B1 (en) | 2025-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220915 |
|
| EEER | Examination request |
Effective date: 20220915 |
|
| EEER | Examination request |
Effective date: 20220915 |
|
| EEER | Examination request |
Effective date: 20220915 |