JP2020527571A5 - - Google Patents
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- JP2020527571A5 JP2020527571A5 JP2020502265A JP2020502265A JP2020527571A5 JP 2020527571 A5 JP2020527571 A5 JP 2020527571A5 JP 2020502265 A JP2020502265 A JP 2020502265A JP 2020502265 A JP2020502265 A JP 2020502265A JP 2020527571 A5 JP2020527571 A5 JP 2020527571A5
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- JP
- Japan
- Prior art keywords
- antigen
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000427 antigen Substances 0.000 claims 44
- 102000036639 antigens Human genes 0.000 claims 44
- 108091007433 antigens Proteins 0.000 claims 44
- 239000000203 mixture Substances 0.000 claims 30
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 21
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 20
- 201000005702 Pertussis Diseases 0.000 claims 13
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 12
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 9
- 230000002163 immunogen Effects 0.000 claims 9
- 239000011780 sodium chloride Substances 0.000 claims 9
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims 8
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 8
- 229910052782 aluminium Inorganic materials 0.000 claims 8
- 229960005323 phenoxyethanol Drugs 0.000 claims 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 8
- 229960000814 tetanus toxoid Drugs 0.000 claims 8
- 238000001179 sorption measurement Methods 0.000 claims 7
- 241000274177 Juniperus sabina Species 0.000 claims 6
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 6
- 241000991587 Enterovirus C Species 0.000 claims 5
- 230000014759 maintenance of location Effects 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 238000002360 preparation method Methods 0.000 claims 5
- 229960003983 diphtheria toxoid Drugs 0.000 claims 4
- 230000002779 inactivation Effects 0.000 claims 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 4
- 101000623895 Bos taurus Mucin-15 Proteins 0.000 claims 3
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000010979 pH adjustment Methods 0.000 claims 3
- 239000001488 sodium phosphate Substances 0.000 claims 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 3
- 229910000406 trisodium phosphate Inorganic materials 0.000 claims 3
- 235000019801 trisodium phosphate Nutrition 0.000 claims 3
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 2
- 108010078791 Carrier Proteins Proteins 0.000 claims 2
- 241000606768 Haemophilus influenzae Species 0.000 claims 2
- 241000700721 Hepatitis B virus Species 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229940001442 combination vaccine Drugs 0.000 claims 2
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 claims 2
- JEVCWSUVFOYBFI-UHFFFAOYSA-N cyanyl Chemical group N#[C] JEVCWSUVFOYBFI-UHFFFAOYSA-N 0.000 claims 2
- 239000013024 dilution buffer Substances 0.000 claims 2
- 239000012897 dilution medium Substances 0.000 claims 2
- 229940047650 haemophilus influenzae Drugs 0.000 claims 2
- 208000002672 hepatitis B Diseases 0.000 claims 2
- 230000005847 immunogenicity Effects 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 230000009257 reactivity Effects 0.000 claims 2
- 238000003756 stirring Methods 0.000 claims 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- 101100456626 Homo sapiens MEF2A gene Proteins 0.000 claims 1
- 101100079042 Mus musculus Myef2 gene Proteins 0.000 claims 1
- 102100021148 Myocyte-specific enhancer factor 2A Human genes 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- HWFSCNOWKORLGJ-UHFFFAOYSA-N hexanedioic acid;dihydrate Chemical compound O.O.OC(=O)CCCCC(O)=O HWFSCNOWKORLGJ-UHFFFAOYSA-N 0.000 claims 1
- 101150014102 mef-2 gene Proteins 0.000 claims 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000012264 purified product Substances 0.000 claims 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims 1
- 229940033663 thimerosal Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201721025513 | 2017-07-18 | ||
| IN201721025513 | 2017-07-18 | ||
| PCT/IB2018/055180 WO2019016654A1 (en) | 2017-07-18 | 2018-07-13 | IMMUNOGENIC COMPOSITION WITH IMPROVED STABILITY, ENHANCED IMMUNOGENICITY, AND LESS REACTOGENICITY, AND PREPARATION METHOD THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020527571A JP2020527571A (ja) | 2020-09-10 |
| JP2020527571A5 true JP2020527571A5 (https=) | 2021-08-19 |
| JP7404226B2 JP7404226B2 (ja) | 2023-12-25 |
Family
ID=63556364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502265A Active JP7404226B2 (ja) | 2017-07-18 | 2018-07-13 | 向上した安定性、高度の免疫原性、及び減少した反応源性を有する免疫原性組成物、並びにその調製プロセス |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11179453B2 (https=) |
| EP (1) | EP3655024A1 (https=) |
| JP (1) | JP7404226B2 (https=) |
| KR (1) | KR102657910B1 (https=) |
| CN (1) | CN111032078A (https=) |
| AU (1) | AU2018302767B2 (https=) |
| BR (1) | BR112020000999A2 (https=) |
| CA (1) | CA3070039A1 (https=) |
| CO (1) | CO2020001765A2 (https=) |
| EA (1) | EA202090316A1 (https=) |
| GE (2) | GEP20227386B (https=) |
| JO (1) | JOP20180069B1 (https=) |
| MX (1) | MX2020000441A (https=) |
| PE (1) | PE20201443A1 (https=) |
| PH (1) | PH12020500133A1 (https=) |
| SG (1) | SG11202000224SA (https=) |
| TW (1) | TWI786153B (https=) |
| UA (1) | UA128204C2 (https=) |
| UY (1) | UY37811A (https=) |
| WO (1) | WO2019016654A1 (https=) |
| ZA (1) | ZA202000889B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8398983B2 (en) * | 2005-06-27 | 2013-03-19 | Glaxosmithkline Biologicals, S.A. | Immunogenic composition |
| EP3800244A1 (en) | 2006-03-10 | 2021-04-07 | Institut Pasteur de Lille | Live attenuated bordetella strains as a single dose vaccine against whooping cough |
| CA2759280C (en) | 2009-04-28 | 2016-09-20 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Vaccine for prophylaxis or treatment of an allergen-driven airway pathology |
| CA3077428A1 (en) * | 2017-10-18 | 2019-04-25 | Institut Pasteur De Lille | Bordetella strains expressing serotype 3 fimbriae |
| MX2021004233A (es) * | 2018-10-12 | 2021-08-16 | Serum Inst Of India Private Ltd | Composicion de vacuna combinada que comprende dosis reducidas del virus inactivado de la polio y metodo de preparacion de la misma. |
| WO2020165920A1 (en) * | 2019-02-12 | 2020-08-20 | Biological E Limited | Multivalent vaccine composition |
| CN112138155B (zh) * | 2019-06-28 | 2022-04-12 | 怡道生物科技(苏州)有限公司 | 一种复合佐剂系统及制备该佐剂的方法 |
| JOP20200214A1 (ar) | 2019-09-03 | 2021-03-03 | Serum Institute Of India Pvt Ltd | تركيبات مولدة للمناعة ضد الأمراض المعوية وطرق لتحضيرها |
| EP3988289A1 (en) | 2020-10-23 | 2022-04-27 | Carl Zeiss Vision International GmbH | Method of manufacturing a spectacle lens |
| EP3988290A1 (en) | 2020-10-23 | 2022-04-27 | Carl Zeiss Vision International GmbH | Method for manufacturing a spectacle lens |
| EP3988288A1 (en) | 2020-10-23 | 2022-04-27 | Carl Zeiss Vision International GmbH | Method of manufacturing a spectacle lens |
| WO2022114921A1 (ko) * | 2020-11-30 | 2022-06-02 | 주식회사 엘지화학 | 알루미늄 부형제를 이용하여 다가 혼합백신 내 백일해 균 유래 엔도톡신 제거 방법 |
| JP7526880B2 (ja) * | 2021-04-20 | 2024-08-01 | Ｋｍバイオロジクス株式会社 | ６種混合液状ワクチン組成物 |
| CN120826235A (zh) * | 2023-03-16 | 2025-10-21 | 艾芬尼维克斯公司 | 免疫原性组合物 |
| CN119799602A (zh) * | 2025-03-17 | 2025-04-11 | 艾美坚持生物制药有限公司 | 一种破伤风梭状芽胞杆菌发酵培养基及培养方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI945483A7 (fi) | 1992-05-23 | 1995-01-20 | Smithkline Beecham Biologicals S A | Hepatiitti B - pinta-antigeenejä ja muita antigeenejä sisältäviä yhdistelmärokotteita |
| PL184872B1 (pl) | 1995-06-23 | 2003-01-31 | Smithkline Beecham Biolog | Kombinowana szczepionkaĆ zestaw do przygotowania kombinowanej szczepionkiĆ sposób wytwarzania kombinowanej szczepionki i jej zastosowanie |
| CA2303105A1 (en) | 1997-09-15 | 1999-03-25 | Pasteur Merieux Msd | Multivalent vaccines |
| GB9806456D0 (en) | 1998-03-25 | 1998-05-27 | Smithkline Beecham Biolog | Vaccine composition |
| EP1004314A1 (fr) | 1998-11-26 | 2000-05-31 | Pasteur Merieux MSD | Vaccin T.d. Polio rappel pour une population vaccinée ou sensibilisée |
| UA79735C2 (uk) | 2000-08-10 | 2007-07-25 | Глаксосмітклайн Байолоджікалз С.А. | Очищення антигенів вірусу гепатиту b (hbv) для використання у вакцинах |
| GB0313916D0 (en) | 2003-06-16 | 2003-07-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| GB0405787D0 (en) | 2004-03-15 | 2004-04-21 | Chiron Srl | Low dose vaccines |
| GB0616226D0 (en) | 2006-08-15 | 2006-09-27 | Novartis Ag | Processes |
| US8945582B2 (en) * | 2006-09-07 | 2015-02-03 | Glaxosmithkline Biologicals S.A. | Vaccine |
| PE20100366A1 (es) | 2008-10-24 | 2010-05-21 | Panacea Biotec Ltd | Novedosas composiciones de vacuna con tos ferina acelular asi como el metodo para su elaboracion |
| PE20100365A1 (es) * | 2008-10-24 | 2010-05-21 | Panacea Biotec Ltd | Novedosas vacunas de combinacion con tos ferina de celulas enteras y metodo para su elaboracion |
| EP3459562B1 (en) * | 2011-01-05 | 2024-03-20 | Bharat Biotech International Limited | A combination heptavalent vaccine |
| AU2014304545A1 (en) * | 2013-08-05 | 2016-02-25 | Glaxosmithkline Biologicals S.A. | Combination immunogenic compositions |
| EA037283B1 (ru) * | 2015-09-16 | 2021-03-04 | ЭлДжи КЕМ, ЛТД. | Комбинированная вакцинная композиция для многократного дозирования |
-
2018
- 2018-07-13 GE GEAP201815276A patent/GEP20227386B/en unknown
- 2018-07-13 JP JP2020502265A patent/JP7404226B2/ja active Active
- 2018-07-13 SG SG11202000224SA patent/SG11202000224SA/en unknown
- 2018-07-13 UA UAA202000861A patent/UA128204C2/uk unknown
- 2018-07-13 EA EA202090316A patent/EA202090316A1/ru unknown
- 2018-07-13 CA CA3070039A patent/CA3070039A1/en active Pending
- 2018-07-13 GE GEAP202115276A patent/GEAP202115276A/en unknown
- 2018-07-13 MX MX2020000441A patent/MX2020000441A/es unknown
- 2018-07-13 CN CN201880048015.1A patent/CN111032078A/zh active Pending
- 2018-07-13 BR BR112020000999-7A patent/BR112020000999A2/pt unknown
- 2018-07-13 KR KR1020207004735A patent/KR102657910B1/ko active Active
- 2018-07-13 US US16/631,965 patent/US11179453B2/en active Active
- 2018-07-13 WO PCT/IB2018/055180 patent/WO2019016654A1/en not_active Ceased
- 2018-07-13 AU AU2018302767A patent/AU2018302767B2/en active Active
- 2018-07-13 PE PE2020000084A patent/PE20201443A1/es unknown
- 2018-07-13 EP EP18768937.7A patent/EP3655024A1/en active Pending
- 2018-07-17 JO JOP/2018/0069A patent/JOP20180069B1/ar active
- 2018-07-17 TW TW107124600A patent/TWI786153B/zh active
- 2018-07-17 UY UY0001037811A patent/UY37811A/es not_active Application Discontinuation
-
2020
- 2020-01-17 PH PH12020500133A patent/PH12020500133A1/en unknown
- 2020-02-11 ZA ZA2020/00889A patent/ZA202000889B/en unknown
- 2020-02-17 CO CONC2020/0001765A patent/CO2020001765A2/es unknown
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