JP2020527139A5 - - Google Patents
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- JP2020527139A5 JP2020527139A5 JP2020501154A JP2020501154A JP2020527139A5 JP 2020527139 A5 JP2020527139 A5 JP 2020527139A5 JP 2020501154 A JP2020501154 A JP 2020501154A JP 2020501154 A JP2020501154 A JP 2020501154A JP 2020527139 A5 JP2020527139 A5 JP 2020527139A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
- compound
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 18
- 201000011510 cancer Diseases 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 9
- 238000011282 treatment Methods 0.000 claims 5
- 229930012538 Paclitaxel Natural products 0.000 claims 4
- 229960001592 paclitaxel Drugs 0.000 claims 4
- 125000003226 pyrazolyl group Chemical group 0.000 claims 4
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 229960000578 gemtuzumab Drugs 0.000 claims 3
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- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
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- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 1
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- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
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- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims 1
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- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 1
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- 206010056305 Hypopharyngeal neoplasm Diseases 0.000 claims 1
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 claims 1
- XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 claims 1
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- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
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- 229940125568 MGD013 Drugs 0.000 claims 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 1
- 108091092878 Microsatellite Proteins 0.000 claims 1
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- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
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- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
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- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 1
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762532932P | 2017-07-14 | 2017-07-14 | |
| US62/532,932 | 2017-07-14 | ||
| US201862662405P | 2018-04-25 | 2018-04-25 | |
| US62/662,405 | 2018-04-25 | ||
| US201862689412P | 2018-06-25 | 2018-06-25 | |
| US62/689,412 | 2018-06-25 | ||
| PCT/US2018/041723 WO2019014402A1 (en) | 2017-07-14 | 2018-07-12 | MODULATORS OF NLRP3 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020527139A JP2020527139A (ja) | 2020-09-03 |
| JP2020527139A5 true JP2020527139A5 (https=) | 2021-07-26 |
| JP7159282B2 JP7159282B2 (ja) | 2022-10-24 |
Family
ID=63036509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020501154A Active JP7159282B2 (ja) | 2017-07-14 | 2018-07-12 | Ｎｌｒｐ３モジュレーター |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11344543B2 (https=) |
| EP (1) | EP3652166B1 (https=) |
| JP (1) | JP7159282B2 (https=) |
| KR (1) | KR102698385B1 (https=) |
| CN (2) | CN111793060B (https=) |
| AU (1) | AU2018301681B2 (https=) |
| BR (1) | BR112020000523A2 (https=) |
| CA (1) | CA3069524A1 (https=) |
| CL (1) | CL2020000085A1 (https=) |
| CO (1) | CO2020000227A2 (https=) |
| ES (1) | ES3002968T3 (https=) |
| IL (1) | IL271935A (https=) |
| MY (1) | MY201080A (https=) |
| NZ (1) | NZ761519A (https=) |
| PE (1) | PE20200296A1 (https=) |
| SG (1) | SG11202000248UA (https=) |
| TW (1) | TWI791556B (https=) |
| WO (1) | WO2019014402A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20210160A1 (es) | 2018-04-25 | 2021-01-26 | Innate Tumor Immunity Inc | Moduladores de nlrp3 |
| WO2020150116A1 (en) * | 2019-01-14 | 2020-07-23 | Innate Tumor Immunity, Inc. | Nlrp3 modulators |
| ES2930151T3 (es) * | 2019-01-14 | 2022-12-07 | Innate Tumor Immunity Inc | Moduladores heterocíclicos de NLRP3, para su uso en el tratamiento del cáncer |
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