JP2020519672A5 - - Google Patents
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- Publication number
- JP2020519672A5 JP2020519672A5 JP2019563217A JP2019563217A JP2020519672A5 JP 2020519672 A5 JP2020519672 A5 JP 2020519672A5 JP 2019563217 A JP2019563217 A JP 2019563217A JP 2019563217 A JP2019563217 A JP 2019563217A JP 2020519672 A5 JP2020519672 A5 JP 2020519672A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- inhibitor
- ret
- combination according
- mtorc1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- GBLBJPZSROAGMF-RWYJCYHVSA-N C[C@@H](c(cc1)cnc1-[n]1ncc(F)c1)NC([C@](CC1)(CC[C@@H]1c1nc(Nc2n[nH]c(C)c2)cc(C)n1)OC)=O Chemical compound C[C@@H](c(cc1)cnc1-[n]1ncc(F)c1)NC([C@](CC1)(CC[C@@H]1c1nc(Nc2n[nH]c(C)c2)cc(C)n1)OC)=O GBLBJPZSROAGMF-RWYJCYHVSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762506334P | 2017-05-15 | 2017-05-15 | |
| US62/506,334 | 2017-05-15 | ||
| US201862652284P | 2018-04-03 | 2018-04-03 | |
| US62/652,284 | 2018-04-03 | ||
| US201862656297P | 2018-04-11 | 2018-04-11 | |
| US62/656,297 | 2018-04-11 | ||
| US201862657605P | 2018-04-13 | 2018-04-13 | |
| US62/657,605 | 2018-04-13 | ||
| PCT/US2018/032794 WO2018213329A1 (en) | 2017-05-15 | 2018-05-15 | Combinations of ret inhibitors and mtorc1 inhibitors and uses thereof for the treatment of cancer mediated by aberrant ret activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020519672A JP2020519672A (ja) | 2020-07-02 |
| JP2020519672A5 true JP2020519672A5 (https=) | 2021-07-26 |
Family
ID=62567777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019563217A Withdrawn JP2020519672A (ja) | 2017-05-15 | 2018-05-15 | ＲＥＴ阻害剤とｍＴＯＲＣ１阻害剤との組合せ及び異常なＲＥＴ活性によって媒介されるがんを処置するためのその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20210290620A1 (https=) |
| EP (1) | EP3624802A1 (https=) |
| JP (1) | JP2020519672A (https=) |
| CN (1) | CN110891573A (https=) |
| WO (1) | WO2018213329A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| PL3371171T3 (pl) | 2015-11-02 | 2024-03-25 | Blueprint Medicines Corporation | Inhibitory RET |
| SI3773589T1 (sl) * | 2018-04-03 | 2024-03-29 | Blueprint Medicines Corporation | Inhibitor RET za uporabo pri zdravljenju raka, ki ima RET spremembo |
| CN111961034A (zh) * | 2019-05-20 | 2020-11-20 | 浙江同源康医药股份有限公司 | 用作ret激酶抑制剂的化合物及其应用 |
| JP2023501757A (ja) * | 2020-05-29 | 2023-01-18 | ブループリント メディシンズ コーポレイション | プラルセチニブ薬学的組成物 |
| JP2023527412A (ja) | 2020-05-29 | 2023-06-28 | ブループリント メディシンズ コーポレイション | プラルセチニブの固体形態 |
| CN116867492A (zh) * | 2020-11-20 | 2023-10-10 | 赫尔森保健股份公司 | 使用4-氨基-n-[4-(甲氧基甲基)苯基]-7-(1-甲基环丙基)-6-(3-吗啉代丙-1-炔-1-基)-7h-吡咯并[2,3-d]嘧啶-5-羧酰胺治疗肿瘤的方法 |
| EP4687905A1 (en) | 2023-03-30 | 2026-02-11 | Revolution Medicines, Inc. | Compositions for inducing ras gtp hydrolysis and uses thereof |
| AU2024265078A1 (en) | 2023-05-04 | 2025-12-11 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| IL326136A (en) | 2023-08-07 | 2026-03-01 | Revolution Medicines Inc | RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein |
| US20250154171A1 (en) | 2023-10-12 | 2025-05-15 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006128042A2 (en) | 2005-05-26 | 2006-11-30 | The Johns Hopkins University | Methods of identifying mutations in nucleic acid |
| US20090012045A1 (en) * | 2007-06-26 | 2009-01-08 | Rigel Pharmaceuticals, Inc. | Methods of Treating Cell Proliferative Disorders |
| WO2009100536A1 (en) | 2008-02-15 | 2009-08-20 | Methylgene Inc. | Inhibitors of kinase activity with 1,2-di-cyclyl substituted alkyne structures |
| EP2740742B1 (en) | 2011-08-04 | 2018-03-14 | National Cancer Center | Fusion gene of kif5b gene and ret gene, and method for determining effectiveness of cancer treatment targeting fusion gene |
| EP3564261B1 (en) | 2011-08-23 | 2024-11-13 | Foundation Medicine, Inc. | Kif5b-ret fusion molecules and uses thereof |
| US20130096136A1 (en) | 2011-09-30 | 2013-04-18 | Methylgene Inc. | Inhibitors of Protein Tyrosine Kinase Activity |
| JP2015109806A (ja) | 2012-03-22 | 2015-06-18 | アステラス製薬株式会社 | 新規ｒｅｔ融合体の検出法 |
| AU2013259267A1 (en) * | 2012-05-10 | 2014-11-06 | Synta Pharmaceuticals Corp. | Treating cancer with Hsp90 inhibitory compounds |
| US20150177246A1 (en) | 2012-07-26 | 2015-06-25 | Lsip, Llc | Fusion gene of cep55 gene and ret gene |
| SI2902029T1 (sl) | 2012-09-25 | 2018-11-30 | Chugai Seiyaku Kabushiki Kaisha | Inhibitor ret |
| BR112015023618A2 (pt) | 2013-03-15 | 2017-07-18 | Glaxosmithkline Ip Dev Ltd | derivados de piridina como inibidores de quinase reorganizada durante a transfecção (ret) |
| WO2015006875A1 (en) | 2013-07-18 | 2015-01-22 | Methylgene Inc. | Process for the preparation of substituted pyrimidines |
| US20150057335A1 (en) | 2013-08-20 | 2015-02-26 | National Cancer Center | Novel fusion genes identified in lung cancer |
| GB201321146D0 (en) | 2013-11-29 | 2014-01-15 | Cancer Rec Tech Ltd | Quinazoline compounds |
| EA032030B1 (ru) | 2014-09-10 | 2019-03-29 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Соединения в качестве ингибиторов реаранжированной во время трансфекции (ret) киназы |
| PE20170705A1 (es) | 2014-09-10 | 2017-05-21 | Glaxosmithkline Ip Dev Ltd | Nuevos compuestos como inhibidores de ret (reorganizado durante la transfeccion) |
| ES2792036T3 (es) | 2014-11-14 | 2020-11-06 | Nerviano Medical Sciences Srl | Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de cinasa |
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| BR112018000808A2 (pt) | 2015-07-16 | 2018-09-04 | Array Biopharma Inc | compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase |
| CN105255927B (zh) | 2015-09-30 | 2018-07-27 | 温州医科大学附属第一医院 | 一种kiaa1217-ret融合基因 |
| PL3371171T3 (pl) | 2015-11-02 | 2024-03-25 | Blueprint Medicines Corporation | Inhibitory RET |
| TW201738228A (zh) | 2016-03-17 | 2017-11-01 | 藍圖醫藥公司 | Ｒｅｔ之抑制劑 |
| US10227329B2 (en) | 2016-07-22 | 2019-03-12 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to RET |
| WO2018022761A1 (en) | 2016-07-27 | 2018-02-01 | Blueprint Medicines Corporation | Substituted cyclopentane-amides for treating disorders related to ret |
-
2018
- 2018-05-15 JP JP2019563217A patent/JP2020519672A/ja not_active Withdrawn
- 2018-05-15 US US16/613,625 patent/US20210290620A1/en not_active Abandoned
- 2018-05-15 CN CN201880046867.7A patent/CN110891573A/zh active Pending
- 2018-05-15 EP EP18730519.8A patent/EP3624802A1/en not_active Withdrawn
- 2018-05-15 WO PCT/US2018/032794 patent/WO2018213329A1/en not_active Ceased
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