JP2020524178A - ファルネソイドｘ受容体および可溶性エポキシドヒドロラーゼの二重調節剤 - Google Patents

ファルネソイドｘ受容体および可溶性エポキシドヒドロラーゼの二重調節剤 Download PDF

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JP2020524178A
JP2020524178A JP2020515285A JP2020515285A JP2020524178A JP 2020524178 A JP2020524178 A JP 2020524178A JP 2020515285 A JP2020515285 A JP 2020515285A JP 2020515285 A JP2020515285 A JP 2020515285A JP 2020524178 A JP2020524178 A JP 2020524178A
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fxr
seh
compound
disease
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JP2020524178A5 (enExample
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ダニエル メルク
ダニエル メルク
ユレマ シュミット
ユレマ シュミット
ユジェニジ プロシャク
ユジェニジ プロシャク
マンフレート シューベルト−ツズィラヴェツ
マンフレート シューベルト−ツズィラヴェツ
モーリッツ ヘルムスタッター
モーリッツ ヘルムスタッター
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ヨハン ヴォルフガング ゲーテ−ウニヴェルズィテート フランクフルト アム マイン
ヨハン ヴォルフガング ゲーテ−ウニヴェルズィテート フランクフルト アム マイン
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    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/73—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C233/76—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
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    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C255/00—Carboxylic acid nitriles
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    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
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JP2020515285A 2017-05-24 2018-05-24 ファルネソイドｘ受容体および可溶性エポキシドヒドロラーゼの二重調節剤 Pending JP2020524178A (ja)

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PCT/EP2017/062692 WO2018215070A1 (en) 2017-05-24 2017-05-24 Dual modulators of farnesoid x receptor and soluble epoxide hydrolase
EPPCT/EP2017/062692 2017-05-24
PCT/EP2018/063699 WO2018215610A1 (en) 2017-05-24 2018-05-24 Dual modulators of farnesoid x receptor and soluble epoxide hydrolase

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JP2020524178A true JP2020524178A (ja) 2020-08-13
JP2020524178A5 JP2020524178A5 (enExample) 2021-07-26

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US (1) US20200172473A1 (enExample)
EP (1) EP3630085A1 (enExample)
JP (1) JP2020524178A (enExample)
KR (1) KR20200010387A (enExample)
CN (1) CN110891560A (enExample)
AU (1) AU2018274652A1 (enExample)
BR (1) BR112019023820A2 (enExample)
CA (1) CA3062388A1 (enExample)
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WO2021009332A1 (en) 2019-07-18 2021-01-21 Enyo Pharma Method for decreasing adverse-effects of interferon
WO2021053234A1 (en) * 2019-09-19 2021-03-25 Johann Wolfgang Goethe-Universität Frankfurt am Main Compounds and compositions for treating kidney disease
IL293892A (en) 2020-01-15 2022-08-01 Inserm Institut National De La Sant? Et De La Rech M?Dicale Use of fxr agonists for treating an infection by hepatitis d virus
CN112062665A (zh) * 2020-09-24 2020-12-11 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 2,5-双(2,6-二氟亚苄基)-环戊酮及其制备方法和应用
MX2023008365A (es) 2021-01-14 2023-10-04 Enyo Pharma Efecto sinérgico de un agonista de fxr e ifn para el tratamiento de infección por hbv.
TW202308629A (zh) 2021-04-28 2023-03-01 法商Ｅｎｙｏ製藥公司 使用fxr激動劑作為組合治療以增強tlr3激動劑之療效
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02117650A (ja) * 1988-09-03 1990-05-02 Boehringer Mannheim Gmbh 心臓疾患および循環器系疾患を治療するための医薬品、ならびに新規フエニルアミド
US20030153596A1 (en) * 2000-08-21 2003-08-14 Suh Young Ger Novel thiourea derivatives and the pharmaceutical compositions containing the same
JP2005507910A (ja) * 2001-10-17 2005-03-24 グラクソ　グループ　リミテッド ２’−メチル−５’−（１，３，４−オキサジアゾール−２−イル）−１，１’−ビフェニル−４−カルボキサミド誘導体およびｐ３８キナーゼ阻害剤としてのそれらの使用
WO2007050124A1 (en) * 2005-05-19 2007-05-03 Xenon Pharmaceuticals Inc. Fused piperidine derivatives and their uses as therapeutic agents
WO2008120759A1 (ja) * 2007-03-30 2008-10-09 Japan Tobacco Inc. ウレア化合物およびその用途
WO2008123469A1 (ja) * 2007-03-30 2008-10-16 Japan Tobacco Inc. ６員環アミド化合物およびその用途
WO2008126731A1 (ja) * 2007-04-05 2008-10-23 Daiichi Sankyo Company, Limited アリール誘導体
WO2010123139A1 (ja) * 2009-04-24 2010-10-28 持田製薬株式会社 スルファモイル基を有するアリールカルボキサミド誘導体
CN105439914A (zh) * 2014-09-17 2016-03-30 复旦大学 4-氨酰基苯氧乙酰胺类化合物及其药物用途
WO2016144704A2 (en) * 2015-03-11 2016-09-15 Pharmakea, Inc. Heterocyclic autotaxin inhibitor compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ523882A (en) * 2000-08-21 2004-11-26 Pacific Corp Novel thiourea derivatives and the pharmaceutical compositions containing the same
WO2003030937A1 (en) * 2001-10-05 2003-04-17 Ono Pharmaceutical Co., Ltd. Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists
JP4736043B2 (ja) * 2003-03-14 2011-07-27 小野薬品工業株式会社 含窒素複素環誘導体およびそれらを有効成分とする薬剤
JP4737084B2 (ja) * 2004-03-12 2011-07-27 堺化学工業株式会社 アミド化合物、医薬組成物及びｒｘｒ機能調節剤
BR112015007513A2 (pt) * 2012-10-26 2017-07-04 Hoffmann La Roche inibidores de tirosina quinase de bruton
CN107001362A (zh) * 2014-10-06 2017-08-01 默克专利有限公司 用作btk抑制剂的杂芳基化合物及其用途
CA2969944A1 (en) * 2014-12-10 2016-06-16 Celgene International Ii Sarl Glp-1 receptor modulators
EP3034499A1 (en) * 2014-12-17 2016-06-22 Gilead Sciences, Inc. Novel FXR (NR1H4) modulating compounds
WO2017004525A1 (en) * 2015-07-02 2017-01-05 The Medical College Of Wisconsin, Inc. Diabetes and metabolic syndrome treatment with a novel dual modulator of soluble epoxide hydrolase and peroxisome proliferator-activated receptors

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02117650A (ja) * 1988-09-03 1990-05-02 Boehringer Mannheim Gmbh 心臓疾患および循環器系疾患を治療するための医薬品、ならびに新規フエニルアミド
US20030153596A1 (en) * 2000-08-21 2003-08-14 Suh Young Ger Novel thiourea derivatives and the pharmaceutical compositions containing the same
JP2005507910A (ja) * 2001-10-17 2005-03-24 グラクソ　グループ　リミテッド ２’−メチル−５’−（１，３，４−オキサジアゾール−２−イル）−１，１’−ビフェニル−４−カルボキサミド誘導体およびｐ３８キナーゼ阻害剤としてのそれらの使用
WO2007050124A1 (en) * 2005-05-19 2007-05-03 Xenon Pharmaceuticals Inc. Fused piperidine derivatives and their uses as therapeutic agents
WO2008120759A1 (ja) * 2007-03-30 2008-10-09 Japan Tobacco Inc. ウレア化合物およびその用途
WO2008123469A1 (ja) * 2007-03-30 2008-10-16 Japan Tobacco Inc. ６員環アミド化合物およびその用途
WO2008126731A1 (ja) * 2007-04-05 2008-10-23 Daiichi Sankyo Company, Limited アリール誘導体
WO2010123139A1 (ja) * 2009-04-24 2010-10-28 持田製薬株式会社 スルファモイル基を有するアリールカルボキサミド誘導体
CN105439914A (zh) * 2014-09-17 2016-03-30 复旦大学 4-氨酰基苯氧乙酰胺类化合物及其药物用途
WO2016144704A2 (en) * 2015-03-11 2016-09-15 Pharmakea, Inc. Heterocyclic autotaxin inhibitor compounds

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BAN, SHINTARO ET AL.: "Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phen", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19(10),, JPN7022001742, 2011, pages 3183 - 3191, ISSN: 0004969303 *
MAEDA, TAISHI ET AL.: "Potent histone deacetylase inhibitors: N-hydroxybenzamides with antitumor activities", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, no. 16, JPN5020007077, July 2004 (2004-07-01), pages 4351 - 4360, ISSN: 0004969302 *
NISHIMORI, I. ET AL.: "Carbonic Anhydrase Inhibitors : DNA Cloning and Inhibition Studies of the α-Carbonic Anhydrase from", JOURNAL OF MEDICAL CHEMISTRY, vol. 49, no. 6, JPN5020007073, 16 February 2006 (2006-02-16), pages 2117 - 2126, ISSN: 0004745843 *

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