AU2018274652A1 - Dual modulators of farnesoid X receptor and soluble epoxide hydrolase - Google Patents

Dual modulators of farnesoid X receptor and soluble epoxide hydrolase Download PDF

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AU2018274652A1
AU2018274652A1 AU2018274652A AU2018274652A AU2018274652A1 AU 2018274652 A1 AU2018274652 A1 AU 2018274652A1 AU 2018274652 A AU2018274652 A AU 2018274652A AU 2018274652 A AU2018274652 A AU 2018274652A AU 2018274652 A1 AU2018274652 A1 AU 2018274652A1
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fxr
seh
compound
disease
subject
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AU2018274652A
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Inventor
Moritz HELMSTÄDTER
Daniel Merk
Ewgenij PROSCHAK
Jurema SCHMIDT
Manfred Schubert-Zsilavecz
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Goethe Universitaet Frankfurt am Main
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Goethe Universitaet Frankfurt am Main
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    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/73—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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AU2018274652A 2017-05-24 2018-05-24 Dual modulators of farnesoid X receptor and soluble epoxide hydrolase Abandoned AU2018274652A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2017/062692 WO2018215070A1 (en) 2017-05-24 2017-05-24 Dual modulators of farnesoid x receptor and soluble epoxide hydrolase
AUPCT/EP2017/062692 2017-05-24
PCT/EP2018/063699 WO2018215610A1 (en) 2017-05-24 2018-05-24 Dual modulators of farnesoid x receptor and soluble epoxide hydrolase

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AU2018274652A1 true AU2018274652A1 (en) 2020-01-16

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AU2018274652A Abandoned AU2018274652A1 (en) 2017-05-24 2018-05-24 Dual modulators of farnesoid X receptor and soluble epoxide hydrolase

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US (1) US20200172473A1 (enExample)
EP (1) EP3630085A1 (enExample)
JP (1) JP2020524178A (enExample)
KR (1) KR20200010387A (enExample)
CN (1) CN110891560A (enExample)
AU (1) AU2018274652A1 (enExample)
BR (1) BR112019023820A2 (enExample)
CA (1) CA3062388A1 (enExample)
IL (1) IL270736A (enExample)
RU (1) RU2019143106A (enExample)
WO (2) WO2018215070A1 (enExample)

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CA3159163A1 (en) 2020-01-15 2021-07-22 Raphael Darteil Use of fxr agonists for treating an infection by hepatitis d virus
CN112062665A (zh) * 2020-09-24 2020-12-11 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 2,5-双(2,6-二氟亚苄基)-环戊酮及其制备方法和应用
CA3204800A1 (en) 2021-01-14 2022-07-21 Raphael Darteil Synergistic effect of a fxr agonist and ifn for the treatment of hbv infection
US20240216364A1 (en) 2021-04-28 2024-07-04 Enyo Pharma Strong potentiation of tlr3 agonists effects using fxr agonists as a combined treatment
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

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EP3630085A1 (en) 2020-04-08
WO2018215610A1 (en) 2018-11-29
IL270736A (en) 2020-01-30
JP2020524178A (ja) 2020-08-13
US20200172473A1 (en) 2020-06-04
CN110891560A (zh) 2020-03-17
WO2018215070A1 (en) 2018-11-29
RU2019143106A (ru) 2021-06-24
KR20200010387A (ko) 2020-01-30
BR112019023820A2 (pt) 2020-06-09
CA3062388A1 (en) 2018-11-29

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