BR112019023820A2 - moduladores duplos de receptor de farnesoide x e epóxido hidrolas solúvel - Google Patents

moduladores duplos de receptor de farnesoide x e epóxido hidrolas solúvel Download PDF

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BR112019023820A2
BR112019023820A2 BR112019023820A BR112019023820A BR112019023820A2 BR 112019023820 A2 BR112019023820 A2 BR 112019023820A2 BR 112019023820 A BR112019023820 A BR 112019023820A BR 112019023820 A BR112019023820 A BR 112019023820A BR 112019023820 A2 BR112019023820 A2 BR 112019023820A2
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farnesoid
receptor
soluble
hydrolas
epoxide
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BR112019023820A
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Merk Daniel
Proschak Ewgenij
Schmidt Jurema
Schubert-Zsilavecz Manfred
Helmstädter Moritz
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Johann Wolfgang Goethe Univ Frankfurt Am Main
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    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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Abstract

a presente invenção refere-se a moduladores duplos do receptor de farnesoide x (fxr) e de epóxido hidrolase solúvel (seh). os moduladores da invenção foram concebidos para prover compostos que carregam uma atividade dupla como agonistas de fxr e inibidores (antagonistas) de seh. a invenção também provê métodos para tratar indivíduos que sofrem de doenças associadas a fxr e seh, tais como distúrbios metabólicos, em particular fígado gorduroso não alcoólico ou esteato-hepatite não alcoólica (nash).
BR112019023820A 2017-05-24 2018-05-24 moduladores duplos de receptor de farnesoide x e epóxido hidrolas solúvel BR112019023820A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2017/062692 WO2018215070A1 (en) 2017-05-24 2017-05-24 Dual modulators of farnesoid x receptor and soluble epoxide hydrolase
PCT/EP2018/063699 WO2018215610A1 (en) 2017-05-24 2018-05-24 Dual modulators of farnesoid x receptor and soluble epoxide hydrolase

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BR112019023820A2 true BR112019023820A2 (pt) 2020-06-09

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US (1) US20200172473A1 (pt)
EP (1) EP3630085A1 (pt)
JP (1) JP2020524178A (pt)
KR (1) KR20200010387A (pt)
CN (1) CN110891560A (pt)
AU (1) AU2018274652A1 (pt)
BR (1) BR112019023820A2 (pt)
CA (1) CA3062388A1 (pt)
IL (1) IL270736A (pt)
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WO (2) WO2018215070A1 (pt)

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WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

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CA3062388A1 (en) 2018-11-29
RU2019143106A (ru) 2021-06-24
IL270736A (en) 2020-01-30
US20200172473A1 (en) 2020-06-04
AU2018274652A1 (en) 2020-01-16
JP2020524178A (ja) 2020-08-13
EP3630085A1 (en) 2020-04-08
WO2018215610A1 (en) 2018-11-29
KR20200010387A (ko) 2020-01-30
CN110891560A (zh) 2020-03-17
WO2018215070A1 (en) 2018-11-29

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