JP2020518669A5 - - Google Patents
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- JP2020518669A5 JP2020518669A5 JP2020511737A JP2020511737A JP2020518669A5 JP 2020518669 A5 JP2020518669 A5 JP 2020518669A5 JP 2020511737 A JP2020511737 A JP 2020511737A JP 2020511737 A JP2020511737 A JP 2020511737A JP 2020518669 A5 JP2020518669 A5 JP 2020518669A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- pharmaceutically acceptable
- acceptable salt
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 18
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000006747 (C2-C10) heterocycloalkyl group Chemical group 0.000 claims 8
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 230000004655 Hippo pathway Effects 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000000762 glandular Effects 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000007538 neurilemmoma Diseases 0.000 claims 1
- 201000003733 ovarian melanoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010039667 schwannoma Diseases 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 0 CC(C)Nc1c(*)cccc1 Chemical compound CC(C)Nc1c(*)cccc1 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762500937P | 2017-05-03 | 2017-05-03 | |
| US62/500,937 | 2017-05-03 | ||
| PCT/US2018/030721 WO2018204532A1 (en) | 2017-05-03 | 2018-05-02 | Non-fused tricyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020518669A JP2020518669A (ja) | 2020-06-25 |
| JP2020518669A5 true JP2020518669A5 (https=) | 2021-07-26 |
Family
ID=64016799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020511737A Pending JP2020518669A (ja) | 2017-05-03 | 2018-05-02 | 非縮合三環式化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11186554B2 (https=) |
| EP (1) | EP3618818A4 (https=) |
| JP (1) | JP2020518669A (https=) |
| CN (1) | CN111132673A (https=) |
| AU (1) | AU2018263921A1 (https=) |
| CA (1) | CA3062294A1 (https=) |
| WO (1) | WO2018204532A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018204532A1 (en) | 2017-05-03 | 2018-11-08 | Vivace Therapeutics, Inc. | Non-fused tricyclic compounds |
| CA3073543A1 (en) | 2017-08-21 | 2019-02-28 | Vivace Therapeutics, Inc. | Benzosulfonyl compounds |
| US11524943B1 (en) | 2017-12-06 | 2022-12-13 | Vivace Therapeutics, Inc. | Benzocarbonyl compounds |
| EP3793551A4 (en) | 2018-05-16 | 2022-01-26 | Vivace Therapeutics, Inc. | OXADIAZOLE COMPOUNDS |
| CN109260200A (zh) * | 2018-11-21 | 2019-01-25 | 南方科技大学 | 化合物dCTB在制备治疗癌性疼痛的药物中的应用 |
| GB201819659D0 (en) | 2018-12-03 | 2019-01-16 | Vib Vzw | Cancer regression by inducing a regeneration-like reponse |
| EP3937943A4 (en) * | 2019-03-15 | 2022-12-07 | The General Hospital Corporation | NEW SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS |
| HUE070525T2 (hu) * | 2019-04-16 | 2025-06-28 | Vivace Therapeutics Inc | Biciklusos vegyületek |
| KR20220030222A (ko) * | 2019-05-31 | 2022-03-10 | 이케나 온콜로지, 인코포레이티드 | Tead 억제제 및 이의 용도 |
| WO2020243423A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| AU2020320008A1 (en) | 2019-07-29 | 2022-03-17 | Basilea Pharmaceutica International AG | 1,2,4-oxadiazol-5-one derivatives for the treatment of cancer |
| EP4146652A1 (en) * | 2020-05-08 | 2023-03-15 | Merck Patent GmbH | Tricyclic heterocycles useful as tead binders |
| AU2021283892A1 (en) * | 2020-06-03 | 2023-02-02 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcriptional enhanced associate domain (TEAD) and uses thereof |
| US11787775B2 (en) | 2020-07-24 | 2023-10-17 | Genentech, Inc. | Therapeutic compounds and methods of use |
| PE20240017A1 (es) | 2020-09-30 | 2024-01-04 | Univ Leuven Kath | Derivados de 1,2,3,4-tetrahidroquinolina como inhibidores de la activacion de yap/taz-tead para el tratamiento del cancer |
| WO2022120355A1 (en) | 2020-12-02 | 2022-06-09 | Ikena Oncology, Inc. | Tead degraders and uses thereof |
| MX2023008420A (es) | 2021-01-25 | 2023-09-29 | Ikena Oncology Inc | Combinación de un inhibidor de dominios asociados mejorados transcripcionales (tead) de 3-(imidazol-4-il)-4-(amino)- bencenosulfonamida con un inhibidor del factor de crecimiento epidérmico (egfr) y/o un inhibidor de proteína cinasa-cinasas activadas por mitógen (mek) para usarse en el tratamiento de cáncer de pulmón. |
| JP2024514879A (ja) | 2021-04-16 | 2024-04-03 | イケナ オンコロジー， インコーポレイテッド | Ｍｅｋ阻害剤及びその使用 |
| CN115594680A (zh) * | 2021-07-07 | 2023-01-13 | 武汉人福创新药物研发中心有限公司（Cn） | 一种tead抑制剂 |
| CN113461643A (zh) * | 2021-07-20 | 2021-10-01 | 韶远科技（上海)有限公司 | 一种4-甲基苯磺酸[(3-氟氧杂环丁烷-3-基)甲基]酯的合成方法 |
| CA3224341A1 (en) | 2021-09-01 | 2023-03-09 | Novartis Ag | Pharmaceutical combinations comprising a tead inhibitor and uses thereof for the treatment of cancers |
| WO2023057371A1 (en) | 2021-10-04 | 2023-04-13 | Basilea Pharmaceutica International Ag, Allschwil | 1,2,4-oxadiazol-5-one derivatives for the treatment of cancer |
| WO2023060227A1 (en) | 2021-10-07 | 2023-04-13 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| US20250145608A1 (en) | 2021-12-01 | 2025-05-08 | Boehringer Ingelheim Int'l GmbH Corp. | Kras degrading compounds comprising annulated 2-amino-3-cyano thiophenes |
| JP2024543982A (ja) | 2021-12-01 | 2024-11-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | がんの処置のための縮環２－アミノ－３－シアノチオフェン及び誘導体 |
| US20250313553A1 (en) | 2021-12-01 | 2025-10-09 | Boehringer Ingelheim Int'l GmbH Corp. | Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer |
| US20250129096A1 (en) | 2021-12-01 | 2025-04-24 | Boehringer Ingelheim Int'l GmbH Corp. | Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer |
| WO2023099624A1 (en) | 2021-12-01 | 2023-06-08 | Boehringer Ingelheim International Gmbh | Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer |
| CN118647620A (zh) | 2021-12-01 | 2024-09-13 | 勃林格殷格翰国际有限公司 | 用于治疗癌症的环状2-氨基-3-氰基噻吩及其衍生物 |
| EP4452253A4 (en) * | 2021-12-23 | 2026-04-15 | The Katholieke Univ Leuven | 2-PYRAZOLE, ANILINES AND RELATED ANALOGUES TO INHIBIT YAP/TAZ-TEAD |
| CN116332922A (zh) * | 2021-12-24 | 2023-06-27 | 武汉人福创新药物研发中心有限公司 | 作为tead抑制剂的杂环化合物 |
| CN118632836A (zh) * | 2022-01-14 | 2024-09-10 | 株式会社大熊制药 | 具有癌细胞生长抑制作用的新型氨基苯衍生物以及含有其作为活性成分的预防或治疗药物组合物 |
| CN118715221A (zh) * | 2022-01-30 | 2024-09-27 | 希格生科（深圳）有限公司 | 三环化合物及其应用 |
| WO2023173057A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
| WO2023173053A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
| WO2023204822A1 (en) * | 2022-04-22 | 2023-10-26 | Vivace Therapeutics, Inc. | Phenyl phosphine oxide compounds and methods of use thereof |
| WO2023209090A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Bicyclic heteroaromatic compounds and their application in the treatment of cancer |
| PE20250268A1 (es) | 2022-04-28 | 2025-01-29 | Astrazeneca Ab | Compuestos heteroaromaticos biciclicos condensados y uso en el tratamiento del cancer |
| WO2023209086A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Bicyclic heteroaromatic compounds for treating cancer |
| WO2023209088A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Bicyclic heteroaromatic compounds and their use in the treatment of cancer |
| IL316768A (en) | 2022-05-25 | 2025-01-01 | Ikena Oncology Inc | MEK inhibitors and their uses |
| US20260055126A1 (en) * | 2022-09-23 | 2026-02-26 | Hangzhou Phecdamed Co., Ltd. | Small molecule compounds with phosphorylated aryl structures and use thereof |
| AU2023349151A1 (en) | 2022-09-29 | 2025-04-03 | Insilico Medicine Ip Limited | Tead inhibitors and methods of uses thereof |
| WO2024092116A1 (en) | 2022-10-26 | 2024-05-02 | Ikena Oncology, Inc. | Combination of tead inhibitors and egfr inhibitors and uses thereof |
| TW202421158A (zh) | 2022-11-18 | 2024-06-01 | 瑞士商諾華公司 | 藥物組合及其用途 |
| WO2024173761A1 (en) | 2023-02-17 | 2024-08-22 | Ikena Oncology, Inc. | Combinations comprising mek inhibitors for use in the treatment of cancer |
| WO2024176130A1 (en) | 2023-02-23 | 2024-08-29 | Novartis Ag | Tead- and her2-inhibitor combinations for treating cancer |
| WO2024176131A1 (en) | 2023-02-23 | 2024-08-29 | Novartis Ag | Tead- and kras g12d-inhibitor combinations for treating cancer |
| EP4719603A1 (en) | 2023-05-30 | 2026-04-08 | Boehringer Ingelheim International GmbH | Spirocyclic annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer |
| WO2025088571A1 (en) | 2023-10-26 | 2025-05-01 | Astrazeneca Ab | Crystalline forms of tead inhibitor |
| WO2025141118A1 (en) | 2023-12-27 | 2025-07-03 | Institut National de la Santé et de la Recherche Médicale | Arylalkyloxyindole compounds and derivatives and their use |
| WO2025215527A2 (en) | 2024-04-10 | 2025-10-16 | Novartis Ag | Pharmaceutical combinations and uses thereof |
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| US3903106A (en) | 1974-04-12 | 1975-09-02 | Lilly Co Eli | Pyrazole-3-carboxylic acids |
| DE2419970C3 (de) | 1974-04-25 | 1980-06-12 | Hoechst Ag, 6000 Frankfurt | 3-<l-Pyrrolidinyl)-4-phenoxy-5sulfamoylbenzoesäure und Verfahren zu ihrer Herstellung |
| JP2630432B2 (ja) | 1987-08-24 | 1997-07-16 | コニカ株式会社 | 新規なシアンカプラーを含有するハロゲン化銀カラー写真感光材料 |
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| FI902771A7 (fi) | 1989-06-09 | 1990-12-10 | Warner Lambert Co | Menetelmä anti-inflammatoristen 1,3,4-tiadiatsolien ja 1,3,4-oksadiatsolien valmistamiseksi |
| US4962119A (en) | 1989-06-09 | 1990-10-09 | Warner-Lambert Company | Triazole derivatives of fenamates as antiinflammatory agents |
| US5114958A (en) | 1991-05-09 | 1992-05-19 | Warner-Lambert Company | 1,2,4-oxadiazole and 1,2,4-thiadiazole derivatives of fenamates as antiinflammatory agents |
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| US6310060B1 (en) * | 1998-06-24 | 2001-10-30 | Warner-Lambert Company | 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
| US6211209B1 (en) | 1997-08-08 | 2001-04-03 | Warner-Lambert Company | Method of inhibiting connective tissue degradation |
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| WO2004052280A2 (en) * | 2002-12-10 | 2004-06-24 | Imclone Systems Incorporated | Anti-angiogenic compounds and their use in cancer treatment |
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| WO2005004818A2 (en) | 2003-07-09 | 2005-01-20 | Imclone Systems Incorporated | Heterocyclic compounds and their use as anticancer agents |
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| KR20180084153A (ko) * | 2011-06-10 | 2018-07-24 | 메르크 파텐트 게엠베하 | Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물의 조성물 및 제조방법 |
| EP2858635A1 (en) | 2012-06-11 | 2015-04-15 | The Regents of The University of California | Inhibitors of hippo-yap signaling pathway |
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| KR20170134980A (ko) | 2015-04-03 | 2017-12-07 | 브리스톨-마이어스 스큅 컴퍼니 | 암의 치료를 위한 인돌아민-2,3-디옥시게나제의 억제제 |
| WO2017058716A1 (en) | 2015-09-28 | 2017-04-06 | Vivace Therapeutics, Inc. | Tricyclic compounds |
| PL3371165T3 (pl) * | 2015-11-04 | 2022-05-02 | Merck Patent Gmbh | Inhibitor btk do zastosowania w terapii rakowej |
| WO2018204532A1 (en) | 2017-05-03 | 2018-11-08 | Vivace Therapeutics, Inc. | Non-fused tricyclic compounds |
| CA3073543A1 (en) | 2017-08-21 | 2019-02-28 | Vivace Therapeutics, Inc. | Benzosulfonyl compounds |
| US11524943B1 (en) | 2017-12-06 | 2022-12-13 | Vivace Therapeutics, Inc. | Benzocarbonyl compounds |
| EP3793551A4 (en) | 2018-05-16 | 2022-01-26 | Vivace Therapeutics, Inc. | OXADIAZOLE COMPOUNDS |
-
2018
- 2018-05-02 WO PCT/US2018/030721 patent/WO2018204532A1/en not_active Ceased
- 2018-05-02 JP JP2020511737A patent/JP2020518669A/ja active Pending
- 2018-05-02 AU AU2018263921A patent/AU2018263921A1/en not_active Abandoned
- 2018-05-02 EP EP18794672.8A patent/EP3618818A4/en not_active Withdrawn
- 2018-05-02 CA CA3062294A patent/CA3062294A1/en not_active Abandoned
- 2018-05-02 CN CN201880045048.0A patent/CN111132673A/zh active Pending
- 2018-05-02 US US16/609,715 patent/US11186554B2/en active Active
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