JP2020518641A5 - - Google Patents
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- Publication number
- JP2020518641A5 JP2020518641A5 JP2019560665A JP2019560665A JP2020518641A5 JP 2020518641 A5 JP2020518641 A5 JP 2020518641A5 JP 2019560665 A JP2019560665 A JP 2019560665A JP 2019560665 A JP2019560665 A JP 2019560665A JP 2020518641 A5 JP2020518641 A5 JP 2020518641A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- antibody
- antigen
- antagonist
- aplnr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762502621P | 2017-05-06 | 2017-05-06 | |
| US62/502,621 | 2017-05-06 | ||
| PCT/US2018/031255 WO2018208625A1 (en) | 2017-05-06 | 2018-05-04 | Methods of treating eye disorders with aplnr antagonists and vegf inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020518641A JP2020518641A (ja) | 2020-06-25 |
| JP2020518641A5 true JP2020518641A5 (enExample) | 2021-06-10 |
| JP7161494B2 JP7161494B2 (ja) | 2022-10-26 |
Family
ID=62555166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019560665A Active JP7161494B2 (ja) | 2017-05-06 | 2018-05-04 | Ａｐｌｎｒアンタゴニストおよびｖｅｇｆ阻害剤によって眼疾患を治療する方法 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP3618876A1 (enExample) |
| JP (1) | JP7161494B2 (enExample) |
| KR (1) | KR102667021B1 (enExample) |
| CN (1) | CN110709104A (enExample) |
| AU (1) | AU2018266324B2 (enExample) |
| EA (1) | EA201992630A1 (enExample) |
| IL (1) | IL270267B2 (enExample) |
| MX (1) | MX389729B (enExample) |
| WO (1) | WO2018208625A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4150766B1 (en) | 2020-05-11 | 2026-03-25 | Ascava, Inc. | Exploiting locality of prime data for efficient retrieval of data that has been losslessly reduced using a prime data sieve |
| CN115920057A (zh) * | 2023-01-03 | 2023-04-07 | 中国科学院合肥物质科学研究院 | 靶向aplnr蛋白棕榈酰化修饰的多肽及其在癌痛治疗中的应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0747045B2 (ja) | 1986-10-15 | 1995-05-24 | 株式会社大協精工 | 積層した注射器用滑栓 |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| EP0940468A1 (en) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| JP3100727B2 (ja) | 1992-01-23 | 2000-10-23 | 株式会社大協精工 | 変性ポリシロキサン組成物及び該組成物を被覆した衛生ゴム製品 |
| JP3172057B2 (ja) | 1995-04-05 | 2001-06-04 | 株式会社大協精工 | ラミネートゴム栓 |
| US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| JP3512349B2 (ja) | 1999-01-29 | 2004-03-29 | 株式会社大協精工 | 柱状ゴム要素の成形型 |
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| US7306799B2 (en) | 1999-06-08 | 2007-12-11 | Regeneron Pharmaceuticals, Inc. | Use of VEGF inhibitors for treatment of eye disorders |
| US7070959B1 (en) | 1999-06-08 | 2006-07-04 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
| US6629949B1 (en) | 2000-05-08 | 2003-10-07 | Sterling Medivations, Inc. | Micro infusion drug delivery device |
| US6659982B2 (en) | 2000-05-08 | 2003-12-09 | Sterling Medivations, Inc. | Micro infusion drug delivery device |
| JP2002209975A (ja) | 2001-01-19 | 2002-07-30 | Daikyo Seiko Ltd | 医薬バイアル用ラミネートゴム栓 |
| EP1613348B1 (en) | 2003-03-12 | 2010-06-23 | The Arizona Board of Regents on Behalf of the University of Arizona | Methods for modulating angiogenesis with apelin compositions |
| EP1877438A2 (en) | 2005-02-02 | 2008-01-16 | Regeneron Pharmaceuticals, Inc. | Method of treating eye injury with local administration of a vegf inhibitor |
| EP3753548A1 (en) | 2006-06-16 | 2020-12-23 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations suitable for intravitreal administration |
| US8946382B2 (en) | 2009-02-27 | 2015-02-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Apelin peptides and methods of use |
| JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| WO2013012855A1 (en) | 2011-07-18 | 2013-01-24 | Amgen Inc. | Apelin antigen-binding proteins and uses thereof |
| AU2013212587B2 (en) | 2012-01-23 | 2017-07-20 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-Ang2 antibodies |
| EP2836510A1 (en) | 2012-04-11 | 2015-02-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Polypeptides as apelin inhibitors and uses thereof |
| JP5775851B2 (ja) | 2012-06-27 | 2015-09-09 | 東京エレクトロン株式会社 | 塗布装置および塗布液充填方法 |
| TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
| JP6525951B2 (ja) * | 2013-03-14 | 2019-06-05 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | アペリン融合タンパク質およびその使用 |
| EA201691027A1 (ru) * | 2013-11-20 | 2016-12-30 | Ридженерон Фармасьютикалз, Инк. | Модуляторы aplnr и их применение |
| AU2015233370A1 (en) | 2014-03-20 | 2016-09-22 | Centre National De La Recherche Scientifique (Cnrs) | Use of compounds inhibiting Apelin / APJ / GP130 signaling for treating cancer |
| US20160144025A1 (en) | 2014-11-25 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and formulations for treating vascular eye diseases |
| CN108137681B (zh) * | 2015-09-23 | 2024-06-18 | 豪夫迈·罗氏有限公司 | 抗-vegf抗体的优化的变体 |
-
2018
- 2018-05-04 WO PCT/US2018/031255 patent/WO2018208625A1/en not_active Ceased
- 2018-05-04 EP EP18729829.4A patent/EP3618876A1/en active Pending
- 2018-05-04 KR KR1020197035953A patent/KR102667021B1/ko active Active
- 2018-05-04 CN CN201880037918.XA patent/CN110709104A/zh active Pending
- 2018-05-04 IL IL270267A patent/IL270267B2/en unknown
- 2018-05-04 MX MX2019012985A patent/MX389729B/es unknown
- 2018-05-04 AU AU2018266324A patent/AU2018266324B2/en active Active
- 2018-05-04 JP JP2019560665A patent/JP7161494B2/ja active Active
- 2018-05-04 EA EA201992630A patent/EA201992630A1/ru unknown
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