JP2020517678A5 - - Google Patents
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- Publication number
- JP2020517678A5 JP2020517678A5 JP2019557789A JP2019557789A JP2020517678A5 JP 2020517678 A5 JP2020517678 A5 JP 2020517678A5 JP 2019557789 A JP2019557789 A JP 2019557789A JP 2019557789 A JP2019557789 A JP 2019557789A JP 2020517678 A5 JP2020517678 A5 JP 2020517678A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- group
- cycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 208000036110 Neuroinflammatory disease Diseases 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 208000007400 Relapsing-Remitting Multiple Sclerosis Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL251949 | 2017-04-26 | ||
| IL251949A IL251949A0 (en) | 2017-04-26 | 2017-04-26 | Small organic molecules for use in the treatment of neuro-inflammatory diseases |
| PCT/IL2018/050463 WO2018198123A1 (en) | 2017-04-26 | 2018-04-26 | Small organic molecules for use in the treatment of neuroinflammatory disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020517678A JP2020517678A (ja) | 2020-06-18 |
| JP2020517678A5 true JP2020517678A5 (enExample) | 2021-04-01 |
| JP6997800B2 JP6997800B2 (ja) | 2022-02-04 |
Family
ID=62454780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019557789A Active JP6997800B2 (ja) | 2017-04-26 | 2018-04-26 | 神経炎症性障害の処置に使用される小有機分子 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11103479B2 (enExample) |
| EP (1) | EP3615022B1 (enExample) |
| JP (1) | JP6997800B2 (enExample) |
| CN (1) | CN110869015B (enExample) |
| AU (1) | AU2018260535B2 (enExample) |
| CA (1) | CA3061296A1 (enExample) |
| ES (1) | ES2948767T3 (enExample) |
| IL (2) | IL251949A0 (enExample) |
| WO (1) | WO2018198123A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019122202A1 (en) * | 2017-12-20 | 2019-06-27 | Ecole Polytechnique Federale De Lausanne (Epfl) | Sting inhibitors |
| CN112867489A (zh) * | 2018-06-07 | 2021-05-28 | 达萨玛治疗公司 | Sarm1抑制剂 |
| CA3123215C (en) * | 2018-12-19 | 2024-04-02 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 in combination with neuroprotective agents |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY109202A (en) | 1992-07-10 | 1996-12-31 | Nihon Nohyaku Co Ltd | Isothiazole derivatives and processes for preparing the same as well as termite controlling agents comprising the same as active ingredient |
| IT1313601B1 (it) | 1999-08-05 | 2002-09-09 | Isagro Ricerca Srl | Fenilpirazoli ad attivita' erbicida |
| EP1088822A1 (en) * | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl hydrazide derivatives |
| US6989451B2 (en) | 2002-06-04 | 2006-01-24 | Valeant Research & Development | Heterocyclic compounds and uses thereof |
| US6727241B2 (en) * | 2002-06-12 | 2004-04-27 | Chemocentryx | Anti-inflammatory compositions and methods of use |
| GB0306357D0 (en) | 2003-03-20 | 2003-04-23 | Astrazeneca Ab | Chemical compounds |
| EP1670425A4 (en) | 2003-10-07 | 2008-04-16 | Quark Pharmaceuticals Inc | BONE MORPHOGENETIC PROTEIN (BMP) 2A AND ITS APPLICATIONS |
| US20060217390A1 (en) | 2005-02-24 | 2006-09-28 | Esmir Gunic | Cycloalkl, aryl and heteroaryl amino isothiazoles for the treatment of Hepatitis C virus |
| WO2006124874A2 (en) | 2005-05-12 | 2006-11-23 | Kalypsys, Inc. | Inhibitors of b-raf kinase |
| CN100396667C (zh) * | 2006-02-20 | 2008-06-25 | 中国医学科学院医药生物技术研究所 | 一组具有上调骨形成蛋白bmp-2表达活性的五元不饱和杂环化合物 |
| AU2007288337B2 (en) | 2006-08-21 | 2012-02-16 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| WO2008118626A2 (en) | 2007-03-08 | 2008-10-02 | Burnham Institute For Medical Research | Inhibitors of jnk and methods for identifying inhibitors of jnk |
| US8507501B2 (en) * | 2008-03-13 | 2013-08-13 | The Brigham And Women's Hospital, Inc. | Inhibitors of the BMP signaling pathway |
| CA2805033A1 (en) * | 2009-07-14 | 2011-01-20 | Beth Israel Deaconess Medical Center, Inc. | Methods of increasing liver proliferation |
| AU2010282698A1 (en) | 2009-08-11 | 2012-03-15 | Allergan, Inc. | Isothiozoles for treating conditions of the eye |
| JP5725469B2 (ja) * | 2010-11-15 | 2015-05-27 | 学校法人北里研究所 | 骨分化阻害剤およびその製造方法 |
| WO2013186777A2 (en) * | 2012-06-14 | 2013-12-19 | The Medical Researth, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | Use of blocking agents of bone morphogenie protein (bmp) signaling for the treatment of neuroinflammatory and neurodegenerative diseases |
| US9682983B2 (en) * | 2013-03-14 | 2017-06-20 | The Brigham And Women's Hospital, Inc. | BMP inhibitors and methods of use thereof |
| EP3179857B1 (en) | 2014-08-14 | 2021-09-08 | Mamoun M. Alhamadsheh | Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life |
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2017
- 2017-04-26 IL IL251949A patent/IL251949A0/en unknown
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2018
- 2018-04-26 JP JP2019557789A patent/JP6997800B2/ja active Active
- 2018-04-26 US US16/606,114 patent/US11103479B2/en active Active
- 2018-04-26 AU AU2018260535A patent/AU2018260535B2/en active Active
- 2018-04-26 CN CN201880043208.8A patent/CN110869015B/zh active Active
- 2018-04-26 CA CA3061296A patent/CA3061296A1/en active Pending
- 2018-04-26 ES ES18791845T patent/ES2948767T3/es active Active
- 2018-04-26 WO PCT/IL2018/050463 patent/WO2018198123A1/en not_active Ceased
- 2018-04-26 EP EP18791845.3A patent/EP3615022B1/en active Active
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2019
- 2019-10-07 IL IL269894A patent/IL269894B/en unknown
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2021
- 2021-07-22 US US17/382,664 patent/US11779565B2/en active Active