CA3061296A1 - Small organic molecules for use in the treatment of neuroinflammatory disorders - Google Patents
Small organic molecules for use in the treatment of neuroinflammatory disorders Download PDFInfo
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- CA3061296A1 CA3061296A1 CA3061296A CA3061296A CA3061296A1 CA 3061296 A1 CA3061296 A1 CA 3061296A1 CA 3061296 A CA3061296 A CA 3061296A CA 3061296 A CA3061296 A CA 3061296A CA 3061296 A1 CA3061296 A1 CA 3061296A1
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- 230000008733 trauma Effects 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 229940079023 tysabri Drugs 0.000 description 1
- 230000028048 ureteric bud development Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/345—Nitrofurans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL251949A IL251949A0 (en) | 2017-04-26 | 2017-04-26 | Small organic molecules for use in the treatment of neuro-inflammatory diseases |
| IL251949 | 2017-04-26 | ||
| PCT/IL2018/050463 WO2018198123A1 (en) | 2017-04-26 | 2018-04-26 | Small organic molecules for use in the treatment of neuroinflammatory disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3061296A1 true CA3061296A1 (en) | 2018-11-01 |
Family
ID=62454780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3061296A Pending CA3061296A1 (en) | 2017-04-26 | 2018-04-26 | Small organic molecules for use in the treatment of neuroinflammatory disorders |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11103479B2 (enExample) |
| EP (1) | EP3615022B1 (enExample) |
| JP (1) | JP6997800B2 (enExample) |
| CN (1) | CN110869015B (enExample) |
| AU (1) | AU2018260535B2 (enExample) |
| CA (1) | CA3061296A1 (enExample) |
| ES (1) | ES2948767T3 (enExample) |
| IL (2) | IL251949A0 (enExample) |
| WO (1) | WO2018198123A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2019122202A1 (en) * | 2017-12-20 | 2019-06-27 | Ecole Polytechnique Federale De Lausanne (Epfl) | Sting inhibitors |
| CN112867489A (zh) * | 2018-06-07 | 2021-05-28 | 达萨玛治疗公司 | Sarm1抑制剂 |
| EP3897670A4 (en) * | 2018-12-19 | 2022-09-07 | Disarm Therapeutics, Inc. | MRSA1 INHIBITORS IN COMBINATION WITH NEUROPROTECTIVE AGENTS |
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| MY109202A (en) | 1992-07-10 | 1996-12-31 | Nihon Nohyaku Co Ltd | Isothiazole derivatives and processes for preparing the same as well as termite controlling agents comprising the same as active ingredient |
| IT1313601B1 (it) | 1999-08-05 | 2002-09-09 | Isagro Ricerca Srl | Fenilpirazoli ad attivita' erbicida |
| EP1088822A1 (en) * | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl hydrazide derivatives |
| US6989451B2 (en) | 2002-06-04 | 2006-01-24 | Valeant Research & Development | Heterocyclic compounds and uses thereof |
| US6727241B2 (en) | 2002-06-12 | 2004-04-27 | Chemocentryx | Anti-inflammatory compositions and methods of use |
| GB0306357D0 (en) | 2003-03-20 | 2003-04-23 | Astrazeneca Ab | Chemical compounds |
| EP1670425A4 (en) | 2003-10-07 | 2008-04-16 | Quark Pharmaceuticals Inc | BONE MORPHOGENETIC PROTEIN (BMP) 2A AND ITS APPLICATIONS |
| US20060217390A1 (en) | 2005-02-24 | 2006-09-28 | Esmir Gunic | Cycloalkl, aryl and heteroaryl amino isothiazoles for the treatment of Hepatitis C virus |
| WO2006124874A2 (en) | 2005-05-12 | 2006-11-23 | Kalypsys, Inc. | Inhibitors of b-raf kinase |
| CN100396667C (zh) * | 2006-02-20 | 2008-06-25 | 中国医学科学院医药生物技术研究所 | 一组具有上调骨形成蛋白bmp-2表达活性的五元不饱和杂环化合物 |
| CA2661440A1 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| WO2008118626A2 (en) | 2007-03-08 | 2008-10-02 | Burnham Institute For Medical Research | Inhibitors of jnk and methods for identifying inhibitors of jnk |
| JP5638961B2 (ja) * | 2008-03-13 | 2014-12-10 | ザ ジェネラル ホスピタル コーポレイション | Ｂｍｐシグナル伝達経路のインヒビター |
| EP2453882A1 (en) * | 2009-07-14 | 2012-05-23 | Beth Israel Deaconess Medical Center, Inc. | Methods of increasing liver proliferation |
| KR20120081585A (ko) | 2009-08-11 | 2012-07-19 | 알러간, 인코포레이티드 | 안질환을 치료하기 위한 이소티오졸 |
| JP5725469B2 (ja) * | 2010-11-15 | 2015-05-27 | 学校法人北里研究所 | 骨分化阻害剤およびその製造方法 |
| EP3521310A1 (en) | 2012-06-14 | 2019-08-07 | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | Use of blocking agents of bone morphogenic protein (bmp) signaling for the treatment of neuroinflammatory and neurodegenerative diseases |
| US9682983B2 (en) | 2013-03-14 | 2017-06-20 | The Brigham And Women's Hospital, Inc. | BMP inhibitors and methods of use thereof |
| JP6543342B2 (ja) | 2014-08-14 | 2019-07-10 | アルハマドシャー，マモウン，エム． | 血清半減期を延長するための、調節可能リンカーを介した薬学的活性剤とトランスサイレチンリガンドのコンジュゲーション |
-
2017
- 2017-04-26 IL IL251949A patent/IL251949A0/en unknown
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2018
- 2018-04-26 EP EP18791845.3A patent/EP3615022B1/en active Active
- 2018-04-26 ES ES18791845T patent/ES2948767T3/es active Active
- 2018-04-26 CA CA3061296A patent/CA3061296A1/en active Pending
- 2018-04-26 AU AU2018260535A patent/AU2018260535B2/en active Active
- 2018-04-26 CN CN201880043208.8A patent/CN110869015B/zh active Active
- 2018-04-26 JP JP2019557789A patent/JP6997800B2/ja active Active
- 2018-04-26 WO PCT/IL2018/050463 patent/WO2018198123A1/en not_active Ceased
- 2018-04-26 US US16/606,114 patent/US11103479B2/en active Active
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2019
- 2019-10-07 IL IL269894A patent/IL269894B/en unknown
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2021
- 2021-07-22 US US17/382,664 patent/US11779565B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN110869015A (zh) | 2020-03-06 |
| AU2018260535A1 (en) | 2019-10-31 |
| JP2020517678A (ja) | 2020-06-18 |
| ES2948767T3 (es) | 2023-09-18 |
| EP3615022A4 (en) | 2021-03-31 |
| AU2018260535B2 (en) | 2023-09-28 |
| US20200046680A1 (en) | 2020-02-13 |
| IL269894B (en) | 2022-03-01 |
| WO2018198123A1 (en) | 2018-11-01 |
| IL251949A0 (en) | 2017-07-31 |
| EP3615022C0 (en) | 2023-06-07 |
| EP3615022B1 (en) | 2023-06-07 |
| EP3615022A1 (en) | 2020-03-04 |
| US11103479B2 (en) | 2021-08-31 |
| US11779565B2 (en) | 2023-10-10 |
| CN110869015B (zh) | 2023-08-18 |
| US20210393582A1 (en) | 2021-12-23 |
| JP6997800B2 (ja) | 2022-02-04 |
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