JP2020515282A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020515282A5 JP2020515282A5 JP2019556410A JP2019556410A JP2020515282A5 JP 2020515282 A5 JP2020515282 A5 JP 2020515282A5 JP 2019556410 A JP2019556410 A JP 2019556410A JP 2019556410 A JP2019556410 A JP 2019556410A JP 2020515282 A5 JP2020515282 A5 JP 2020515282A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- antigen
- sequence
- cell
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims 38
- 102000036639 antigens Human genes 0.000 claims 38
- 108091007433 antigens Proteins 0.000 claims 38
- 108090000765 processed proteins & peptides Proteins 0.000 claims 24
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims 21
- 230000011664 signaling Effects 0.000 claims 21
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 150000007523 nucleic acids Chemical class 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims 11
- 102000004127 Cytokines Human genes 0.000 claims 10
- 108090000695 Cytokines Proteins 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 10
- 241000700605 Viruses Species 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 230000000813 microbial effect Effects 0.000 claims 8
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 7
- 102000003812 Interleukin-15 Human genes 0.000 claims 7
- 108090000172 Interleukin-15 Proteins 0.000 claims 7
- 102100035971 Molybdopterin molybdenumtransferase Human genes 0.000 claims 7
- 101710119577 Molybdopterin molybdenumtransferase Proteins 0.000 claims 7
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 7
- 210000002865 immune cell Anatomy 0.000 claims 7
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 6
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 6
- 206010038389 Renal cancer Diseases 0.000 claims 6
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 6
- 201000010982 kidney cancer Diseases 0.000 claims 6
- -1 LAGE-la Proteins 0.000 claims 5
- 108010057085 cytokine receptors Proteins 0.000 claims 5
- 102000003675 cytokine receptors Human genes 0.000 claims 5
- 210000005260 human cell Anatomy 0.000 claims 4
- 230000004068 intracellular signaling Effects 0.000 claims 4
- 210000004962 mammalian cell Anatomy 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 208000003200 Adenoma Diseases 0.000 claims 3
- 206010001233 Adenoma benign Diseases 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
- 208000017604 Hodgkin disease Diseases 0.000 claims 3
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 3
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 3
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 206010039491 Sarcoma Diseases 0.000 claims 3
- 208000000453 Skin Neoplasms Diseases 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 201000010881 cervical cancer Diseases 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 201000007270 liver cancer Diseases 0.000 claims 3
- 208000014018 liver neoplasm Diseases 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 208000021039 metastatic melanoma Diseases 0.000 claims 3
- 210000000822 natural killer cell Anatomy 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 230000019491 signal transduction Effects 0.000 claims 3
- 201000000849 skin cancer Diseases 0.000 claims 3
- 210000000115 thoracic cavity Anatomy 0.000 claims 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims 3
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 2
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 2
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 2
- 241000701806 Human papillomavirus Species 0.000 claims 2
- 108010017842 Telomerase Proteins 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 238000009169 immunotherapy Methods 0.000 claims 2
- 210000003757 neuroblast Anatomy 0.000 claims 2
- 230000036961 partial effect Effects 0.000 claims 2
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 2
- 210000001236 prokaryotic cell Anatomy 0.000 claims 2
- 101150047061 tag-72 gene Proteins 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 210000005253 yeast cell Anatomy 0.000 claims 2
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 1
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims 1
- 101710163573 5-hydroxyisourate hydrolase Proteins 0.000 claims 1
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 1
- 102100030840 AT-rich interactive domain-containing protein 4B Human genes 0.000 claims 1
- 102100023635 Alpha-fetoprotein Human genes 0.000 claims 1
- 101710145634 Antigen 1 Proteins 0.000 claims 1
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 1
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 102000015735 Beta-catenin Human genes 0.000 claims 1
- 108060000903 Beta-catenin Proteins 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 102100035793 CD83 antigen Human genes 0.000 claims 1
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims 1
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 1
- 102100025466 Carcinoembryonic antigen-related cell adhesion molecule 3 Human genes 0.000 claims 1
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 claims 1
- 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 claims 1
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 1
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 1
- 102100028073 Fibroblast growth factor 5 Human genes 0.000 claims 1
- 108090000380 Fibroblast growth factor 5 Proteins 0.000 claims 1
- 101710113436 GTPase KRas Proteins 0.000 claims 1
- 102100039554 Galectin-8 Human genes 0.000 claims 1
- 102100022132 High affinity immunoglobulin epsilon receptor subunit gamma Human genes 0.000 claims 1
- 108091010847 High affinity immunoglobulin epsilon receptor subunit gamma Proteins 0.000 claims 1
- 101000792935 Homo sapiens AT-rich interactive domain-containing protein 4B Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101100165850 Homo sapiens CA9 gene Proteins 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims 1
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims 1
- 101000914337 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 3 Proteins 0.000 claims 1
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 claims 1
- 101000608769 Homo sapiens Galectin-8 Proteins 0.000 claims 1
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims 1
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 1
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 1
- 101001014223 Homo sapiens MAPK/MAK/MRK overlapping kinase Proteins 0.000 claims 1
- 101000934372 Homo sapiens Macrosialin Proteins 0.000 claims 1
- 101001005719 Homo sapiens Melanoma-associated antigen 3 Proteins 0.000 claims 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 1
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims 1
- 101001062222 Homo sapiens Receptor-binding cancer antigen expressed on SiSo cells Proteins 0.000 claims 1
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 1
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 101000671653 Homo sapiens U3 small nucleolar RNA-associated protein 14 homolog A Proteins 0.000 claims 1
- 108010031794 IGF Type 1 Receptor Proteins 0.000 claims 1
- 101710123134 Ice-binding protein Proteins 0.000 claims 1
- 101710082837 Ice-structuring protein Proteins 0.000 claims 1
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 1
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 1
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 1
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 1
- 108010030506 Integrin alpha6beta4 Proteins 0.000 claims 1
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims 1
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 1
- 102100031520 MAPK/MAK/MRK overlapping kinase Human genes 0.000 claims 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims 1
- 102100025136 Macrosialin Human genes 0.000 claims 1
- 102000000440 Melanoma-associated antigen Human genes 0.000 claims 1
- 108050008953 Melanoma-associated antigen Proteins 0.000 claims 1
- 102100025082 Melanoma-associated antigen 3 Human genes 0.000 claims 1
- 102000003735 Mesothelin Human genes 0.000 claims 1
- 108090000015 Mesothelin Proteins 0.000 claims 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 101710160107 Outer membrane protein A Proteins 0.000 claims 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 1
- 101800001295 Putative ATP-dependent helicase Proteins 0.000 claims 1
- 101800001006 Putative helicase Proteins 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 101710100968 Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 102100029165 Receptor-binding cancer antigen expressed on SiSo cells Human genes 0.000 claims 1
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 1
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims 1
- 101150031162 TM4SF1 gene Proteins 0.000 claims 1
- 102100034902 Transmembrane 4 L6 family member 1 Human genes 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 101710107540 Type-2 ice-structuring protein Proteins 0.000 claims 1
- 102100040099 U3 small nucleolar RNA-associated protein 14 homolog A Human genes 0.000 claims 1
- 102000040856 WT1 Human genes 0.000 claims 1
- 108700020467 WT1 Proteins 0.000 claims 1
- 101150084041 WT1 gene Proteins 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims 1
- 229940084986 human chorionic gonadotropin Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000031146 intracellular signal transduction Effects 0.000 claims 1
- 230000002147 killing effect Effects 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 238000012737 microarray-based gene expression Methods 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 238000012243 multiplex automated genomic engineering Methods 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 claims 1
- 108091005703 transmembrane proteins Proteins 0.000 claims 1
- 102000035160 transmembrane proteins Human genes 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611246563.4A CN108250301A (zh) | 2016-12-29 | 2016-12-29 | 一种多靶点嵌合抗原受体 |
| CN201611246563.4 | 2016-12-29 | ||
| PCT/CN2017/118980 WO2018121604A1 (zh) | 2016-12-29 | 2017-12-27 | 一种多靶点嵌合抗原受体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020515282A JP2020515282A (ja) | 2020-05-28 |
| JP2020515282A5 true JP2020515282A5 (https=) | 2021-07-29 |
Family
ID=62707871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019556410A Pending JP2020515282A (ja) | 2016-12-29 | 2017-12-27 | 多標的キメラ抗原受容体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220064595A1 (https=) |
| EP (1) | EP3575325A4 (https=) |
| JP (1) | JP2020515282A (https=) |
| CN (2) | CN108250301A (https=) |
| WO (1) | WO2018121604A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108395482B (zh) | 2017-02-08 | 2021-02-05 | 西比曼生物科技（香港）有限公司 | 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定 |
| CN110862967A (zh) * | 2018-08-27 | 2020-03-06 | 天津天锐生物科技有限公司 | 一种不依赖细胞因子培养的自然杀伤细胞系silk-nk |
| CN109678965B (zh) * | 2018-10-12 | 2023-04-07 | 中国人民解放军总医院 | 嵌合抗原受体及其基因和重组表达载体、cd22-cd19双靶向性的t细胞及其应用 |
| CN109468283A (zh) * | 2018-11-30 | 2019-03-15 | 北京美康基免生物科技有限公司 | 一种基于cd19和bcma的双重嵌合抗原受体基因修饰的免疫细胞及其应用 |
| CN109485734B (zh) * | 2018-12-30 | 2020-05-12 | 广州百暨基因科技有限公司 | 一种靶向bcma和cd19的双特异性嵌合抗原受体及其应用 |
| CN113474012B (zh) * | 2019-01-25 | 2023-09-08 | 湖南远泰生物技术有限公司 | Epcam抗体和epcam-car-t细胞 |
| WO2020190771A1 (en) * | 2019-03-15 | 2020-09-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric adaptor and kinase signaling proteins and their use in immunotherapy |
| CA3141778A1 (en) * | 2019-06-12 | 2020-12-17 | CSL Innovation Pty Ltd | Soluble complement receptor type 1 variant conjugates and uses thereof |
| CN118165120A (zh) * | 2019-07-22 | 2024-06-11 | 南京助天中科科技发展有限公司 | 一种嵌合抗原受体及其应用 |
| EP4077370A4 (en) * | 2019-12-17 | 2024-02-28 | The Johns Hopkins University | MANABODIES TARGETING TUMOR ANTIGENS AND METHODS OF USE |
| CN113402612A (zh) | 2020-03-17 | 2021-09-17 | 西比曼生物科技（香港）有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
| CN113461824A (zh) * | 2020-03-31 | 2021-10-01 | 普米斯生物技术(珠海)有限公司 | 一种构建多特异性抗体的平台 |
| CN113493524A (zh) * | 2020-04-03 | 2021-10-12 | 重庆精准生物技术有限公司 | 双特异性嵌合抗原受体及其应用 |
| CN111411085A (zh) * | 2020-04-10 | 2020-07-14 | 格源致善(上海)生物科技有限公司 | 一种嵌合抗原受体t细胞及其应用 |
| CN113603787B (zh) * | 2020-05-04 | 2023-05-23 | 英诺康生物医药科技(广州)有限公司 | 一种非分泌型的人白细胞介素15及应用 |
| CN111848820B (zh) * | 2020-07-31 | 2022-05-17 | 广东昭泰体内生物医药科技有限公司 | Cd19和bcma双靶点嵌合抗原受体及其应用 |
| CN111748044B (zh) * | 2020-07-31 | 2022-02-18 | 广东昭泰体内生物医药科技有限公司 | Cd19和pd-l1双靶点嵌合抗原受体及其应用 |
| CN112877346B (zh) * | 2020-08-12 | 2023-01-03 | 山东兴瑞生物科技有限公司 | 抗b7-h3嵌合抗原受体的编码基因、制备方法、具有该基因的质粒、免疫细胞及其应用 |
| CN113234685A (zh) * | 2021-05-25 | 2021-08-10 | 临沂大学 | 一种双靶点cd19/cd20联用嵌合抗原受体t细胞及其制备方法和应用 |
| CN115491359B (zh) * | 2021-06-18 | 2026-03-17 | 南京北恒生物科技有限公司 | 靶向cd30和bcma的工程化免疫细胞 |
| CN114149978B (zh) * | 2022-02-09 | 2022-04-26 | 深圳博雅感知药业有限公司 | 制备car-t细胞的方法 |
| CN114634580B (zh) * | 2022-03-21 | 2024-01-30 | 皖南医学院第一附属医院（皖南医学院弋矶山医院） | 一种膜锚定式il-15超级复合物的研制及其在肿瘤免疫细胞治疗中的应用 |
| CN114478806B (zh) * | 2022-04-14 | 2022-07-01 | 呈诺再生医学科技(北京)有限公司 | 一种提升免疫细胞杀伤活性的嵌合受体及其应用 |
| CN115925989B (zh) * | 2022-09-26 | 2025-09-30 | 东南大学 | 长效的双靶点嵌合抗原受体、核酸分子、重组载体、细胞及其应用 |
| JP2025535502A (ja) * | 2022-10-28 | 2025-10-24 | バイオサイトジェン ファーマシューティカルズ （ベイジン） カンパニー リミテッド | 抗ｗｔ１／ｈｌａ抗体及びその使用 |
| CN116903757B (zh) * | 2023-07-21 | 2024-09-24 | 杭州荣谷生物科技有限公司 | Cd70纳米抗体和双靶向嵌合抗原受体 |
| CN120647773A (zh) * | 2024-03-14 | 2025-09-16 | 上海恩凯细胞技术有限公司 | 嵌合转换受体及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1777294A1 (en) * | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
| DK2160401T3 (da) * | 2007-05-11 | 2014-10-20 | Altor Bioscience Corp | Fusionsmolekyler og il-15-varianter |
| CN107880136B (zh) * | 2010-09-21 | 2021-11-12 | 阿尔托生物科学有限公司 | 多聚体il-15可溶性融合分子与其制造与使用方法 |
| EP2537933A1 (en) * | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
| JP6850528B2 (ja) * | 2012-02-13 | 2021-03-31 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | 二重特異性キメラ抗原受容体およびその治療的使用 |
| LT4461308T (lt) * | 2012-07-13 | 2025-06-10 | The Trustees Of The University Of Pennsylvania | Car priešnavikinio aktyvumo toksiškumo valdymas |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| EP3783098A1 (en) * | 2013-05-14 | 2021-02-24 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| RU2689717C2 (ru) * | 2014-01-08 | 2019-05-28 | Шанхай Хэнжуй Фармасьютикал Ко., Лтд. | Гетеродимерный белок il-15 и его применения |
| WO2015164107A1 (en) * | 2014-04-23 | 2015-10-29 | Emory University | Compositions of gm-csf and interleukin fusions for immune modulation and uses related thereto |
| EP2990416B1 (en) * | 2014-08-29 | 2018-06-20 | GEMoaB Monoclonals GmbH | Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders |
| ES2869972T3 (es) * | 2015-01-26 | 2021-10-26 | Cellectis | Sistemas de receptores de antígenos quiméricos dirigidos por mAb para clasificar/agotar células inmunitarias genomanipuladas |
-
2016
- 2016-12-29 CN CN201611246563.4A patent/CN108250301A/zh active Pending
-
2017
- 2017-12-27 US US16/475,030 patent/US20220064595A1/en not_active Abandoned
- 2017-12-27 WO PCT/CN2017/118980 patent/WO2018121604A1/zh not_active Ceased
- 2017-12-27 EP EP17886078.9A patent/EP3575325A4/en not_active Withdrawn
- 2017-12-27 CN CN201780029218.1A patent/CN109153730B/zh active Active
- 2017-12-27 JP JP2019556410A patent/JP2020515282A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020515282A5 (https=) | ||
| JP2020504628A5 (https=) | ||
| EP3575325A1 (en) | Multi-target chimeric antigen receptor | |
| US11806365B2 (en) | Modified T lymphocytes comprising a CD52 antibody-inducible caspase and methods of apoptosis | |
| US11530264B2 (en) | Multifunctional protein | |
| JP7267321B2 (ja) | 改善された特異性を有する改変型ｔリンパ球 | |
| JP2021519580A5 (https=) | ||
| JP2020508663A5 (https=) | ||
| RU2020135106A (ru) | Векторы экспрессии для химерных рецепторов поглощения, генетически модифицированные клетки-хозяева и их применения | |
| JP2017500009A5 (https=) | ||
| JP2019518424A5 (https=) | ||
| JP2021532742A5 (https=) | ||
| JPWO2019191339A5 (https=) | ||
| JP2019500394A5 (https=) | ||
| JP2018525033A5 (https=) | ||
| US20170166866A1 (en) | Methods of improving vector transduction efficiency into t lymphocytes | |
| JP2021514631A5 (https=) | ||
| JPWO2020106843A5 (https=) | ||
| CN109053899A (zh) | 一种含人转铁蛋白抗原表位序列的嵌合体抗原受体 | |
| US11458169B2 (en) | TIM3-binding chimeric antigen receptors | |
| JPWO2021163616A5 (https=) | ||
| JPWO2023044456A5 (https=) | ||
| US20190276555A1 (en) | Tag-72-binding chimeric antigen receptors | |
| CN106478823B (zh) | Her1靶向性的嵌合抗原受体和nkt细胞及其制法和应用 | |
| JPWO2023158978A5 (https=) |