CN108250301A - 一种多靶点嵌合抗原受体 - Google Patents

一种多靶点嵌合抗原受体 Download PDF

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Publication number
CN108250301A
CN108250301A CN201611246563.4A CN201611246563A CN108250301A CN 108250301 A CN108250301 A CN 108250301A CN 201611246563 A CN201611246563 A CN 201611246563A CN 108250301 A CN108250301 A CN 108250301A
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Chinese (zh)
Inventor
王磊
高斌
吴亚松
司远
吕丹
魏卿
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Tianjin Tian Rui Biotechnology Co Ltd
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Tianjin Tian Rui Biotechnology Co Ltd
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Priority to CN201611246563.4A priority Critical patent/CN108250301A/zh
Priority to US16/475,030 priority patent/US20220064595A1/en
Priority to PCT/CN2017/118980 priority patent/WO2018121604A1/zh
Priority to EP17886078.9A priority patent/EP3575325A4/en
Priority to CN201780029218.1A priority patent/CN109153730B/zh
Priority to JP2019556410A priority patent/JP2020515282A/ja
Publication of CN108250301A publication Critical patent/CN108250301A/zh
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    • C07—ORGANIC CHEMISTRY
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/00—Cellular immunotherapy
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CN201611246563.4A 2016-12-29 2016-12-29 一种多靶点嵌合抗原受体 Pending CN108250301A (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN201611246563.4A CN108250301A (zh) 2016-12-29 2016-12-29 一种多靶点嵌合抗原受体
US16/475,030 US20220064595A1 (en) 2016-12-29 2017-12-27 Multi-target chimeric antigen receptor
PCT/CN2017/118980 WO2018121604A1 (zh) 2016-12-29 2017-12-27 一种多靶点嵌合抗原受体
EP17886078.9A EP3575325A4 (en) 2016-12-29 2017-12-27 MULTI-TARGET CHEMICAL ANTIGEN RECEPTOR
CN201780029218.1A CN109153730B (zh) 2016-12-29 2017-12-27 一种多靶点嵌合抗原受体
JP2019556410A JP2020515282A (ja) 2016-12-29 2017-12-27 多標的キメラ抗原受容体

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CN201611246563.4A CN108250301A (zh) 2016-12-29 2016-12-29 一种多靶点嵌合抗原受体

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CN108250301A true CN108250301A (zh) 2018-07-06

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CN201780029218.1A Active CN109153730B (zh) 2016-12-29 2017-12-27 一种多靶点嵌合抗原受体

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EP (1) EP3575325A4 (https=)
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CN (2) CN108250301A (https=)
WO (1) WO2018121604A1 (https=)

Cited By (18)

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CN109468283A (zh) * 2018-11-30 2019-03-15 北京美康基免生物科技有限公司 一种基于cd19和bcma的双重嵌合抗原受体基因修饰的免疫细胞及其应用
CN109485734A (zh) * 2018-12-30 2019-03-19 广州百暨基因科技有限公司 一种靶向bcma和cd19的双特异性嵌合抗原受体及其应用
CN109678965A (zh) * 2018-10-12 2019-04-26 中国人民解放军总医院 嵌合抗原受体及其基因和重组表达载体、cd22-cd19双靶向性的t细胞及其应用
WO2020043076A1 (zh) * 2018-08-27 2020-03-05 天津天锐生物科技有限公司 一种不依赖细胞因子培养的自然杀伤细胞系silk-nk
CN111411085A (zh) * 2020-04-10 2020-07-14 格源致善(上海)生物科技有限公司 一种嵌合抗原受体t细胞及其应用
CN111748044A (zh) * 2020-07-31 2020-10-09 广东昭泰体内生物医药科技有限公司 Cd19和pd-l1双靶点嵌合抗原受体及其应用
CN111848820A (zh) * 2020-07-31 2020-10-30 广东昭泰体内生物医药科技有限公司 Cd19和bcma双靶点嵌合抗原受体及其应用
CN112279923A (zh) * 2019-07-22 2021-01-29 北京助天科技发展有限公司 一种嵌合抗原受体及其应用
CN113234685A (zh) * 2021-05-25 2021-08-10 临沂大学 一种双靶点cd19/cd20联用嵌合抗原受体t细胞及其制备方法和应用
CN113474012A (zh) * 2019-01-25 2021-10-01 普洛迈博生物技术公司 Epcam抗体和epcam-car-t细胞
CN113461824A (zh) * 2020-03-31 2021-10-01 普米斯生物技术(珠海)有限公司 一种构建多特异性抗体的平台
CN113710697A (zh) * 2019-03-15 2021-11-26 美国政府(由卫生和人类服务部的部长所代表) 嵌合衔接子和激酶信号传导蛋白及其在免疫疗法中的用途
CN114072425A (zh) * 2019-06-12 2022-02-18 杰特创新股份有限公司 可溶性补体受体1型变体缀合物及其用途
CN114149978A (zh) * 2022-02-09 2022-03-08 深圳博雅感知药业有限公司 制备car-t细胞的方法
CN114634580A (zh) * 2022-03-21 2022-06-17 皖南医学院第一附属医院（皖南医学院弋矶山医院） 一种膜锚定式il-15超级复合物的研制及其在肿瘤免疫细胞治疗中的应用
CN115210255A (zh) * 2019-12-17 2022-10-18 约翰斯霍普金斯大学 靶向肿瘤抗原的mana抗体及其使用方法
CN115491359A (zh) * 2021-06-18 2022-12-20 南京北恒生物科技有限公司 靶向cd30和bcma的工程化免疫细胞
WO2025190008A1 (zh) * 2024-03-14 2025-09-18 上海恩凯细胞技术有限公司 嵌合转换受体及其应用

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CN108395482B (zh) 2017-02-08 2021-02-05 西比曼生物科技（香港）有限公司 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定
CN113402612A (zh) 2020-03-17 2021-09-17 西比曼生物科技（香港）有限公司 靶向cd19和cd20的联合嵌合抗原受体及其应用
CN113493524A (zh) * 2020-04-03 2021-10-12 重庆精准生物技术有限公司 双特异性嵌合抗原受体及其应用
CN113603787B (zh) * 2020-05-04 2023-05-23 英诺康生物医药科技(广州)有限公司 一种非分泌型的人白细胞介素15及应用
CN112877346B (zh) * 2020-08-12 2023-01-03 山东兴瑞生物科技有限公司 抗b7-h3嵌合抗原受体的编码基因、制备方法、具有该基因的质粒、免疫细胞及其应用
CN114478806B (zh) * 2022-04-14 2022-07-01 呈诺再生医学科技(北京)有限公司 一种提升免疫细胞杀伤活性的嵌合受体及其应用
CN115925989B (zh) * 2022-09-26 2025-09-30 东南大学 长效的双靶点嵌合抗原受体、核酸分子、重组载体、细胞及其应用
JP2025535502A (ja) * 2022-10-28 2025-10-24 バイオサイトジェン ファーマシューティカルズ （ベイジン） カンパニー リミテッド 抗ｗｔ１／ｈｌａ抗体及びその使用
CN116903757B (zh) * 2023-07-21 2024-09-24 杭州荣谷生物科技有限公司 Cd70纳米抗体和双靶向嵌合抗原受体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1777294A1 (en) * 2005-10-20 2007-04-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
DK2160401T3 (da) * 2007-05-11 2014-10-20 Altor Bioscience Corp Fusionsmolekyler og il-15-varianter
CN107880136B (zh) * 2010-09-21 2021-11-12 阿尔托生物科学有限公司 多聚体il-15可溶性融合分子与其制造与使用方法
EP2537933A1 (en) * 2011-06-24 2012-12-26 Institut National de la Santé et de la Recherche Médicale (INSERM) An IL-15 and IL-15Ralpha sushi domain based immunocytokines
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EP3783098A1 (en) * 2013-05-14 2021-02-24 Board Of Regents, The University Of Texas System Human application of engineered chimeric antigen receptor (car) t-cells
RU2689717C2 (ru) * 2014-01-08 2019-05-28 Шанхай Хэнжуй Фармасьютикал Ко., Лтд. Гетеродимерный белок il-15 и его применения
WO2015164107A1 (en) * 2014-04-23 2015-10-29 Emory University Compositions of gm-csf and interleukin fusions for immune modulation and uses related thereto
EP2990416B1 (en) * 2014-08-29 2018-06-20 GEMoaB Monoclonals GmbH Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders
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