JP2020508663A5 - - Google Patents
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- JP2020508663A5 JP2020508663A5 JP2019545731A JP2019545731A JP2020508663A5 JP 2020508663 A5 JP2020508663 A5 JP 2020508663A5 JP 2019545731 A JP2019545731 A JP 2019545731A JP 2019545731 A JP2019545731 A JP 2019545731A JP 2020508663 A5 JP2020508663 A5 JP 2020508663A5
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762462098P | 2017-02-22 | 2017-02-22 | |
| US62/462,098 | 2017-02-22 | ||
| US201762541439P | 2017-08-04 | 2017-08-04 | |
| US62/541,439 | 2017-08-04 | ||
| PCT/US2018/019281 WO2018156802A1 (en) | 2017-02-22 | 2018-02-22 | Compositions and methods for treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020508663A JP2020508663A (ja) | 2020-03-26 |
| JP2020508663A5 true JP2020508663A5 (https=) | 2021-04-08 |
Family
ID=63253021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019545731A Pending JP2020508663A (ja) | 2017-02-22 | 2018-02-22 | 癌の治療のための組成物及び方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20210130494A1 (https=) |
| EP (1) | EP3585817A4 (https=) |
| JP (1) | JP2020508663A (https=) |
| KR (1) | KR20200003367A (https=) |
| CN (1) | CN110637033A (https=) |
| AU (1) | AU2018225164A1 (https=) |
| BR (1) | BR112019017403A2 (https=) |
| CA (1) | CA3054304A1 (https=) |
| CL (1) | CL2019002368A1 (https=) |
| IL (1) | IL268814A (https=) |
| MA (1) | MA47613A (https=) |
| MX (1) | MX2019010040A (https=) |
| WO (1) | WO2018156802A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11643463B2 (en) | 2017-05-19 | 2023-05-09 | Wuxi Biologics (Shanghai) Co., Ltd. | Monoclonal antibodies to cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) |
| MX2020006297A (es) * | 2017-12-15 | 2020-12-07 | Aleta Biotherapeutics Inc | Variantes de cd19. |
| CN109504660B (zh) * | 2018-11-02 | 2021-08-06 | 温州启星生物技术有限公司 | 一种第四代car-t细胞及其构建方法和应用 |
| WO2020113224A2 (en) * | 2018-11-30 | 2020-06-04 | Dana-Farber Cancer Institute, Inc. | Chimeric antigen receptor factories and methods of use thereof |
| BR112021012536A2 (pt) | 2018-12-26 | 2021-09-14 | City Of Hope | Proteínas de ligação anti-ctla4 mascaradas ativáveis |
| WO2020177992A1 (en) | 2019-03-01 | 2020-09-10 | Universität Für Bodenkultur Wien | Stabilized extracellular domain of cd19 |
| CN110256582B (zh) * | 2019-07-10 | 2021-09-17 | 杭州普科亭生物医药有限公司 | 包含cd28和4-1bb的嵌合抗原受体及其应用 |
| CN115916817A (zh) * | 2019-12-06 | 2023-04-04 | 朱诺治疗学股份有限公司 | 针对bcma靶向结合结构域的抗独特型抗体及相关组合物和方法 |
| US20220057381A1 (en) * | 2020-06-08 | 2022-02-24 | Janssen Biotech, Inc. | Cell-based assay for determining the in vitro tumor killing activity of chimeric antigen expressing immune cells |
| WO2022049217A1 (en) | 2020-09-04 | 2022-03-10 | Miltenyi Biotec B.V. & Co. KG | System for inducible expression of an adapter in immune cells |
| CN116615443A (zh) | 2020-09-14 | 2023-08-18 | Vor生物制药股份有限公司 | 针对cd33的单结构域抗体 |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| CN115128267B (zh) * | 2021-03-25 | 2025-11-14 | 青岛海兰深生物科技有限公司 | 检测抗乳腺癌天然抗体的检测试剂、试剂盒及其应用 |
| WO2022214089A1 (zh) * | 2021-04-08 | 2022-10-13 | 克莱格医学有限公司 | 细胞免疫治疗的应用 |
| MX2023014352A (es) * | 2021-06-01 | 2024-03-14 | Janssen Biotech Inc | Anticuerpos antiidiotipicos contra anticuerpos anti-cd79b. |
| EP4507794A1 (en) | 2022-04-11 | 2025-02-19 | Vor Biopharma Inc. | Binding agents and methods of use thereof |
| CN115725738A (zh) * | 2022-08-17 | 2023-03-03 | 深圳市龙岗区耳鼻咽喉医院 | 一种长链非编码rna分子标志物组合及其应用 |
| WO2024238565A1 (en) | 2023-05-15 | 2024-11-21 | Vor Biopharma Inc. | Egf-like module containing mucin-like hormone-like 2 (erm2) binding agents and methods of use thereof |
| EP4470555A1 (en) | 2023-05-31 | 2024-12-04 | Miltenyi Biotec B.V. & Co. KG | Anti-tag chimeric antigen receptors with specificity for mutated peptides derived from human fgfr2 |
Family Cites Families (14)
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| JP2000511403A (ja) * | 1996-03-20 | 2000-09-05 | イムノメディクス，インコーポレイテッド | 抗癌胎児抗原抗イディオタイプ抗体のヒト化と腫瘍ワクチンとしての使用及びターゲッティング用途のための使用 |
| US20060018911A1 (en) * | 2004-01-12 | 2006-01-26 | Dana Ault-Riche | Design of therapeutics and therapeutics |
| GB0404187D0 (en) * | 2004-02-25 | 2004-03-31 | Biotransformations Ltd | Binding agents |
| CA2697032C (en) * | 2007-08-22 | 2021-09-14 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
| US20100189651A1 (en) * | 2009-01-12 | 2010-07-29 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| EP2723380B1 (en) * | 2011-06-24 | 2019-08-21 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
| GB201203442D0 (en) * | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
| AU2014268364A1 (en) * | 2013-05-24 | 2015-12-10 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
| ES3063961T3 (en) * | 2014-02-14 | 2026-04-21 | Cellectis | Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells |
| JP7020909B2 (ja) * | 2014-07-25 | 2022-02-16 | シトムクス セラピューティクス，インコーポレイティド | 抗－ｃｄ３抗体、活性化可能抗－ｃｄ３抗体、多重特異的抗－ｃｄ３抗体、多重特異的活性化可能抗－ｃｄ３抗体、及びそれらの使用方法 |
| WO2016210447A1 (en) * | 2015-06-26 | 2016-12-29 | University Of Southern California | Masking chimeric antigen receptor t cells for tumor-specific activation |
| JP7115982B2 (ja) * | 2015-10-30 | 2022-08-09 | アレタ・バイオセラピューティクス・インコーポレイテッド | 癌の治療のための組成物及び方法 |
| CR20180453A (es) * | 2016-03-22 | 2018-12-05 | Hoffmann La Roche | Moleculas biespecíficas de células t activadas por proteasas |
| CN109153727A (zh) * | 2016-04-15 | 2019-01-04 | 酵活有限公司 | 靶向免疫治疗剂的多特异性抗原结合构建体 |
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2018
- 2018-02-22 MA MA047613A patent/MA47613A/fr unknown
- 2018-02-22 EP EP18758228.3A patent/EP3585817A4/en not_active Withdrawn
- 2018-02-22 US US16/487,750 patent/US20210130494A1/en not_active Abandoned
- 2018-02-22 AU AU2018225164A patent/AU2018225164A1/en not_active Abandoned
- 2018-02-22 KR KR1020197027551A patent/KR20200003367A/ko not_active Withdrawn
- 2018-02-22 JP JP2019545731A patent/JP2020508663A/ja active Pending
- 2018-02-22 CN CN201880025774.6A patent/CN110637033A/zh active Pending
- 2018-02-22 BR BR112019017403A patent/BR112019017403A2/pt not_active IP Right Cessation
- 2018-02-22 MX MX2019010040A patent/MX2019010040A/es unknown
- 2018-02-22 CA CA3054304A patent/CA3054304A1/en not_active Abandoned
- 2018-02-22 WO PCT/US2018/019281 patent/WO2018156802A1/en not_active Ceased
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2019
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- 2019-08-22 CL CL2019002368A patent/CL2019002368A1/es unknown
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