JP2020514419A5 - - Google Patents
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- JP2020514419A5 JP2020514419A5 JP2020500010A JP2020500010A JP2020514419A5 JP 2020514419 A5 JP2020514419 A5 JP 2020514419A5 JP 2020500010 A JP2020500010 A JP 2020500010A JP 2020500010 A JP2020500010 A JP 2020500010A JP 2020514419 A5 JP2020514419 A5 JP 2020514419A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- alkyl
- substituted
- alkenyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 CCCN(CCC)C(C(CC(N)=Nc1c2)=Cc1ccc2C(Nc1cccc(C(*)=O)c1)=O)=O Chemical compound CCCN(CCC)C(C(CC(N)=Nc1c2)=Cc1ccc2C(Nc1cccc(C(*)=O)c1)=O)=O 0.000 description 3
- QVSQMRFWFRSZMS-UHFFFAOYSA-N CCCN(CCC)C(C(CC(N)=Nc1c2)=Cc1ccc2C(Nc(cc1)ccc1N(CC1)CCC1O)=O)=O Chemical compound CCCN(CCC)C(C(CC(N)=Nc1c2)=Cc1ccc2C(Nc(cc1)ccc1N(CC1)CCC1O)=O)=O QVSQMRFWFRSZMS-UHFFFAOYSA-N 0.000 description 1
- APUDKOSUPNXOIR-UHFFFAOYSA-N CCCN(CCC)C(C(CC(N)=Nc1c2)=Cc1ccc2C(Nc(cc1)ccc1N(CCC1)CC1O)=O)=O Chemical compound CCCN(CCC)C(C(CC(N)=Nc1c2)=Cc1ccc2C(Nc(cc1)ccc1N(CCC1)CC1O)=O)=O APUDKOSUPNXOIR-UHFFFAOYSA-N 0.000 description 1
- JGQSALJLSDESHS-UHFFFAOYSA-N CCCN(CCC)C1OC1C(CC(N)=Nc1c2)=Cc1ccc2C(Nc(cc1)cnc1N(CCC1)CC1NOC(c1ccccc1)=O)=O Chemical compound CCCN(CCC)C1OC1C(CC(N)=Nc1c2)=Cc1ccc2C(Nc(cc1)cnc1N(CCC1)CC1NOC(c1ccccc1)=O)=O JGQSALJLSDESHS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762471886P | 2017-03-15 | 2017-03-15 | |
| US62/471,886 | 2017-03-15 | ||
| US201762573630P | 2017-10-17 | 2017-10-17 | |
| US62/573,630 | 2017-10-17 | ||
| US201862622780P | 2018-01-26 | 2018-01-26 | |
| US62/622,780 | 2018-01-26 | ||
| PCT/US2018/022510 WO2018170179A1 (en) | 2017-03-15 | 2018-03-14 | Benzazepine compounds, conjugates, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020514419A JP2020514419A (ja) | 2020-05-21 |
| JP2020514419A5 true JP2020514419A5 (enExample) | 2021-04-30 |
Family
ID=63523998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020500010A Ceased JP2020514419A (ja) | 2017-03-15 | 2018-03-14 | ベンズアゼピン化合物、そのコンジュゲート及び使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US10239862B2 (enExample) |
| EP (2) | EP3595668B1 (enExample) |
| JP (1) | JP2020514419A (enExample) |
| KR (1) | KR20200031560A (enExample) |
| CN (1) | CN110612104A (enExample) |
| AU (1) | AU2018236272B2 (enExample) |
| BR (1) | BR112019019116A2 (enExample) |
| CA (1) | CA3055652A1 (enExample) |
| DK (1) | DK3595668T3 (enExample) |
| ES (1) | ES2894731T3 (enExample) |
| HU (1) | HUE056427T2 (enExample) |
| IL (1) | IL269283B2 (enExample) |
| MX (1) | MX2019010804A (enExample) |
| PT (1) | PT3595668T (enExample) |
| SG (5) | SG10202110183VA (enExample) |
| WO (1) | WO2018170179A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7022702B2 (ja) * | 2016-05-23 | 2022-02-18 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 第二級アミド基を有するベンズアゼピンジカルボキサミド化合物 |
| KR102726248B1 (ko) | 2016-07-07 | 2024-11-05 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 항체-애쥬번트 접합체 |
| MX2019010804A (es) | 2017-03-15 | 2020-01-23 | Silverback Therapeutics Inc | Compuestos de benzazepina, conjugados y usos de los mismos. |
| KR20200100113A (ko) * | 2017-12-15 | 2020-08-25 | 실버백 테라퓨틱스, 인크. | 간염 치료용 항체 구조물-약물 접합체 |
| AU2019270178A1 (en) | 2018-05-17 | 2021-01-07 | Bolt Biotherapeutics, Inc. | Immunoconjugates |
| EP3810640A1 (en) | 2018-06-25 | 2021-04-28 | University of Washington | De novo design of potent and selective interleukin mimetics |
| SG11202101980VA (en) * | 2018-09-12 | 2021-03-30 | Silverback Therapeutics Inc | Methods and composition for the treatment of disease with immune stimulatory conjugates |
| WO2020056194A1 (en) * | 2018-09-12 | 2020-03-19 | Silverback Therapeutics, Inc. | Benzazepine compounds, conjugates, and uses thereof |
| US20220048895A1 (en) * | 2018-09-12 | 2022-02-17 | Silverback Therapeutics, Inc. | Substituted benzazepine compounds, conjugates, and uses thereof |
| MX2021005593A (es) | 2018-11-20 | 2021-08-11 | Univ Washington | Miméticos de interleucina dividida y sus usos. |
| CA3130794A1 (en) | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| JP7675016B2 (ja) * | 2019-05-08 | 2025-05-12 | メモリアル スローン ケタリング キャンサー センター | ムチン－１６に対するヒト化抗体およびそれを使用する方法 |
| CA3142887A1 (en) * | 2019-06-13 | 2020-12-17 | Bolt Biotherapeutics, Inc. | Aminobenzazepine compounds, immunoconjugates, and uses thereof |
| US12570610B2 (en) | 2019-06-13 | 2026-03-10 | Bolt Biotherapeutics, Inc. | Macromolecule-supported aminobenzazepine compounds |
| WO2020257407A1 (en) | 2019-06-19 | 2020-12-24 | Silverback Therapeutics, Inc. | Anti-mesothelin antibodies and immunoconjugates thereof |
| BR112022002720A2 (pt) | 2019-08-15 | 2022-10-11 | Silverback Therapeutics Inc | Formulações de conjugados de benzazepinas e usos das mesmas |
| WO2021067242A1 (en) * | 2019-09-30 | 2021-04-08 | Bolt Biotherapeutics, Inc. | Amide-linked, aminobenzazepine immunoconjugates, and uses thereof |
| CA3151322A1 (en) * | 2019-10-01 | 2021-04-08 | Silverback Therapeutics, Inc. | Combination therapy with immune stimulatory conjugates |
| WO2021072330A1 (en) | 2019-10-09 | 2021-04-15 | Silverback Therapeutics, Inc. | Galnac-tgfbr1 inhibitor conjugates for the treatment of liver diseases |
| US20210130473A1 (en) | 2019-10-09 | 2021-05-06 | Silverback Therapeutics, Inc. | TGFßR1 INHIBITOR-ASGR ANTIBODY CONJUGATES AND USES THEREOF |
| US11554999B2 (en) | 2019-11-15 | 2023-01-17 | Goodrich Corporation | Inflation systems for evacuation slides and life rafts |
| EP4106819A1 (en) | 2020-02-21 | 2022-12-28 | Silverback Therapeutics, Inc. | Nectin-4 antibody conjugates and uses thereof |
| EP4121449A2 (en) | 2020-03-16 | 2023-01-25 | Neoleukin Therapeutics, Inc. | Interleukin-2 receptor beta (il-2rb) binding polypeptides |
| EP4132964A2 (en) | 2020-04-07 | 2023-02-15 | Neoleukin Therapeutics, Inc. | De novo protein decoys of angiotensin-converting enzyme 2 (ace2) |
| IL299508A (en) | 2020-07-01 | 2023-02-01 | Ars Pharmaceuticals Inc | Anti-asgr1 antibody conjugates and uses thereof |
| JP2023536629A (ja) * | 2020-08-04 | 2023-08-28 | エグゼリクシス， インコーポレイテッド | Ｃｄ４７結合性作用剤およびその使用 |
| CN116390951A (zh) * | 2020-08-04 | 2023-07-04 | 埃克塞里艾克西斯公司 | Pd-l1结合剂及其用途 |
| US20230263903A1 (en) * | 2020-08-13 | 2023-08-24 | Bolt Biotherapeutics, Inc. | Pyrazoloazepine immunoconjugates, and uses thereof |
| US20220195066A1 (en) * | 2020-12-11 | 2022-06-23 | Bolt Biotherapeutics, Inc. | Anti-cea immunoconjugates, and uses thereof |
| WO2022188740A1 (en) * | 2021-03-08 | 2022-09-15 | Genequantum Healthcare (Suzhou) Co., Ltd. | Antibody-immune agonist conjugate and applications thereof |
| CA3215049A1 (en) | 2021-04-10 | 2022-10-13 | Baiteng ZHAO | Folr1 binding agents, conjugates thereof and methods of using the same |
| WO2022226317A1 (en) | 2021-04-23 | 2022-10-27 | Profoundbio Us Co. | Anti-cd70 antibodies, conjugates thereof and methods of using the same |
| AU2022279185A1 (en) * | 2021-05-19 | 2024-01-04 | Shanghai De Novo Pharmatech Co., Ltd. | Nitrogen-containing compound, conjugate containing said compound, and application thereof |
| TW202320857A (zh) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
| WO2023044318A2 (en) | 2021-09-15 | 2023-03-23 | Neoleukin Therapeutics, Inc. | Interleukin-2 receptor βeta (il-2rβ) binding polypeptides |
| WO2023154318A1 (en) * | 2022-02-09 | 2023-08-17 | Bolt Biotherapeutics, Inc. | Anti-tr0p2, aminobenzazepine immunoconjugates, and uses thereof |
| WO2024067841A1 (zh) * | 2022-09-30 | 2024-04-04 | 上海迪诺医药科技有限公司 | 苯并氮杂卓衍生物、含其的偶联物及其应用 |
| WO2025027529A1 (en) | 2023-07-31 | 2025-02-06 | Advesya | Anti-il-1rap antibody drug conjugates and methods of use thereof |
| AR133955A1 (es) | 2023-09-26 | 2025-11-19 | Profoundbio Us Co | Agentes de unión a ptk7, conjugados de éstos y métodos de uso de los mismos |
| WO2025126157A1 (en) | 2023-12-15 | 2025-06-19 | Advesya | Anti-il-1rap binding domains and antibody-drug conjugates thereof |
| TW202547866A (zh) | 2024-01-10 | 2025-12-16 | 丹麥商珍美寶股份有限公司 | Ｓｌｉｔｒｋ６結合劑、其共軛物及使用彼之方法 |
| US20250381289A1 (en) | 2024-02-29 | 2025-12-18 | Genmab A/S | Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same |
| TW202547884A (zh) * | 2024-03-15 | 2025-12-16 | 美商艾爾維克醫療公司 | Ｍｕｃ１６／ｎａｐｉ－２ｂ抗體及使用方法 |
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| ES2293638T3 (es) | 1994-03-25 | 2008-03-16 | Isotechnika, Inc. | Mejora de la eficacia de farmacos por deuteracion. |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US6130217A (en) * | 1995-09-20 | 2000-10-10 | Pfizer Inc | Compounds enhancing antitumor activity of other cytotoxic agents |
| ATE216366T1 (de) | 1996-08-16 | 2002-05-15 | Pfizer | 2-aminobenzazepin-derivate und ihre verwendung für die behandlung von immunosuppression |
| US20040141983A1 (en) | 1999-03-15 | 2004-07-22 | Protein Design Labs, Inc. | Compositions against cancer antigen LIV-1 and uses thereof |
| US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| US7585326B2 (en) | 2004-08-06 | 2009-09-08 | Spinalmotion, Inc. | Methods and apparatus for intervertebral disc prosthesis insertion |
| EA019344B1 (ru) | 2005-07-01 | 2014-03-31 | МЕДАРЕКС, Эл.Эл.Си. | Человеческие моноклональные антитела против лиганда-1 запрограммированной гибели клеток (pd-l1) и их применения |
| TW201402124A (zh) * | 2005-08-19 | 2014-01-16 | Array Biopharma Inc | 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯 |
| JP5756804B2 (ja) | 2009-08-18 | 2015-07-29 | ベンティアールエックス ファーマシューティカルズ， インコーポレイテッドＶｅｎｔｉＲｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | Ｔｏｌｌ様レセプターモジュレーターとしての置換ベンゾアゼピン |
| RU2580320C2 (ru) | 2009-08-18 | 2016-04-10 | Вентиркс Фармасьютикалз, Инк. | Замещенные бензоазепины в качестве модуляторов toll-подобного рецептора |
| CA2793753C (en) | 2010-03-26 | 2018-06-05 | Memorial Sloan-Kettering Cancer Center | Antibodies to muc16 and methods of use thereof |
| MX379481B (es) | 2010-12-06 | 2025-03-11 | Seagen Inc | Anticuerpos humanizados a liv-1 y uso de los mismos para tratar cancer |
| WO2012097177A2 (en) | 2011-01-12 | 2012-07-19 | Ventirx Pharmaceuticals, Inc. | Substituted benzoazepines as toll-like receptor modulators |
| BR112013017943A2 (pt) | 2011-01-12 | 2018-12-18 | Array Biopharma Inc | benzoazepinas substituídas como moduladores receptores do tipo toll |
| US9034336B2 (en) * | 2011-08-30 | 2015-05-19 | Regents Of The University Of Minnesota | Immunomodulators and immunomodulator conjugates |
| US9504756B2 (en) | 2012-05-15 | 2016-11-29 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| CN112587671A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| KR101871088B1 (ko) * | 2014-01-27 | 2018-06-25 | 화이자 인코포레이티드 | 이관능성 세포독성제 |
| HUE047952T2 (hu) | 2014-04-25 | 2020-05-28 | Pf Medicament | Ellenanyag-drog konjugátum és alkalmazása rák kezelésében történõ alkalmazásra |
| CN112546230A (zh) | 2014-07-09 | 2021-03-26 | 博笛生物科技有限公司 | 用于治疗癌症的联合治疗组合物和联合治疗方法 |
| US20190100512A1 (en) | 2014-12-16 | 2019-04-04 | Celgene Corporation | Solid forms comprising (1e, 4e)-2-amino-n,n-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3h-benzo[b]azepine-4-carboxamide, compositions thereof, and uses thereof |
| WO2016096778A1 (en) | 2014-12-18 | 2016-06-23 | F. Hoffmann-La Roche Ag | Benzazepine sulfonamide compounds |
| ES2747386T3 (es) | 2015-01-14 | 2020-03-10 | Bristol Myers Squibb Co | Dímeros de benzodiacepina unidos por heteroarileno, conjugados de los mismos y métodos de preparación y uso |
| PE20171456A1 (es) | 2015-03-06 | 2017-10-06 | Hoffmann La Roche | Compuestos de dicarboxamida de benzazepinas |
| US9943416B2 (en) | 2015-03-10 | 2018-04-17 | Simplify Medical Pty Limited | Intervertebral spacer that dynamically promotes bone growth |
| WO2017180910A1 (en) | 2016-04-13 | 2017-10-19 | Siluria Technologies, Inc. | Oxidative coupling of methane for olefin production |
| LT3453707T (lt) | 2016-05-06 | 2022-03-10 | Shanghai De Novo Pharmatech Co., Ltd. | Benzazepino darinys, gamybos būdas, farmacinė kompozicija ir jos naudojimas |
| JP6918838B2 (ja) * | 2016-05-23 | 2021-08-11 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 第三級アミド基を有するベンズアゼピンジカルボキサミド化合物 |
| JP7022702B2 (ja) * | 2016-05-23 | 2022-02-18 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 第二級アミド基を有するベンズアゼピンジカルボキサミド化合物 |
| EP3468963B1 (en) | 2016-06-12 | 2021-10-27 | F. Hoffmann-La Roche AG | Dihydropyrimidinyl benzazepine carboxamide compounds |
| US20190336615A1 (en) * | 2017-01-27 | 2019-11-07 | Silverback Therapeutics, Inc. | Tumor targeting conjugates and methods of use thereof |
| EP3576782A4 (en) | 2017-02-02 | 2020-12-30 | Silverback Therapeutics, Inc. | COMPOSITIONS OF RECOMBINATION PRODUCT-PEPTIDE AND THEIR METHODS OF USE |
| MX2019010804A (es) | 2017-03-15 | 2020-01-23 | Silverback Therapeutics Inc | Compuestos de benzazepina, conjugados y usos de los mismos. |
-
2018
- 2018-03-14 MX MX2019010804A patent/MX2019010804A/es unknown
- 2018-03-14 PT PT187670120T patent/PT3595668T/pt unknown
- 2018-03-14 HU HUE18767012A patent/HUE056427T2/hu unknown
- 2018-03-14 BR BR112019019116A patent/BR112019019116A2/pt not_active IP Right Cessation
- 2018-03-14 SG SG10202110183V patent/SG10202110183VA/en unknown
- 2018-03-14 JP JP2020500010A patent/JP2020514419A/ja not_active Ceased
- 2018-03-14 SG SG10202110182P patent/SG10202110182PA/en unknown
- 2018-03-14 EP EP18767012.0A patent/EP3595668B1/en active Active
- 2018-03-14 WO PCT/US2018/022510 patent/WO2018170179A1/en not_active Ceased
- 2018-03-14 US US15/774,262 patent/US10239862B2/en active Active
- 2018-03-14 SG SG10202110181R patent/SG10202110181RA/en unknown
- 2018-03-14 SG SG10202110184X patent/SG10202110184XA/en unknown
- 2018-03-14 SG SG11201908131R patent/SG11201908131RA/en unknown
- 2018-03-14 CN CN201880030959.6A patent/CN110612104A/zh active Pending
- 2018-03-14 CA CA3055652A patent/CA3055652A1/en active Pending
- 2018-03-14 DK DK18767012.0T patent/DK3595668T3/da active
- 2018-03-14 KR KR1020197030167A patent/KR20200031560A/ko not_active Withdrawn
- 2018-03-14 ES ES18767012T patent/ES2894731T3/es active Active
- 2018-03-14 AU AU2018236272A patent/AU2018236272B2/en not_active Ceased
- 2018-03-14 EP EP21179495.3A patent/EP3949969A3/en not_active Withdrawn
- 2018-05-07 US US15/973,506 patent/US10519131B2/en not_active Expired - Fee Related
-
2019
- 2019-02-12 US US16/274,132 patent/US10442790B2/en active Active
- 2019-02-12 US US16/274,130 patent/US10428045B2/en active Active
- 2019-08-07 US US16/534,903 patent/US20200031798A1/en not_active Abandoned
- 2019-09-11 IL IL269283A patent/IL269283B2/en unknown
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