JP2020513829A5 - - Google Patents
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- JP2020513829A5 JP2020513829A5 JP2019552109A JP2019552109A JP2020513829A5 JP 2020513829 A5 JP2020513829 A5 JP 2020513829A5 JP 2019552109 A JP2019552109 A JP 2019552109A JP 2019552109 A JP2019552109 A JP 2019552109A JP 2020513829 A5 JP2020513829 A5 JP 2020513829A5
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- 239000013598 vector Substances 0.000 claims 11
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 7
- 108091008874 T cell receptors Proteins 0.000 claims 7
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 7
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 7
- 210000001744 T-lymphocyte Anatomy 0.000 claims 7
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 5
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 5
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims 4
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 4
- 102100025390 Integrin beta-2 Human genes 0.000 claims 4
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims 4
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 4
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 4
- 230000011664 signaling Effects 0.000 claims 4
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 3
- 108010029180 Sialic Acid Binding Ig-like Lectin 3 Proteins 0.000 claims 3
- 102000001555 Sialic Acid Binding Ig-like Lectin 3 Human genes 0.000 claims 3
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 3
- 230000004068 intracellular signaling Effects 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 2
- 102100027207 CD27 antigen Human genes 0.000 claims 2
- 102100025221 CD70 antigen Human genes 0.000 claims 2
- -1 CD86 Proteins 0.000 claims 2
- 102100037904 CD9 antigen Human genes 0.000 claims 2
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims 2
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims 2
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 2
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 2
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims 2
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims 2
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 2
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims 2
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 2
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 2
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 2
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 2
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 2
- 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 claims 2
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 2
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 2
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 2
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 2
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 2
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 2
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 2
- 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 claims 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000025321 B-lymphoblastic leukemia/lymphoma Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000016778 CD4+/CD56+ hematodermic neoplasm Diseases 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 208000017815 Dendritic cell tumor Diseases 0.000 claims 1
- 101000801227 Homo sapiens Tumor necrosis factor receptor superfamily member 19 Proteins 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 208000009052 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 208000017414 Precursor T-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 102100033760 Tumor necrosis factor receptor superfamily member 19 Human genes 0.000 claims 1
- 208000037832 acute lymphoblastic B-cell leukemia Diseases 0.000 claims 1
- 208000037833 acute lymphoblastic T-cell leukemia Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000013601 cosmid vector Substances 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000005134 plasmacytoid dendritic cell Anatomy 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 208000017426 precursor B-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022139092A JP7448896B2 (ja) | 2017-03-24 | 2022-09-01 | 抗ｃｄ３３免疫療法によりがんを処置するための組成物および方法 |
| JP2024021341A JP2024073443A (ja) | 2017-03-24 | 2024-02-15 | 抗ｃｄ３３免疫療法によりがんを処置するための組成物および方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762476438P | 2017-03-24 | 2017-03-24 | |
| US62/476,438 | 2017-03-24 | ||
| US201862620139P | 2018-01-22 | 2018-01-22 | |
| US62/620,139 | 2018-01-22 | ||
| PCT/US2018/024183 WO2018175988A1 (en) | 2017-03-24 | 2018-03-23 | Compositions and methods for treating cancer with anti-cd33 immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022139092A Division JP7448896B2 (ja) | 2017-03-24 | 2022-09-01 | 抗ｃｄ３３免疫療法によりがんを処置するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020513829A JP2020513829A (ja) | 2020-05-21 |
| JP2020513829A5 true JP2020513829A5 (enExample) | 2021-03-11 |
| JP7137896B2 JP7137896B2 (ja) | 2022-09-15 |
Family
ID=62090025
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019552109A Active JP7137896B2 (ja) | 2017-03-24 | 2018-03-23 | 抗ｃｄ３３免疫療法によりがんを処置するための組成物および方法 |
| JP2022139092A Active JP7448896B2 (ja) | 2017-03-24 | 2022-09-01 | 抗ｃｄ３３免疫療法によりがんを処置するための組成物および方法 |
| JP2024021341A Pending JP2024073443A (ja) | 2017-03-24 | 2024-02-15 | 抗ｃｄ３３免疫療法によりがんを処置するための組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022139092A Active JP7448896B2 (ja) | 2017-03-24 | 2022-09-01 | 抗ｃｄ３３免疫療法によりがんを処置するための組成物および方法 |
| JP2024021341A Pending JP2024073443A (ja) | 2017-03-24 | 2024-02-15 | 抗ｃｄ３３免疫療法によりがんを処置するための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10426797B2 (enExample) |
| EP (1) | EP3601356A1 (enExample) |
| JP (3) | JP7137896B2 (enExample) |
| CN (2) | CN110997719B (enExample) |
| AU (2) | AU2018240556B2 (enExample) |
| CA (1) | CA3057838A1 (enExample) |
| WO (1) | WO2018175988A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3184548A1 (en) | 2015-12-23 | 2017-06-28 | Miltenyi Biotec GmbH | Chimeric antigen receptor with cytokine receptor activating or blocking domain |
| CN117298260A (zh) | 2016-09-02 | 2023-12-29 | 莱蒂恩技术公司 | 用DuoCAR治疗癌症的组合物和方法 |
| SG11201907580SA (en) | 2017-02-17 | 2019-09-27 | Hutchinson Fred Cancer Res | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| WO2018175988A1 (en) | 2017-03-24 | 2018-09-27 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-cd33 immunotherapy |
| BR112020008638A2 (pt) | 2017-11-01 | 2020-10-20 | Juno Therapeutics Inc | receptores de antígenos quiméricos específicos para antígenos de maturação de células b (bcma) |
| AU2018359907A1 (en) | 2017-11-06 | 2020-05-07 | Fred Hutchinson Cancer Center | Combination of a cell therapy and a gamma secretase inhibitor |
| AU2019372331A1 (en) | 2018-11-01 | 2021-05-27 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for B-cell maturation antigen |
| US20220073585A1 (en) * | 2018-11-06 | 2022-03-10 | Washington University | Chimeric antigen receptor memory-like (carml) nk cells and methods of making and using same |
| AU2020212534A1 (en) * | 2019-01-22 | 2021-07-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | High affinity monoclonal antibodies targeting glypican-1 and methods of use |
| JP7650809B2 (ja) * | 2019-03-06 | 2025-03-25 | レンティジェン・テクノロジー・インコーポレイテッド | 自己駆動型キメラ抗原受容体を用いてがんを処置するための組成物および方法 |
| SG11202111130SA (en) | 2019-04-30 | 2021-11-29 | Senti Biosciences Inc | Chimeric receptors and methods of use thereof |
| BR112021021048A2 (pt) | 2019-05-04 | 2021-12-14 | Inhibrx Inc | Polipeptídeos que se ligam a cd33 e seus usos |
| CN114206928B (zh) * | 2019-05-08 | 2025-08-08 | 印希彼生物科学公司 | Cd33靶向免疫疗法 |
| CN113150167A (zh) * | 2020-01-22 | 2021-07-23 | 中国人民解放军总医院第五医学中心 | 一种能够反转pd-1免疫抑制信号的car t细胞结构em1设计 |
| CN115348973A (zh) * | 2020-03-31 | 2022-11-15 | 弗莱德哈钦森癌症中心 | 靶向cd33的嵌合抗原受体 |
| CN111848819A (zh) * | 2020-07-31 | 2020-10-30 | 广东昭泰体内生物医药科技有限公司 | 一种靶向msln的嵌合抗原受体及其应用 |
| US20250017962A1 (en) * | 2021-11-09 | 2025-01-16 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Igg4 hinge-containing chimeric antigen receptors targeting glypican-3 (gpc3) and use thereof |
| CN114133457B (zh) * | 2021-12-08 | 2022-08-19 | 郑州源创吉因实业有限公司 | 一种靶向ror1和cd33的双特异性嵌合抗原受体(car)及其应用 |
| EP4562043A2 (en) | 2022-07-28 | 2025-06-04 | Lentigen Technology, Inc. | Chimeric antigen receptor therapies for treating solid tumors |
| EP4572772A1 (en) | 2022-08-17 | 2025-06-25 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| CN119907810A (zh) | 2022-08-26 | 2025-04-29 | 莱蒂恩技术公司 | 用于用全人抗cd20/cd19免疫治疗来治疗癌症的组合物和方法 |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025006799A1 (en) | 2023-06-27 | 2025-01-02 | Capstan Therapeutics, Inc. | Extracorporeal and ex vivo engineering of select cell populations from peripheral blood |
| US20250127728A1 (en) | 2023-10-05 | 2025-04-24 | Capstan Therapeutics, Inc. | Constrained Ionizable Cationic Lipids and Lipid Nanoparticles |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| WO2025090985A1 (en) * | 2023-10-27 | 2025-05-01 | Duke University | Compositions comprising chimeric antigen receptors targeting citrullinated vimentin and methods of use thereof |
| WO2025096878A1 (en) | 2023-11-02 | 2025-05-08 | Capstan Therapeutics, Inc. | Rna for in vivo transfection with increased expression |
| WO2025129201A1 (en) | 2023-12-15 | 2025-06-19 | Capstan Therapeutics, Inc. | Humanized anti-cd8 antibodies and uses thereof |
| US20250302763A1 (en) | 2024-02-22 | 2025-10-02 | Capstan Therapeutics, Inc. | Immune engineering amplification |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| CN120485285A (zh) * | 2025-07-18 | 2025-08-15 | 天津医科大学总医院 | 一种质粒载体、嵌合mog抗体受体t细胞及其应用 |
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-
2018
- 2018-03-23 WO PCT/US2018/024183 patent/WO2018175988A1/en not_active Ceased
- 2018-03-23 AU AU2018240556A patent/AU2018240556B2/en active Active
- 2018-03-23 EP EP18721179.2A patent/EP3601356A1/en active Pending
- 2018-03-23 CA CA3057838A patent/CA3057838A1/en active Pending
- 2018-03-23 CN CN201880032715.1A patent/CN110997719B/zh active Active
- 2018-03-23 JP JP2019552109A patent/JP7137896B2/ja active Active
- 2018-03-23 CN CN202011342007.3A patent/CN112695050B/zh active Active
- 2018-03-23 US US15/934,770 patent/US10426797B2/en active Active
-
2019
- 2019-09-30 US US16/588,357 patent/US11464801B2/en active Active
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2022
- 2022-08-18 US US17/820,724 patent/US20230241103A1/en active Pending
- 2022-09-01 JP JP2022139092A patent/JP7448896B2/ja active Active
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2024
- 2024-02-15 JP JP2024021341A patent/JP2024073443A/ja active Pending
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2025
- 2025-05-26 AU AU2025203880A patent/AU2025203880A1/en active Pending
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