AU2018240556B2 - Compositions and methods for treating cancer with anti-CD33 immunotherapy - Google Patents
Compositions and methods for treating cancer with anti-CD33 immunotherapy Download PDFInfo
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- AU2018240556B2 AU2018240556B2 AU2018240556A AU2018240556A AU2018240556B2 AU 2018240556 B2 AU2018240556 B2 AU 2018240556B2 AU 2018240556 A AU2018240556 A AU 2018240556A AU 2018240556 A AU2018240556 A AU 2018240556A AU 2018240556 B2 AU2018240556 B2 AU 2018240556B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/4203—Receptors for growth factors
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- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2025203880A AU2025203880A1 (en) | 2017-03-24 | 2025-05-26 | Compositions and methods for treating cancer with anti-CD33 immunotherapy |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762476438P | 2017-03-24 | 2017-03-24 | |
| US62/476,438 | 2017-03-24 | ||
| US201862620139P | 2018-01-22 | 2018-01-22 | |
| US62/620,139 | 2018-01-22 | ||
| PCT/US2018/024183 WO2018175988A1 (en) | 2017-03-24 | 2018-03-23 | Compositions and methods for treating cancer with anti-cd33 immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2025203880A Division AU2025203880A1 (en) | 2017-03-24 | 2025-05-26 | Compositions and methods for treating cancer with anti-CD33 immunotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2018240556A1 AU2018240556A1 (en) | 2019-10-10 |
| AU2018240556B2 true AU2018240556B2 (en) | 2025-02-27 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018240556A Active AU2018240556B2 (en) | 2017-03-24 | 2018-03-23 | Compositions and methods for treating cancer with anti-CD33 immunotherapy |
| AU2025203880A Pending AU2025203880A1 (en) | 2017-03-24 | 2025-05-26 | Compositions and methods for treating cancer with anti-CD33 immunotherapy |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2025203880A Pending AU2025203880A1 (en) | 2017-03-24 | 2025-05-26 | Compositions and methods for treating cancer with anti-CD33 immunotherapy |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10426797B2 (enExample) |
| EP (1) | EP3601356A1 (enExample) |
| JP (3) | JP7137896B2 (enExample) |
| CN (2) | CN110997719B (enExample) |
| AU (2) | AU2018240556B2 (enExample) |
| CA (1) | CA3057838A1 (enExample) |
| WO (1) | WO2018175988A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3184548A1 (en) | 2015-12-23 | 2017-06-28 | Miltenyi Biotec GmbH | Chimeric antigen receptor with cytokine receptor activating or blocking domain |
| CN117298260A (zh) | 2016-09-02 | 2023-12-29 | 莱蒂恩技术公司 | 用DuoCAR治疗癌症的组合物和方法 |
| SG11201907580SA (en) | 2017-02-17 | 2019-09-27 | Hutchinson Fred Cancer Res | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| WO2018175988A1 (en) | 2017-03-24 | 2018-09-27 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-cd33 immunotherapy |
| BR112020008638A2 (pt) | 2017-11-01 | 2020-10-20 | Juno Therapeutics Inc | receptores de antígenos quiméricos específicos para antígenos de maturação de células b (bcma) |
| AU2018359907A1 (en) | 2017-11-06 | 2020-05-07 | Fred Hutchinson Cancer Center | Combination of a cell therapy and a gamma secretase inhibitor |
| AU2019372331A1 (en) | 2018-11-01 | 2021-05-27 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for B-cell maturation antigen |
| US20220073585A1 (en) * | 2018-11-06 | 2022-03-10 | Washington University | Chimeric antigen receptor memory-like (carml) nk cells and methods of making and using same |
| AU2020212534A1 (en) * | 2019-01-22 | 2021-07-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | High affinity monoclonal antibodies targeting glypican-1 and methods of use |
| JP7650809B2 (ja) * | 2019-03-06 | 2025-03-25 | レンティジェン・テクノロジー・インコーポレイテッド | 自己駆動型キメラ抗原受容体を用いてがんを処置するための組成物および方法 |
| SG11202111130SA (en) | 2019-04-30 | 2021-11-29 | Senti Biosciences Inc | Chimeric receptors and methods of use thereof |
| BR112021021048A2 (pt) | 2019-05-04 | 2021-12-14 | Inhibrx Inc | Polipeptídeos que se ligam a cd33 e seus usos |
| CN114206928B (zh) * | 2019-05-08 | 2025-08-08 | 印希彼生物科学公司 | Cd33靶向免疫疗法 |
| CN113150167A (zh) * | 2020-01-22 | 2021-07-23 | 中国人民解放军总医院第五医学中心 | 一种能够反转pd-1免疫抑制信号的car t细胞结构em1设计 |
| CN115348973A (zh) * | 2020-03-31 | 2022-11-15 | 弗莱德哈钦森癌症中心 | 靶向cd33的嵌合抗原受体 |
| CN111848819A (zh) * | 2020-07-31 | 2020-10-30 | 广东昭泰体内生物医药科技有限公司 | 一种靶向msln的嵌合抗原受体及其应用 |
| US20250017962A1 (en) * | 2021-11-09 | 2025-01-16 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Igg4 hinge-containing chimeric antigen receptors targeting glypican-3 (gpc3) and use thereof |
| CN114133457B (zh) * | 2021-12-08 | 2022-08-19 | 郑州源创吉因实业有限公司 | 一种靶向ror1和cd33的双特异性嵌合抗原受体(car)及其应用 |
| EP4562043A2 (en) | 2022-07-28 | 2025-06-04 | Lentigen Technology, Inc. | Chimeric antigen receptor therapies for treating solid tumors |
| EP4572772A1 (en) | 2022-08-17 | 2025-06-25 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| CN119907810A (zh) | 2022-08-26 | 2025-04-29 | 莱蒂恩技术公司 | 用于用全人抗cd20/cd19免疫治疗来治疗癌症的组合物和方法 |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025006799A1 (en) | 2023-06-27 | 2025-01-02 | Capstan Therapeutics, Inc. | Extracorporeal and ex vivo engineering of select cell populations from peripheral blood |
| US20250127728A1 (en) | 2023-10-05 | 2025-04-24 | Capstan Therapeutics, Inc. | Constrained Ionizable Cationic Lipids and Lipid Nanoparticles |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| WO2025090985A1 (en) * | 2023-10-27 | 2025-05-01 | Duke University | Compositions comprising chimeric antigen receptors targeting citrullinated vimentin and methods of use thereof |
| WO2025096878A1 (en) | 2023-11-02 | 2025-05-08 | Capstan Therapeutics, Inc. | Rna for in vivo transfection with increased expression |
| WO2025129201A1 (en) | 2023-12-15 | 2025-06-19 | Capstan Therapeutics, Inc. | Humanized anti-cd8 antibodies and uses thereof |
| US20250302763A1 (en) | 2024-02-22 | 2025-10-02 | Capstan Therapeutics, Inc. | Immune engineering amplification |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| CN120485285A (zh) * | 2025-07-18 | 2025-08-15 | 天津医科大学总医院 | 一种质粒载体、嵌合mog抗体受体t细胞及其应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015150526A2 (en) * | 2014-04-03 | 2015-10-08 | Cellectis | Cd33 specific chimeric antigen receptors for cancer immunotherapy |
| WO2016014576A1 (en) * | 2014-07-21 | 2016-01-28 | Novartis Ag | Treatment of cancer using a cd33 chimeric antigen receptor |
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| US20230241103A1 (en) | 2023-08-03 |
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