JP2020513019A5 - - Google Patents

Download PDF

Info

Publication number
JP2020513019A5
JP2020513019A5 JP2019554912A JP2019554912A JP2020513019A5 JP 2020513019 A5 JP2020513019 A5 JP 2020513019A5 JP 2019554912 A JP2019554912 A JP 2019554912A JP 2019554912 A JP2019554912 A JP 2019554912A JP 2020513019 A5 JP2020513019 A5 JP 2020513019A5
Authority
JP
Japan
Prior art keywords
amino
conjugate
higg4
acetyl
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2019554912A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020513019A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2018/058550 external-priority patent/WO2018185131A2/en
Publication of JP2020513019A publication Critical patent/JP2020513019A/ja
Publication of JP2020513019A5 publication Critical patent/JP2020513019A5/ja
Withdrawn legal-status Critical Current

Links

JP2019554912A 2017-04-05 2018-04-04 オリゴマー伸長インスリン−Fcコンジュゲート Withdrawn JP2020513019A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP17164950 2017-04-05
EP17164950.2 2017-04-05
EP17208780.1 2017-12-20
EP17208780 2017-12-20
EP18151228 2018-01-11
EP18151228.6 2018-01-11
CN201810276163 2018-03-30
CN201810276163.0 2018-03-30
PCT/EP2018/058550 WO2018185131A2 (en) 2017-04-05 2018-04-04 Oligomer extended insulin-fc conjugates

Publications (2)

Publication Number Publication Date
JP2020513019A JP2020513019A (ja) 2020-04-30
JP2020513019A5 true JP2020513019A5 (https=) 2021-04-22

Family

ID=61868527

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019554912A Withdrawn JP2020513019A (ja) 2017-04-05 2018-04-04 オリゴマー伸長インスリン−Fcコンジュゲート

Country Status (6)

Country Link
US (1) US11471537B2 (https=)
EP (1) EP3606560A2 (https=)
JP (1) JP2020513019A (https=)
CN (1) CN110505885A (https=)
MA (1) MA49339A (https=)
WO (1) WO2018185131A2 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2784603T3 (es) 2015-06-02 2020-09-29 Novo Nordisk As Insulinas con extensiones recombinantes polares
EP3355931B1 (en) 2015-10-01 2024-06-26 Novo Nordisk A/S Protein conjugates
JP2020513019A (ja) 2017-04-05 2020-04-30 ノヴォ ノルディスク アー/エス オリゴマー伸長インスリン−Fcコンジュゲート
US20210188895A1 (en) * 2017-10-13 2021-06-24 Bonac Corporation Single-stranded nucleic acid molecule, and production method therefor
WO2020074544A1 (en) * 2018-10-10 2020-04-16 Novo Nordisk A/S Oligomer extended insulin-fc conjugates and their medical use
BR112021005320A2 (pt) * 2018-12-17 2021-06-15 Remegen Co., Ltd. ligante para conjugados de anticorpo-fármaco e seu uso
CN111217915B (zh) * 2019-01-08 2021-05-14 东莞太力生物工程有限公司 GLP-1类似物Fc融合多肽及其应用
CN113968911B (zh) * 2020-07-24 2023-10-10 江苏晟斯生物制药有限公司 胰岛素-Fc融合蛋白及其应用
WO2023064711A2 (en) * 2021-10-14 2023-04-20 Akston Biosciences Corporation Ultra-long acting insulin-fc fusion proteins and methods of use
TWI871539B (zh) 2021-11-15 2025-02-01 美商美國禮來大藥廠 可保存之調配物
JP2025522529A (ja) * 2022-06-23 2025-07-15 サノフイ 一本鎖インスリン及びそのFc結合体
CN115947822B (zh) * 2022-07-04 2023-08-18 北京惠之衡生物科技有限公司 一种长效酰化胰岛素衍生物及其药物组合物和应用
WO2025098472A1 (zh) * 2023-11-08 2025-05-15 北京拓界生物医药科技有限公司 融合蛋白及其医药用途
JP2026031900A (ja) * 2024-07-24 2026-02-25 イーライ リリー アンド カンパニー Fc-アシル化ポリペプチドコンジュゲート
CN118955627B (zh) * 2024-10-17 2025-02-07 山东华涛食品有限公司 一种混合型抑制α-葡萄糖苷酶活性的甘薯肽组合物

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE257197C (https=)
DE286509C (https=)
US3914252A (en) 1971-03-15 1975-10-21 Continental Oil Co Preparation of N-iodocompounds
SE509359C2 (sv) 1989-08-01 1999-01-18 Cemu Bioteknik Ab Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
CA2095633C (en) 1990-12-03 2003-02-04 Lisa J. Garrard Enrichment method for variant proteins with altered binding properties
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
DK0851925T3 (da) 1995-09-21 2005-11-28 Genentech Inc Humane Væksthormonvarianter
JP4046354B2 (ja) 1996-03-18 2008-02-13 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 増大した半減期を有する免疫グロブリン様ドメイン
AU5065198A (en) 1996-11-15 1998-06-10 Maria Grazia Masucci Fusion proteins having increased half-lives
ES2297889T3 (es) 1997-07-14 2008-05-01 Bolder Biotechnology, Inc. Derivados de hormona de crecimiento y proteinas relacionadas.
US7754855B1 (en) 1999-07-13 2010-07-13 Bolder Biotechnology, Inc. Immunoglobulin fusion proteins
EP1240337B1 (en) 1999-12-24 2006-08-23 Genentech, Inc. Methods and compositions for prolonging elimination half-times of bioactive compounds
US20050287153A1 (en) 2002-06-28 2005-12-29 Genentech, Inc. Serum albumin binding peptides for tumor targeting
AU2002219021A1 (en) 2001-01-11 2002-07-24 Maxygen Aps Variant growth hormone molecules conjugated with macromolecular compounds
US20060183197A1 (en) 2001-01-11 2006-08-17 Andersen Kim V Variant growth hormone molecules conjugated with macromolecules compounds
US20020169125A1 (en) 2001-03-21 2002-11-14 Cell Therapeutics, Inc. Recombinant production of polyanionic polymers and uses thereof
EP1444262A2 (en) 2001-11-12 2004-08-11 University of Wales College of Medicine Growth hormone variations in humans and their uses
GB2384001B (en) 2001-12-14 2004-02-04 Asterion Ltd Chimeric growth hormone-growth hormone receptor proteins
EP1553975B8 (en) 2002-09-27 2023-04-12 Xencor, Inc. Optimized fc variants and methods for their generation
US20040180054A1 (en) 2003-03-13 2004-09-16 Hanmi Pharm. Co., Ltd. Physiologically active polypeptide conjugate having prolonged in vivo half-life
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
ES2383300T3 (es) 2003-11-13 2012-06-20 Hanmi Holdings Co., Ltd Fragmento Fc de IgG para un vehículo de fármacos y procedimiento para su preparación
KR100594607B1 (ko) 2004-11-03 2006-06-30 재단법인서울대학교산학협력재단 신규한 경구투여용 재조합 인간 성장호르몬 분비미생물제제 및 그 제조방법
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
BRPI0606934A2 (pt) 2005-01-25 2017-07-11 Cell Therapeutics Inc Conjugado de proteína biologicamente ativa, composição, molécula de dna quimérica, vetor, célula, e, métodos para preparar conjugado de proteína biologicamente ativa, e para determinar se um dado conjugado de proteína exibe uma meia-vida de plasma modificada comparada com a meia-vida intrínseca do polipeptídeo biologicamente ativo não conjungado
JP2008528549A (ja) 2005-01-27 2008-07-31 ノボ ノルディスク アクティーゼルスカブ 構造的に充分に定義された分岐ポリマーと接合されたインスリン誘導体
CA2601745A1 (en) 2005-02-16 2006-08-24 Novo Nordisk A/S Insulinotropic agents conjugated with structurally well defined branched polymers
KR100754667B1 (ko) 2005-04-08 2007-09-03 한미약품 주식회사 비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물
US8008443B2 (en) 2005-04-26 2011-08-30 Medimmune, Llc Modulation of antibody effector function by hinge domain engineering
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
CN101330931B (zh) 2005-12-12 2012-09-05 创新生物科学有限公司 制备缀合物
WO2007073486A2 (en) 2005-12-20 2007-06-28 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
AU2007223855B2 (en) 2006-03-06 2013-05-16 Amunix Operating Inc. Unstructured recombinant polymers and uses thereof
US9505823B2 (en) 2006-08-07 2016-11-29 TEV A Biopharmaceuticals USA, Inc. Albumin-insulin fusion proteins
RU2524150C2 (ru) 2006-09-22 2014-07-27 Ново Нордиск А/С Аналоги инсулина, устойчивые к протеазам
WO2008052108A2 (en) 2006-10-26 2008-05-02 Centocor Ortho Biotech Inc. Methods for use in human-adapting monoclonal antibodies
WO2008049711A1 (en) 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins
US20100303723A1 (en) 2006-11-20 2010-12-02 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
WO2008092117A2 (en) 2007-01-25 2008-07-31 Xencor, Inc. Immunoglobulins with modifications in the fcr binding region
KR20080095141A (ko) 2007-04-23 2008-10-28 포항공과대학교 산학협력단 인간 알부민 링커를 통하여 면역글로불린의 Fc에 결합된생리학적 활성 폴리펩티드의 융합 폴리펩티드, 및 이의제조방법
ES2623925T3 (es) 2007-05-30 2017-07-12 Postech Academy-Industry- Foundation Proteínas de fusión de inmunoglobulina
JP6071165B2 (ja) 2007-05-31 2017-02-01 ゲンマブ エー/エス 安定なIgG4抗体
WO2009015345A1 (en) 2007-07-25 2009-01-29 Amgen Inc. Pharmaceutical compositions comprising fc fusion proteins
JP2010536341A (ja) 2007-08-15 2010-12-02 アムニクス, インコーポレイテッド 生物学的に活性なポリペプチドの特性を改変するための組成物および方法
EP2203180B1 (en) * 2007-10-22 2012-11-21 Merck Serono S.A. Single ifn-beta fused to a mutated igg fc fragment
WO2009155513A2 (en) 2008-06-20 2009-12-23 Novartis Ag Immunoglobulins with reduced aggregation
WO2010001196A1 (en) 2008-07-02 2010-01-07 Koninklijke Philips Electronics N.V. V-spring configuration and end attachment assemblies therefor for use in a personal care appliance
MX2011000861A (es) 2008-07-23 2011-06-21 Hanmi Holdings Co Ltd Un complejo polipeptidico que consiste en un polimero no-peptidil que posee tres terminaciones funcionales.
ES2610356T3 (es) 2009-02-03 2017-04-27 Amunix Operating Inc. Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos
GB0914110D0 (en) 2009-08-12 2009-09-16 Medical Res Council Peptide libraries
WO2011028952A1 (en) * 2009-09-02 2011-03-10 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
CN104147611A (zh) 2009-09-30 2014-11-19 葛兰素集团有限公司 具有延长的半衰期的药物融合体和缀合物
ES2622102T3 (es) 2009-10-29 2017-07-05 Janssen Biotech, Inc. Variantes de anticuerpo de glicosilación
US8637637B2 (en) 2010-01-12 2014-01-28 Bill Nai-Chau Sun Fc fusion proteins of human growth hormone
AR081066A1 (es) * 2010-04-02 2012-06-06 Hanmi Holdings Co Ltd Conjugado de insulina donde se usa un fragmento de inmunoglobulina
US9221882B2 (en) 2010-05-21 2015-12-29 Technische Universitat Munchen Biosynthetic proline/alanine random coil polypeptides and their uses
KR101337797B1 (ko) 2010-07-14 2013-12-06 한미사이언스 주식회사 지속형 인간 성장 호르몬 결합체 액상 제제
US9783571B2 (en) 2011-04-05 2017-10-10 Warham Lance Martin Isolation of cysteine containing peptides
UA117901C2 (uk) 2011-07-06 2018-10-25 Ґенмаб Б.В. Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
JP6355563B2 (ja) 2012-02-27 2018-07-11 アムニクス オペレーティング インコーポレイテッド Xten共役組成物およびそれを製造する方法
CA2873112A1 (en) 2012-05-11 2013-11-14 Alexander Krantz Site-specific labeling and targeted delivery of proteins for the treatment of cancer
JP2016521701A (ja) 2013-06-07 2016-07-25 ノヴォ ノルディスク アー/エス 成熟インスリンポリペプチドを作製するための方法
JP6822839B2 (ja) 2013-09-13 2021-01-27 ザ・スクリップス・リサーチ・インスティテュート 修飾された治療剤、及びその組成物
WO2015081073A2 (en) 2013-11-26 2015-06-04 The Brigham And Women's Hospital, Inc. Compositions and methods for modulating an immune response
AR099569A1 (es) * 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
MX2016010951A (es) 2014-03-05 2016-11-29 Ucb Biopharma Sprl Proteinas de fc multimericas.
JP6783754B2 (ja) 2014-09-17 2020-11-11 ノヴォ ノルディスク アー/エス 組織因子経路インヒビター(1〜161)上の2つのエピトープに結合する能力がある抗体
EP3260139A4 (en) 2015-02-17 2018-09-05 Hanmi Pharm. Co., Ltd. Long-acting insulin or insulin analogue complex
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
ES2784603T3 (es) * 2015-06-02 2020-09-29 Novo Nordisk As Insulinas con extensiones recombinantes polares
CN107921030B (zh) * 2015-08-14 2024-07-02 荣昌生物制药(烟台)股份有限公司 抗体-药物偶联物的共价连接子及其制备方法与应用
EP3355931B1 (en) 2015-10-01 2024-06-26 Novo Nordisk A/S Protein conjugates
JP2020513019A (ja) 2017-04-05 2020-04-30 ノヴォ ノルディスク アー/エス オリゴマー伸長インスリン−Fcコンジュゲート

Similar Documents

Publication Publication Date Title
JP2020513019A5 (https=)
JP4698579B2 (ja) 可逆的peg化薬物
CA2739615C (en) Fgf21 mutants comprising polyethylene glycol and uses thereof
JP2020513019A (ja) オリゴマー伸長インスリン−Fcコンジュゲート
JP2012506402A5 (https=)
JP2004248677A5 (https=)
JP2006502741A5 (https=)
RU2010116152A (ru) Антитело против рецептора il-6
JP2013543497A5 (https=)
RU2007134155A (ru) Glp-1 соединения с увеличенным временем полужизни
CA2526957A1 (en) Long lasting insulin derivatives and methods thereof
HRP20161677T1 (hr) Pegilirani fab protiv amiloida beta
JP2006514607A5 (https=)
JP2022095872A5 (https=)
SA518391996B1 (ar) نظائر عامل النمو الجلدي شبيه مجال أ ببدائل حمض دهني
JP2020506685A5 (https=)
JP2021521781A5 (https=)
JP2009529509A (ja) 造血を促進する修飾分子
JP2014516049A5 (https=)
KR20160091980A (ko) Psd-95의 이량체 억제제의 지방산 유도체
JP7356677B2 (ja) 複合体
JP2022502467A (ja) オリゴマー伸長インスリン−fcコンジュゲートおよびそれらの医学的使用
JP2024500605A5 (https=)
IL314832A (en) Hiv-specific binding molecules and tcr
JP2024521092A5 (https=)