JP2021521781A5 - - Google Patents
Info
- Publication number
- JP2021521781A5 JP2021521781A5 JP2020557151A JP2020557151A JP2021521781A5 JP 2021521781 A5 JP2021521781 A5 JP 2021521781A5 JP 2020557151 A JP2020557151 A JP 2020557151A JP 2020557151 A JP2020557151 A JP 2020557151A JP 2021521781 A5 JP2021521781 A5 JP 2021521781A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- amino acid
- sequence
- acid sequence
- mutation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862659047P | 2018-04-17 | 2018-04-17 | |
| US62/659,047 | 2018-04-17 | ||
| PCT/US2019/027816 WO2019204398A1 (en) | 2018-04-17 | 2019-04-17 | Trivalent trispecific antibody constructs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021521781A JP2021521781A (ja) | 2021-08-30 |
| JP2021521781A5 true JP2021521781A5 (https=) | 2022-04-22 |
Family
ID=68240367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020557151A Pending JP2021521781A (ja) | 2018-04-17 | 2019-04-17 | 三価三重特異性抗体構築物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20210179734A1 (https=) |
| JP (1) | JP2021521781A (https=) |
| KR (1) | KR20200143730A (https=) |
| CN (1) | CN112384243A (https=) |
| AU (1) | AU2019255270A1 (https=) |
| BR (1) | BR112020021279A2 (https=) |
| CA (1) | CA3097605A1 (https=) |
| IL (1) | IL278073A (https=) |
| MX (1) | MX2020011027A (https=) |
| WO (1) | WO2019204398A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018005232A (es) * | 2015-11-03 | 2018-08-15 | Ambrx Inc | Anticuerpos anti-cd3 novedosos y sus usos. |
| CN110177805B (zh) * | 2016-10-19 | 2024-04-02 | 英温拉公司 | 抗体构建体 |
| CN113563473A (zh) * | 2020-04-29 | 2021-10-29 | 三生国健药业（上海）股份有限公司 | 四价双特异性抗体、其制备方法和用途 |
| TW202216777A (zh) * | 2020-07-10 | 2022-05-01 | 美商生質分子控股有限責任公司 | 四面體抗體 |
| MX2023008966A (es) * | 2021-02-07 | 2023-09-29 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Anticuerpo biespecifico. |
| JP2024527977A (ja) | 2021-07-27 | 2024-07-26 | ノヴァブ， インコーポレイテッド | 免疫エフェクター機能を有する操作されたｖｌｒｂ抗体 |
| TW202506725A (zh) * | 2023-04-07 | 2025-02-16 | 美商麥迪紐有限責任公司 | 三特異性工程化抗體 |
| EP4702058A2 (en) * | 2023-04-28 | 2026-03-04 | Xencor, Inc. | Orthogonal multimeric proteins |
| AU2024341660A1 (en) * | 2023-09-11 | 2026-03-12 | Evolveimmune Therapeutics, Inc. | Bispecific antibody fusion molecules targeting b7-h4 and cd3 and methods of use thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006074399A2 (en) * | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
| WO2014116846A2 (en) * | 2013-01-23 | 2014-07-31 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
| LT2961771T (lt) * | 2013-02-26 | 2020-03-10 | Roche Glycart Ag | Bispecifinės t ląstelę aktyvinančios antigeną surišančios molekulės, specifinės cd3 ir cea antigenams |
| SG11201608054YA (en) * | 2014-04-02 | 2016-10-28 | Hoffmann La Roche | Method for detecting multispecific antibody light chain mispairing |
| EA035419B9 (ru) * | 2014-05-29 | 2020-08-07 | Мэкроудженикс, Инк. | Триспецифичные связывающие молекулы и способы их применения |
| DK3221357T3 (da) * | 2014-11-20 | 2020-08-10 | Hoffmann La Roche | Fælles letkæder og fremgangsmåder til anvendelse |
| EP4141032B1 (en) * | 2014-11-20 | 2024-05-29 | F. Hoffmann-La Roche AG | Combination therapy of t cell activating bispecific antigen binding molecules and pd-1 axis binding antagonists |
| WO2016087650A1 (en) * | 2014-12-05 | 2016-06-09 | Merck Patent Gmbh | Domain-exchanged antibody |
| CN107531788B (zh) * | 2015-06-24 | 2022-06-21 | 豪夫迈·罗氏有限公司 | 对her2和血脑屏障受体特异性的三特异性抗体及使用方法 |
| JP2018536389A (ja) * | 2015-10-02 | 2018-12-13 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | メソテリンとｃｄ３に結合する二重特異性細胞活性化抗原結合分子 |
| EP3156417A1 (en) * | 2015-10-13 | 2017-04-19 | Affimed GmbH | Multivalent fv antibodies |
| CA3020633A1 (en) * | 2016-04-13 | 2017-10-19 | Sanofi | Trispecific and/or trivalent binding proteins |
| GEP20227398B (en) * | 2016-04-15 | 2022-07-25 | Macrogenics Inc | Novel b7-h3 binding molecules, antibody drug conjugates thereof and usage thereof |
-
2019
- 2019-04-17 CN CN201980040529.7A patent/CN112384243A/zh active Pending
- 2019-04-17 KR KR1020207032932A patent/KR20200143730A/ko not_active Ceased
- 2019-04-17 CA CA3097605A patent/CA3097605A1/en active Pending
- 2019-04-17 BR BR112020021279-2A patent/BR112020021279A2/pt unknown
- 2019-04-17 JP JP2020557151A patent/JP2021521781A/ja active Pending
- 2019-04-17 AU AU2019255270A patent/AU2019255270A1/en not_active Abandoned
- 2019-04-17 WO PCT/US2019/027816 patent/WO2019204398A1/en not_active Ceased
- 2019-04-17 US US17/048,482 patent/US20210179734A1/en not_active Abandoned
- 2019-04-17 MX MX2020011027A patent/MX2020011027A/es unknown
-
2020
- 2020-10-15 IL IL278073A patent/IL278073A/en unknown
-
2023
- 2023-06-15 US US18/335,995 patent/US20250026861A1/en not_active Abandoned
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