JP2024534545A5 - - Google Patents

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Publication number
JP2024534545A5
JP2024534545A5 JP2024518144A JP2024518144A JP2024534545A5 JP 2024534545 A5 JP2024534545 A5 JP 2024534545A5 JP 2024518144 A JP2024518144 A JP 2024518144A JP 2024518144 A JP2024518144 A JP 2024518144A JP 2024534545 A5 JP2024534545 A5 JP 2024534545A5
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JP
Japan
Prior art keywords
amino acid
seq
fragment
acid sequence
immune complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024518144A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024534545A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CN2022/120265 external-priority patent/WO2023045977A1/zh
Publication of JP2024534545A publication Critical patent/JP2024534545A/ja
Publication of JP2024534545A5 publication Critical patent/JP2024534545A5/ja
Pending legal-status Critical Current

Links

JP2024518144A 2021-09-22 2022-09-21 インターロイキン２変異体およびその融合タンパク質 Pending JP2024534545A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202111110032 2021-09-22
CN202111110032.3 2021-09-22
PCT/CN2022/120265 WO2023045977A1 (zh) 2021-09-22 2022-09-21 白介素2突变体以及其融合蛋白

Publications (2)

Publication Number Publication Date
JP2024534545A JP2024534545A (ja) 2024-09-20
JP2024534545A5 true JP2024534545A5 (https=) 2025-11-11

Family

ID=85720093

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024518144A Pending JP2024534545A (ja) 2021-09-22 2022-09-21 インターロイキン２変異体およびその融合タンパク質

Country Status (14)

Country Link
US (2) US20240391973A1 (https=)
EP (1) EP4406965A4 (https=)
JP (1) JP2024534545A (https=)
KR (1) KR20240082364A (https=)
CN (1) CN118119635A (https=)
AU (2) AU2022350407B2 (https=)
CA (1) CA3233075A1 (https=)
CL (1) CL2024000834A1 (https=)
CO (1) CO2024004910A2 (https=)
IL (1) IL311643A (https=)
MX (1) MX2024003535A (https=)
PE (1) PE20241994A1 (https=)
TW (1) TWI858393B (https=)
WO (1) WO2023045977A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3854805A4 (en) 2018-09-21 2022-08-24 Innovent Biologics (Suzhou) Co., Ltd. NOVEL INTERLEUKIN 2 AND ITS USE
JP2023518434A (ja) * 2020-03-19 2023-05-01 イノベント バイオロジクス（スーチョウ）カンパニー，リミティド インターロイキン２変異体およびその使用
WO2025007037A1 (en) * 2023-06-28 2025-01-02 Dragonfly Therapeutics, Inc. Variant il-2 proteins
WO2025031434A1 (zh) * 2023-08-08 2025-02-13 北京志道生物科技有限公司 经修饰的细胞因子与cd40激动剂的联用组合物及其抗肿瘤用途
WO2025140535A1 (zh) * 2023-12-28 2025-07-03 福佑泰生物制药（新加坡）公司 Pd-1/il-2r双特异性抗体融合蛋白及其用途和使用方法
CN118373896B (zh) * 2024-04-19 2025-07-29 上海科棋药业科技有限公司 抗pd-1抗体与il-2突变体的双功能融合蛋白
WO2025252212A1 (zh) * 2024-06-07 2025-12-11 福佑泰生物制药公司 抗pd-1抗体与细胞因子il-12突变蛋白的免疫缀合物以及其应用
WO2026012466A1 (en) * 2024-07-12 2026-01-15 Vibrant Pharma Limited Interleukin-2 muteins and uses thereof
CN118546233B (zh) * 2024-07-30 2024-10-18 成都微芯新域生物技术有限公司 白介素-21突变体及其应用
CN121293311A (zh) * 2025-08-01 2026-01-09 合肥天港免疫药物有限公司 Il-2变体及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518584A (en) 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
NZ234674A (en) * 1989-08-02 1992-02-25 Seragen Inc Mutant interleukin-2,dna encoding it, host cells, cytotoxic and toxin-mutant il-2 conjugates
DZ2788A1 (fr) 1998-05-15 2003-12-01 Bayer Ag Agonistes et antagonistes selectifs à IL-2.
US6955807B1 (en) * 1998-05-15 2005-10-18 Bayer Pharmaceuticals Corporation IL-2 selective agonists and antagonists
WO2017024465A1 (en) * 2015-08-10 2017-02-16 Innovent Biologics (Suzhou) Co., Ltd. Pd-1 antibodies
MY201482A (en) 2017-04-03 2024-02-26 Hoffmann La Roche Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15
JP7148539B2 (ja) * 2017-04-03 2022-10-05 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 免疫抱合体
IL275426B2 (en) * 2017-12-19 2025-03-01 Xencor Inc Engineered il-2 fc fusion proteins
US12280118B2 (en) * 2017-12-27 2025-04-22 Kyowa Kirin Co., Ltd. IL-2 variant
EP3854805A4 (en) * 2018-09-21 2022-08-24 Innovent Biologics (Suzhou) Co., Ltd. NOVEL INTERLEUKIN 2 AND ITS USE
WO2020252418A2 (en) * 2019-06-14 2020-12-17 Cugene, Inc. Novel interleukin-2 variants for the treatment of cancer
WO2020252421A2 (en) * 2019-06-14 2020-12-17 Cugene, Inc. Novel interleukin-2 variants and bifunctional fusion molecules thereof
JP2023518434A (ja) * 2020-03-19 2023-05-01 イノベント バイオロジクス（スーチョウ）カンパニー，リミティド インターロイキン２変異体およびその使用
AU2021237518B2 (en) * 2020-03-19 2024-08-15 Fortvita Biologics (Singapore) Pte.Ltd. Interleukin-2 mutant and use thereof

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