JP2020512302A5 - - Google Patents
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- JP2020512302A5 JP2020512302A5 JP2019545923A JP2019545923A JP2020512302A5 JP 2020512302 A5 JP2020512302 A5 JP 2020512302A5 JP 2019545923 A JP2019545923 A JP 2019545923A JP 2019545923 A JP2019545923 A JP 2019545923A JP 2020512302 A5 JP2020512302 A5 JP 2020512302A5
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- optionally substituted
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- 150000001875 compounds Chemical class 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 229920000642 polymer Polymers 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000011780 sodium chloride Substances 0.000 claims 7
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 5
- 125000001931 aliphatic group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000004432 carbon atoms Chemical group C* 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drugs Drugs 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N Thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- 230000000975 bioactive Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 230000001225 therapeutic Effects 0.000 claims 2
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 1
- 229960000643 Adenine Drugs 0.000 claims 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Natural products NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- 208000006673 Asthma Diseases 0.000 claims 1
- OPTASPLRGRRNAP-UHFFFAOYSA-N Cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 1
- 229940104302 Cytosine Drugs 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108010008165 Etanercept Proteins 0.000 claims 1
- 108020005128 Glycosidases Proteins 0.000 claims 1
- UYTPUPDQBNUYGX-UHFFFAOYSA-N Guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 1
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims 1
- 108090000604 Hydrolases Proteins 0.000 claims 1
- 102000004157 Hydrolases Human genes 0.000 claims 1
- 108010019598 Liraglutide Proteins 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 229960000470 Omalizumab Drugs 0.000 claims 1
- 108010029597 Omalizumab Proteins 0.000 claims 1
- 108020005203 Oxidases Proteins 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 108091005771 Peptidases Proteins 0.000 claims 1
- 102000035443 Peptidases Human genes 0.000 claims 1
- 229940113082 Thymine Drugs 0.000 claims 1
- 229940035893 Uracil Drugs 0.000 claims 1
- 206010046736 Urticarias Diseases 0.000 claims 1
- 230000002378 acidificating Effects 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 230000002009 allergen Effects 0.000 claims 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000001684 chronic Effects 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960000403 etanercept Drugs 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- YSDQQAXHVYUZIW-QCIJIYAXSA-N liraglutide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 YSDQQAXHVYUZIW-QCIJIYAXSA-N 0.000 claims 1
- 229960002701 liraglutide Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- -1 poly (alkylene glycol Chemical compound 0.000 claims 1
- 229920000765 poly(2-oxazolines) Polymers 0.000 claims 1
- 229920001583 poly(oxyethylated polyols) Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 235000019833 protease Nutrition 0.000 claims 1
- 239000002342 ribonucleoside Substances 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 0 CCC(C(C)C)C1C*CC1 Chemical compound CCC(C(C)C)C1C*CC1 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022155899A JP7381684B2 (ja) | 2017-03-10 | 2022-09-29 | 遊離可能コンジュゲート |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762469989P | 2017-03-10 | 2017-03-10 | |
| US62/469,989 | 2017-03-10 | ||
| US201762564820P | 2017-09-28 | 2017-09-28 | |
| US62/564,820 | 2017-09-28 | ||
| PCT/IB2018/051579 WO2018163131A1 (en) | 2017-03-10 | 2018-03-10 | Releasable conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022155899A Division JP7381684B2 (ja) | 2017-03-10 | 2022-09-29 | 遊離可能コンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020512302A JP2020512302A (ja) | 2020-04-23 |
| JP2020512302A5 true JP2020512302A5 (US06780888-20040824-C00057.png) | 2021-04-22 |
| JP7152408B2 JP7152408B2 (ja) | 2022-10-12 |
Family
ID=61764062
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019545923A Active JP7152408B2 (ja) | 2017-03-10 | 2018-03-10 | 遊離可能コンジュゲート |
| JP2022155899A Active JP7381684B2 (ja) | 2017-03-10 | 2022-09-29 | 遊離可能コンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022155899A Active JP7381684B2 (ja) | 2017-03-10 | 2022-09-29 | 遊離可能コンジュゲート |
Country Status (11)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110545850A (zh) | 2017-03-10 | 2019-12-06 | 奎亚培格制药公司 | 可释放的缀合物 |
| CA3086651C (en) | 2018-03-09 | 2023-01-17 | Quiapeg Pharmaceuticals Ab | Releasable antibody conjugates |
| WO2020053815A1 (en) | 2018-09-12 | 2020-03-19 | Quiapeg Pharmaceuticals Ab | Releasable glp-1 conjugates |
| CN111175387B (zh) * | 2018-11-13 | 2022-06-07 | 成都康弘药业集团股份有限公司 | 一种米那普仑异构体的检测方法 |
| US10768173B1 (en) | 2019-09-06 | 2020-09-08 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
| CN112168820B (zh) * | 2019-07-05 | 2023-09-29 | 中国科学院生物物理研究所 | SRCAP ATPase抑制剂在结直肠癌治疗中的应用 |
| US11287422B2 (en) | 2019-09-23 | 2022-03-29 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
| KR102398574B1 (ko) | 2019-10-10 | 2022-05-13 | 주식회사 엘지에너지솔루션 | 전지 모듈 및 이를 포함하는 전지 팩 |
| CN110946844A (zh) * | 2019-12-11 | 2020-04-03 | 正大制药（青岛）有限公司 | 一种含有艾地骨化醇的复方控释制剂 |
| CN113456824B (zh) * | 2020-03-31 | 2023-03-31 | 四川大学华西医院 | 一种抗肿瘤载药纳米复合材料 |
| WO2022029178A1 (en) | 2020-08-05 | 2022-02-10 | Ascendis Pharma A/S | Conjugates comprising reversible linkers and uses thereof |
| CN112138170B (zh) * | 2020-09-28 | 2022-05-20 | 广东药科大学 | 一种预防顺铂药源性聋的缀合物及其制备方法和应用 |
| CN112316156B (zh) * | 2020-10-27 | 2022-03-15 | 四川大学 | 具抗氧化和抗菌性的胶原蛋白修复膜、其制备方法及应用 |
| CN112402620A (zh) * | 2020-12-07 | 2021-02-26 | 南开大学 | 肿瘤微环境还原响应性的纳米药物及其制备方法 |
| CN112457383B (zh) * | 2020-12-16 | 2022-06-17 | 阿南达 | 一种多肽、制备方法及其医药用途 |
| CN112516285B (zh) * | 2020-12-18 | 2022-09-02 | 中南大学 | 一种预防或治疗缺血/再灌注损伤的药物组合物及应用 |
| CN112574272B (zh) * | 2020-12-25 | 2021-09-21 | 中国医学科学院药用植物研究所 | 一种灵芝酸a衍生物的制备及其应用 |
| WO2022166720A1 (zh) * | 2021-02-05 | 2022-08-11 | 华南理工大学 | 基于血清白蛋白的融合蛋白、纳米组装体及其制备方法和应用 |
| CN112999196B (zh) * | 2021-03-03 | 2023-04-28 | 西安医学院 | 用于长效稳定释放的吗替麦考酚酯纳米制剂及其制备方法 |
| CN113133989B (zh) * | 2021-03-09 | 2023-04-25 | 西安医学院 | 一种用于抗结核药物利福平的长效制剂及制备方法 |
| CN114617876B (zh) * | 2022-01-28 | 2023-04-07 | 四川大学华西医院 | 一种抗肿瘤联合用药物 |
| CN114886817B (zh) * | 2022-06-02 | 2023-06-27 | 杭州配方师科技有限公司 | 一种弗来歇氏柳叶菜和酵母菌锌发酵复合物、制备方法及应用 |
| WO2023244517A1 (en) * | 2022-06-16 | 2023-12-21 | Merck Sharp & Dohme Llc | Interleukin-2 prodrugs |
| KR102623104B1 (ko) * | 2023-08-23 | 2024-01-11 | 에프아이씨씨주식회사 | 보툴리눔톡신 결합체와 줄기세포 엑소좀 복합체를 유효성분으로 함유하는 피부 재생 및 주름 개선용 화장료 조성물 및 그의 제조 방법 |
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| WO2016145536A1 (en) | 2015-03-18 | 2016-09-22 | Immunobiochem Corporation | Conjugates for the treatment of cancer targeted at intracellular tumor-associated antigens |
| TWI715611B (zh) | 2015-08-14 | 2021-01-11 | 美商Ｒｃ生物科技公司 | 抗體藥物偶聯物的共價鍵連接子及其製備方法與應用 |
| WO2017118693A1 (en) | 2016-01-08 | 2017-07-13 | Ascendis Pharma Growth Disorders A/S | Cnp prodrugs with large carrier moieties |
| EP3400019B1 (en) | 2016-01-08 | 2022-09-28 | Ascendis Pharma Growth Disorders A/S | Cnp prodrugs with carrier attachment at the ring moiety |
| GB201607827D0 (en) | 2016-05-04 | 2016-06-15 | Bicycle Therapeutics Ltd | Bicyclic peptide-toxin conjugates specific for MT1-MMP |
| US10624968B2 (en) | 2017-01-06 | 2020-04-21 | Bicyclerd Limited | Compounds for treating cancer |
| CN110545850A (zh) | 2017-03-10 | 2019-12-06 | 奎亚培格制药公司 | 可释放的缀合物 |
| CA3086651C (en) * | 2018-03-09 | 2023-01-17 | Quiapeg Pharmaceuticals Ab | Releasable antibody conjugates |
| WO2020053815A1 (en) * | 2018-09-12 | 2020-03-19 | Quiapeg Pharmaceuticals Ab | Releasable glp-1 conjugates |
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2018
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- 2018-03-10 CA CA3051173A patent/CA3051173A1/en active Pending
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- 2018-03-10 WO PCT/IB2018/051579 patent/WO2018163131A1/en active Application Filing
- 2018-03-10 JP JP2019545923A patent/JP7152408B2/ja active Active
- 2018-03-10 DK DK18713014.1T patent/DK3592393T3/da active
- 2018-03-10 BR BR112019017103A patent/BR112019017103A2/pt active Search and Examination
- 2018-03-10 EP EP21208889.2A patent/EP4011396A1/en active Pending
- 2018-03-10 KR KR1020197024541A patent/KR20190125310A/ko not_active Application Discontinuation
- 2018-03-10 SI SI201830575T patent/SI3592393T1/sl unknown
- 2018-03-10 EP EP18713014.1A patent/EP3592393B1/en active Active
- 2018-03-12 US US15/918,944 patent/US11786599B2/en active Active
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2022
- 2022-09-29 JP JP2022155899A patent/JP7381684B2/ja active Active
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2023
- 2023-08-15 US US18/234,142 patent/US20230381323A1/en active Pending
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2024
- 2024-02-26 AU AU2024201279A patent/AU2024201279A1/en active Pending
